Search Results - "SCHAPPE, Timothy"

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia by Romee, Rizwan, Rosario, Maximillian, Berrien-Elliott, Melissa M, Wagner, Julia A, Jewell, Brea A, Schappe, Timothy, Leong, Jeffrey W, Abdel-Latif, Sara, Schneider, Stephanie E, Willey, Sarah, Neal, Carly C, Yu, Liyang, Oh, Stephen T, Lee, Yi-Shan, Mulder, Arend, Claas, Frans, Cooper, Megan A, Fehniger, Todd A

“…Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute myeloid leukemia (AML); however, the best approach to maximize NK cell…”
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CD56bright NK cells exhibit potent antitumor responses following IL-15 priming by Wagner, Julia A, Rosario, Maximillian, Romee, Rizwan, Berrien-Elliott, Melissa M, Schneider, Stephanie E, Leong, Jeffrey W, Sullivan, Ryan P, Jewell, Brea A, Becker-Hapak, Michelle, Schappe, Timothy, Abdel-Latif, Sara, Ireland, Aaron R, Jaishankar, Devika, King, Justin A, Vij, Ravi, Clement, Dennis, Goodridge, Jodie, Malmberg, Karl-Johan, Wong, Hing C, Fehniger, Todd A

“…NK cells, lymphocytes of the innate immune system, are important for defense against infectious pathogens and cancer. Classically, the CD56dim NK cell subset…”
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MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells by Berrien-Elliott, Melissa M., Sun, Yaping, Neal, Carly, Ireland, Aaron, Trissal, Maria C., Sullivan, Ryan P., Wagner, Julia A., Leong, Jeffrey W., Wong, Pamela, Mah-Som, Annelise Y., Wong, Terrence N., Schappe, Timothy, Keppel, Catherine R., Cortez, Victor S., Stamatiades, Efstathios G., Li, Ming O., Colonna, Marco, Link, Daniel C., French, Anthony R., Cooper, Megan A., Wang, Wei-Le, Boldin, Mark P., Reddy, Pavan, Fehniger, Todd A.

“…Natural killer (NK) cells are cytotoxic type 1 innate lymphoid cells (ILCs) that defend against viruses and mediate anti-tumor responses, yet mechanisms…”
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Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity by Wagner, Julia A., Wong, Pamela, Schappe, Timothy, Berrien-Elliott, Melissa M., Cubitt, Celia, Jaeger, Natalia, Lee, Madeline, Keppel, Cassie R., Marin, Nancy D., Foltz, Jennifer A., Marsala, Lynne, Neal, Carly C., Sullivan, Ryan P., Schneider, Stephanie E., Keppel, Molly P., Saucier, Nermina, Cooper, Megan A., Fehniger, Todd A.

“…Natural killer (NK) cells are cytotoxic innate lymphoid cells (ILCs) that mediate antiviral and antitumor responses and require the transcriptional regulator…”
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Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile by LOVE-GREGORY, Latisha, SHERVA, Richard, SCHAPPE, Timothy, QI, Jian-Shen, MCCREA, Jennifer, KLEIN, Samuel, CONNELLY, Margery A, ABUMRAD, Nada A

“…Membrane CD36 functions in the uptake of fatty acids (FAs), oxidized lipoproteins and in signal transduction after binding these ligands. In rodents, CD36 is…”
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T-BET and EOMES sustain mature human NK cell identity and antitumor function by Wong, Pamela, Foltz, Jennifer A, Chang, Lily, Neal, Carly C, Yao, Tony, Cubitt, Celia C, Tran, Jennifer, Kersting-Schadek, Samantha, Palakurty, Sathvik, Jaeger, Natalia, Russler-Germain, David A, Marin, Nancy D, Gang, Margery, Wagner, Julia A, Zhou, Alice Y, Jacobs, Miriam T, Foster, Mark, Schappe, Timothy, Marsala, Lynne, McClain, Ethan, Pence, Patrick, Becker-Hapak, Michelle, Fisk, Bryan, Petti, Allegra A, Griffith, Obi L, Griffith, Malachi, Berrien-Elliott, Melissa M, Fehniger, Todd A

“…Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell…”
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PTEN regulates natural killer cell trafficking in vivo by Leong, Jeffrey W., Schneider, Stephanie E., Sullivan, Ryan P., Parikh, Bijal A., Anthony, Bryan A., Singh, Anvita, Jewell, Brea A., Schappe, Timothy, Wagner, Julia A., Link, Daniel C., Yokoyama, Wayne M., Fehniger, Todd A.

