Search Results - "SCARPI, D"

Structural diversity of bicyclic amino acids by Trabocchi, A, Scarpi, D, Guarna, A

“…Over the years biomedical research has been constantly oriented towards the development of new therapeutics based on bioactive peptides and their analogues. In…”
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Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity by Scarpi, D, Cirelli, D, Matrone, C, Castronovo, G, Rosini, P, Occhiato, E G, Romano, F, Bartali, L, Clemente, A M, Bottegoni, G, Cavalli, A, De Chiara, G, Bonini, P, Calissano, P, Palamara, A T, Garaci, E, Torcia, M G, Guarna, A, Cozzolino, F

“…Exploitation of the biologic activity of neurotrophins is desirable for medical purposes, but their protein nature intrinsically bears adverse pharmacokinetic…”
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Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity by Scarpi, D, Cirelli, D, Matrone, C, Castronovo, G, Rosini, P, Occhiato, E G, Romano, F, Bartali, L, Clemente, A M, Bottegoni, G, Cavalli, A, De Chiara, G, Bonini, P, Calissano, P, Palamara, A T, Garaci, E, Torcia, M G, Guarna, A, Cozzolino, F

“…Exploitation of the biologic activity of neurotrophins is desirable for medical purposes, but their protein nature intrinsically bears adverse pharmacokinetic…”
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Determinants and mediators of the intention to upgrade the contract in buyer–seller relationships by Visentin, Marco, Scarpi, Daniele

“…This study presents a dynamic model of a business-to-business relationship aimed at explaining the motivation to upgrade a contract. It considers social and…”
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Inhibition of human β-tryptase by Bowman-Birk inhibitor derived peptides by Scarpi, D., McBride, J.D., Leatherbarrow, R.J.

“…: Four 11‐residue peptides based on the Bowman–Birk inhibitor (BBI) structure were synthesized. These were tested for their ability to inhibit human…”
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Selectivity of Daucus carota roots and baker’s yeast in the enantioselective reduction of γ-nitroketones by Scarpi, Dina, Occhiato, Ernesto G., Guarna, Antonio

“…[Display omitted] The enantioselective reduction of a series of aromatic γ-nitroketones was achieved by using Daucus carota roots in water, which afforded the…”
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3-Aza-8,10-dioxa-bicyclo[5.2.1]decane (9- exo BTKa) carboxylic acid as a new reverse turn inducer: synthesis and conformational analysis of a model peptide by Scarpi, Dina, Stranges, Daniela, Trabocchi, Andrea, Guarna, Antonio

“…Dipeptide isostere 5 , belonging to the class of 9- exo BTKa, was synthesised starting from R, R-tartaric acid and 4-nitro-1-(3-nitrophenyl)butan-1-one. The…”
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Erratum: Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity by Scarpi, D, Cirelli, D, Matrone, C, Castronovo, G, Rosini, P, Occhiato, E G, Romano, F, Bartali, L, Clemente, A M, Bottegoni, G, Cavalli, A, De Chiara, G, Bonini, P, Calissano, P, Palamara, A T, Garaci, E, Torcia, M G, Guarna, A, Cozzolino, F

“…Correction to: Cell Death and Disease (2012) 3, e339; doi:10.1038/cddis.2012.80; published online 5 July 2012 Since the publication of this article the authors…”
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Inhibition of human β-tryptase by Bowman–Birk inhibitor derived peptides: creation of a new tri-functional inhibitor by Scarpi, Dina, McBride, Jeffrey D., Leatherbarrow, Robin J.

“…[Display omitted] Bowman–Birk inhibitor proteins (BBIs), which are potent inhibitors of chymotrypsin-like proteases, do not inhibit human β-tryptase despite…”
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Synthesis of new molecular scaffolds: 3-aza-7,9-dioxa-bicyclo[4.2.1]nonane (8- exo BTKa) and 3-aza-8,10-dioxa-bicyclo[5.2.1]decane (9- exo BTKa) carboxylic acids by Scarpi, Dina, Stranges, Daniela, Cecchi, Luca, Guarna, Antonio

