Search Results - "SCHAPER, Jutta"

Fibrosis in endstage human heart failure: Severe changes in collagen metabolism and MMP/TIMP profiles by Polyakova, Victoria, Loeffler, Ivo, Hein, Stefan, Miyagawa, Shigeru, Piotrowska, Izabela, Dammer, Sebastian, Risteli, Juha, Schaper, Jutta, Kostin, Sawa

“…Abstract Objectives We studied fibrosis, collagen metabolism, MMPs/TIMPs and cytokine expression in various forms of human heart failure (HF) by quantitative…”
Get full text

Nitric Oxide Increases Arterial Endotheial Permeability through Mediating VE-Cadherin Expression during Arteriogenesis by Yang, Baolin, Cai, Baizhen, Deng, Panyue, Wu, Xiaoqiong, Guan, Yinglu, Zhang, Bin, Cai, Weijun, Schaper, Jutta, Schaper, Wolfgang

“…Macrophage invasion is an important event during arteriogenesis, but the underlying mechanism is still only partially understood. The present study tested the…”
Get full text

Laminin-α4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells by KNOLL, Ralph, POSTEL, Ruben, KUBE, Dieter, KNOLL, Gudrun, SCHÄFER, Katrin, HAYASHI, Takeharu, HOLM, Torbjorn, KIMURA, Akinori, SCHORK, Nicholas, MOHAMMAD REZA TOLIAT, NÜRNBERG, Peter, SCHULTHEISS, Heinz-Peter, JIANMING WANG, SCHAPER, Wolfgang, SCHAPER, Jutta, BOS, Erik, DEN HERTOG, Jeroen, VAN EEDEN, Fredericus J. M, PETERS, Peter J, HASENFUSS, Gerd, CHIEN, Kenneth R, BAKKERS, Jeroen, KRÄTZNER, Ralph, HENNECKE, Gerrit, VACARU, Andrei M, VAKEEL, Padmanabhan, SCHUBERT, Cornelia, MURTHY, Kenton, RANA, Brinda K

“…Background— Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying…”
Get full text

Myocytes Die by Multiple Mechanisms in Failing Human Hearts by Kostin, Sawa, Pool, Lieven, Elsässer, Albrecht, Hein, Stefan, Drexler, Hannes C.A, Arnon, Eyal, Hayakawa, Yukihiro, Zimmermann, René, Bauer, Erwin, Klövekorn, Wolf-Peter, Schaper, Jutta

“…We tested the hypothesis that myocyte loss in failing human hearts occurs by different mechanismsapoptosis, oncosis, and autophagic cell death. Explanted…”
Get full text

microRNA-352 regulates collateral vessel growth induced by elevated fluid shear stress in the rat hind limb by Guan, Yinglu, Cai, Baizhen, Wu, Xiaoqiong, Peng, Song, Gan, Liaoying, Huang, Da, Liu, Guangmin, Dong, Liping, Xiao, Lin, Liu, Junwen, Zhang, Bin, Cai, Wei-Jun, Schaper, Jutta, Schaper, Wolfgang

“…Although collateral vessel growth is distinctly enhanced by elevated fluid shear stress (FSS), the underlying regulatory mechanism of this process remains…”
Get full text

Immunohistochemical study of the growth factors, aFGF, bFGF, PDGF-AB, VEGF-A and its receptor (Flk-1) during arteriogenesis by Wu, Song, Wu, Xiaoqiong, Zhu, Wu, Cai, Wei-Jun, Schaper, Jutta, Schaper, Wolfgang

“…Growth factors are viewed as main arteriogenic stimulators for collateral vessel growth. However, the information about their native expression and…”
Get full text

Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death by Elsässer, Albrecht, Vogt, Achim M, Nef, Holger, Kostin, Sawa, Möllmann, Helge, Skwara, Woitek, Bode, Christoph, Hamm, Christian, Schaper, Jutta

“…The aim of the present study was to objectify the loss of myocytes and the mechanism by which myocytes die in human hibernating myocardium (HHM). Intracellular…”
Get full text

Unresolved Issues Regarding the Role of Apoptosis in the Pathogenesis of Ischemic Injury and Heart Failure by Elsässer, Albrecht, Suzuki, Keisuke, Schaper, Jutta

“…Apoptosis is “suicidal” programmed cell death followed by necrosis, i.e. cellular degradation. This review presents a critical evaluation of the methods used…”
Get full text

Increased Expression of Cytoskeletal, Linkage, and Extracellular Proteins in Failing Human Myocardium by Heling, Annette, Zimmermann, René, Kostin, Sawa, Maeno, Yoshi, Hein, Stefan, Devaux, Bruno, Bauer, Erwin, Klövekorn, Wolf-Peter, Schlepper, Martin, Schaper, Wolfgang, Schaper, Jutta

“…Experimental studies have shown that in hypertrophy and heart failure, accumulation of microtubules occurs that impedes sarcomere motion and contributes to…”
Get full text

