Search Results - "SAVARESE, J. J"

Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man by Heerdt, Paul M, Sunaga, Hiroshi, Owen, Joel S, Murrell, Matthew T, Malhotra, Jaideep K, Godfrey, Deena, Steinkamp, Michelle, Savard, Peter, Savarese, John J, Lien, Cynthia A

“…BACKGROUND:CW002 is a benzylisoquinolinium nondepolarizing neuromuscular-blocking drug found to be inactivated by cysteine in preclinical studies. The current…”
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Novel neuromuscular blocking drugs and antagonists by Heerdt, Paul M, Sunaga, Hiroshi, Savarese, John J

“…This review summarizes recent progress in the development of new muscle relaxants that are inactivated by cysteine, and considers the evolving paradigm of…”
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Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs by HEERDT, Paul M, MALHOTRA, Jaideep K, PAN, Brian Y, SUNAGA, Hiroshi, SAVARESE, John J

“…CW002 is a novel neuromuscular blocking drug with a duration dependent on the rate of cysteine adduction to the molecule. The current study characterized the…”
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Clinical pharmacology of GW280430A in humans by BELMONT, Matthew R, LIEN, Cynthia A, TJAN, Joseph, BRADLEY, Eleanor, STEIN, Brenna, PATEL, Sanjay S, SAVARESE, John J

“…An ultrashort-acting nondepolarizing neuromuscular blocking agent that could be an alternative to succinylcholine has been the focus of a concerted effort in…”
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Gantacurium and CW002 Do Not Potentiate Muscarinic Receptor-mediated Airway Smooth Muscle Constriction in Guinea Pigs by SUNAGA, Hiroshi, YI ZHANG, SAVARESE, John J, EMALA, Charles W

“…Neuromuscular blocking agents are an integral component of general anesthesia. In addition to their intended pharmacologic target on skeletal muscle nicotinic…”
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The cardiovascular effects and histamine-releasing properties of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia by LIEN, C. A, BELMONT, M. R, ABALOS, A, EPPICH, L, QUESSY, S, ABOU-DONIA, M. M, SAVARESE, J. J

“…Atracurium consists of a mixture of ten stereoisomers. One of these isomers, 51W89, is a potent intermediate-acting nondepolarizing neuromuscular blocking…”
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Fumarates: Unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine by Lien, Cynthia A., MD, Savard, Peter, MD, Belmont, Matthew, MD, Sunaga, Hiorshi, MD, Savarese, John J., MD

“…Table 3 - Recovery intervals after increasing doses of gantacurium in anesthetized human volunteers (mean ± SD) Table 4 - Pharmacodynamics of gantacurium and…”
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Multimodal analgesia as an alternative to the risks of opioid monotherapy in surgical pain management by Savarese, John J., Tabler, Norman G.

“…Clinicians have long been aware of the danger of overreliance on opioids to manage acute pain, such as the pain accompanying surgery. The risk of adverse drug…”
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The clinical neuromuscular pharmacology of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia by Belmont, M R, Lien, C A, Quessy, S, Abou-Donia, M M, Abalos, A, Eppich, L, Savarese, J J

“…Atracurium is a mixture of ten stereoisomers. 51W89, one of these isomers, is a potent nondepolarizing intermediate-duration neuromuscular blocking agent…”
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Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs by HEERDT, Paul M, KANG, Richard, THE', Andrew, HASHIM, Mir, MOOK, Robert J, SAVARESE, John J

“…This investigation determined the cardiopulmonary side effects of a novel nondepolarizing neuromuscular blocking drug with an ultrashort duration of action in…”
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The Clinical Neuromuscular Pharmacology of Mivacurium Chloride (BW B1090U). A Short-acting Nondepolarizing Ester Neuromuscular Blocking Drug by Savarese, John J, Ali, Hassan H, Basta, Salvatore J, Embree, Patricia B, Scott, Ralph P. F, Sunder, N, Weakly, J Neal, Wastilla, William B, El-Sayad, Hassan A