“…Two classes of enantiopure molecular scaffolds were prepared, whose lactam structure formally derives from the coupling between tartaric acid and β- or…”
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Enantioselective addition of diethylzinc to aldehydes using 1,4-aminoalcohols as chiral ligands by Scarpi, Dina, Lo Galbo, Fabrizio, Occhiato, Ernesto G., Guarna, Antonio

“…Graphic Conformationally constrained, optically active 1,4-aminoalcohols have been used as chiral ligands in the addition of diethylzinc to aromatic aldehydes…”
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Synthesis of a new enantiopure bicyclic γ/δ-amino acid (BTKa) derived from tartaric acid and α-amino acetophenone by Guarna, Antonio, Bucelli, Ilaria, Machetti, Fabrizio, Menchi, Gloria, Occhiato, Ernesto G, Scarpi, Dina, Trabocchi, Andrea

“…The synthesis of a novel enantiopure γ/δ-amino acid having the 3-aza-6,8-dioxabicyclo[3.2.1]octane structure was realized by the combination of tartaric acid…”
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Synthesis and Reactivity of Bicycles Derived from Tartaric Acid and α-Amino Acids:  A Novel Class of Conformationally Constrained Dipeptide Isosteres Based upon Enantiopure 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid by Guarna, Antonio, Guidi, Antonio, Machetti, Fabrizio, Menchi, Gloria, Occhiato, Ernesto G, Scarpi, Dina, Sisi, Sauro, Trabocchi, Andrea

“…3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic acids (named BTAa) derived from (R,R)-, (S,S)-, or meso-tartaric acid and natural (l), unnatural (d), or…”
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Benzo[c]quinolizin-3-ones:  A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 by Guarna, Antonio, Machetti, Fabrizio, Occhiato, Ernesto G, Scarpi, Dina, Comerci, Alessandra, Danza, Giovanna, Mancina, Rosa, Serio, Mario, Hardy, Kimber

“…The synthesis and biological evaluation of a series of novel, selective inhibitors of isoenzyme 1 of human 5α-reductase (5αR) (EC 1.3.99.5) are reported. The…”
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Synthesis of 17β- N-Substituted 19-Nor-10-azasteroids as Inhibitors of Human 5α-Reductases I and II by Scarpi, Dina, Occhiato, Ernesto G., Danza, Giovanna, Serio, Mario, Guarna, Antonio

“…The synthesis of 17β-[ N-(phenyl)methyl/phenyl-amido] substituted 10-azasteroids has been accomplished by either the TiCl 4- or TMSOTf-catalysed reaction of…”
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Modification of the Aza-Robinson Annulation for the Synthesis of 4-Methyl-Benzo[c]quinolizin-3-ones, Potent Inhibitors of Steroid 5α-Reductase 1 by Guarna, Antonio, Lombardi, Elena, Machetti, Fabrizio, Occhiato, Ernesto G, Scarpi, Dina

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Stereoselective Meisenheimer rearrangement using BTAa's as chiral auxiliaries by Guarna, Antonio, Occhiato, Ernesto G, Pizzetti, Mirco, Scarpi, Dina, Sisi, Sauro, van Sterkenburg, Matthijs

“…The Meisenheimer rearrangement involves the [2,3]-sigmatropic rearrangement of allylic tertiary amine- N-oxides to O-allyl hydroxylamines. Various BTAa's…”
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Effect of C-ring modifications in benzo[ c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1 by Guarna, Antonio, Occhiato, Ernesto G., Machetti, Fabrizio, Trabocchi, Andrea, Scarpi, Dina, Danza, Giovanna, Mancina, Rosa, Comerci, Alessandra, Serio, Mario

“…The synthesis and the inhibition potency of octahydro- and decahydrobenzo[ c]quinolizin-3-one derivatives 3– 7, as new non-steroidal selective inhibitors of…”
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Modification of the aza-robinson annulation for the synthesis of 4-methyl-benzo[c]quinolizin-3-ones, potent inhibitors of steroid 5alpha-reductase 1 by Guarna, A, Lombardi, E, Machetti, F, Occhiato, E G, Scarpi, D

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A Concise Route to 19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. 3. Synthesis of (+)-19-Nor-10-azatestosterone and (+)-17β-(Acetyloxy)-(5β)-10-azaestr-1-en-3-one by Guarna, Antonio, Occhiato, Ernesto G, Machetti, Fabrizio, Scarpi, Dina

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