Search Results - "SAWYER, Michael B"

Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index by MARTIN, Lisa, BIRDSELL, Laura, MACDONALD, Neil, REIMAN, Tony, CLANDININ, M. Thomas, MCCARGAR, Linda J, MURPHY, Rachel, GHOSH, Sunita, SAWYER, Michael B, BARACOS, Vickie E

“…Emerging evidence suggests muscle depletion predicts survival of patients with cancer. At a cancer center in Alberta, Canada, consecutive patients with cancer…”
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Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study by Prado, Carla MM, BSc, Lieffers, Jessica R, RD, McCargar, Linda J, Prof, Reiman, Tony, MD, Sawyer, Michael B, MD, Martin, Lisa, MSc, Baracos, Vickie E, Prof

“…Summary Background Emerging evidence on body composition suggests that sarcopenic obesity (obesity with depleted muscle mass) might be predictive of morbidity…”
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Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment by PRADO, Carla M. M, BARACOS, Vickie E, MCCARGAR, Linda J, REIMAN, Tony, MOURTZAKIS, Marina, TONKIN, Katia, MACKEY, John R, KOSKI, Sheryl, PITUSKIN, Edith, SAWYER, Michael B

“…Purpose: Body composition has emerged as an important prognostic factor in cancer patients. Severe depletion of skeletal muscle (sarcopenia) and, hence, of…”
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Association of Skeletal Muscle Wasting With Treatment With Sorafenib in Patients With Advanced Renal Cell Carcinoma: Results From a Placebo-Controlled Study by ANTOUN, Sami, BIRDSELL, Laura, SAWYER, Michael B, VENNER, Peter, ESCUDIER, Bernard, BARACOS, Vickie E

“…PURPOSE Effects of specific antineoplastic therapies on progression of cancer-associated wasting remain uncharacterized. We selected a targeted therapy,…”
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats by Lin, Xiaoxi B, Farhangfar, Arazm, Valcheva, Rosica, Sawyer, Michael B, Dieleman, Levinus, Schieber, Andreas, Gänzle, Michael G, Baracos, Vickie

“…CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity…”
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1H-NMR urinary metabolomic profiling for diagnosis of gastric cancer by Chan, Angela W, Mercier, Pascal, Schiller, Daniel, Bailey, Robert, Robbins, Sarah, Eurich, Dean T, Sawyer, Michael B, Broadhurst, David

“…Background: Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic…”
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Sarcopenia as a Prognostic Index of Nutritional Status in Concurrent Cirrhosis and Hepatocellular Carcinoma by Meza-Junco, Judith, Montano-Loza, Aldo J, Baracos, Vickie E, Prado, Carla M.M, Bain, Vincent G, Beaumont, Crystal, Esfandiari, Nina, Lieffers, Jessica R, Sawyer, Michael B

“…BACKGROUND AND AIMS:Abnormal body composition such as severe skeletal muscle depletion or sarcopenia has emerged as an independent predictor of clinical…”
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Urine Metabolite Analysis Offers Potential Early Diagnosis of Ovarian and Breast Cancers by SLUPSKY, Carolyn M, STEED, Helen, WELLS, Tiffany H, DABBS, Kelly, SCHEPANSKY, Alexandra, CAPSTICK, Valerie, FAUGHT, Wylam, SAWYER, Michael B

“…Metabolomics is a new, rapidly expanding field dedicated to the global study of metabolites in biological systems. In this article metabolomics is applied to…”
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A Nutritional Perspective of Ketogenic Diet in Cancer: A Narrative Review by Oliveira, Camila L.P., MSc, Mattingly, Stephanie, PhD, Schirrmacher, Ralf, MD, Sawyer, Michael B., MD, Fine, Eugene J., MD, Prado, Carla M., PhD, RD

“…Abstract The predominant use of glucose anaerobically by cancer cells (Warburg effect) may be the most important characteristic the majority of these cells…”
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Body composition is prognostic and predictive of ipilimumab activity in metastatic melanoma by Chu, Michael P., Li, Yuetong, Ghosh, Sunita, Sass, Shelley, Smylie, Michael, Walker, John, Sawyer, Michael B.

“…Background Body composition is minimally investigated in an immunotherapy era. Specific body composition signals such as myosteatosis may reflect aspects of…”
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Prediction of whole body composition utilizing cross-sectional abdominal imaging in pediatrics by Deyell, Rebecca J., Desai, Sunil, Gallivan, Andrea, Lim, Alecia, Sawyer, Michael B., Heymsfield, Steven B., Shen, Wei, Baracos, Vickie E.

