Search Results - "SAYLES, Leanne C"

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma by Mazur, Pawel K, Herner, Alexander, Mello, Stephano S, Wirth, Matthias, Hausmann, Simone, Sánchez-Rivera, Francisco J, Lofgren, Shane M, Kuschma, Timo, Hahn, Stephan A, Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noël, Peter B, Braren, Rickmer, Erkan, Mert, Kleeff, Jörg, Sipos, Bence, Sayles, Leanne C, Heikenwalder, Mathias, Heßmann, Elisabeth, Ellenrieder, Volker, Esposito, Irene, Jacks, Tyler, Bradner, James E, Khatri, Purvesh, Sweet-Cordero, E Alejandro, Attardi, Laura D, Schmid, Roland M, Schneider, Guenter, Sage, Julien, Siveke, Jens T

“…The bromodomain and extraterminal (BET) inhibitor JQ1 synergizes with the histone deacetylase inhibitor SAHA to suppress tumor growth in mouse models of…”
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Genome-Informed Targeted Therapy for Osteosarcoma by Sayles, Leanne C, Breese, Marcus R, Koehne, Amanda L, Leung, Stanley G, Lee, Alex G, Liu, Heng-Yi, Spillinger, Aviv, Shah, Avanthi T, Tanasa, Bogdan, Straessler, Krystal, Hazard, Florette K, Spunt, Sheri L, Marina, Neyssa, Kim, Grace E, Cho, Soo-Jin, Avedian, Raffi S, Mohler, David G, Kim, Mi-Ok, DuBois, Steven G, Hawkins, Douglas S, Sweet-Cordero, E Alejandro

“…Osteosarcoma is a highly aggressive cancer for which treatment has remained essentially unchanged for more than 30 years. Osteosarcoma is characterized by…”
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Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis by Chuang, Chen-Hua, Greenside, Peyton G, Rogers, Zoë N, Brady, Jennifer J, Yang, Dian, Ma, Rosanna K, Caswell, Deborah R, Chiou, Shin-Heng, Winters, Aidan F, Grüner, Barbara M, Ramaswami, Gokul, Spencley, Andrew L, Kopecky, Kimberly E, Sayles, Leanne C, Sweet-Cordero, E Alejandro, Li, Jin Billy, Kundaje, Anshul, Winslow, Monte M

“…In vivo screening of pro-metastatic factors in a genetically engineered mouse model of lung cancer uncovered the CD109–JAK–STAT3 axis as a key contributor of…”
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An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer by Vallejo, Adrian, Perurena, Naiara, Guruceaga, Elisabet, Mazur, Pawel K., Martinez-Canarias, Susana, Zandueta, Carolina, Valencia, Karmele, Arricibita, Andrea, Gwinn, Dana, Sayles, Leanne C., Chuang, Chen-Hua, Guembe, Laura, Bailey, Peter, Chang, David K., Biankin, Andrew, Ponz-Sarvise, Mariano, Andersen, Jesper B., Khatri, Purvesh, Bozec, Aline, Sweet-Cordero, E. Alejandro, Sage, Julien, Lecanda, Fernando, Vicent, Silve

“…KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper…”
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Antitumor activity of an engineered decoy receptor targeting CLCF1–CNTFR signaling in lung adenocarcinoma by Kim, Jun W., Marquez, Cesar P., Kostyrko, Kaja, Koehne, Amanda L., Marini, Kieren, Simpson, David R., Lee, Alex G., Leung, Stanley G., Sayles, Leanne C., Shrager, Joseph, Ferrer, Irene, Paz-Ares, Luis, Gephart, Melanie Hayden, Vicent, Silvestre, Cochran, Jennifer R., Sweet-Cordero, E. Alejandro

“…Proinflammatory cytokines in the tumor microenvironment can promote tumor growth, yet their value as therapeutic targets remains underexploited. We validated…”
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Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo by VICENT, Silvestre, SAYLES, Leanne C, SHRAGER, Joseph, HOANG, Chuong D, PLEVRITIS, Sylvia, BUTTE, Atul J, ALEJANDRO SWEET-CORDERO, E, VAKA, Dedeepya, KHATRI, Purvesh, GEVAERT, Olivier, CHEN, Ron, ZHENG, Yanyan, GILLESPIE, Anna K, CLARKE, Nicole, YUE XU

“…Cancer-associated fibroblasts (CAF) have been reported to support tumor progression by a variety of mechanisms. However, their role in the progression of…”
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Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer by Oliver, Trudy G, Mercer, Kim L, Sayles, Leanne C, Burke, James R, Mendus, Diana, Lovejoy, Katherine S, Cheng, Mei-Hsin, Subramanian, Aravind, Mu, David, Powers, Scott, Crowley, Denise, Bronson, Roderick T, Whittaker, Charles A, Bhutkar, Arjun, Lippard, Stephen J, Golub, Todd, Thomale, Juergen, Jacks, Tyler, Sweet-Cordero, E Alejandro

