Search Results - "SAVINA, P. M"

5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile by DALUGE, S. M, PURIFOY, D. J. M, FYFE, J. A, BLUM, M. R, AVERETT, D. R, DORNSIFE, R. E, DOMIN, B. A, FERONE, R, LEWIS, D. A, KRENITSKY, T. A, SAVINA, P. M, ST. CLAIR, M. H, PARRY, N. R, DEV, I. K, NOVAK, P, AYERS, K. M, REARDON, J. E, ROBERTS, G. B

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Probenecid-impaired biliary excretion of acetaminophen glucuronide and sulfate in the rat by Savina, P M, Brouwer, K L

“…Acetaminophen (APAP; 100 mg/kg iv) and probenecid (50 mg/kg bolus + 11.4 mg/hr/kg infusion) were administered to male Sprague-Dawley rats to examine the…”
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Safety and pharmacokinetics of 5-chloro-2',3'-dideoxy-3'-fluorouridine (935U83) following oral administration of escalating single doses in human immunodeficiency virus-infected adults by RIDDLER, S. A, WANG, L. H, BARTLETT, J. A, SAVINA, P. M, PACKARD, M. V, MCMAHON, D. K, BLUM, M. R, DUNN, J. A, ELKINS, M. M, MELLORS, J. W

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Hyperthermia-Induced Enhancement of Melphalan Activity against a Melphalan-Resistant Human Rhabdomyosarcoma Xenograft by Laskowitz, Daniel T., Elion, Gertrude B., Dewhirst, Mark W., Griffith, Owen W., Savina, Paul M., Blum, M. Robert, Prescott, Deborah M., Bigner, Darell D., Friedman, Henry S.

“…The effects of regional hyperthermia (42°C for 70 min) on the antitumor activity of melphalan were examined in athymic mice bearing melphalan-resistant human…”
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Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma by FRIEDMAN, H. S, SKAPEK, S. X, COLVIN, O. M, ELION, G. B, BLUM, M. R, SAVINA, P. M, HILTON, J, CLIFFORD SCHOLD, S. JR, KURTZBERG, J, BIGNER, D. D

“…Melphalan transport, glutathione levels, and glutathione-S-transferase activity were measured in two continuous human medulloblastoma cell lines and…”
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Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR by LILLEY, E. R, ELION, G. B, DEWHIRST, M. W, SCHOLD, S. C, BLUM, M. R, SAVINA, P. M, LAMSKOWITZ, D. T, BIGNER, D. D, FRIEDMAN, H. S

“…Investigations with the melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR were carried out to identify patterns of cross-resistance and collateral…”
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Evaluation of the Carcinogenic Potential of Clofibrate in FVB/Tg.AC Mouse After Oral Administration—Part I by Torrey, Carla E., Wall, Henry G., Campbell, James A., Kwanyuen, Puntipa, Hoivik, Debie J., Miller, Richard T., Allen, Jane S., Jayo, Manuel J., Selinger, Krzysztof, Savina, Paul M., Santostefano, Michael J.

“…This study was conducted as part of the International Life Sciences Institute (ILSI) program to evaluate the carcinogenic potential of clofibrate, a…”
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Validation of a high-performance liquid chromatographic-mass spectrometric method for the measurement of 5-chloro-2′,3′-dideoxy-3′-fluorouridine (935U83) in human plasma by Dunn, John A., Savina, Paul M.

“…An isocratic reversed-phase LC-MS method for measuring concentrations of 5-chloro-2′,3′-dideoxy-3′-fluorouridine (935U83; I) directly and its 5′-glucuronide…”
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Evaluation of the Carcinogenic Potential of Clofibrate in the p53 super(+/-) Mouse by Torrey, CE, Campbell, JA, Hoivik, D J, Miller, R T, Allen, J S, Mann, P C, Selinger, K, Rickert, D, Savina, P M, Santostefano, MJ

“…This study was conducted as part of International Life Sciences Institute (ILSI) program to evaluate the carcinogenic potential of clofibrate, a nongenotoxic,…”
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Evaluation of the Carcinogenic Potential of Clofibrate in the p53+ / − Mouse by Torrey, Carla E., Campbell, James A., Hoivik, Debie J., Miller, Richard T., Allen, Jane S., Mann, Peter C., Selinger, Krzysztof, Rickert, Douglas, Savina, Paul M., Santostefano, Michael J.

“…This study was conducted as part of International Life Sciences Institute (ILSI) program to evaluate the carcinogenic potential of clofibrate, a nongenotoxic,…”
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Optimal perfusion rate determined for in situ intestinal absorption studies in rats by Savina, P M, Staubus, A E, Gaginella, T S, Smith, D F

“…Iopanoic acid was used as a model compound to study the effect of the intestinal perfusion rate on the mean absorption clearance. Absorption of iopanoic acid…”
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