Search Results - "SCHAEFER, Georg"

The Glucocorticoid Receptor Is a Key Player for Prostate Cancer Cell Survival and a Target for Improved Antiandrogen Therapy by Puhr, Martin, Hoefer, Julia, Eigentler, Andrea, Ploner, Christian, Handle, Florian, Schaefer, Georg, Kroon, Jan, Leo, Angela, Heidegger, Isabel, Eder, Iris, Culig, Zoran, Van der Pluijm, Gabri, Klocker, Helmut

“…The major obstacle in the management of advanced prostate cancer is the occurrence of resistance to endocrine therapy. Although the androgen receptor (AR) has…”
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Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity by Kerick, Martin, Isau, Melanie, Timmermann, Bernd, Sültmann, Holger, Herwig, Ralf, Krobitsch, Sylvia, Schaefer, Georg, Verdorfer, Irmgard, Bartsch, Georg, Klocker, Helmut, Lehrach, Hans, Schweiger, Michal R

“…Massively parallel sequencing technologies have brought an enormous increase in sequencing throughput. However, these technologies need to be further improved…”
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Evaluation of the PI-RADS scoring system for mpMRI of the prostate: a whole-mount step-section analysis by Junker, Daniel, Quentin, Michael, Nagele, Udo, Edlinger, Michael, Richenberg, Jonathan, Schaefer, Georg, Ladurner, Michael, Jaschke, Werner, Horninger, Wolfgang, Aigner, Friedrich

“…Purpose Evaluation of the Prostate Imaging Reporting and Data System (PI-RADS) scoring system for classifying multi-parametric magnetic resonance imaging…”
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Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients by Schlick, Bettina, Massoner, Petra, Lueking, Angelika, Charoentong, Pornpimol, Blattner, Mirjam, Schaefer, Georg, Marquart, Klaus, Theek, Carmen, Amersdorfer, Peter, Zielinski, Dirk, Kirchner, Matthias, Trajanoski, Zlatko, Rubin, Mark A, Müllner, Stefan, Schulz-Knappe, Peter, Klocker, Helmut

“…Chronic inflammation is frequently observed on histological analysis of malignant and non-malignant prostate specimens. It is a suspected supporting factor for…”
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MALDI-MS tissue imaging identification of biliverdin reductase B overexpression in prostate cancer by Pallua, Johannes Dominikus, Schaefer, Georg, Seifarth, Christof, Becker, Michael, Meding, Stephan, Rauser, Sandra, Walch, Axel, Handler, Michael, Netzer, Michael, Popovscaia, Marina, Osl, Melanie, Baumgartner, Christian, Lindner, Herbert, Kremser, Leopold, Sarg, Bettina, Bartsch, Georg, Huck, Christian W., Bonn, Günther K., Klocker, Helmut

“…New biomarkers are needed to improve the specificity of prostate cancer detection and characterisation of individual tumors. In a proteomics profiling approach…”
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Long‐term follow up of renal anastomosing hemangioma mimicking renal angiosarcoma by Heidegger, Isabel, Pichler, Renate, Schäfer, Georg, Zelger, Bernhard, Zelger, Bettina, Aigner, Friedrich, Bektic, Jasmin, Horninger, Wolfgang

“…Anastomosing hemangioma of the kidney is a very rare neoplasm, currently 19 cases have been reported in the literature. First described in 2009,…”
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Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk by Demichelis, Francesca, Setlur, Sunita R., Banerjee, Samprit, Chakravarty, Dimple, Chen, Jin Yun Helen, Chen, Chen X., Huang, Julie, Beltran, Himisha, Oldridge, Derek A., Kitabayashi, Naoki, Stenzel, Birgit, Schaefer, Georg, Horninger, Wolfgang, Bektic, Jasmin, Chinnaiyan, Arul M., Goldenberg, Sagit, Siddiqui, Javed, Regan, Meredith M., Kearney, Michale, Soong, T. David, Rickman, David S., Elemento, Olivier, Wei, John T., Scherr, Douglas S., Sanda, Martin A., Bartsch, Georg, Lee, Charles, Klocker, Helmut, Rubin, Mark A.

“…Copy number variants (CNVs) are a recently recognized class of human germ line polymorphisms and are associated with a variety of human diseases, including…”
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Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy by Wasylyk, Christine, Zambrano, Alberto, Zhao, Chunhua, Brants, Jan, Abecassis, Joseph, Schalken, Jack A., Rogatsch, Hermann, Schaefer, Georg, Pycha, Armin, Klocker, Helmut, Wasylyk, Bohdan

“…Prostate cancer is a common cause of death, and an important goal is to establish the pathways and functions of causative genes. We isolated RNAs that are…”
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EpCAM Overexpression is Associated with High-grade Urothelial Carcinoma in the Renal Pelvis by BRUNNER, Andrea, SCHAEFER, Georg, VEITS, Lothar, BRUNNER, Barbara, PRELOG, Martina, ENSINGER, Christian

“…Background: EpCAM serves as an attractive target for immunotherapy due to its expression on the surface of most epithelial cancer cells. Urothelial carcinoma…”
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Inhibition of Nox4‐dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal‐mediated protumorigenic interactions by Sampson, Natalie, Brunner, Elena, Weber, Anja, Puhr, Martin, Schäfer, Georg, Szyndralewiez, Cedric, Klocker, Helmut