“…Chemotherapy resistance is a major obstacle in cancer treatment, yet the mechanisms of response to specific therapies have been largely unexplored in vivo…”
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A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal by Zheng, Yanyan, de la Cruz, Cecile C., Sayles, Leanne C., Alleyne-Chin, Chris, Vaka, Dedeepya, Knaak, Tim D., Bigos, Marty, Xu, Yue, Hoang, Chuong D., Shrager, Joseph B., Fehling, Hans Joerg, French, Dorothy, Forrest, William, Jiang, Zhaoshi, Carano, Richard A.D., Barck, Kai H., Jackson, Erica L., Sweet-Cordero, E. Alejandro

“…Sustained tumor progression has been attributed to a distinct population of tumor-propagating cells (TPCs). To identify TPCs relevant to lung cancer…”
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Introduction of an Additional Pathway for Lactate Oxidation in the Treatment of Lactic Acidosis and Mitochondrial Dysfunction in Caenorhabditis elegans by Leslie I. Grad, Leanne C. Sayles, Lemire, Bernard D., Schatz, Gottfried

“…Mitochondrial dysfunction, with an estimated incidence of 1 in 5,000 births, is associated with a wide variety of multisystem degenerative diseases. Among the…”
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Pharmacologic inhibition of eIF4A blocks NRF2 synthesis to prevent osteosarcoma metastasis by Lizardo, Michael M, Hughes, Christopher, Huang, Yue Z, Shyp, Taras, Delaidelli, Alberto, Zhang, Hai-Feng, Shaool, Sol Snir, Renner, Annalena F, Burwag, Fares, Sayles, Leanne C, Lee, Alex G, Sweet-Cordero, E Alejandro, Sorensen, Poul H

“…Effective therapies for metastatic osteosarcoma (OS) remain a critical unmet need. Targeting mRNA translation in metastatic OS offers a promising option, as…”
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Direct transposition of native DNA for sensitive multimodal single-molecule sequencing by Nanda, Arjun S., Wu, Ke, Irkliyenko, Iryna, Woo, Brian, Ostrowski, Megan S., Clugston, Andrew S., Sayles, Leanne C., Xu, Lingru, Satpathy, Ansuman T., Nguyen, Hao G., Alejandro Sweet-Cordero, E., Goodarzi, Hani, Kasinathan, Sivakanthan, Ramani, Vijay

“…Concurrent readout of sequence and base modifications from long unamplified DNA templates by Pacific Biosciences of California (PacBio) single-molecule…”
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Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities by Sun, Claire Xin, Daniel, Paul, Bradshaw, Gabrielle, Shi, Hui, Loi, Melissa, Chew, Nicole, Parackal, Sarah, Tsui, Vanessa, Liang, Yuqing, Koptyra, Mateusz, Adjumain, Shazia, Sun, Christie, Chong, Wai Chin, Fernando, Dasun, Drinkwater, Caroline, Tourchi, Motahhareh, Habarakada, Dilru, Sooraj, Dhanya, Carvalho, Diana, Storm, Phillip B., Baubet, Valerie, Sayles, Leanne C., Fernandez, Elisabet, Nguyen, Thy, Pörksen, Mia, Doan, Anh, Crombie, Duncan E., Panday, Monty, Zhukova, Nataliya, Dun, Matthew D., Ludlow, Louise E., Day, Bryan, Stringer, Brett W., Neeman, Naama, Rubens, Jeffrey A., Raabe, Eric H., Vinci, Maria, Tyrrell, Vanessa, Fletcher, Jamie I., Ekert, Paul G., Dumevska, Biljana, Ziegler, David S., Tsoli, Maria, Syed Sulaiman, Nur Farhana, Loh, Amos Hong Pheng, Low, Sharon Yin Yee, Sweet-Cordero, E. Alejandro, Monje, Michelle, Resnick, Adam, Jones, Chris, Downie, Peter, Williams, Bryan, Rosenbluh, Joseph, Gough, Daniel, Cain, Jason E., Firestein, Ron

