Search Results - "SCHÖDEL, Johannes"

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq by Schödel, Johannes, Oikonomopoulos, Spyros, Ragoussis, Jiannis, Pugh, Christopher W., Ratcliffe, Peter J., Mole, David R.

“…Hypoxia-inducible factor (HIF) regulates the major transcriptional cascade central to the response of all mammalian cells to alterations in oxygen tension…”
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Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer by Schödel, Johannes, Grampp, Steffen, Maher, Eamonn R, Moch, Holger, Ratcliffe, Peter J, Russo, Paul, Mole, David R

“…Abstract Context Renal cancer is a common urologic malignancy, and therapeutic options for metastatic disease are limited. Most clear cell renal cell…”
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Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner by Safi, Wajima, Kraus, Andre, Grampp, Steffen, Schödel, Johannes, Buchholz, Bjoern

“…Progressive cyst growth leads to decline of renal function in polycystic kidney disease. Macrophage migration inhibitory factor (MIF) was found to be…”
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Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases by Chan, Mun Chiang, Ilott, Nicholas E., Schödel, Johannes, Sims, David, Tumber, Anthony, Lippl, Kerstin, Mole, David R., Pugh, Christopher W., Ratcliffe, Peter J., Ponting, Chris P., Schofield, Christopher J.

“…The hypoxia-inducible factor (HIF) system orchestrates cellular responses to hypoxia in animals. HIF is an α/β-heterodimeric transcription factor that…”
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Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer by Grampp, Steffen, Platt, James L., Lauer, Victoria, Salama, Rafik, Kranz, Franziska, Neumann, Viviana K., Wach, Sven, Stöhr, Christine, Hartmann, Arndt, Eckardt, Kai-Uwe, Ratcliffe, Peter J., Mole, David R., Schödel, Johannes

“…Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel–Lindau tumour suppressor (VHL) and unrestrained activation of…”
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KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies by Stanzick, Kira J, Stark, Klaus J, Gorski, Mathias, Schödel, Johannes, Krüger, René, Kronenberg, Florian, Warth, Richard, Heid, Iris M, Winkler, Thomas W

“…Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these findings with post-GWAS…”
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Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1 by Pasutto, Francesca, Zenkel, Matthias, Hoja, Ursula, Berner, Daniel, Uebe, Steffen, Ferrazzi, Fulvia, Schödel, Johannes, Liravi, Panah, Ozaki, Mineo, Paoli, Daniela, Frezzotti, Paolo, Mizoguchi, Takanori, Nakano, Satoko, Kubota, Toshiaki, Manabe, Shinichi, Salvi, Erika, Manunta, Paolo, Cusi, Daniele, Gieger, Christian, Wichmann, Heinz-Erich, Aung, Tin, Khor, Chiea Chuen, Kruse, Friedrich E., Reis, André, Schlötzer-Schrehardt, Ursula

“…Although lysyl oxidase-like 1 ( LOXL1 ) is known as the principal genetic risk factor for pseudoexfoliation (PEX) syndrome, a major cause of glaucoma and…”
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Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α) by Thalhammer, Armin, Bencokova, Zuzana, Poole, Rachel, Loenarz, Christoph, Adam, Julie, O'Flaherty, Linda, Schödel, Johannes, Mole, David, Giaslakiotis, Konstantinos, Schofield, Christopher J, Hammond, Ester M, Ratcliffe, Peter J, Pollard, Patrick J

“…Human 2-oxoglutarate oxygenases catalyse a range of biological oxidations including the demethylation of histone and nucleic acid substrates and the…”
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Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen by Siegert, Isabel, Schödel, Johannes, Nairz, Manfred, Schatz, Valentin, Dettmer, Katja, Dick, Christopher, Kalucka, Joanna, Franke, Kristin, Ehrenschwender, Martin, Schley, Gunnar, Beneke, Angelika, Sutter, Jörg, Moll, Matthias, Hellerbrand, Claus, Wielockx, Ben, Katschinski, Dörthe M., Lang, Roland, Galy, Bruno, Hentze, Matthias W., Koivunen, Peppi, Oefner, Peter J., Bogdan, Christian, Weiss, Günter, Willam, Carsten, Jantsch, Jonathan

“…Both hypoxic and inflammatory conditions activate transcription factors such as hypoxia-inducible factor (HIF)-1α and nuclear factor (NF)-κB, which play a…”
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Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1 by Gimm, Tina, Wiese, Melanie, Teschemacher, Barbara, Deggerich, Anke, Schödel, Johannes, Knaup, Karl X, Hackenbeck, Thomas, Hellerbrand, Claus, Amann, Kerstin, Wiesener, Michael S, Höning, Stefan, Eckardt, Kai-Uwe, Warneck, Christina

