Search Results - "SCANLON, Kevin"

Anti-genes: siRNA, ribozymes and antisense by Scanlon, Kevin J

“…Scientists have been working on strategies to selectively turn off specific genes in diseased tissues for the past thirty years. In the 1980's,…”
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Cancer Gene Therapy: Challenges and Opportunities by SCANLON, Kevin J

“…Understanding the molecular basis of human disease has been the corner-stone of rationally designed molecular therapies. Medicine has a long history of…”
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Ribozyme against mutant K-ras mRNA suppresses tumor growth of pancreatic cancer by Kijima, Hiroshi, Yamazaki, Hitoshi, Nakamura, Masato, Scanlon, Kevin J, Osamura, R Yoshiyuki, Ueyama, Yoshito

“…Point mutations in the K-ras gene are observed at a high incidence in human pancreatic carcinomas. These alterations can be used as potential targets for…”
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Reversal of drug resistance using hammerhead ribozymes against multidrug resistance-associated protein and multidrug resistance 1 gene by Nagata, Junko, Kijima, Hiroshi, Hatanaka, Hiroyuki, Asai, Satomi, Miyachi, Hayato, Abe, Yoshiyuki, Yamazaki, Hitoshi, Nakamura, Masato, Watanabe, Norihito, Mine, Tetsuya, Kondo, Takahito, Scanlon, Kevin J, Ueyama, Yoshito

“…We examined the effects of suppressing multidrug resistance-associated protein (MRP) and multidrug resistance 1 (MDR1) gene expression in HCT-8DDP human colon…”
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Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme by MAELANDSMO, G. M, HOVIG, E, SKREDE, M, ENGEBRAATEN, O, FLØRENES, V. A, MYKLEBOST, O, GRIGORIAN, M, LUKANIDIN, E, SCANLON, K. J, FODSTAD, Ø

“…The putative role of the CAPL gene in enhancing the development of human cancer metastasis was examined by transfecting human high-expressing osteosarcoma…”
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Commercializing medical technology by Scanlon, Kevin J, Lieberman, Mark A

“…As medicine moves into the 21st century, life saving therapies will move from inception into medical products faster if there is a better synergy between…”
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Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme by FENG, M, CABRERA, G, DESHANE, J, SCANLON, K. J, CURIEL, D. T

“…Strategies have been developed to abrogate the aberrant expression of dominant oncogenes as a means to accomplish targeted tumor eradication. We have…”
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Improved cancer vaccines through gene transfer by Sobol, Robert E, Scanlon, Kevin J

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The Relevance of Ethical Standards among Veteran Superintendents by Scanlon, Kevin

“…Ethical violations in education exist worldwide. Superintendents of schools are in the unique position of exerting their authority and influence on the entire…”
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Ribozyme-Mediated Reversal of the Multidrug-Resistant Phenotype by Scanlon, Kevin J., Ishida, Hironori, Kashani-Sabet, Mohammed

“…This study examined the effects of suppressing c-fos oncogene expression on multidrug resistance (MDR). A2780S human ovarian carcinoma cells with resistance to…”
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Construction and Transfection of a Ribozyme Targeting Human Caspase-3 by CRONIN, Deirdre, DALY, Carmel, O'DOHERTY, Toni, HEENAN, Mary, SCANLON, Kevin J, CLYNES, Martin

“…Caspase-3 is a key executioner cysteine protease involved in programmed cell death or apoptosis. A ribozyme to human caspase-3 was designed, tested by in vitro…”
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Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme by MOHAMMED KASHANI-SABET, FUNATO, T, FLORENES, V. A, FODSTAD, O, SCANLON, K. J

“…In this study, the efficacy of an anti-ras ribozyme in reversing the neoplastic phenotype was investigated. Murine NIH3T3 cells were transfected with cellular…”
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Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins by Iida, T, Kijima, H, Urata, Y, Goto, S, Ihara, Y, Oka, M, Kohno, S, Scanlon, K J, Kondo, T

“…Multidrug resistance in cancer cells is often associated with an elevation in the concentration of glutathione (GSH) and the expression of…”
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Ribozyme as an approach for growth suppression of human pancreatic cancer by KIJIMA, H, SCANLON, K. J

“…Ribozymes (catalytic RNAs, RNA enzymes) are effective modulators of gene expression because of their simple structure, site-specific cleavage activity, and…”
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Anti-K-ras ribozyme induces growth inhibition and increased chemosensitivity in human colon cancer cells by Funato, T, Ishii, T, Kambe, M, Scanlon, K J, Sasaki, T

“…Colon cancer is one of the carcinomas that is resistant to a variety of therapies. To develop a new therapy by regulating the activated K-ras gene in colon…”
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Ribozymes as Therapeutic Agents: Are We Getting Closer? by Scanlon, Kevin J., Kashani-Sabet, Mohammed

“…An editorial addresses a study by Yamazaki et al in which they extend the utility of ribozymes for target validation in human cancer. A hammerhead ribozyme…”
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Ribozyme-Mediated Cancer Gene Therapy by Irie, Akira, Bouffard, David Y., Scanlon, Kevin J.

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Characterization of a cisplatin-resistant human ovarian carcinoma cell line expressing cross-resistance to 5-fluorouracil but collateral sensitivity to methotrexate by HILL, B. T, SHELLARD, S. A, HOSKING, L. K, DEMPKE, W. C. M, FICHTINGER, A. M. J, TAKESHI, S, TONE, T, SCANLON, K. J, WHELAN, R. D. H

“…In vitro exposure of the TR170 ovarian carcinoma cell line to six intermittent 24-h treatments with a 90% inhibitory concentration of cisplatin (CDDP) (0.15…”
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Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro by OHNUMA, T, LO, R. J, SCANLON, K. J, KAMEN, B. A, OHNOSHI, T, WOLMAN, S. R, HOLLAND, J. F

“…A human acute lymphoblastic T-cell line, MOLT-3, was fed with Roswell Park Memorial Institute Medium 1640 supplemented with 10% fetal bovine serum and…”
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Galaxy of stars Unite4:Humanity at Inaugural Event: Swanky dinner party boasts Demi Lovato's acoustic perf of 'Skyscraper' and 'Warrior' by Scanlon, Kevin

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