Search Results - "SAXEN, Harri"

Antibiotics in early life associate with specific gut microbiota signatures in a prospective longitudinal infant cohort by Korpela, Katri, Salonen, Anne, Saxen, Harri, Nikkonen, Anne, Peltola, Ville, Jaakkola, Tytti, de Vos, Willem, Kolho, Kaija-Leena

“…BACKGROUND The effects of antibiotics on infant gut microbiota are unclear. We hypothesized that the use of common antibiotics results in long-term aberration…”
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Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria by Bohlen, Jonathan, Zhou, Qinhua, Philippot, Quentin, Ogishi, Masato, Rinchai, Darawan, Nieminen, Tea, Seyedpour, Simin, Parvaneh, Nima, Rezaei, Nima, Yazdanpanah, Niloufar, Momenilandi, Mana, Conil, Clément, Neehus, Anna-Lena, Schmidt, Carltin, Arango-Franco, Carlos A, Voyer, Tom Le, Khan, Taushif, Yang, Rui, Puchan, Julia, Erazo, Lucia, Roiuk, Mykola, Vatovec, Taja, Janda, Zarah, Bagarić, Ivan, Materna, Marie, Gervais, Adrian, Li, Hailun, Rosain, Jérémie, Peel, Jessica N, Seeleuthner, Yoann, Han, Ji Eun, L'Honneur, Anne-Sophie, Moncada-Vélez, Marcela, Martin-Fernandez, Marta, Horesh, Michael E, Kochetkov, Tatiana, Schmidt, Monika, AlShehri, Mohammed A, Salo, Eeva, Saxen, Harri, ElGhazali, Gehad, Yatim, Ahmad, Soudée, Camille, Sallusto, Federica, Ensser, Armin, Marr, Nico, Zhang, Peng, Bogunovic, Dusan, Cobat, Aurélie, Shahrooei, Mohammad, Béziat, Vivien, Abel, Laurent, Wang, Xiaochuan, Boisson-Dupuis, Stéphanie, Teleman, Aurelio A, Bustamante, Jacinta, Zhang, Qian, Casanova, Jean-Laurent

“…Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men…”
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Mycoplasma pneumoniae outbreak, Southeastern Finland, 2017–2018: molecular epidemiology and laboratory diagnostic lessons by Kurkela, Satu, Puolakkainen, Mirja, Hokynar, Kati, Nieminen, Tea, Saxen, Harri, Mannonen, Laura, Pietikäinen, Risto

“…This study characterizes a large Mycoplasma pneumoniae outbreak observed in Kymenlaakso in Southeastern Finland during August 2017–January 2018. The first part…”
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The Burden of Congenital Cytomegalovirus Infection: A Prospective Cohort Study of 20 000 Infants in Finland by Puhakka, Laura, Lappalainen, Maija, Lönnqvist, Tuula, Niemensivu, Riina, Lindahl, Päivi, Nieminen, Tea, Seuri, Raija, Nupponen, Irmeli, Pati, Sunil, Boppana, Suresh, Saxen, Harri

“…Congenital cytomegalovirus (cCMV) infection is the most common congenital infection and causes significant morbidity. This study was undertaken to evaluate the…”
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Primary versus non-primary maternal cytomegalovirus infection as a cause of symptomatic congenital infection - register-based study from Finland by Puhakka, Laura, Renko, Marjo, Helminen, Merja, Peltola, Ville, Heiskanen-Kosma, Tarja, Lappalainen, Maija, Surcel, Heljä-Marja, Lönnqvist, Tuula, Saxen, Harri

“…Background: Both primary and non-primary maternal cytomegalovirus (CMV) infection during pregnancy can lead to vertical transmission. We evaluated the…”
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Comparative Genomics of Shiga Toxin-Producing Escherichia coli Strains Isolated from Pediatric Patients with and without Hemolytic Uremic Syndrome from 2000 to 2016 in Finland by Bai, Xiangning, Ylinen, Elisa, Zhang, Ji, Salmenlinna, Saara, Halkilahti, Jani, Saxen, Harri, Narayanan, Aswathy, Jahnukainen, Timo, Matussek, Andreas

“…Shiga toxin-producing Escherichia coli (STEC) infection can cause mild to severe illness, such as nonbloody or bloody diarrhea, and the fatal hemolytic uremic…”
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Evaluation of Antimicrobial Therapy of Blood Culture Positive Healthcare-Associated Infections in Children by Laine, Niina, Vaara, Martti, Anttila, Veli-Jukka, Hoppu, Kalle, Laaksonen, Raisa, Airaksinen, Marja, Saxen, Harri

“…Knowledge of the quality of antimicrobial therapy (AMT) used for invasive healthcare-associated infections (HAIs) in paediatrics is scarce. Influence of the…”
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Parachlamydia acanthamoebae Detected during a Pneumonia Outbreak in Southeastern Finland, in 2017⁻2018 by Hokynar, Kati, Kurkela, Satu, Nieminen, Tea, Saxen, Harri, Vesterinen, Eero J, Mannonen, Laura, Pietikäinen, Risto, Puolakkainen, Mirja

“…Community-acquired pneumonia (CAP) is a common disease responsible for significant morbidity and mortality. However, the definite etiology of CAP often remains…”
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Vaccine Responses in Congenital Cytomegalovirus Infection by Kokkola, Eeva, Puhakka, Laura, Saxén, Harri, Nieminen, Tea