“…Hypoxia-inducible protein 2 (HIG2) has been implicated in canonical Wnt signaling, both as target and activator. The potential link between hypoxia and an…”
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Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway by Grampp, Steffen, Schmid, Virginia, Salama, Rafik, Lauer, Victoria, Kranz, Franziska, Platt, James L, Smythies, James, Choudhry, Hani, Goppelt-Struebe, Margarete, Ratcliffe, Peter J, Mole, David R, Schödel, Johannes

“…Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von…”
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Hypoxia-inducible Transcription Factors Stabilization in the Thick Ascending Limb Protects against Ischemic Acute Kidney Injury by SCHLEY, Gunnar, KLANKE, Bernd, MAXWELL, Patrick H, WILLAM, Carsten, SCHÖDEL, Johannes, FORSTREUTER, Frauke, SHUKLA, Deepa, KURTZ, Armin, AMANN, Kerstin, WIESENER, Michael S, ROSEN, Seymour, ECKARDT, Kai-Uwe

“…Hypoxia-inducible transcription factors (HIF) protect cells against oxygen deprivation, and HIF stabilization before ischemia mitigates tissue injury. Because…”
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Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression by Jantsch, Jonathan, Wiese, Melanie, Schödel, Johannes, Castiglione, Kirstin, Gläsner, Joachim, Kolbe, Sophie, Mole, David, Schleicher, Ulrike, Eckardt, Kai‐Uwe, Hensel, Michael, Lang, Roland, Bogdan, Christian, Schnare, Markus, Willam, Carsten

“…In contrast to hypoxia, TLR‐Iigands stabilize HIFlA in a predominantly MYD88‐dependent manner and result in activation of a different set of HIFlA target…”
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Hypoxia induces polycystin-1 expression in the renal epithelium by Grampp, Steffen, Kraus, Andre, Skoczynski, Kathrin, Schiffer, Mario, Krüger, René, Naas, Stephanie, Schödel, Johannes, Buchholz, Bjoern

“…Mutations in polycystin-1 which is encoded by the gene are the main causes for the development of autosomal dominant polycystic kidney disease. However, only…”
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Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression by Orlando, Ilaria M C, Lafleur, Véronique N, Storti, Federica, Spielmann, Patrick, Crowther, Lisa, Santambrogio, Sara, Schödel, Johannes, Hoogewijs, David, Mole, David R, Wenger, Roland H

“…While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an…”
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Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts by Schietke, Ruth E, Hackenbeck, Thomas, Tran, Maxine, Günther, Regina, Klanke, Bernd, Warnecke, Christina L, Knaup, Karl X, Shukla, Deepa, Rosenberger, Christian, Koesters, Robert, Bachmann, Sebastian, Betz, Peter, Schley, Gunnar, Schödel, Johannes, Willam, Carsten, Winkler, Thomas, Amann, Kerstin, Eckardt, Kai-Uwe, Maxwell, Patrick, Wiesener, Michael S

“…The Hypoxia-inducible transcription Factor (HIF) represents an important adaptive mechanism under hypoxia, whereas sustained activation may also have…”
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Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation by Scholz, Julia Katharina, Kraus, Andre, Lüder, Dominik, Skoczynski, Kathrin, Schiffer, Mario, Grampp, Steffen, Schödel, Johannes, Buchholz, Bjoern

“…Autosomal dominant polycystic kidney disease is the most common monogenic disease that causes end-stage renal failure. It primarily results from mutations in…”
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Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells by Schödel, Johannes, Bohr, Daniela, Klanke, Bernd, Schley, Gunnar, Schlötzer-Schrehardt, Ursula, Warnecke, Christina, Kurtz, Armin, Amann, Kerstin, Eckardt, Kai-Uwe, Willam, Carsten

“…The two hypoxia-inducible factors (HIF-1α and HIF-2α) are transcription factors that regulate the response to hypoxia. Recently, the factor inhibiting HIF…”
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HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia by Hackenbeck, Thomas, Knaup, Karl Xaver, Schietke, Ruth E., Schödel, Johannes, Willam, Carsten, Wu, Xiaoqing, Warnecke, Christina, Eckardt, Kai-Uwe, Wiesener, Michael

“…Hypoxia is a severe stress which induces physiological and molecular adaptations, where the latter is dominated by the Hypoxia-inducible transcription Factor…”
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Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA by Vonbrunn, Eva, Serikova, Sofya, Daniel, Christoph, Amann, Kerstin, Schödel, Johannes, Buchholz, Björn, Ferrazzi, Fulvia, Heller, Katharina, Apel, Hendrik, Büttner-Herold, Maike

“…The quality of a renal transplant can influence the clinical course after transplantation. Glomerular immune reactivity in renal transplants has previously…”
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