Search Results - "SCHAPHORST, KANE L."

Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products by Schaphorst, Kane L, Chiang, Eddie, Jacobs, Keri N, Zaiman, Ari, Natarajan, Viswanathan, Wigley, Frederick, Garcia, Joe G N

“…In vitro and in vivo evidence indicates that circulating platelets affect both vascular integrity and hemostasis. How platelets enhance the permeability…”
Get more information

Critical involvement of p38 MAP kinase in pertussis toxin‐induced cytoskeletal reorganization and lung permeability by GARCIA, JOE G. N., WANG, PEIYI, SCHAPHORST, KANE L., BECKER, PATRICE M., BORBIEV, TALAIBEK, LIU, FENG, BIRUKOVA, ANNA, JACOBS, KERI, BOGATCHEVA, NATALIA, VERIN, ALEXANDER D.

“…ABSTRACT Bordetella pertussis is an important cause of infection in humans worldwide, with full expression of the syndrome associated with characteristic…”
Get full text

Heterogeneity of barrier function in the lung reflects diversity in endothelial cell junctions by Ofori-Acquah, Solomon F., King, Judy, Voelkel, Norbert, Schaphorst, Kane L., Stevens, Troy

“…Endothelial cells assemble unique barriers that confer specific permeability requirements at different vascular segments. We examined lung microvascular and…”
Get full text

Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation by Garcia, Joe G. N, Schaphorst, Kane L, Verin, Alexander D, Vepa, Suryanarayana, Patterson, Carolyn E, Natarajan, Viswanathan

“…1  Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224; and 2  Department of Medicine,…”
Get full text

Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stability by Young, Bradford A, Sui, Xiufen, Kiser, Timothy D, Hyun, Sang Won, Wang, Ping, Sakarya, Serhan, Angelini, Daniel J, Schaphorst, Kane L, Hasday, Jeffrey D, Cross, Alan S, Romer, Lewis H, Passaniti, Antonino, Goldblum, Simeon E

“…Protein tyrosine phosphorylation is tightly regulated through the actions of both protein tyrosine kinases and protein tyrosine phosphatases. In this study, we…”
Get more information

Thrombin-mediated Focal Adhesion Plaque Reorganization in Endothelium: Role of Protein Phosphorylation by Schaphorst, Kane L, Pavalko, Frederick M, Patterson, Carolyn E, Garcia, Joe G. N

“…Endothelial cell (EC) gap formation and barrier function are subject to dual regulation by (1) axial contractile forces, regulated by myosin light chain kinase…”
Get full text

Mechanisms of ionomycin-induced endothelial cell barrier dysfunction by Garcia, J G, Schaphorst, K L, Shi, S, Verin, A D, Hart, C M, Callahan, K S, Patterson, C E

“…Myosin light chain (MLC) phosphorylation catalyzed by the Ca(2+)- calmodulin-dependent MLC kinase (MLCK) is critical to thrombin-mediated endothelial cell gap…”
Get full text

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3β by LIU, FENG, SCHAPHORST, KANE L., VERIN, ALEXANDER D., JACOBS, KERI, BIRUKOVA, ANNA, DAY, REGINA M., BOGATCHEVA, NATALIA, BOTTARO, D. P., GARCIA, JOE G. N.

“…ABSTRACT The stabilization of endothelial cell (EC) barrier function within newly formed capillaries is a critical feature of angiogenesis. We examined human…”
Get full text

Regulation of endothelial cell gap formation and paracellular permeability by Garcia, J G, Schaphorst, K L

“…Investigation of the regulation of permeability properties of the endothelium has yielded evidence to support the concept of a dual regulation of EC gap…”
Get full text

Regulation of thrombin-mediated endothelial cell contraction and permeability by Garcia, J G, Verin, A D, Schaphorst, K L

“…A variety of physical forces exist in a dynamic equilibrium in the vascular endothelium (EC) monolayer and serve to maintain EC responsiveness while preserving…”
Get more information

Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial cell barrier dysfunction by Patterson, C E, Davis, H W, Schaphorst, K L, Garcia, J G

“…Thrombin-induced endothelial cell (EC) activation leads to compromise of monolayer barrier function due to cellular retraction/contraction and intercellular…”
Get more information

Regulation of endothelial barrier function by the cAMP-dependent protein kinase by Patterson, C E, Lum, H, Schaphorst, K L, Verin, A D, Garcia, J G

“…Elevation of cAMP promotes the endothelial cell (EC) barrier and protects the lung from edema development. Thus, we tested the hypothesis that both increases…”
Get more information

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta by Liu, Feng, Schaphorst, Kane L, Verin, Alexander D, Jacobs, Keri, Birukova, Anna, Day, Regina M, Bogatcheva, Natalia, Bottaro, D P, Garcia, Joe G N

“…The stabilization of endothelial cell (EC) barrier function within newly formed capillaries is a critical feature of angiogenesis. We examined human lung EC…”
Get full text