“…Carcinoma‐associated fibroblasts (CAFs) play a key onco‐supportive role during prostate cancer (PCa) development and progression. We previously reported that…”
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Tumor-infiltrating immune cell subpopulations influence the oncologic outcome after intravesical Bacillus Calmette-Guérin therapy in bladder cancer by Pichler, Renate, Fritz, Josef, Zavadil, Claudia, Schäfer, Georg, Culig, Zoran, Brunner, Andrea

“…Although Bacillus Calmette-Guérin (BCG) is the most successful immunotherapy for high-risk non-muscle-invasive bladder cancer, approximately 30% of patients…”
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The Oncogenic Protein Kinase/ATPase RIOK1 Is Up-Regulated via the c-myc/E2F Transcription Factor Axis in Prostate Cancer by Handle, Florian, Puhr, Martin, Gruber, Martina, Andolfi, Chiara, Schäfer, Georg, Klocker, Helmut, Haybaeck, Johannes, De Wulf, Peter, Culig, Zoran

“…The atypical protein kinase/ATPase RIO kinase (RIOK)-1 is involved in pre-40S ribosomal subunit production, cell-cycle progression, and protein arginine…”
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OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation by Schöpf, Bernd, Weissensteiner, Hansi, Schäfer, Georg, Fazzini, Federica, Charoentong, Pornpimol, Naschberger, Andreas, Rupp, Bernhard, Fendt, Liane, Bukur, Valesca, Giese, Irina, Sorn, Patrick, Sant’Anna-Silva, Ana Carolina, Iglesias-Gonzalez, Javier, Sahin, Ugur, Kronenberg, Florian, Gnaiger, Erich, Klocker, Helmut

“…Rewiring of energy metabolism and adaptation of mitochondria are considered to impact on prostate cancer development and progression. Here, we report on…”
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Targeting the glucocorticoid receptor signature gene Mono Amine Oxidase-A enhances the efficacy of chemo- and anti-androgen therapy in advanced prostate cancer by Puhr, Martin, Eigentler, Andrea, Handle, Florian, Hackl, Hubert, Ploner, Christian, Heidegger, Isabel, Schaefer, Georg, Brandt, Maximilian P., Hoefer, Julia, Van der Pluijm, Gabri, Klocker, Helmut

“…Despite increasing options for treatment of castration-resistant prostate cancer, development of drug resistance is inevitable. The glucocorticoid receptor…”
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Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205 by Puhr, Martin, Hoefer, Julia, Schäfer, Georg, Erb, Holger H.H, Oh, Su Jung, Klocker, Helmut, Heidegger, Isabel, Neuwirt, Hannes, Culig, Zoran

“…Docetaxel is a standard chemotherapy for patients with metastatic prostate cancer. However, the response is rather limited and not all of the patients benefit…”
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Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer by Heidegger, Isabel, Fotakis, Georgios, Offermann, Anne, Goveia, Jermaine, Daum, Sophia, Salcher, Stefan, Noureen, Asma, Timmer-Bosscha, Hetty, Schäfer, Georg, Walenkamp, Annemiek, Perner, Sven, Beatovic, Aleksandar, Moisse, Matthieu, Plattner, Christina, Krogsdam, Anne, Haybaeck, Johannes, Sopper, Sieghart, Thaler, Stefanie, Keller, Markus A, Klocker, Helmut, Trajanoski, Zlatko, Wolf, Dominik, Pircher, Andreas

“…Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication…”
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Performance of PI-RADS version 1 versus version 2 regarding the relation with histopathological results by Auer, Thomas, Edlinger, Michael, Bektic, Jasmin, Nagele, Udo, Herrmann, Thomas, Schäfer, Georg, Aigner, Friedrich, Junker, Daniel

“…Purpose Aim of this study was to compare the diagnostic performance of PI-RADS version 1 (v1) and version 2 (v2) in the detection of prostate cancer (PCa)…”
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Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts by Eigentler, Andrea, Handle, Florian, Schanung, Silvia, Degen, Antonia, Hackl, Hubert, Erb, Holger H. H., Fotakis, Georgios, Hoefer, Julia, Ploner, Christian, Jöhrer, Karin, Heidegger, Isabel, Pircher, Andreas, Klotz, Werner, Herold, Manfred, Schäfer, Georg, Culig, Zoran, Puhr, Martin

“…Despite significant therapeutic advances in recent years, treatment of metastatic prostate cancer (PCa) remains palliative, owing to the inevitable occurrence…”
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Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells by Schöpf, Bernd, Schäfer, Georg, Weber, Anja, Talasz, Heribert, Eder, Iris E., Klocker, Helmut, Gnaiger, Erich

“…Altered mitochondrial metabolism plays a pivotal role in the development and progression of various diseases, including cancer. Cell lines are frequently used…”
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Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway by LUKONG, SCHÄFER, Georg, HUAJIEBU, YONGZHANG, YUXIANG ZHANG, KLOCKER, Helmut

“…Prostate cancer (PC) remains the second most common cause of cancer-related death in Western countries. A previous proteomics study suggested that the nuclear…”
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