Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity: a randomized trial

To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity. We randomized 49 women who received cisplatin (75 mg/m(2) every 3 weeks) into one of the three hydration arms. The 24-h creatinine clearance was measured before and on...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 52; no. 1; pp. 13 - 18
Main Authors:	SANTOSO, Joseph T, LUCCI, Joseph A, COLEMAN, Robert L, SCHAFER, Ilona, HANNIGAN, Edward V
Format:	Journal Article
Language:	English
Published:	Berlin Springer 01-07-2003 Springer Nature B.V
Subjects:	Adult Aged Antiemetics - therapeutic use Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Biological and medical sciences Cisplatin - administration & dosage Cisplatin - adverse effects Cisplatin - therapeutic use Creatinine - blood Creatinine - pharmacokinetics Diuretics Drug Therapy, Combination Drug toxicity and drugs side effects treatment Female Furosemide - administration & dosage Furosemide - therapeutic use Humans Infusions, Intravenous Kidney Diseases - chemically induced Kidney Diseases - prevention & control Mannitol - administration & dosage Mannitol - therapeutic use Medical sciences Metabolic Clearance Rate Middle Aged Neoplasms - drug therapy Neoplasms - metabolism Pharmacology. Drug treatments Sodium Chloride - therapeutic use Toxicity: urogenital system Kidney disease Antineoplastic agent Human Sulfanilamide derivatives Urinary system disease Sulfonamide Hydration Toxicity Malignant tumor Cisplatin Furosemide Kidney Cisplatin nephrotoxicity Diuretic Prevention Alkylating agent Chemotherapy Treatment Mannitol Female Saline solution Comparative study Platinum II Complexes
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity. We randomized 49 women who received cisplatin (75 mg/m(2) every 3 weeks) into one of the three hydration arms. The 24-h creatinine clearance was measured before and on day 6 after cisplatin infusion. The patients of each arm received 2 l of saline hydration. In the saline + furosemide arm, 40 mg of furosemide was given after hydration. In the saline + mannitol arm, 50 g of mannitol was mixed with the cisplatin. For the first cycle of chemotherapy, 15 women were randomized to saline, 17 to saline + furosemide, and 17 to saline + mannitol. For each group, the creatinine clearances before cisplatin infusion were (means+/-SD, milliliters per minute) 84.5+/-26.8, 82.5+/-24.0 and 87.4+/-25.6, and after cisplatin infusion were 79.1+/-31.9, 68.7+/-21.5, and 56.4+/-22.9, respectively. The decreases in creatinine clearance were similar between the saline group and the saline + furosemide group ( P=0.66), but different between the saline + mannitol group and the saline group ( P=0.02) or the saline + furosemide group ( P=0.02). As each woman received multiple courses of cisplatin, 15 who received saline contributed 41 paired datasets, 17 who received saline + furosemide contributed 49 paired datasets, and 17 who received saline + mannitol contributed 36 paired datasets showed similar patterns. Hydration with saline or saline + furosemide appears to be associated with less cisplatin nephrotoxicity than saline + mannitol.
ISSN:	0344-5704 1432-0843
DOI:	10.1007/s00280-003-0620-1