Search Results - "SAWAI, Hirozumi"

IGF-1 Mediates PTEN Suppression and Enhances Cell Invasion and Proliferation via Activation of the IGF-1/PI3K/Akt Signaling Pathway in Pancreatic Cancer Cells by Ma, Jiachi, M.D, Sawai, Hirozumi, M.D., Ph.D, Matsuo, Yoichi, M.D., Ph.D, Ochi, Nobuo, M.D., Ph.D, Yasuda, Akira, M.D., Ph.D, Takahashi, Hiroki, M.D., Ph.D, Wakasugi, Takehiro, M.D., Ph.D, Funahashi, Hitoshi, M.D., Ph.D, Sato, Mikinori, M.D., Ph.D, Takeyama, Hiromitsu, M.D., Ph.D

“…Background Type-1 insulin-like growth factor (IGF-1) up-regulates cell proliferation and invasiveness through activation of PI3K/Akt signaling pathway. IGF-1…”
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PTEN regulate angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells by Ma, Jiachi, Sawai, Hirozumi, Ochi, Nobuo, Matsuo, Yoichi, Xu, Donghui, Yasuda, Akira, Takahashi, Hiroki, Wakasugi, Takehiro, Takeyama, Hiromitsu

“…Phosphoinositide 3-kinase (PI3K) pathway exerts its effects through Akt, its downstream target molecule, and thereby regulates various cell functions including…”
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Clinical Outcomes of Intraoperative Radiotherapy, Postoperative Radiotherapy, and Definitive Radiotherapy for Non-metastatic Pancreatic Cancer by Yanagi, Takeshi, Takama, Natsuko, Kato, Eriko, Baba, Fumiya, Kitase, Masanori, Shimohira, Masashi, Sawai, Hirozumi, Kato, Tomokatsu, Matsuo, Yoichi, Shibamoto, Yuta

“…The aim of this study is to evaluate the utility of adjuvant radiotherapy (intraoperative radiotherapy, IORT; postoperative radiotherapy, PORT), and definitive…”
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Adenosquamous carcinoma coexisting with intraductal papillary mucinous neoplasm of the pancreas: a case report by Sawai, Hirozumi, Kiriyama, Yuka, Kuzuya, Hiromasa, Fujii, Yoshiaki, Ueno, Shuhei, Koide, Shuji, Kurimoto, Masaaki, Yamao, Kenji, Matsuo, Yoichi, Morimoto, Mamoru, Koide, Hajime, Kamiya, Atsushi

“…Adenosquamous carcinoma of the pancreas is a rare variant, with a worse prognosis than pancreatic ductal adenocarcinoma; moreover, it has characteristic…”
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Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival by Sawai, Hirozumi, Yasuda, Akira, Ochi, Nobuo, Ma, Jiachi, Matsuo, Yoichi, Wakasugi, Takehiro, Takahashi, Hiroki, Funahashi, Hitoshi, Sato, Mikinori, Takeyama, Hiromitsu

“…The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between…”
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Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation by Sawai, Hirozumi, Okada, Yuji, Funahashi, Hitoshi, Matsuo, Yoichi, Takahashi, Hiroki, Takeyama, Hiromitsu, Manabe, Tadao

“…Interaction with integrin and focal adhesion kinase (FAK) regulates the cancer cell adhesion and invasion into extracellular matrix (ECM). In addition,…”
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The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells by Yasuda, Akira, Sawai, Hirozumi, Takahashi, Hiroki, Ochi, Nobuo, Matsuo, Yoichi, Funahashi, Hitoshi, Sato, Mikinori, Okada, Yuji, Takeyama, Hiromitsu, Manabe, Tadao

“…The transmembrane protein c-kit is a receptor tyrosine kinase (KIT) and KIT is expressed in solid tumors and hematological malignancies such as…”
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Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth by Funahashi, Hitoshi, Satake, Makoto, Hasan, Sascha, Sawai, Hirozumi, Newman, Robert A, Reber, Howard A, Hines, Oscar J, Eibl, Guido

“…Epidemiologic studies suggest that fish oil, rich in n-3 polyunsaturated fatty acids (PUFA), possesses antitumor activity, whereas n-6 PUFAs may stimulate the…”
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Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway by YASUDA, Akira, SAWAI, Hirozumi, TAKAHASHI, Hiroki, OCHI, Nobuo, MATSUO, Yoichi, FUNAHASHI, Hitoshi, SATO, Mikinori, OKADA, Yuji, TAKEYAMA, Hiromitsu, MANABE, Tadao

“…In this study, we examined the role of c-kit receptor (KIT) signal transduction on the proliferation and invasion of colorectal cancer cells. We found that…”
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The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling by SAWAI, Hirozumi, OKADA, Yuji, KAZANJIAN, Kevork, KIM, Joseph, HASAN, Sascha, HINES, Oscar J, REBER, Howard A, HOON, Dave S. B, EIBL, Guido

“…Mutations of the RET proto-oncogene are responsible for several inherited human diseases and may function as genetic modifiers of the disease. However, the…”
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Interleukin-1α Enhances Angiogenesis and Is Associated With Liver Metastatic Potential in Human Gastric Cancer Cell Lines by Ma, Jiachi, M.D, Sawai, Hirozumi, M.D., Ph.D, Matsuo, Yoichi, M.D., Ph.D, Ochi, Nobuo, M.D., Ph.D, Yasuda, Akira, M.D., Ph.D, Takahashi, Hiroki, M.D., Ph.D, Wakasugi, Takehiro, M.D., Ph.D, Funahashi, Hitoshi, M.D., Ph.D, Sato, Mikinori, M.D., Ph.D, Okada, Yuji, M.D., Ph.D, Takeyama, Hiromitsu, M.D., Ph.D, Manabe, Tadao, M.D., Ph.D

