Search Results - "SAYDAM, Nurten"

Deficiency of Ku Induces Host Cell Exploitation in Human Cancer Cells by Saydam, Okay, Saydam, Nurten

“…Cancer metastasis is the major cause of death from cancer (Massague and Obenauf, 2016; Steeg, 2016). The extensive genetic heterogeneity and cellular…”
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Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance by Madlener, Sibylle, Ströbel, Thomas, Vose, Sarah, Saydam, Okay, Price, Brendan D., Demple, Bruce, Saydam, Nurten

“…The major mammalian apurinic/apyrimidinic endonuclease Ape1 is a multifunctional protein operating in protection of cells from oxidative stress via its DNA…”
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miRNA-7 Attenuation in Schwannoma Tumors Stimulates Growth by Upregulating Three Oncogenic Signaling Pathways by SAYDAM, Okay, SENOL, Ozlem, BRENNER, Gary J, BREAKEFIELD, Xandra O, WÜRDINGER, Thomas, MIZRAK, Arda, BARIS OZDENER, Gokhan, STEMMER-RACHAMIMOV, Anat O, MING YI, STEPHENS, Robert M, KRICHEVSKY, Anna M, SAYDAM, Nurten

“…Micro RNAs (miRNA) negatively regulate protein-coding genes at the posttranscriptional level and are critical in tumorigenesis. Schwannomas develop from…”
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The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas by Ampudia-Mesias, Elisabet, Cameron, Charles S, Yoo, Eunjae, Kelly, Marcus, Anderson, Sarah M, Manning, Riley, Abrahante Lloréns, Juan E, Moertel, Christopher L, Yim, Hyungshin, Odde, David J, Saydam, Nurten, Saydam, Okay

“…Medulloblastoma (MB) encompasses diverse subgroups, and leptomeningeal disease/metastasis (LMD) plays a substantial role in associated fatalities. Despite…”
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Circulating Tumor Biomarkers in Meningiomas Reveal a Signature of Equilibrium Between Tumor Growth and Immune Modulation by Erkan, Erdogan Pekcan, Ströbel, Thomas, Dorfer, Christian, Sonntagbauer, Markus, Weinhäusel, Andreas, Saydam, Nurten, Saydam, Okay

“…Meningiomas are primary central nervous system (CNS) tumors that originate from the arachnoid cells of the meninges. Recurrence occurs in higher grade…”
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Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors by Saydam, Nurten, Kanagaraj, Radhakrishnan, Dietschy, Tobias, Garcia, Patrick L, Peña-Diaz, Javier, Shevelev, Igor, Stagljar, Igor, Janscak, Pavel

“…Werner syndrome (WS) is a severe recessive disorder characterized by premature aging, cancer predisposition and genomic instability. The gene mutated in WS…”
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Nucleo-cytoplasmic Trafficking of Metal-regulatory Transcription Factor 1 Is Regulated by Diverse Stress Signals by Saydam, N, Georgiev, O, Nakano, M Y, Greber, U F, Schaffner, W

“…The metal-regulatory transcription factor 1 (MTF-1) is a key regulator of heavy metal-induced transcription of metallothionein I and II and other genes in…”
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Heat and Heavy Metal Stress Synergize to Mediate Transcriptional Hyperactivation by Metal-responsive Transcription Factor MTF-1 by Saydam, Nurten, Steiner, Florian, Georgiev, Oleg, Schaffner, Walter

“…Mammalian cells react to heavy metal stress by transcribing a number of genes that contain metal-response elements (MREs) in their promoter/enhancer region;…”
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Activation of Gene Expression by Metal-Responsive Signal Transduction Pathways by Adams, Timothy K., Saydam, Nurten, Steiner, Florian, Schaffner, Walter, Freedman, Jonathan H.

“…Metallothioneins are small, cysteine-rich, metal-binding proteins that play important roles in maintaining intracellular metal homeostasis and in transition…”
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Regulation of Metallothionein Transcription by the Metal-responsive Transcription Factor MTF-1 by Saydam, Nurten, Adams, Timothy K., Steiner, Florian, Schaffner, Walter, Freedman, Jonathan H.

