Search Results - "SAWADA, Kohei"

Deep learning-based quality control of cultured human-induced pluripotent stem cell-derived cardiomyocytes by Orita, Ken, Sawada, Kohei, Koyama, Ryuta, Ikegaya, Yuji

“…Using bright-field images of cultured human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), we trained a convolutional neural network (CNN),…”
Get full text

Development of torsadogenic risk assessment using human induced pluripotent stem cell-derived cardiomyocytes: Japan iPS Cardiac Safety Assessment (JiCSA) update by Kanda, Yasunari, Yamazaki, Daiju, Osada, Tomoharu, Yoshinaga, Takashi, Sawada, Kohei

“…Cardiac safety assessment is challenging because a better understanding of torsadogenic mechanisms beyond hERG blockade and QT interval prolongation is…”
Get full text

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment by Blinova, Ksenia, Dang, Qianyu, Millard, Daniel, Smith, Godfrey, Pierson, Jennifer, Guo, Liang, Brock, Mathew, Lu, Hua Rong, Kraushaar, Udo, Zeng, Haoyu, Shi, Hong, Zhang, Xiaoyu, Sawada, Kohei, Osada, Tomoharu, Kanda, Yasunari, Sekino, Yuko, Pang, Li, Feaster, Tromondae K., Kettenhofen, Ralf, Stockbridge, Norman, Strauss, David G., Gintant, Gary

“…To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the…”
Get full text

Assessment of Testing Methods for Drug-Induced Repolarization Delay and Arrhythmias in an iPS Cell–Derived Cardiomyocyte Sheet: Multi-site Validation Study by Nakamura, Yuji, Matsuo, Junko, Miyamoto, Norimasa, Ojima, Atsuko, Ando, Kentaro, Kanda, Yasunari, Sawada, Kohei, Sugiyama, Atsushi, Sekino, Yuko

“…A prospective comparison study across 3 independent research laboratories of a pure IKr blocker E-4031 was conducted by using the same batch of human iPS…”
Get full text

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm by Fermini, Bernard, Hancox, Jules C, Abi-Gerges, Najah, Bridgland-Taylor, Matthew, Chaudhary, Khuram W, Colatsky, Thomas, Correll, Krystle, Crumb, William, Damiano, Bruce, Erdemli, Gul, Gintant, Gary, Imredy, John, Koerner, John, Kramer, James, Levesque, Paul, Li, Zhihua, Lindqvist, Anders, Obejero-Paz, Carlos A, Rampe, David, Sawada, Kohei, Strauss, David G, Vandenberg, Jamie I

“…For the past decade, cardiac safety screening to evaluate the propensity of drugs to produce QT interval prolongation and Torsades de Pointes (TdP) arrhythmia…”
Get more information

Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential by Yamamoto, Wataru, Asakura, Keiichi, Ando, Hiroyuki, Taniguchi, Tomohiko, Ojima, Atsuko, Uda, Takaaki, Osada, Tomoharu, Hayashi, Seiji, Kasai, Chieko, Miyamoto, Norimasa, Tashibu, Hiroyuki, Yoshinaga, Takashi, Yamazaki, Daiju, Sugiyama, Atsushi, Kanda, Yasunari, Sawada, Kohei, Sekino, Yuko

“…The aims of this study were to (1) characterize basic electrophysiological elements of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)…”
Get full text

Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes by Hinata, Yuto, Kagawa, Yuki, Kubo, Hirotsugu, Kato, Eriko, Baba, Atsushi, Sasaki, Daisuke, Matsuura, Katsuhisa, Sawada, Kohei, Shimizu, Tatsuya

“…Cardiac contractility evaluation using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has recently attracted much attention as a…”
Get full text

Arrhythmic hazard map for a 3D whole‐ventricle model under multiple ion channel block by Okada, Jun‐ichi, Yoshinaga, Takashi, Kurokawa, Junko, Washio, Takumi, Furukawa, Tetsushi, Sawada, Kohei, Sugiura, Seiryo, Hisada, Toshiaki

“…Background and Purpose To date, proposed in silico models for preclinical cardiac safety testing are limited in their predictability and usability. We…”
Get full text

Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway by Kimura, Takayuki, Uesugi, Mai, Takase, Kazuma, Miyamoto, Norimasa, Sawada, Kohei

“…Sunitinib malate (sunitinib) is an orally available, multitargeted tyrosine kinase inhibitor with antitumor and antiangiogenic activities. Although sunitinib…”
Get full text

Low-density plating is sufficient to induce cardiac hypertrophy and electrical remodeling in highly purified human iPS cell-derived cardiomyocytes by Uesugi, Mai, Ojima, Atsuko, Taniguchi, Tomohiko, Miyamoto, Norimasa, Sawada, Kohei