“…Mivacurium chloride (BW B1090U), a bis-benzylisoquinolinium diester compound, was found to undergo hydrolysis in vitro by purified human plasma cholinesterase…”
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Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: A comparison with mivacurium by SAVARESE, John J, BELMONT, Matthew R, SPITZER, Timothy, COHN, Douglas L, MORGAN, Philip, WASTILA, William B, HASHIM, Mir A, MOOK, Robert A, BOROS, Eric E, SAMANO, Vicente, PATEL, Sanjay S, FELDMAN, Paul L, SCHULTZ, Jan-Ake I, MCNULTY, Michael

“…No replacement for succinylcholine is yet available. GW280430A (AV430A) is a representative of a new class of nondepolarizing neuromuscular blocking drugs…”
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Comparative pharmacology of cisatracurium (51W89), atracurium, and five isomers in cats by WASTILA, W. B, MAEHR, R. B, TURNER, G. L, HILL, D. A, PHIL, M, SAVARESE, J. J

“…Atracurium has four chiral centers and the marketed product is a mixture of ten optical and geometric isomers. Six of the isomers were prepared and evaluated…”
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Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine by Savarese, John J, Sunaga, Hiroshi, McGilvra, Jeff D, Belmont, Matthew R, Murrell, Matthew T, Jeannotte, Erin, Cooke, Farrell E, Wastila, William B, Heerdt, Paul M

“…WHAT WE ALREADY KNOW ABOUT THIS TOPIC WHAT THIS ARTICLE TELLS US THAT IS NEW BACKGROUND:Structure–activity studies were performed to identify a new…”
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Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers by Kaullen, Josh D, Owen, Joel S, Brouwer, Kim L R, Heerdt, Paul M, Lien, Cynthia A, Savarese, John J, Schmith, Virginia D

“…BACKGROUND:CW002 is an investigational nondepolarizing, neuromuscular blocking agent with a rapid onset and intermediate duration of action in animals. This is…”
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Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia by LIEN, C. A, SCHMITH, V. D, BELMONT, M. R, ABALOS, A, KISOR, D. F, SAVARESE, J. J

“…Cisatracurium, one of the ten isomers in atracurium, is a nondepolarizing muscle relaxant with an intermediate duration of action. It is more potent and less…”
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Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates:  New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers by Boros, Eric E, Bigham, Eric C, Boswell, G. Evan, Mook, Robert A, Patel, Sanjay S, Savarese, John J, Ray, John A, Thompson, James B, Hashim, Mir A, Wisowaty, James C, Feldman, Paul L, Samano, Vicente

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Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine—Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat by Sunaga, Hiroshi, Savarese, John J, McGilvra, Jeff D, Heerdt, Paul M, Belmont, Matthew R, Van Ornum, Scott G, Murrell, Matthew T, Malhotra, Jaideep K, Savard, Peter M, Jeannotte, Erin, Petty, Bryce J, Allen, Erica, Carnathan, Gilbert W

“…BACKGROUND:CW002, a novel nondepolarizing neuromuscular blocking agent of intermediate duration, is degraded in vitro by L-cysteine; CW002-induced…”
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Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles by Heerdt, Paul M., Wagner, Christa L., DeMais, Marissa, Savarese, John J.

“…Non-invasive measurement of cardiac output (CO) using bioreactance signals (NICOM) was recently validated in swine and human adults. The present study was…”
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The pharmacokinetics and pharmacodynamics of the stereoisomers of mivacurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia by Lien, C A, Schmith, V D, Embree, P B, Belmont, M R, Wargin, W A, Savarese, J J

“…Mivacurium consists of a mixture of three stereoisomers: cis-trans (34-40%), trans-trans (52-60%), and cis-cis (4-8%). These isomers differ in potency (the…”
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