Search Results - "SCANLON, K. J"

Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice by ZHANG, Y.-A, NEMUNAITIS, J, SCANLON, K. J, TONG, A. W

“…Approximately 15-30% of human non-small cell lung cancers (NSCLC) carry K-ras mutations, among which point mutations at codon 12 are the most common. This…”
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Adenovirus-mediated ribozyme targeting of HER-2/neu inhibits in vivo growth of breast cancer cells by SUZUKI, T, ANDEREGG, B, OHKAWA, T, IRIE, A, ENGEBRAATEN, O, HALKS-MILLER, M, HOLM, P. S, CURIEL, D. T, KASHANI-SABET, M, SCANLON, K. J

“…HER-2/neu is overexpressed in 25-30% of human breast cancers. We prepared an anti-HER-2/neu hammerhead ribozyme expressed by a recombinant adenovirus…”
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Biochemical Basis for Cisplatin and 5-fluorouracil Synergism in Human Ovarian Carcinoma Cells by Scanlon, K. J., Newman, E. M., Lu, Y., Priest, D. G.

“…The human ovarian cell line A2780 was exposed to either cisplatin (10 μ M) or 5-fluorouracil (5FUra) (5 μ M) for 1 hr. Cytotoxicity was less than 14% with…”
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Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme by HOLM, P. S, SCANLON, K. J, DIETEL, M

“…A major problem in cytostatic treatment of many tumours is the development of multidrug resistance (MDR4). This is most often accompanied by the overexpression…”
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Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme by MAELANDSMO, G. M, HOVIG, E, SKREDE, M, ENGEBRAATEN, O, FLØRENES, V. A, MYKLEBOST, O, GRIGORIAN, M, LUKANIDIN, E, SCANLON, K. J, FODSTAD, Ø

“…The putative role of the CAPL gene in enhancing the development of human cancer metastasis was examined by transfecting human high-expressing osteosarcoma…”
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Growth inhibition efficacy of an adenovirus expressing dual therapeutic genes, wild-type p53, and anti-erbB2 ribozyme, against human bladder cancer cells by Irie, A, Matsumoto, K, Anderegg, B, Kuruma, H, Kashani-Sabet, M, Scanlon, K J, Uchida, T, Baba, S

“…The altered expression of both p53 and erbB2 is strongly related to the disease status and the outcome of bladder cancers. We examined the antitumor efficacy…”
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Cisplatin resistance in human cancers by Scanlon, K J, Kashani-Sabet, M, Tone, T, Funato, T

“…Cancer chemotherapeutic agents primarily act by damaging cellular DNA directly or indirectly. Tumor cells, in contrast to normal cells, respond to cisplatin…”
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Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme by FENG, M, CABRERA, G, DESHANE, J, SCANLON, K. J, CURIEL, D. T

“…Strategies have been developed to abrogate the aberrant expression of dominant oncogenes as a means to accomplish targeted tumor eradication. We have…”
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Elevated Expression of Thymidylate Synthase Cycle Genes in Cisplatin-Resistant Human Ovarian Carcinoma A2780 Cells by Scanlon, Kevin J., Kashani-Sabet, Mohammed

“…Activity of the thymidylate synthase cycle was compared in the human ovarian carcinoma cell line A2780 and a subline that is resistant to cisplatin by a factor…”
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Ribozyme-Mediated Reversal of the Multidrug-Resistant Phenotype by Scanlon, Kevin J., Ishida, Hironori, Kashani-Sabet, Mohammed

“…This study examined the effects of suppressing c-fos oncogene expression on multidrug resistance (MDR). A2780S human ovarian carcinoma cells with resistance to…”
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Altered expression of mRNAs for apoptosis‐modulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdr1 mRNA by NicAmhlaoibh, Róisín, Heenan, Mary, Cleary, Irene, Touhey, Samantha, O'Loughlin, Colette, Daly, Carmel, Nuñez, Gabriel, Scanlon, Kevin J., Clynes, Martin

“…An in vitro model that might be relevant to cancer cell chemoresistance in vivo was generated by exposing the human lung carcinoma clonal cell line DLKP‐SQ to…”
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Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme by MOHAMMED KASHANI-SABET, FUNATO, T, FLORENES, V. A, FODSTAD, O, SCANLON, K. J

“…In this study, the efficacy of an anti-ras ribozyme in reversing the neoplastic phenotype was investigated. Murine NIH3T3 cells were transfected with cellular…”
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The Journal of Cancer Gene and Cellular Therapies by Sobol, R E, Scanlon, K J

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Ribozyme as an approach for growth suppression of human pancreatic cancer by KIJIMA, H, SCANLON, K. J

“…Ribozymes (catalytic RNAs, RNA enzymes) are effective modulators of gene expression because of their simple structure, site-specific cleavage activity, and…”
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Cyclosporin A suppresses cisplatin-induced c-fos gene expression in ovarian carcinoma cells by Kashani-Sabet, M, Wang, W, Scanlon, K J

“…Cisplatin-resistant A2780DDP human ovarian carcinoma cells, 1 and 3 h following cisplatin treatment, display 3.2-6.1-fold enhancement of mRNA expression for…”
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An overview of the Tenth International Conference on Cancer Gene Therapy by Scanlon, K J

“…Dr. Scanlon, the new president (2001-2002) of the International Society of Cancer Gene Therapy, gave the conference summary and an overview of gene therapy in…”
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Biochemical and molecular properties of cisplatin-resistant A2780 cells grown in folinic acid by Lu, Y, Han, J, Scanlon, K J

“…In this study, A2780 human ovarian carcinoma cells were grown in folinic acid in contrast to folic acid, and the molecular and biochemical properties of…”
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Tissue-Specific Expression of an Anti-ras Ribozyme Inhibits Proliferation of Human Malignant Melanoma Cells by Ohta, Yukinori, Kijima, Hiroshi, Ohkawa, Tsukasa, Kashani-Sabet, Mohammed, Scanlon, Kevin J.

“…In this study, we have compared the efficacy of a tissue-specific promoter (tyrosinase promoter) with a viral promoter to express anti-ras ribozyme RNA in…”
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Gene expression in X-irradiated human tumour cell lines expressing cisplatin resistance and altered DNA repair capacity by Taverna, P, Hansson, J, Scanlon, K J, Hill, B T

“…Previous studies have indicated that excision repair genes, such as ERCC1, or early response genes, such as c-fos, may play a significant role in regulating…”
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Ribozymes as Therapeutic Agents: Are We Getting Closer? by Scanlon, Kevin J., Kashani-Sabet, Mohammed

“…An editorial addresses a study by Yamazaki et al in which they extend the utility of ribozymes for target validation in human cancer. A hammerhead ribozyme…”
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