“…Pediatric solid and central nervous system tumors are the leading cause of cancer-related death among children. Identifying new targeted therapies necessitates…”
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The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas by Valencia, Karmele, Erice, Oihane, Kostyrko, Kaja, Hausmann, Simone, Guruceaga, Elizabeth, Tathireddy, Anuradha, Flores, Natasha M, Sayles, Leanne C, Lee, Alex G, Fragoso, Rita, Sun, Tian-Qiang, Vallejo, Adrian, Roman, Marta, Entrialgo-Cadierno, Rodrigo, Migueliz, Itziar, Razquin, Nerea, Fortes, Puri, Lecanda, Fernando, Lu, Jun, Ponz-Sarvise, Mariano, Chen, Chang-Zheng, Mazur, Pawel K, Sweet-Cordero, E Alejandro, Vicent, Silvestre

“…Few therapies are currently available for patients with KRAS-driven cancers, highlighting the need to identify new molecular targets that modulate central…”
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Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach by Schott, Courtney R, Koehne, Amanda L, Sayles, Leanne C, Young, Elizabeth P, Luck, Cuyler, Yu, Katherine, Lee, Alex G, Breese, Marcus R, Leung, Stanley G, Xu, Hang, Shah, Avanthi Tayi, Liu, Heng-Yi, Spillinger, Aviv, Behroozfard, Inge H, Marini, Kieren D, Dinh, Phuong T, Pons Ventura, María V, Vanderboon, Emma N, Hazard, Florette K, Cho, Soo-Jin, Avedian, Raffi S, Mohler, David G, Zimel, Melissa, Wustrack, Rosanna, Curtis, Christina, Sirota, Marina, Sweet-Cordero, E Alejandro

“…Models to study metastatic disease in rare cancers are needed to advance preclinical therapeutics and to gain insight into disease biology. Osteosarcoma is a…”
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Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation by Solomon, Paige E., Kirkemo, Lisa L., Wilson, Gary M., Leung, Kevin K., Almond, Mark H., Sayles, Leanne C., Sweet-Cordero, E. Alejandro, Rosenberg, Oren S., Coon, Joshua J., Wells, James A.

“…Since the discovery of oncogenes, there has been tremendous interest to understand their mechanistic basis and to develop broadly actionable therapeutics. Some…”
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Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma by Mazur, Pawel K., Herner, Alexander, Mello, Stephano S., Wirth, Matthias, Hausmann, Simone, Sánchez-Rivera, Francisco J., Lofgren, Shane M., Kuschma, Timo, Hahn, Stephan A., Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noël, Peter B., Braren, Rickmer, Erkan, Mert, Kleeff, Jörg, Sipos, Bence, Sayles, Leanne C., Heikenwalder, Mathias, Heßmann, Elisabeth, Ellenrieder, Volker, Esposito, Irene, Jacks, Tyler, Bradner, James E., Khatri, Purvesh, Sweet-Cordero, E. Alejandro, Attardi, Laura D., Schmid, Roland M., Schneider, Guenter, Sage, Julien, Siveke, Jens T.

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A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal by Zheng, Yanyan, de la Cruz, Cecile C, Sayles, Leanne C, Alleyne-Chin, Chris, Vaka, Dedeepya, Knaak, Tim D, Bigos, Marty, Xu, Yue, Hoang, Chuong D, Shrager, Joseph B, Fehling, Hans Joerg, French, Dorothy, Forrest, William, Jiang, Zhaoshi, Carano, Richard A D, Barck, Kai H, Jackson, Erica L, Sweet-Cordero, E Alejandro

“…Sustained tumor progression has been attributed to a distinct population of tumor-propagating cells (TPCs). To identify TPCs relevant to lung cancer…”
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Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models by Vicent, Silvestre, Chen, Ron, Sayles, Leanne C, Lin, Chenwei, Walker, Randal G, Gillespie, Anna K, Subramanian, Aravind, Hinkle, Gregory, Yang, Xiaoping, Saif, Sakina, Root, David E, Huff, Vicki, Hahn, William C, Sweet-Cordero, E Alejandro

“…KRAS is one of the most frequently mutated human oncogenes. In some settings, oncogenic KRAS can trigger cellular senescence, whereas in others it produces…”
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A 3D Osteosarcoma Model with Bone‐Mimicking Cues Reveals a Critical Role of Bone Mineral and Informs Drug Discovery by González Díaz, Eva C., Lee, Alex G., Sayles, Leanne C., Feria, Criselle, Sweet‐Cordero, E. Alejandro, Yang, Fan

“…Osteosarcoma (OS) is an aggressive bone cancer for which survival has not improved over three decades. While biomaterials have been widely used to engineer 3D…”
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Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease by DeCorby, Adrienne, Gášková, Dana, Sayles, Leanne C., Lemire, Bernard D.

“…The NADH:ubiquinone oxidoreductase or complex I of the mitochondrial respiratory chain is an intricate enzyme with a vital role in energy metabolism. Mutations…”
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