“…Background Although body composition is an important determinant of pediatric health outcomes, we lack tools to routinely assess it in clinical practice. We…”
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Irinotecan (CPT-11) chemotherapy alters intestinal microbiota in tumour bearing rats by Lin, Xiaoxi B, Dieleman, Levinus A, Ketabi, Ali, Bibova, Ilona, Sawyer, Michael B, Xue, Hongyu, Field, Catherine J, Baracos, Vickie E, Gänzle, Michael G

“…Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The…”
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Barriers to the Interpretation of Body Composition in Colorectal Cancer: A Review of the Methodological Inconsistency and Complexity of the CT-Defined Body Habitus by Hopkins, Jessica J., Skubleny, Daniel, Bigam, David L., Baracos, Vickie E., Eurich, Dean T., Sawyer, Michael B.

“…Background Measurement of body composition by computed tomography (CT) is an advancing field. Sarcopenia, myosteatosis, and visceral obesity (VO) have been…”
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Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity by PRADO, Carla M. M, BARACOS, Vickie E, MCCARGAR, Linda J, MOURTZAKIS, Marina, MULDER, Karen E, REIMAN, Tony, BUTTS, Charles A, SCARFE, Andrew G, SAWYER, Michael B

“…Purpose: Evidence suggests that lean body mass (LBM) may be useful to normalize doses of chemotherapy. Data from a prospective study were used to determine if…”
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Potential role of metabolomics in diagnosis and surveillance of gastric cancer by Chan, Angela W, Gill, Richdeep S, Schiller, Daniel, Sawyer, Michael B

“…Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early…”
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Phase III Randomized, Placebo-Controlled Study of Cetuximab Plus Brivanib Alaninate Versus Cetuximab Plus Placebo in Patients With Metastatic, Chemotherapy-Refractory, Wild-Type K-RAS Colorectal Carcinoma: The NCIC Clinical Trials Group and AGITG CO.20 Trial by SIU, Lillian L, SHAPIRO, Jeremy D, NOTT, Louise M, CHARPENTIER, Danielle, LIAUW, Winston, SAWYER, Michael B, JEFFORD, Michael, MAGOSKI, Nadine M, HAYDON, Andrew, WALTERS, Ian, RINGASH, Jolie, DONGSHENG TU, JONKER, Derek J, O'CALLAGHAN, Chris J, KARAPETIS, Chris S, ZALCBERG, John R, SIMES, John, COUTURE, Felix, MOORE, Malcolm J, PRICE, Timothy J, SIDDIQUI, Jehan

“…The antiepidermal growth factor receptor monoclonal antibody cetuximab has improved survival in patients with metastatic, chemotherapy-refractory, wild-type…”
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Effects of Proton Pump Inhibitors on FOLFOX and CapeOx Regimens in Colorectal Cancer by Wong, Grace G., Ha, Vincent, Chu, Michael P., Dersch-Mills, Deonne, Ghosh, Sunita, Chambers, Carole R., Sawyer, Michael B.

“…Proton pump inhibitors (PPIs) have been implicated in the impaired absorption of various oral oncologic therapies. Significantly reduced 3-year recurrence-free…”
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Assessment of nutritional status in cancer--the relationship between body composition and pharmacokinetics by Prado, Carla M M, Maia, Yara L M, Ormsbee, Michael, Sawyer, Michael B, Baracos, Vickie E

“…Several nutritional assessment tools have been used in oncology settings to monitor nutritional status and its associated prognostic significance. Body…”
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Skeletal muscle radio-density is an independent predictor of response and outcomes in follicular lymphoma treated with chemoimmunotherapy by Chu, Michael P, Lieffers, Jessica, Ghosh, Sunita, Belch, Andrew R, Chua, Neil S, Fontaine, Amelie, Sangha, Randeep, Turner, A Robert, Baracos, Vickie E, Sawyer, Michael B

“…Skeletal muscle radio-density (SMD) measures muscle radiation attenuation (in Hounsfield Units, HU) on computed tomography (CT) scans. Low SMD is prognostic of…”
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Two faces of drug therapy in cancer: drug-related lean tissue loss and its adverse consequences to survival and toxicity by Prado, Carla MM, Antoun, Sami, Sawyer, Michael B, Baracos, Vickie E

“…PURPOSE OF REVIEWA common feature of cancer patients is loss of lean tissue, specifically skeletal muscle, which may be the result of the tumor or a…”
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