“…Every living organism must detoxify nonessential metals and carefully control the intracellular concentration of essential metals. Metallothioneins, which are…”
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The IOTX2/I Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas by Ampudia-Mesias, Elisabet, Cameron, Charles S, Yoo, Eunjae, Kelly, Marcus, Anderson, Sarah M, Manning, Riley, Abrahante Lloréns, Juan E, Moertel, Christopher L, Yim, Hyungshin, Odde, David J, Saydam, Nurten, Saydam, Okay

“…Medulloblastoma (MB) encompasses diverse subgroups, and leptomeningeal disease/metastasis (LMD) plays a substantial role in associated fatalities. Despite…”
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Human RECQ5β helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork by Kanagaraj, Radhakrishnan, Saydam, Nurten, Garcia, Patrick L., Zheng, Lu, Janscak, Pavel

“…The role of the human RECQ5 beta helicase in the maintenance of genomic stability remains elusive. Here we show that RECQ5 beta promotes strand exchange…”
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Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma by Ströbel, Thomas, Madlener, Sibylle, Tuna, Serkan, Vose, Sarah, Lagerweij, Tonny, Wurdinger, Thomas, Vierlinger, Klemens, Wöhrer, Adelheid, Price, Brendan D., Demple, Bruce, Saydam, Okay, Saydam, Nurten

“…Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cells, and a key factor in base-excision repair of DNA. High expression or…”
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SRPX Emerges as a Potential Tumor Marker in the Extracellular Vesicles of Glioblastoma by Ampudia-Mesias, Elisabet, El-Hadad, Samia, Cameron, Charles Scott, Wöhrer, Adelheid, Ströbel, Thomas, Saydam, Nurten, Saydam, Okay

“…Extracellular vesicles (EVs) may be used as a non-invasive screening platform to discover markers associated with early diagnosis, prognosis, and treatment…”
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Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications by Senfter, Daniel, Erkan, Erdogan Pekcan, Özer, Erdener, Jungwirth, Gerhard, Madlener, Sibylle, Kool, Marcel, Ströbel, Thomas, Saydam, Nurten, Saydam, Okay

“…Background Overexpression of minichromosome maintenance (MCM) proteins 2, 3, and 7 is associated with migration and invasion in medulloblastoma (MB). However,…”
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Extracellular-Vesicle-Based Cancer Panels Diagnose Glioblastomas with High Sensitivity and Specificity by Mut, Melike, Adiguzel, Zelal, Cakir-Aktas, Canan, Hanalioğlu, Şahin, Gungor-Topcu, Gamze, Kiyga, Ezgi, Isikay, Ilkay, Sarac, Aydan, Soylemezoglu, Figen, Strobel, Thomas, Ampudia-Mesias, Elisabet, Cameron, Charles, Aslan, Tulay, Tekirdas, Eray, Hayran, Mutlu, Oguz, Kader Karli, Henzler, Christine, Saydam, Nurten, Saydam, Okay

“…Glioblastoma is one of the most devastating neoplasms of the central nervous system. This study focused on the development of serum extracellular vesicle…”
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Abstract B26: Ape1/Ref-1 directs DNA repair pathway choice, linked to Chk2 signaling, critical for glioblastoma response to chemotherapy by Stroebel, Thomas, Madlener, Sibylle, Tuna, Serkan, Vose, Sarah, Morse, Daniella, Tannous, Bakhos A., Lagerweij, Tonny, Wurdinger, Thomas, Marosi, Christine, Slavc, Irene, Vierlinger, Klemens, Saydam, Okay, Price, Brendan D., Demple, Bruce, Saydam, Nurten

“…The predominant human apurinic/apyrimidinic (AP) endonuclease 1, Ape1 (also known as Ref-1) plays a central role in the pathways of base excision repair (BER)…”
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Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription by Saydam, Nurten, Adams, Timothy K, Steiner, Florian, Schaffner, Walter, Freedman, Jonathan H

“…Every living organism must detoxify nonessential metals and carefully control the intracellular concentration of essential metals. Metallothioneins, which are…”
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Human RECQ5[beta] helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork by Radhakrishnan Kanagaraj, Saydam, Nurten, Garcia, Patrick L, Lu, Zheng, Janscak, Pavel

“…The role of the human RECQ5β helicase in the maintenance of genomic stability remains elusive. Here we show that RECQ5β promotes strand exchange between arms…”
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Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork by Kanagaraj, Radhakrishnan, Saydam, Nurten, Garcia, Patrick L, Zheng, Lu, Janscak, Pavel

“…The role of the human RECQ5beta helicase in the maintenance of genomic stability remains elusive. Here we show that RECQ5beta promotes strand exchange between…”
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