“…Cardiac hypertrophy is a leading cause of many cardiovascular diseases, including heart failure, but its pathological mechanism is not fully understood. This…”
Get full text

Growth of structure-controlled polycrystalline silicon ingots for solar cells by casting by Fujiwara, Kozo, Pan, Wugen, Usami, Noritaka, Sawada, Kohei, Tokairin, Masatoshi, Nose, Yoshitaro, Nomura, Akiko, Shishido, Toetsu, Nakajima, Kazuo

“…We propose a new concept of growing a polycrystalline Si ingot suitable for solar cells by casting based on the directional growth behavior of polycrystalline…”
Get full text

Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID‐19: A simulation study by Okada, Jun‐ichi, Yoshinaga, Takashi, Washio, Takumi, Sawada, Kohei, Sugiura, Seiryo, Hisada, Toshiaki

“…The risk of fatal arrhythmias is the major concern for using chloroquine (CQ) or hydroxychloroquine (HCQ) to treat coronavirus disease 2019 (COVID‐19), but the…”
Get full text

Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator by Okada, Jun-Ichi, Yoshinaga, Takashi, Kurokawa, Junko, Washio, Takumi, Furukawa, Tetsushi, Sawada, Kohei, Sugiura, Seiryo, Hisada, Toshiaki

“…To save time and cost for drug discovery, a paradigm shift in cardiotoxicity testing is required. We introduce a novel screening system for drug-induced…”
Get full text

Emotion estimation using a wearable heart rate monitoring device in Asian elephants (Elephas maximus) during veterinary clinical procedures by KIDO, Nobuhide, TANAKA, Sohei, OMIYA, Tomoko, KAMITE, Yuko, SAWADA, Kohei, KOMATSU, Yoko, SHOJI, Yasuyuki, SENZAKI, Masaru, HANZAWA, Sayuri, ANDO, Masato, SUTO, Ikko

“…Fatal accidents in captive elephants occasionally occur because humans are unable to gauge elephants’ emotions solely by their behavior. The intellectual…”
Get full text

A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval by Yamazaki, Kazuto, Hihara, Taro, Taniguchi, Tomohiko, Kohmura, Naohiro, Yoshinaga, Takashi, Ito, Masashi, Sawada, Kohei

“…► We use human embryonic stem cell-derived cardiomyocyte clusters (hES-CMCs). ► Responsiveness of hES-CMCs to hERG blockers differed widely. ► hES-CMCs are…”
Get full text

Synthesis of an Amphiphilic Macromonomer Bearing a Terminal Fluorene Moiety and Its Application to the Preparation of Fluorescent Polymer Particles by Motoyanagi, Jin, Nagura, Katsutoshi, Sawada, Kohei, Miki, Sadao, Minoda, Masahiko

“…A new amphiphilic macromonomer MA-PMEEVE-FmPH bearing a methacryloyl group at the α-terminus and a fluorene moiety at the ω-terminus was synthesized by living…”
Get full text

Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives by Cui, Yong-Mei, Yasutomi, Eriko, Otani, Yuko, Ido, Katsutoshi, Yoshinaga, Takashi, Sawada, Kohei, Ohwada, Tomohiko

“…Oxime ether derivatives at the benzylic position of unsubstituted, dichloro, trichloro, and monobromo derivatives of the aromatic C-ring of dehydroabietic acid…”
Get full text

K+-Channel Openers Suppress Epileptiform Activities Induced by 4-Aminopyridine in Cultured Rat Hippocampal Neurons by Kobayashi, Kiyoaki, Nishizawa, Yukio, Sawada, Kohei, Ogura, Hiroo, Miyabe, Masayuki

“…K+ channels are key modulators of neuronal excitability, and mutations in certain types of these channels are known to cause epileptic seizures. Activation of…”
Get full text

A patient presenting painful chest wall swelling: Tietze syndrome by Sawada, Kohei, Ihoriya, Hiromi, Yamada, Taihei, Yumoto, Tetsuya, Tsukahara, Kohei, Osako, Takaaki, Naito, Hiromichi, Nakao, Atsunori

“…[10] Manual palpation of pain and motion of muscles and joints of the chest wall and cervicothoracic spine are important; however, pain localization does not…”
Get full text

Comparison of donepezil and memantine for protective effect against amyloid-beta(1–42) toxicity in rat septal neurons by Kimura, Manami, Komatsu, Hiroko, Ogura, Hiroo, Sawada, Kohei

“…Donepezil, a potent acetylcholinesterase (AChE) inhibitor and memantine, an N-methyl- d-aspartate (NMDA) receptor antagonist, have been used for the treatment…”
Get full text