Search Results - "SCHÜLTER, E"

HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir by THEYS, K, VERCAUTEREN, J, GROSSMAN, Z, STRUCK, D, VANDAMME, A.-M, ABECASIS, A. B, SNOECK, J, ZAZZI, M, CAMACHO, R. J, TORTI, C, SCHÜLTER, E, CLOTET, B, SÖNNERBORG, A, DE LUCA, A

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Prediction of response to antiretroviral therapy by human experts and by the EuResist data‐driven expert system (the EVE study) by Zazzi, M, Kaiser, R, Sönnerborg, A, Struck, D, Altmann, A, Prosperi, M, Rosen‐Zvi, M, Petroczi, A, Peres, Y, Schülter, E, Boucher, CA, Brun‐Vezinet, F, Harrigan, PR, Morris, L, Obermeier, M, Perno, C‐F, Phanuphak, P, Pillay, D, Shafer, RW, Vandamme, A‐M, van Laethem, K, Wensing, AMJ, Lengauer, T, Incardona, F

“…Objectives The EuResist expert system is a novel data‐driven online system for computing the probability of 8‐week success for any given pair of HIV‐1 genotype…”
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Transmission of human immunodeficiency virus I drug resistance - a case report. What are the clinical implications? by Anadol, E, Kaiser, R, Verheyen, J, Schülter, E, Emmelkamp, J, Schwarze-Zander, C, Kupfer, B, Wasmuth, J C, Rockstroh, J K

“…The success of first-line antiretroviral therapy can be challenged by the acquisition of primary drug resistance. Here we report a case where baseline…”
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Evolution of raltegravir resistance during therapy by Sichtig, Nadine, Sierra, Saleta, Kaiser, Rolf, Däumer, Martin, Reuter, Stefan, Schülter, Eugen, Altmann, Andre, Fätkenheuer, Gerd, Dittmer, Ulf, Pfister, Herbert, Esser, Stefan

“…Objectives We investigated the prevalence of raltegravir resistance-associated mutations at baseline and their evolution during raltegravir therapy in patients…”
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Prediction of response to antiretroviral therapy by human experts and by the EuResist data-driven expert system (the EVE study): EuResist vs. experts (EVE) study by Zazzi, M, Kaiser, R, Sönnerborg, A, Struck, D, Altmann, A, Prosperi, M, Rosen-Zvi, M, Petroczi, A, Peres, Y, Schülter, E, Boucher, CA, Brun-Vezinet, F, Harrigan, PR, Morris, L, Obermeier, M, Perno, C-F, Phanuphak, P, Pillay, D, Shafer, RW, Vandamme, A-M, van Laethem, K, Wensing, AMJ, Lengauer, T, Incardona, F

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Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries by Neogi, Ujjwal, Häggblom, Amanda, Singh, Kamalendra, Rogers, Leonard C, Rao, Shwetha D, Amogne, Wondwossen, Schülter, Eugen, Zazzi, Maurizio, Arnold, Eddy, Sarafianos, Stefan G, Sönnerborg, Anders

“…The use of the NNRTI rilpivirine in low- and middle-income countries (LMICs) is under debate. The main objective of this study was to provide further clinical…”
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Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients by Neogi, Ujjwal, Rao, Shwetha D, Bontell, Irene, Verheyen, Jens, Rao, Vasudev R, Gore, Sagar C, Soni, Neelesh, Shet, Anita, Schülter, Eugen, Ekstrand, Maria L, Wondwossen, Amogne, Kaiser, Rolf, Madhusudhan, Mallur S, Prasad, Vinayaka R, Sonnerborg, Anders

“…A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds…”
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Predicting response to antiretroviral treatment by machine learning: the EuResist project by Zazzi, Maurizio, Incardona, Francesca, Rosen-Zvi, Michal, Prosperi, Mattia, Lengauer, Thomas, Altmann, Andre, Sonnerborg, Anders, Lavee, Tamar, Schülter, Eugen, Kaiser, Rolf

“…For a long time, the clinical management of antiretroviral drug resistance was based on sequence analysis of the HIV genome followed by estimating drug…”
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Selecting anti-HIV therapies based on a variety of genomic and clinical factors by Rosen-Zvi, Michal, Altmann, Andre, Prosperi, Mattia, Aharoni, Ehud, Neuvirth, Hani, Sönnerborg, Anders, Schülter, Eugen, Struck, Daniel, Peres, Yardena, Incardona, Francesca, Kaiser, Rolf, Zazzi, Maurizio, Lengauer, Thomas

“…Motivation: Optimizing HIV therapies is crucial since the virus rapidly develops mutations to evade drug pressure. Recent studies have shown that genotypic…”
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Predicting the Response to Combination Antiretroviral Therapy: Retrospective Validation of geno2pheno-THEO on a Large Clinical Database by Altmann, André, Däumer, Martin, Beerenwinkel, Niko, Peres, Yardena, Schülter, Eugen, Büch, Joachim, Rhee, Soo-Yon, Sönnerborg, Anders, Fessel, W. Jeffrey, Shafer, Robert W., Zazzi, Maurizio, Kaiser, Rolf, Lengauer, Thomas

