Search Results - "SCHEFF, Jeremy D"

Mathematical Modeling of the Heat-Shock Response in HeLa Cells by Scheff, Jeremy D., Stallings, Jonathan D., Reifman, Jaques, Rakesh, Vineet

“…The heat-shock response is a key factor in diverse stress scenarios, ranging from hyperthermia to protein folding diseases. However, the complex dynamics of…”
Get full text

Assessment of Pharmacologic Area Under the Curve When Baselines are Variable by Scheff, Jeremy D., Almon, Richard R., DuBois, Debra C., Jusko, William J., Androulakis, Ioannis P.

“…ABSTRACT Purpose The area under the curve (AUC) is commonly used to assess the extent of exposure of a drug. The same concept can be applied to generally…”
Get full text

Transcriptional implications of ultradian glucocorticoid secretion in homeostasis and in the acute stress response by Scheff, Jeremy D, Calvano, Steve E, Lowry, Stephen F, Androulakis, Ioannis P

“…Endogenous glucocorticoids are secreted by the hypothalamic-pituitary-adrenal (HPA) axis in response to a wide range of stressors. Glucocorticoids exert…”
Get full text

On heart rate variability and autonomic activity in homeostasis and in systemic inflammation by Scheff, Jeremy D., Griffel, Benjamin, Corbett, Siobhan A., Calvano, Steve E., Androulakis, Ioannis P.

“…•Study models describing the relationship between the autonomic nervous system and patterns of HRV.•Incorporate high frequency autonomic oscillations and…”
Get full text

The Impact of Stochasticity and Its Control on a Model of the Inflammatory Response by Mavroudis, Panteleimon D., Scheff, Jeremy D., Doyle, John C., Vodovotz, Yoram, Androulakis, Ioannis P.

“…The dysregulation of inflammation, normally a self-limited response that initiates healing, is a critical component of many diseases. Treatment of inflammatory…”
Get full text

Modeling the influence of circadian rhythms on the acute inflammatory response by Scheff, Jeremy D., Calvano, Steve E., Lowry, Stephen F., Androulakis, Ioannis P.

“…A wide variety of modeling techniques have been applied towards understanding inflammation. These models have broad potential applications, from optimizing…”
Get full text

Entrainment of peripheral clock genes by cortisol by Mavroudis, Panteleimon D, Scheff, Jeremy D, Calvano, Steve E, Lowry, Stephen F, Androulakis, Ioannis P

“…Circadian rhythmicity in mammals is primarily driven by the suprachiasmatic nucleus (SCN), often called the central pacemaker, which converts the photic…”
Get full text

Predicting critical transitions in a model of systemic inflammation by Scheff, Jeremy D., Calvano, Steve E., Androulakis, Ioannis P.

“…The human body can be viewed as a dynamical system, with physiological states such as health and disease broadly representing steady states. From this…”
Get full text

Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia by Scheff, Jeremy D, Mavroudis, Panteleimon D, Calvano, Steven E, Lowry, Stephen F, Androulakis, Ioannis P

“…Heart rate variability (HRV), the quantification of beat-to-beat variability, has been studied as a potential prognostic marker in inflammatory diseases such…”
Get full text

A late-binding, distributed, NoSQL warehouse for integrating patient data from clinical trials by Yang, Eric, Scheff, Jeremy D, Shen, Shih C, Farnum, Michael A, Sefton, James, Lobanov, Victor S, Agrafiotis, Dimitris K

“…Clinical trial data are typically collected through multiple systems developed by different vendors using different technologies and data standards. That data…”
Get full text

Translational applications of evaluating physiologic variability in human endotoxemia by Scheff, Jeremy D., Mavroudis, Panteleimon D., Calvano, Steve E., Androulakis, Ioannis P.

“…Dysregulation of the inflammatory response is a critical component of many clinically challenging disorders such as sepsis. Inflammation is a biological…”
Get full text

A multiscale modeling approach to inflammation: A case study in human endotoxemia by Scheff, Jeremy D., Mavroudis, Panteleimon D., Foteinou, Panagiota T., An, Gary, Calvano, Steve E., Doyle, John, Dick, Thomas E., Lowry, Stephen F., Vodovotz, Yoram, Androulakis, Ioannis P.

“…Inflammation is a critical component in the body’s response to injury. A dysregulated inflammatory response, in which either the injury is not repaired or the…”
Get full text

Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling by Dick, Thomas E, Molkov, Yaroslav I, Nieman, Gary, Hsieh, Yee-Hsee, Jacono, Frank J, Doyle, John, Scheff, Jeremy D, Calvano, Steve E, Androulakis, Ioannis P, An, Gary, Vodovotz, Yoram

“…Acute inflammation leads to organ failure by engaging catastrophic feedback loops in which stressed tissue evokes an inflammatory response and, in turn,…”
Get full text

A stochastic analysis of the inflammatory response by Scheff, Jeremy D, Doyle, John, Vodovotz, Yoram, Androulakis, Ioannis P

“…The components of the inflammatory response, like all biological processes, exhibit stochasticity, but many mathematical models of inflammation are defined as…”
Get full text

Pulsatile Glucocorticoid Secretion: Origins and Downstream Effects by Scheff, Jeremy D., Kosmides, Alyssa K., Calvano, Steven E., Lowry, Stephen F., Androulakis, Ioannis P.

“…Glucocorticoids are steroid hormones which, among other functions, exert an antiinflammatory effect. Endogenous glucocorticoids are normally secreted by the…”
Get full text

Modeling physiologic variability in human endotoxemia by Scheff, Jeremy D, Mavroudis, Panteleimon D, Foteinou, Panagiota T, Calvano, Steve E, Androulakis, Ioannis P

“…The control and management of inflammation is a key aspect of clinical care for critical illnesses such as sepsis. In an ideal reaction to injury, the…”
Get more information

Multiscale rhythmic influences on heart rate variability in human endotoxemia by Scheff, Jeremy D, Calvano, Steve E, Lowry, Stephen F, Androulakis, Ioannis P

“…Changes in heart rate variability (HRV) reflect alterations in autonomic function, which is potentially a useful predictor of outcome in myocardial infarction,…”
Get full text

Decreased communication leads to diminished physiologic variability in a multiscale model of inflammation by Scheff, Jeremy D, Calvano, Steven E, Lowry, Stephen F, Androulakis, Ioannis P

“…Sample entropy estimates the probability that subseries of data that match within a defined tolerance will also match at the next time point; this allows the…”
Get full text

A new symbolic representation for the identification of informative genes in replicated microarray experiments by Scheff, Jeremy D, Almon, Richard R, DuBois, Debra C, Jusko, William J, Androulakis, Ioannis P

“…Microarray experiments generate massive amounts of data, necessitating innovative algorithms to distinguish biologically relevant information from noise…”
Get more information

Understanding homeostatic dynamics of the HPA axis using a glucocorticoid pulsatile model by Kosmides, Alyssa, Scheff, Jeremy D, Calvano, Steve E, Lowry, Stephen F, Androulakis, Ioannis

“…In silico models are often constructed to aid in the understanding of disease and the production of relevant intervention strategies. Several existing models…”
Get full text