Search Results - "SCHABBAUER, GERNOT"

More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization by Kieler, Markus, Hofmann, Melanie, Schabbauer, Gernot

“…Macrophages represent the first line of defence in innate immune responses and additionally serve important functions for the regulation of host inflammation…”
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Macrophage Rewiring by Nutrient Associated PI3K Dependent Pathways by Sharif, Omar, Brunner, Julia Stefanie, Vogel, Andrea, Schabbauer, Gernot

“…Class 1 Phosphoinositide-3-Kinases (PI3Ks) have been widely studied and mediate essential roles in cellular proliferation, chemotaxis, insulin sensitivity, and…”
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Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis by Thell, Kathrin, Hellinger, Roland, Sahin, Emine, Michenthaler, Paul, Gold-Binder, Markus, Haider, Thomas, Kuttke, Mario, Liutkevičiūtė, Zita, Göransson, Ulf, Gründemann, Carsten, Schabbauer, Gernot, Gruber, Christian W.

“…Multiple sclerosis (MS) is the most common autoimmune disease affecting the central nervous system. It is characterized by autoreactive T cells that induce…”
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Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages by Luyendyk, James P, Schabbauer, Gernot A, Tencati, Michael, Holscher, Todd, Pawlinski, Rafal, Mackman, Nigel

“…LPS stimulation of monocytes/macrophages induces the expression of genes encoding proinflammatory cytokines and the procoagulant protein, tissue factor…”
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Platelets Mediate Oxidized Low-Density Lipoprotein–Induced Monocyte Extravasation and Foam Cell Formation by Badrnya, Sigrun, Schrottmaier, Waltraud C, Kral, Julia B, Yaiw, Koon-Chu, Volf, Ivo, Schabbauer, Gernot, Söderberg-Nauclér, Cecilia, Assinger, Alice

“…OBJECTIVE—A growing body of evidence indicates that platelets contribute to the onset and progression of atherosclerosis by modulating immune responses. We…”
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Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease by Uderhardt, Stefan, Ackermann, Jochen A, Fillep, Tobias, Hammond, Victoria J, Willeit, Johann, Santer, Peter, Mayr, Manuel, Biburger, Markus, Miller, Meike, Zellner, Katie R, Stark, Konstantin, Zarbock, Alexander, Rossaint, Jan, Schubert, Irene, Mielenz, Dirk, Dietel, Barbara, Raaz-Schrauder, Dorette, Ay, Cihan, Gremmel, Thomas, Thaler, Johannes, Heim, Christian, Herrmann, Martin, Collins, Peter W, Schabbauer, Gernot, Mackman, Nigel, Voehringer, David, Nadler, Jerry L, Lee, James J, Massberg, Steffen, Rauh, Manfred, Kiechl, Stefan, Schett, Georg, O'Donnell, Valerie B, Krönke, Gerhard

“…Blood coagulation is essential for physiological hemostasis but simultaneously contributes to thrombotic disease. However, molecular and cellular events…”
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Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages by Sharif, Omar, Brunner, Julia Stefanie, Korosec, Ana, Martins, Rui, Jais, Alexander, Snijder, Berend, Vogel, Andrea, Caldera, Michael, Hladik, Anastasiya, Lakovits, Karin, Saluzzo, Simona, Boehm, Benedikta, Gorki, Anna-Dorothea, Mesteri, Ildiko, Lindroos-Christensen, Josefine, Tillmann, Katharina, Stoiber, Dagmar, Menche, Jörg, Schabbauer, Gernot, Bilban, Martin, Superti-Furga, Giulio, Esterbauer, Harald, Knapp, Sylvia

“…Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering…”
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Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses by Sahin, Emine, Haubenwallner, Stefan, Kuttke, Mario, Kollmann, Isabella, Halfmann, Angela, Dohnal, Alexander M, Dohnal, Alexander B, Chen, Li, Cheng, Paul, Hoesel, Bastian, Einwallner, Elisa, Brunner, Julia, Kral, Julia B, Schrottmaier, Waltraud C, Thell, Kathrin, Saferding, Victoria, Blüml, Stephan, Schabbauer, Gernot

“…The activation of innate immune cells triggers numerous intracellular signaling pathways, which require tight control to mount an adequate immune response. The…”
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Loss of JAK1 Drives Innate Immune Deficiency by Witalisz-Siepracka, Agnieszka, Klein, Klara, Prinz, Daniela, Leidenfrost, Nicoletta, Schabbauer, Gernot, Dohnal, Alexander, Sexl, Veronika

“…The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway is critical in tuning immune responses and its dysregulation…”
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The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells by Ipseiz, Natacha, Uderhardt, Stefan, Scholtysek, Carina, Steffen, Martin, Schabbauer, Gernot, Bozec, Aline, Schett, Georg, Krönke, Gerhard