“…BackgroundExpert-based genotypic interpretation systems are standard methods for guiding treatment selection for patients infected with human immunodeficiency…”
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Comparison of classifier fusion methods for predicting response to anti HIV-1 therapy by Altmann, André, Rosen-Zvi, Michal, Prosperi, Mattia, Aharoni, Ehud, Neuvirth, Hani, Schülter, Eugen, Büch, Joachim, Struck, Daniel, Peres, Yardena, Incardona, Francesca, Sönnerborg, Anders, Kaiser, Rolf, Zazzi, Maurizio, Lengauer, Thomas

“…Analysis of the viral genome for drug resistance mutations is state-of-the-art for guiding treatment selection for human immunodeficiency virus type 1…”
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Time on drug analysis based on real life data by Schülter, Eugen, Kaiser, Rolf, Zazzi, Maurizio, Sönnerborg, Anders, Camacho, Ricardo, Verheyen, Jens

“…Introduction The health condition of HIV‐1 infected patients has improved during the last years, but lifelong antiretroviral treatment is still needed. However…”
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Antiretroviral therapy optimisation without genotype resistance testing: a perspective on treatment history based models by Prosperi, Mattia C F, Rosen-Zvi, Michal, Altmann, André, Zazzi, Maurizio, Di Giambenedetto, Simona, Kaiser, Rolf, Schülter, Eugen, Struck, Daniel, Sloot, Peter, van de Vijver, David A, Vandamme, Anne-Mieke, Sönnerborg, Anders

“…Although genotypic resistance testing (GRT) is recommended to guide combination antiretroviral therapy (cART), funding and/or facilities to perform GRT may not…”
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TbMP42, a Protein Component of the RNA Editing Complex in African Trypanosomes, Has Endo-Exoribonuclease Activity by Brecht, Michael, Niemann, Moritz, Schlüter, Elke, Müller, Ulrich F., Stuart, Ken, Göringer, H. Ulrich

“…RNA editing in trypanosomatids is catalyzed by a high molecular mass RNP complex, which is only partially characterized. TbMP42 is a 42 kDa protein of unknown…”
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Investigation of expert rule bases, logistic regression, and non―linear machine learning techniques for predicting response to antiretroviral treatment by PROSPERI, Mattia Cf, ALTMANN, Andre, VANDAMME, Anne-Mieke, VERCAUTEREN, Jurgen, ZAZZI, Maurizio, ROSEN-ZVI, Michal, AHARONI, Ehud, BORGULYA, Gabor, BAZSO, Fulop, SÖNNERBORG, Anders, SCHÜLTER, Eugen, STRUCK, Daniel, ULIVI, Giovanni

“…The extreme flexibility of the HIV type-1 (HIV-1) genome makes it challenging to build the ideal antiretroviral treatment regimen. Interpretation of HIV-1…”
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Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort by Bartha, István, Assel, Matthias, Sloot, Peter M A, Zazzi, Maurizio, Torti, Carlo, Schülter, Eugen, De Luca, Andrea, Sönnerborg, Anders, Abecasis, Ana B, Van Laethem, Kristel, Rosi, Andrea, Svärd, Jenny, Paredes, Roger, van de Vijver, David A M C, Vandamme, Anne-Mieke, Müller, Viktor

“…Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and…”
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Evolution of protease inhibitor resistance in the gag and pol genes of HIV subtype G isolates by Knops, Elena, Däumer, Martin, Awerkiew, Sabine, Kartashev, Vladimir, Schülter, Eugen, Kutsev, Sergey, Brakier-Gingras, Léa, Kaiser, Rolf, Pfister, Herbert, Verheyen, Jens

“…Objectives To analyse HIV Gag cleavage site (CS) and non-CS mutations in HIV non-B isolates from patients failing antiretroviral therapy. Patients and methods…”
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Efficacy of antiretroviral therapy switch in HIV-infected patients: a 10-year analysis of the EuResist Cohort by Oette, Mark, Schülter, Eugen, Rosen-Zvi, Michal, Peres, Yardena, Zazzi, Maurizio, Sönnerborg, Anders, Struck, Daniel, Altmann, André, Kaiser, Rolf

“…Highly active antiretroviral therapy (HAART) has been shown to be effective in many recent trials. However, there is limited data on time trends of HAART…”
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Advantages of predicted phenotypes and statistical learning models in inferring virological response to antiretroviral therapy from HIV genotype by ALTMANN, André, SING, Tobias, PERES, Yardena, SÖNNERBORG, Anders, FESSEL, W. Jeffrey, INCARDONA, Francesca, ZAZZI, Maurizio, BACHELER, Lee, VAN VLIJMEN, Herman, LENGAUER, Thomas, VERMEIREN, Hans, WINTERS, Bart, VAN CRAENENBROECK, Elke, VAN DER BORGHT, Koen, RHEE, Soo-Yon, SHAFER, Robert W, SCHÜLTER, Eugen, KAISER, Rolf

“…Inferring response to antiretroviral therapy from the viral genotype alone is challenging. The utility of an intermediate step of predicting in vitro drug…”
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Sustaining lamivudine/emtricitabine, abacavir, zidovudine or atazanavir from a previous treatment shows a clinical benefit by Rosen-Zvi, M, Schulter, E, Altmann, A, Sierra-Aragon, S, Zazzi, M, Sonnerborg, A, Oette, M, Lengauer, T, Kaiser, R

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