“…Significance Natural killer (NK) cells are critical players in the response to viruses and transformed cells, but the molecular mechanisms controlling their…”
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Memory-like differentiation enhances NK cell responses against colorectal cancer by Marin, Nancy D, Becker-Hapak, Michelle, Song, Wilbur M, Alayo, Quazim A, Marsala, Lynne, Sonnek, Naomi, Berrien-Elliott, Melissa M, Foster, Mark, Foltz, Jennifer A, Tran, Jennifer, Wong, Pamela, Cubitt, Celia C, Pence, Patrick, Hwang, Kimberly, Zhou, Alice Y, Jacobs, Miriam T, Schappe, Timothy, Russler-Germain, David A, Fields, Ryan C, Ciorba, Matthew A, Fehniger, Todd A

“…Metastatic (m) colorectal cancer (CRC) is an incurable disease with a poor prognosis and thus remains an unmet clinical need. Immune checkpoint blockade…”
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Flow cytometry-based ex vivo murine NK cell cytotoxicity assay by Wong, Pamela, Wagner, Julia A., Berrien-Elliott, Melissa M., Schappe, Timothy, Fehniger, Todd A.

“…Direct killing of diseased cells is a hallmark function of NK cells. This protocol describes a flow-based assay to measure in vivo activated murine NK cells’…”
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A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells by Cubitt, Celia C., McClain, Ethan, Becker-Hapak, Michelle, Foltz, Jennifer A., Wong, Pamela, Wagner, Julia A., Neal, Carly C., Marin, Nancy D., Marsala, Lynne, Foster, Mark, Schappe, Timothy, Soon-Shiong, Patrick, Lee, John, Berrien-Elliott, Melissa M., Fehniger, Todd A.

“…Natural killer (NK) cells are cytotoxic innate lymphoid cells that are emerging as a cellular immunotherapy for various malignancies. NK cells are particularly…”
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531 AFM13-targeted blood and cord-blood-derived memory-like NK cells as therapy for CD30+ malignancies by Kerbauy, Lucila, Marin, Nancy, Kaplan, Mecit, Banerjee, Pinaki, Berrien-Elliott, Melissa, Becker-Hapak, Michelle, Basar, Rafet, Foster, Mark, Melo, Luciana Garcia, Neal, Carly, McClain, Ethan, Daher, May, Nunez Cortes, Ana Karen, Desai, Sweta, Inng Lim, Francesca Wei, Mendt, Mayela Carolina, Schappe, Timothy, Li, Li, Shaim, Hila, Sanabria, Mayra Hernandez, Wong, Pamela, Liu, Enli, Ang, Sonny, Cai, Rong, Nandivada, Vandana, Mohanty, Vakul, Shen, Yifei, Baran, Natalia, Fowlkes, Natalie, Chen, Ken, Muniz-Feliciano, Luis, Koch, Joachim, Treder, Martin, Fischer, Wolfgang, Okamoto, Oswaldo Keith, Nieto, Yago, Champlin, Richard, Shpall, Elizabeth, Fehniger, Todd, Rezvani, Katy

“…BackgroundNatural killer (NK) cells are a nascent cellular immunotherapy for hematologic malignancies. Target recognition of NK cell-resistant cancers remains…”
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CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas by Gang, Margery, Marin, Nancy D., Wong, Pamela, Neal, Carly C., Marsala, Lynne, Foster, Mark, Schappe, Timothy, Meng, Wei, Tran, Jennifer, Schaettler, Maximilian, Davila, Marco, Gao, Feng, Cashen, Amanda F., Bartlett, Nancy L., Mehta-Shah, Neha, Kahl, Brad S., Kim, Miriam Y., Cooper, Matthew L., DiPersio, John F., Berrien-Elliott, Melissa M., Fehniger, Todd A.

“…Natural killer (NK) cells are a promising cellular immunotherapy for cancer. Cytokine-induced memory-like (ML) NK cells differentiate after activation with…”
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Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant by Bednarski, Jeffrey J., Zimmerman, Clare, Berrien-Elliott, Melissa M., Foltz, Jennifer A., Becker-Hapak, Michelle, Neal, Carly C., Foster, Mark, Schappe, Timothy, McClain, Ethan, Pence, Patrick P., Desai, Sweta, Kersting-Schadek, Samantha, Wong, Pamela, Russler-Germain, David A., Fisk, Bryan, Lie, Wen-Rong, Eisele, Jeremy, Hyde, Stephanie, Bhatt, Sima T., Griffith, Obi L., Griffith, Malachi, Petti, Allegra A., Cashen, Amanda F., Fehniger, Todd A.

“…Pediatric and young adult (YA) patients with acute myeloid leukemia (AML) who relapse after allogeneic hematopoietic cell transplantation (HCT) have an…”
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Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30 + Malignancies by Kerbauy, Lucila N, Marin, Nancy D, Kaplan, Mecit, Banerjee, Pinaki P, Berrien-Elliott, Melissa M, Becker-Hapak, Michelle, Basar, Rafet, Foster, Mark, Garcia Melo, Luciana, Neal, Carly C, McClain, Ethan, Daher, May, Nunez Cortes, Ana Karen, Desai, Sweta, Inng Lim, Francesca Wei, Mendt, Mayela Carolina, Schappe, Timothy, Li, Li, Shaim, Hila, Shanley, Mayra, Ensley, Emily L, Uprety, Nadima, Wong, Pamela, Liu, Enli, Ang, Sonny O, Cai, Rong, Nandivada, Vandana, Mohanty, Vakul, Miao, Qi, Shen, Yifei, Baran, Natalia, Fowlkes, Natalie W, Chen, Ken, Muniz-Feliciano, Luis, Champlin, Richard E, Nieto, Yago L, Koch, Joachim, Treder, Martin, Fischer, Wolfgang, Okamoto, Oswaldo Keith, Shpall, Elizabeth J, Fehniger, Todd A, Rezvani, Katayoun