“…Uptake of apoptotic cells (ACs) by macrophages ensures the nonimmunogenic clearance of dying cells, as well as the maintenance of self-tolerance to AC-derived…”
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Environmental arginine controls multinuclear giant cell metabolism and formation by Brunner, Julia S., Vulliard, Loan, Hofmann, Melanie, Kieler, Markus, Lercher, Alexander, Vogel, Andrea, Russier, Marion, Brüggenthies, Johanna B., Kerndl, Martina, Saferding, Victoria, Niederreiter, Birgit, Junza, Alexandra, Frauenstein, Annika, Scholtysek, Carina, Mikami, Yohei, Klavins, Kristaps, Krönke, Gerhard, Bergthaler, Andreas, O’Shea, John J., Weichhart, Thomas, Meissner, Felix, Smolen, Josef S., Cheng, Paul, Yanes, Oscar, Menche, Jörg, Murray, Peter J., Sharif, Omar, Blüml, Stephan, Schabbauer, Gernot

“…Multinucleated giant cells (MGCs) are implicated in many diseases including schistosomiasis, sarcoidosis and arthritis. MGC generation is energy intensive to…”
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Protocol to assess the tolerogenic properties of adoptively transferred dendritic cells during murine experimental autoimmune encephalomyelitis by Vogel, Andrea, Kerndl, Martina, Schabbauer, Gernot, Sharif, Omar

“…By their capacity to induce peripheral T cell tolerance, dendritic cells (DCs) present a promising target cell and therapeutic strategy for treatment of…”
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The human placenta shapes the phenotype of decidual macrophages by Vondra, Sigrid, Höbler, Anna-Lena, Lackner, Andreas Ian, Raffetseder, Johanna, Mihalic, Zala Nikita, Vogel, Andrea, Saleh, Leila, Kunihs, Victoria, Haslinger, Peter, Wahrmann, Markus, Husslein, Heinrich, Oberle, Raimund, Kargl, Julia, Haider, Sandra, Latos, Paulina, Schabbauer, Gernot, Knöfler, Martin, Ernerudh, Jan, Pollheimer, Jürgen

“…During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua…”
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Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism by Gründemann, Carsten, Thell, Kathrin, Lengen, Karin, Garcia-Käufer, Manuel, Huang, Yen-Hua, Huber, Roman, Craik, David J, Schabbauer, Gernot, Gruber, Christian W

“…Cyclotides are a diverse and abundant group of ribosomally synthesized plant peptides containing a unique cyclic cystine-knotted topology that confers them…”
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PAI-1 (Plasminogen Activator Inhibitor-1) Expression Renders Alternatively Activated Human Macrophages Proteolytically Quiescent by Hohensinner, Philipp J, Baumgartner, Johanna, Kral-Pointner, Julia B, Uhrin, Pavel, Ebenbauer, Benjamin, Thaler, Barbara, Doberer, Konstantin, Stojkovic, Stefan, Demyanets, Svitlana, Fischer, Michael B, Huber, Kurt, Schabbauer, Gernot, Speidl, Walter S, Wojta, Johann

“…Macrophages are versatile immune cells capable of polarizing into functional subsets depending on environmental stimulation. In atherosclerotic lesions,…”
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Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation by Oskolkova, Olga V, Afonyushkin, Taras, Preinerstorfer, Beatrix, Bicker, Wolfgang, von Schlieffen, Elena, Hainzl, Eva, Demyanets, Svitlana, Schabbauer, Gernot, Lindner, Wolfgang, Tselepis, Alexandros D, Wojta, Johann, Binder, Bernd R, Bochkov, Valery N

“…Polyunsaturated fatty acids are precursors of multiple pro- and anti-inflammatory molecules generated by enzymatic stereospecific and positionally specific…”
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Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells by Blüml, Stephan, Friedrich, Martin, Lohmeyer, Tobias, Sahin, Emine, Saferding, Victoria, Brunner, Julia, Puchner, Antonia, Mandl, Peter, Niederreiter, Birgit, Smolen, Josef S, Schabbauer, Gernot, Redlich, Kurt

“…Local bone destruction in rheumatic diseases, which often leads to disability and severely reduced quality of life, is almost exclusively mediated by…”
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The human placenta shapes the phenotype of decidual macrophages by Vondra, Sigrid, Höbler, Anna-Lena, Lackner, Andreas Ian, Raffetseder, Johanna, Mihalic, Zala Nikita, Vogel, Andrea, Saleh, Leila, Kunihs, Victoria, Haslinger, Peter, Wahrmann, Markus, Husslein, Heinrich, Oberle, Raimund, Kargl, Julia, Haider, Sandra, Latos, Paulina, Schabbauer, Gernot, Knöfler, Martin, Ernerudh, Jan, Pollheimer, Jürgen

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Determination of Extravasation Effects of Nal-Iri and Trabectedin and Evaluation of Treatment Options for Trabectedin Extravasation in a Preclinical Animal Model by Keritam, Omar, Juhasz, Viktoria, Schöfer, Christian, Thallinger, Christiane, Aretin, Marie-Bernadette, Schabbauer, Gernot, Breuss, Johannes, Unseld, Matthias, Uhrin, Pavel

“…Extravasation during chemotherapy administration can lead to dangerous adverse effects ranging from pain to tissue necrosis. Evidence-based data about…”
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PI3K-Akt Pathway Suppresses Coagulation and Inflammation in Endotoxemic Mice by Schabbauer, Gernot, Tencati, Michael, Pedersen, Brian, Pawlinski, Rafal, Mackman, Nigel

“…OBJECTIVE—In endotoxemia, lipopolysaccharide (LPS) induces a systemic inflammatory response and intravascular coagulation. Monocytes orchestrate the innate…”
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