“…There is limited information on vaccine responses in children with congenital cytomegalovirus infection (cCMV). We studied diphtheria, tetanus, measles, mumps…”
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Respiratory Viruses in Laryngeal Croup of Young Children by Rihkanen, Heikki, MD, PhD, Rönkkö, Esa, Beng, Nieminen, Tea, MD, PhD, Komsi, Kaija-Leena, MD, Räty, Riitta, MSc, Saxen, Harri, MD, PhD, Ziegler, Thedi, PhD, Roivainen, Merja, PhD, Söderlund-Venermo, Maria, PhD, Anne, Lahtinen, Beng, Hovi, Tapani, MD, PhD, Pitkäranta, Anne, MD, PhD

“…Objectives To determine the viral cause of laryngeal croup by use of highly sensitive methods, and including recently recognized viruses in the analysis. Study…”
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Incidence of Haemophilus influenzae type b meningitis during 18 years of vaccine use: observational study using routine hospital data by Peltola, Heikki, Salo, Eeva, Saxén, Harri

“…Replacement of serotypes other than Hib in severe diseases has also raised concern. Because H influenzae meningitis in the Greater Helsinki area has been…”
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Hemolytic uremic syndrome caused by Shiga toxin–producing Escherichia coli in children: incidence, risk factors, and clinical outcome by Ylinen, Elisa, Salmenlinna, Saara, Halkilahti, Jani, Jahnukainen, Timo, Korhonen, Linda, Virkkala, Tiia, Rimhanen-Finne, Ruska, Nuutinen, Matti, Kataja, Janne, Arikoski, Pekka, Linkosalo, Laura, Bai, Xiangning, Matussek, Andreas, Jalanko, Hannu, Saxén, Harri

“…Background Hemolytic uremic syndrome (HUS) is a multisystemic disease. In a nationwide study, we characterized the incidence, clinical course, and prognosis of…”
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Respiratory Syncytial Virus (RSV)–Specific Antibodies in Pregnant Women and Subsequent Risk of RSV Hospitalization in Young Infants by Koivisto, Karoliina, Nieminen, Tea, Mejias, Asuncion, Capella Gonzalez, Cristina, Ye, Fang, Mertz, Sara, Peeples, Mark, Ramilo, Octavio, Saxén, Harri

“…Abstract Background The fusion (F) glycoprotein of respiratory syncytial virus (RSV) represents the major neutralizing antigen, and antibodies against the…”
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Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015 by Koivisto, Karoliina, Puhakka, Laura, Lappalainen, Maija, Blomqvist, Soile, Saxén, Harri, Nieminen, Tea

“…Highlights • Healthcare workers (HCWs) pose a risk to themselves and their patients if not protected against vaccine-preventable diseases. • Reliance on…”
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Long-term outcome of vestibular function and hearing in children with congenital cytomegalovirus infection: a prospective cohort study by Kokkola, Eeva, Niemensivu, Riina, Lappalainen, Maija, Palomäki, Maarit, Nieminen, Tea, Boppana, Suresh, Saxèn, Harri, Puhakka, Laura

“…Purpose Congenital cytomegalovirus infection (cCMV) is the most frequent nonhereditary cause for sensorineural hearing loss (SNHL) in children. Data on…”
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Multi‐inflammatory syndrome and Kawasaki disease in children during the COVID‐19 pandemic: A nationwide register‐based study and time series analysis by Koskela, Ulla, Helve, Otto, Sarvikivi, Emmi, Helminen, Merja, Nieminen, Tea, Peltola, Ville, Renko, Marjo, Saxén, Harri, Pasma, Hanna, Pokka, Tytti, Honkila, Minna, Tapiainen, Terhi

“…Aim We investigated whether the ongoing COVID‐19 pandemic was associated with the occurrence of Kawasaki disease or with multi‐inflammatory syndrome in…”
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Genetic Characterization of Intimin Gene ( eae ) in Clinical Shiga Toxin-Producing Escherichia coli Strains from Pediatric Patients in Finland by Wang, Lei, Bai, Xiangning, Ylinen, Elisa, Zhang, Ji, Saxén, Harri, Matussek, Andreas

“…Shiga toxin (Stx)-producing (STEC) infections cause outbreaks of severe disease in children ranging from bloody diarrhea to hemolytic uremic syndrome (HUS)…”
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Diagnosis of Lyme neuroborreliosis with antibodies to recombinant proteins DbpA, BBK32, and OspC, and VIsE IR6 peptide by PANELIUS, Jaana, LAHDENNE, Pekka, SAXEN, Harri, CARLSSON, Sten-Anders, HEIKKILÄ, Tero, PELTOMAA, Miikka, LAUHIO, Anneli, SEPPÄLÄ, Ilkka

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Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life by Saari, Antti, Virta, Lauri J, Sankilampi, Ulla, Dunkel, Leo, Saxen, Harri

“…Antibiotics have direct effects on the human intestinal microbiota, particularly in infancy. Antibacterial agents promote growth in farm animals by unknown…”
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Clustering of Serratia marcescens Infections in a Neonatal Intensive Care Unit by Sarvikivi, Emmi, Lyytikäinen, Outi, Salmenlinna, Saara, Vuopio‐Varkila, Jaana, Luukkainen, Päivi, Tarkka, Eveliina, Saxén, Harri

“…To study clusters of infections caused by Serratia marcescens in a neonatal intensive care unit (NICU) and to determine risk factors for S. marcescens…”
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