“…Background To better understand the underlying mechanism of liver metastasis formation in human gastric cancer, we evaluated the angiogenic capabilities of…”
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Interleukin-1α Secreted by Pancreatic Cancer Cells Promotes Angiogenesis and Its Therapeutic Implications by Matsuo, Yoichi, M.D., Ph.D, Sawai, Hirozumi, M.D., Ph.D, Ochi, Nobuo, M.D., Ph.D, Yasuda, Akira, M.D., Ph.D, Takahashi, Hiroki, M.D., Ph.D, Funahashi, Hitoshi, M.D., Ph.D, Takeyama, Hiromitsu, M.D., Ph.D, Guha, Sushovan, M.D., Ph.D

“…Background Previously we reported the critical role of interleukin (IL)-1α in liver metastasis from pancreatic cancer (PaCa). However, its role in angiogenesis…”
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Enhanced angiogenesis due to inflammatory cytokines from pancreatic cancer cell lines and relation to metastatic potential by Matsuo, Yoichi, Sawai, Hirozumi, Funahashi, Hitoshi, Takahashi, Hiroki, Sakamoto, Masaki, Yamamoto, Minoru, Okada, Yuji, Hayakawa, Tetsushi, Manabe, Tadao

“…To investigate the mechanisms of metastasis formation in human pancreatic carcinoma, we examined the angiogenic capabilities of human pancreatic cancer cell…”
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Activation of Peroxisome Proliferator-Activated Receptor-γ Decreases Pancreatic Cancer Cell Invasion through Modulation of the Plasminogen Activator System by Sawai, Hirozumi, Liu, Joey, Reber, Howard A, Hines, Oscar J, Eibl, Guido

“…Cancer cell invasion and metastasis require the concerted action of several proteases that degrade extracellular matrix proteins and basement membranes. Recent…”
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Solid variant of serous cystadenoma of the pancreas by Yasuda, Akira, Sawai, Hirozumi, Ochi, Nobuo, Matsuo, Yoichi, Okada, Yuji, Takeyama, Hiromitsu

“…We describe a case of a solid variant of serous cystadenoma of the pancreas. The preoperative examination results led to a diagnosis of a nonfunctional…”
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Limiting vein puncture to three needle passes in subclavian vein catheterization by the infraclavicular approach by Takeyama, Hiromitsu, Taniguchi, Masaaki, Sawai, Hirozumi, Funahashi, Hitoshi, Akamo, Yoshimi, Suzuki, Sadao, Manabe, Tadao

“…With central venous catheterization, each additional vein puncture raises the risk of complications. We assessed the rate of failure and complications using a…”
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Middle-colic artery aneurysm associated with segmental arterial mediolysis, successfully managed by transcatheter arterial embolization: Report of a case by Hirokawa, Takahisa, Sawai, Hirozumi, Yamada, Koji, Wakasugi, Takehiro, Takeyama, Hiromitsu, Ogino, Hiroyuki, Tsurusaki, Masakatsu, Arai, Yasuaki

“…An aneurysm of the middle-colic artery, associated with segmental arterial mediolysis (SAM), is a rare condition. This report describes a case of a…”
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Reactive lymphoid hyperplasia of the liver in a patient with colon cancer: report of two cases by Takahashi, Hiroki, Sawai, Hirozumi, Matsuo, Yoichi, Funahashi, Hitoshi, Satoh, Mikinori, Okada, Yuji, Inagaki, Hiroshi, Takeyama, Hiromitsu, Manabe, Tadao

“…Reactive lymphoid hyperplasia (RLH) of the liver is very rarely reported, and we encountered two cases of RLH of the liver in a patient with colon cancer. In…”
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Basement Membrane Proteins Play an Important Role in the Invasive Processes of Human Pancreatic Cancer Cells by Sawai, Hirozumi, M.D., Ph.D, Okada, Yuji, M.D., Ph.D, Funahashi, Hitoshi, M.D., Ph.D, Takahashi, Hiroki, MD, Ph.D, Matsuo, Yoichi, M.D., Ph.D, Yasuda, Akira, M.D., Ph.D, Ochi, Nobuo, M.D., Ph.D, Takeyama, Hiromitsu, M.D., Ph.D, Manabe, Tadao, M.D., Ph.D

“…Background The invasive interaction between cells and their matrix has important roles in tumor cell invasion. This study investigated modulation of basement…”
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Vascular endothelial growth factor-C secreted by pancreatic cancer cell line promotes lymphatic endothelial cell migration in an in vitro model of tumor lymphangiogenesis by Ochi, Nobuo, Matsuo, Yoichi, Sawai, Hirozumi, Yasuda, Akira, Takahashi, Hiroki, Sato, Mikinori, Funahashi, Hitoshi, Okada, Yuji, Manabe, Tadao

“…To investigate mechanisms underlying lymphatic node metastasis in pancreatic cancer, we examined roles of vascular endothelial growth factor-C (VEGF-C) in…”
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