Search Results - "SCHEIDTMANN, Karl"

Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation by Friedrichs, Nicolaus, Metzger, Eric, Fischer, Kristin, Yin, Na, Potier, Noelle, Higgins, Jonathan M. G, Buettner, Reinhard, Schüle, Roland, Wissmann, Melanie, Patnaik, Debasis, Kunowska, Natalia, Scheidtmann, Karl-Heinz

“…Posttranslational modifications of histones such as methylation, acetylation and phosphorylation regulate chromatin structure and gene expression. Here we show…”
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Par-4 is an essential downstream target of DAP-like kinase (Dlk) in Dlk/Par-4-mediated apoptosis by Boosen, Meike, Vetterkind, Susanne, Kubicek, Jan, Scheidtmann, Karl-Heinz, Illenberger, Susanne, Preuss, Ute

“…Prostate apoptosis response-4 (Par-4) was initially identified as a gene product up-regulated in prostate cancer cells undergoing apoptosis. In rat…”
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DNA Substrate Dependence of p53-Mediated Regulation of Double-Strand Break Repair by Akyuez, N, Boehden, G S, Suesse, S, Rimek, A, Preuss, U, Scheidtmann, K, Wiesmueller, L

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Novel mitosis‐specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase by Preuss, Ute, Landsberg, Gerd, Scheidtmann, Karl Heinz

“…Death‐associated protein (DAP)‐like kinase (Dlk), also known as Zipper interacting protein (ZIP) kinase, is a nuclear serine/threonine‐specific kinase that…”
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Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants by Restle, Anja, Färber, Martin, Baumann, Cindy, Böhringer, Michael, Scheidtmann, Karl Heinz, Müller-Tidow, Carsten, Wiesmüller, Lisa

“…Regulation of homologous recombination (HR) represents the best-characterized DNA repair function of p53. The role of p53 phosphorylation in DNA repair is…”
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Interaction partners of Dlk/ZIP kinase : co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis by PAGE, G, KÖGEL, D, RANGNEKAR, V, SCHEIDTMANN, K. H

“…Dlk/ZIP kinase is a newly discovered serine/threonine kinase which, due to its homology to DAP kinase, was named DAP like kinase, Dlk. This kinase is tightly…”
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Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis by Vetterkind, Susanne, Illenberger, Susanne, Kubicek, Jan, Boosen, Meike, Appel, Sarah, Naim, Hassan Y., Scheidtmann, Karl-Heinz, Preuss, Ute

“…Prostate apoptosis response-4 (Par-4) is a 38-kDa protein originally identified as a gene product upregulated in prostate cancer cells undergoing apoptosis…”
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TSG101 Interacts with Apoptosis-antagonizing Transcription Factor and Enhances Androgen Receptor-mediated Transcription by Promoting Its Monoubiquitination by Burgdorf, Sven, Leister, Peter, Scheidtmann, Karl Heinz

“…Apoptosis-antagonizing transcription factor (AATF), also termed Che-1, was identified as interacting protein of Dlk/ZIP kinase and RNA polymerase II,…”
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Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones by KÖGEL, D, PLÖTTNER, O, LANDSBERG, G, CHRISTIAN, S, SCHEIDTMANN, K. H

“…We cloned a cDNA coding for a novel serine/threonine kinase, Dlk, a protein of 448 amino acids with a predicted molecular weight of 51.3 kDa. The kinase domain…”
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Tumor‐derived p53 mutant C174Y is a gain‐of‐function mutant which activates the fos promoter and enhances colony formation by Preuss, Ute, Kreutzfeld, Rene, Scheidtmann, Karl‐Heinz

“…SV40 large T antigen–induced primitive neuroectodermal tumors of the rat provide a model system to study induction and progression of primitive neuroectodermal…”
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The Rat Homologue of Wiskott-Aldrich Syndrome Protein (WASP)-interacting Protein (WIP) Associates with Actin Filaments, Recruits N-WASP from the Nucleus, and Mediates Mobilization of Actin from Stress Fibers in Favor of Filopodia Formation by Vetterkind, Susanne, Miki, Hiroaki, Takenawa, Tadaomi, Klawitz, Ingrid, Scheidtmann, Karl-Heinz, Preuss, Ute

“…We cloned and characterized the rat homologue of the Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP). Rat WIP shows 86% amino acid sequence…”
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Ectopic expression of Par-4 leads to induction of apoptosis in CNS tumor cell lines by Vetterkind, Susanne, Boosen, Meike, Scheidtmann, Karl-Heinz, Preuss, Ute

“…Prostate apoptosis response-4 (Par-4) is a pro-apoptotic protein originally identified as a gene product upregulated in prostate tumor cells undergoing…”
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Protein Phosphatase 2A is Required for the Initiation of Chromosomal DNA Replication by Lin, Xiao-Hong, Walter, Johannes, Scheidtmann, Karl, Ohst, Kim, Newport, John, Walter, Gernot

“…Protein phosphatase 2A (PP2A) is an abundant, multifunctional serine/threonine-specific phosphatase that stimulates simian virus 40 DNA replication. The…”
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C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity by KÖGEL, D, BIERBAUM, H, PREUSS, U, SCHEIDTMANN, K. H

“…Dlk (also termed ZIP kinase) is a novel serine/threonine kinase with a unique C-terminal domain that is rich in arginine and contains three putative NLS motifs…”
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The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game by Kögel, Donat, Prehn, Jochen H.M., Scheidtmann, Karl Heinz

“…The DAP (Death Associated Protein) kinase family is a novel subfamily of pro‐apoptotic serine/threonine kinases. All five DAP kinase family members identified…”
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Regulation of p53 mediated transactivation by the β-subunit of protein kinase CK2 by Schuster, Norbert, Prowald, Alexandra, Schneider, Eberhard, Scheidtmann, Karl-Heinz, Montenarh, Mathias

“…The growth suppressor protein p53 plays a main part in cellular growth control. Two of its key functions are sequence specific DNA binding and transactivation…”
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Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping by WEGGEN, Sascha, PREUSS, Ute, PIETSCH, Torsten, HILGER, Norbert, KLAWITZ, Ingrid, SCHEIDTMANN, Karl-Heinz, WIESTLER, Otmar D, BAYER, Thomas A

“…Primitive neuroectodermal tumors (PNETs) such as human medulloblastomas are genetically heterogeneous and therefore poorly understood. In a rat model the SV40…”
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Interaction of SV40 large T antigen with components of the nucleo/cytoskeleton by Klawitz, I, Preuss, U, Scheidtmann, K H

“…The SV40 large T antigen is a viral oncoprotein which performs multiple interactions with cellular factors to achieve a proliferative state required for viral…”
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Characterization of Neural Cell Lines Derived from SV40 Large T-Induced Primitive Neuroectodermal Tumors by Weggen, Sascha, Bayer, Thomas A., Koch, Anke, Salewski, Holger, Scheidtmann, Karl-Heinz, Pietsch, Torsten, Wiestler, Otmar D.

“…We recently reported intriguing properties of neural tumors generated by retrovirus‐mediated transfer of the SV40 large T antigen into fetal rat brain…”
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DAP-like kinase, a member of the death-associated protein kinase family, associates with centrosomes, centromers, and the contractile ring during mitosis by Preuss, Ute, Bierbaum, Hanna, Buchenau, Peter, Scheidtmann, Karl Heinz

“…DAP-like kinase (Dlk) is a nuclear serine/threonine-specific kinase which has been implicated in apoptosis. However, induction of apoptosis by Dlk requires its…”
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