Apoptosis is Initiated by Myocardial Ischemia and Executed During Reperfusion by Freude, Bernd, Masters, Thomas N., Robicsek, Francis, Fokin, Alexander, Kostin, Sava, Zimmermann, René, Ullmann, Claudia, Lorenz-Meyer, Silja, Schaper, Jutta

“…Ischemia/reperfusion leading to myocyte cell death has been reported as either necrotic or apoptotic or a combination of both. The importance of necrosis is…”
Get full text

Monocyte Chemotactic Protein-1 Increases Collateral and Peripheral Conductance After Femoral Artery Occlusion by Ito, Wulf D, Arras, Margarete, Winkler, Bernd, Scholz, Dimitri, Schaper, Jutta, Schaper, Wolfgang

“…Monocytes are activated during collateral artery growth in vivo, and monocyte chemotactic protein-1 (MCP-1) has been shown to be upregulated by shear stress in…”
Get full text

Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease by Fielitz, Jens, Hein, Stefan, Mitrovic, Veselin, Pregla, Rainer, Zurbrügg, Heinz R, Warnecke, Christina, Schaper, Jutta, Fleck, Eckart, Regitz-Zagrosek, Vera

“…OBJECTIVES We sought to determine whether the cardiac renin-angiotensin system (RAS) is activated in human aortic valve disease depending on left ventricular…”
Get full text

Progression of myocardial necrosis during reperfusion of ischemic myocardium by MATSUMURA, K, JEREMY, R. W, SCHAPER, J, BECKER, L. C

“…The occurrence of myocyte necrosis during reperfusion of ischemic myocardium is controversial. This study measured myocardial 2-deoxyglucose uptake, correlated…”
Get full text

Spatiotemporal Development and Distribution of Intercellular Junctions in Adult Rat Cardiomyocytes in Culture by Kostin, Sawa, Hein, Stefan, Bauer, Erwin P, Schaper, Jutta

“…The mode of development of the intercalated disk (ID) is largely unknown, and the hypothesis was tested that the assembly of cell adhesion junctions may…”
Get full text

Actin-binding Rho activating protein is expressed in the central nervous system of normal adult rats by Liu, Lihua, Luo, Mingying, Yang, Baolin, Wu, Xiaoqiong, Zhu, Wu, Guan, Yinglu, Cai, Weijun, Troidl, Kerstin, Schaper, Wolfgang, Schaper, Jutta

“…Previous studies show that actin-binding Rho activating protein （Abra） is expressed in cardiomyocytes and vascular smooth muscle cells. In this study, we…”
Get full text

Effect of Shunting of Collateral Flow into the Venous System on Arteriogenesis and Angiogenesis in Rabbit Hind Limb by Yang, Bao-lin, Wu, Song, Wu, Xiaoqiong, Li, Ming Bo, Zhu, Wu, Guan, Yinglu, Liu, Li-Hua, Luo, Ming-ying, Cai, Wei-Jun, Schaper, Jutta, Schaper, Wolfgang

“…The aim of this study was to characterize the vascular remodeling in the external iliac artery (EIA) and the lower leg muscles in a rabbit shunt model created…”
Get full text

Remodeling of the adventitia during coronary arteriogenesis by Cai, Wei-Jun, Koltai, Sophie, Kocsis, Elisabeth, Scholz, Dimitri, Kostin, Sawa, Luo, Xuegang, Schaper, Wolfgang, Schaper, Jutta

“…We studied the role of the adventitia in adaptive arteriogenesis during the phase of active growth of coronary collateral vessels (CV) induced by chronic…”
Get more information

The cytoskeleton and related proteins in the human failing heart by Kostin, S, Hein, S, Arnon, E, Scholz, D, Schaper, J

“…In addition to functional alterations, heart failure has a structural basis as well. This concerns all components of the cardiac myocytes as well as the…”
Get full text

The role of apoptosis in myocardial ischemia: a critical appraisal by Elsässer, A, Suzuki, K, Lorenz-Meyer, S, Bode, C, Schaper, J

“…The role of apoptosis in cardiac ischemia is not clarified yet. Own data show that suicidal cell death is apparently not important in global ischemia where it…”
Get full text

Translocation and Cleavage of Myocardial Dystrophin as a Common Pathway to Advanced Heart Failure: A Scheme for the Progression of Cardiac Dysfunction by Toyo-Oka, Teruhiko, Kawada, Tomie, Nakata, Jumi, Xie, Han, Urabe, Masashi, Masui, Fujiko, Ebisawa, Takashi, Tezuka, Asaki, Iwasawa, Kuniaki, Nakajima, Toshiaki, Uehara, Yoshio, Kumagai, Hiroyuki, Kostin, Sawa, Schaper, Jutta, Nakazawa, Mikio, Ozawa, Keiya, Ebashi, Setsuro

“…Advanced heart failure (HF) is the leading cause of death in developed countries. The mechanism underlying the progression of cardiac dysfunction needs to be…”
Get full text