“…Natural killer (NK)-cell recognition and function against NK-resistant cancers remain substantial barriers to the broad application of NK-cell immunotherapy…”
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CD8α identifies human NK cells with altered proliferation, metabolism, and IL-15 signaling by Cubitt, Celia, Wong, Pamela, Tran, Jennifer, Foltz, Jennifer Ann, Marin, Nancy D., Marsala, Lynne, Foster, Mark, Schappe, Timothy, Berrien-Elliott, Melissa M., Fehniger, Todd A

“…Abstract NK cells are cytotoxic innate lymphoid cells that can differentiate into memory-like (ML) NK cells following IL-12/15/18 stimulation. Previous work…”
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Combined IL-12, IL-15 and IL-18 activation induces epigenetic changes in human NK cells during the memory-like state transition by Tran, Jennifer, Wong, Pamela, Fan, Changxu, Russler-Germain, David, Cubitt, Celia C, Marin, Nancy D, Schappe, Timothy, Berrien-Elliott, Melissa, Wang, Ting, Foltz, Jennifer A, Fehniger, Todd A

“…Abstract NK cells exhibit memory properties after activation with haptens, viral infection, or cytokines with each stimulus having distinct biology…”
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Memory-like Differentiation Enhances NK Cell Responses to Melanoma by Marin, Nancy D, Krasnick, Bradley A, Becker-Hapak, Michelle, Conant, Leah, Goedegebuure, Simon P, Berrien-Elliott, Melissa M, Robbins, Keenan J, Foltz, Jennifer A, Foster, Mark, Wong, Pamela, Cubitt, Celia C, Tran, Jennifer, Wetzel, Christopher B, Jacobs, Miriam, Zhou, Alice Y, Russler-Germain, David, Marsala, Lynne, Schappe, Timothy, Fields, Ryan C, Fehniger, Todd A

“…Treatment of advanced melanoma is a clinical challenge. Natural killer (NK) cells are a promising cellular therapy for T cell-refractory cancers, but are…”
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Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia by Berrien-Elliott, Melissa M, Foltz, Jennifer A, Russler-Germain, David A, Neal, Carly C, Tran, Jennifer, Gang, Margery, Wong, Pamela, Fisk, Bryan, Cubitt, Celia C, Marin, Nancy D, Zhou, Alice Y, Jacobs, Miriam T, Foster, Mark, Schappe, Timothy, McClain, Ethan, Kersting-Schadek, Samantha, Desai, Sweta, Pence, Patrick, Becker-Hapak, Michelle, Eisele, Jeremy, Mosior, Matthew, Marsala, Lynne, Griffith, Obi L, Griffith, Malachi, Khan, Saad M, Spencer, David H, DiPersio, John F, Romee, Rizwan, Uy, Geoffrey L, Abboud, Camille N, Ghobadi, Armin, Westervelt, Peter, Stockerl-Goldstein, Keith, Schroeder, Mark A, Wan, Fei, Lie, Wen-Rong, Soon-Shiong, Patrick, Petti, Allegra A, Cashen, Amanda F, Fehniger, Todd A

“…Natural killer (NK) cells are innate lymphoid cells that eliminate cancer cells, produce cytokines, and are being investigated as a nascent cellular…”
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The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas by Rosario, Maximillian, Liu, Bai, Kong, Lin, Collins, Lynne I, Schneider, Stephanie E, Chen, Xiaoyue, Han, Kaiping, Jeng, Emily K, Rhode, Peter R, Leong, Jeffrey W, Schappe, Timothy, Jewell, Brea A, Keppel, Catherine R, Shah, Keval, Hess, Brian, Romee, Rizwan, Piwnica-Worms, David R, Cashen, Amanda F, Bartlett, Nancy L, Wong, Hing C, Fehniger, Todd A

“…Anti-CD20 monoclonal antibodies (mAb) are an important immunotherapy for B-cell lymphoma, and provide evidence that the immune system may be harnessed as an…”
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Induced CD8[alpha] identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation by Cubitt, Celia C, Wong, Pamela, Dorando, Hannah K, Foltz, Jennifer A, Tran, Jennifer, Marsala, Lynne, Marin, Nancy D, Foster, Mark, Schappe, Timothy, Fatima, Hijab, Becker-Hapak, Michelle, Zhou, Alice Y, Hwang, Kimberly, Jacobs, Miriam T, Russler-Germain, David A, Mace, Emily M, Berrien-Elliott, Melissa M, Payton, Jacqueline E, Fehniger, Todd A

“…The surface receptor CD8[alpha] is present on 20%-80% of human (but not mouse) NK cells, yet its function on NK cells remains poorly understood. CD8[alpha]…”
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