Search Results - "SAUVAGEAU, Guy"

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer by Sauvageau, Martin, Sauvageau, Guy

“…Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify chromatin and participate in the establishment and maintenance of cell…”
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EPCR expression marks UM171-expanded CD34+ cord blood stem cells by Fares, Iman, Chagraoui, Jalila, Lehnertz, Bernhard, MacRae, Tara, Mayotte, Nadine, Tomellini, Elisa, Aubert, Léo, Roux, Philippe P., Sauvageau, Guy

“…A small subset of human cord blood CD34+ cells express endothelial protein C receptor (EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC)…”
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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells by Sauvageau, Guy, Lessard, Julie

“…An emerging concept in the field of cancer biology is that a rare population of 'tumour stem cells' exists among the heterogeneous group of cells that…”
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Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia by Baccelli, Irène, Gareau, Yves, Lehnertz, Bernhard, Gingras, Stéphane, Spinella, Jean-François, Corneau, Sophie, Mayotte, Nadine, Girard, Simon, Frechette, Mélanie, Blouin-Chagnon, Valérie, Leveillé, Koryne, Boivin, Isabel, MacRae, Tara, Krosl, Jana, Thiollier, Clarisse, Lavallée, Vincent-Philippe, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P., Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy

“…To identify therapeutic targets in acute myeloid leukemia (AML), we chemically interrogated 200 sequenced primary specimens. Mubritinib, a known ERBB2…”
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Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal by Fares, Iman, Chagraoui, Jalila, Gareau, Yves, Gingras, Stéphane, Ruel, Réjean, Mayotte, Nadine, Csaszar, Elizabeth, Knapp, David J. H. F., Miller, Paul, Ngom, Mor, Imren, Suzan, Roy, Denis-Claude, Watts, Kori L., Kiem, Hans-Peter, Herrington, Robert, Iscove, Norman N., Humphries, R. Keith, Eaves, Connie J., Cohen, Sandra, Marinier, Anne, Zandstra, Peter W., Sauvageau, Guy

“…The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a…”
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SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism by Priam, Pierre, Krasteva, Veneta, Rousseau, Philippe, D'Angelo, Giovanni, Gaboury, Louis, Sauvageau, Guy, Lessard, Julie A

“…Julie Lessard and colleagues report that ATP-dependent SWI/SNF chromatin-remodeling complex subunit SMARCD2 is essential for granulocyte development. They find…”
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The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias by Lavallée, Vincent-Philippe, Baccelli, Irène, Krosl, Jana, Wilhelm, Brian, Barabé, Frédéric, Gendron, Patrick, Boucher, Geneviève, Lemieux, Sébastien, Marinier, Anne, Meloche, Sylvain, Hébert, Josée, Sauvageau, Guy

“…Guy Sauvageau, Josée Hébert and colleagues analyze exomes and transcriptomes in MLL -rearranged acute myeloid leukemias. They find frequent RAS pathway…”
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Genetic characterization of ABT-199 sensitivity in human AML by Bisaillon, Richard, Moison, Céline, Thiollier, Clarisse, Krosl, Jana, Bordeleau, Marie-Eve, Lehnertz, Bernhard, Lavallée, Vincent-Philippe, MacRae, Tara, Mayotte, Nadine, Labelle, Caroline, Boucher, Geneviève, Spinella, Jean-François, Boivin, Isabel, D’Angelo, Giovanni, Lavallée, Sylvie, Marinier, Anne, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy

“…Acute myeloid leukemias (AML) with mutations in the NPM1 gene (NPM1c+) represent a large AML subgroup with varying response to conventional treatment,…”
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UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal by Chagraoui, Jalila, Lehnertz, Bernhard, Girard, Simon, Spinella, Jean Francois, Fares, Iman, Tomellini, Elisa, Mayotte, Nadine, Corneau, Sophie, MacRae, Tara, Simon, Laura, Sauvageau, Guy

“…Elucidation of the molecular cues required to balance adult stem cell self-renewal and differentiation is critical for advancing cellular therapies. Herein, we…”
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Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors by Lavallée, Vincent-Philippe, Krosl, Jana, Lemieux, Sébastien, Boucher, Geneviève, Gendron, Patrick, Pabst, Caroline, Boivin, Isabel, Marinier, Anne, Guidos, Cynthia J., Meloche, Sylvain, Hébert, Josée, Sauvageau, Guy

“…In this study, we analyzed RNA-sequencing data of 14 samples characterized by biallelic CEBPA (CEBPAbi) mutations included in the Leucegene collection of 415…”
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Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells by Tomellini, Elisa, Fares, Iman, Lehnertz, Bernhard, Chagraoui, Jalila, Mayotte, Nadine, MacRae, Tara, Bordeleau, Marie-Ève, Corneau, Sophie, Bisaillon, Richard, Sauvageau, Guy

“…Transplantation of expanded hematopoietic stem cells (HSCs) and gene therapy based on HSC engineering have emerged as promising approaches for the treatment of…”
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EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations by Lavallée, Vincent-Philippe, Gendron, Patrick, Lemieux, Sébastien, D’Angelo, Giovanni, Hébert, Josée, Sauvageau, Guy

“…The genetic and transcriptional signature of EVI1 (ecotropic viral integration site 1)-rearranged (EVI1-r) acute myeloid leukemias (AMLs) remains poorly…”
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Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1–2 safety and feasibility study by Cohen, Sandra, Roy, Jean, Lachance, Silvy, Delisle, Jean-Sébastien, Marinier, Anne, Busque, Lambert, Roy, Denis-Claude, Barabé, Frédéric, Ahmad, Imran, Bambace, Nadia, Bernard, Léa, Kiss, Thomas, Bouchard, Philippe, Caudrelier, Pierre, Landais, Sévérine, Larochelle, Fannie, Chagraoui, Jalila, Lehnertz, Bernhard, Corneau, Sophie, Tomellini, Elisa, van Kampen, Jeroen J A, Cornelissen, Jan J, Dumont-Lagacé, Maude, Tanguay, Mégane, Li, Qi, Lemieux, Sébastien, Zandstra, Peter W, Sauvageau, Guy

“…Benefits of cord blood transplantation include low rates of relapse and chronic graft-versus-host disease (GVHD). However, the use of cord blood is rapidly…”
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Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance by Buscarlet, Manuel, Krasteva, Veneta, Ho, Lena, Simon, Camille, Hébert, Josée, Wilhelm, Brian, Crabtree, Gerald R., Sauvageau, Guy, Thibault, Pierre, Lessard, Julie A.

“…In mammals, combinatorial assembly of alternative families of subunits confers functional specificity to adenosine triphosphate (ATP)-dependent SWI/SNF-like…”
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Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers by Rouette, Alexandre, Trofimov, Assya, Haberl, David, Boucher, Geneviève, Lavallée, Vincent-Philippe, D’Angelo, Giovanni, Hébert, Josée, Sauvageau, Guy, Lemieux, Sébastien, Perreault, Claude

“…Based on transcriptomic analyses of thousands of samples from The Cancer Genome Atlas, we report that expression of constitutive proteasome (CP) genes ( PSMB5,…”
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Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia by Supper, Emmanuelle, Rudat, Saskia, Iyer, Vivek, Droop, Alastair, Wong, Kim, Spinella, Jean-François, Thomas, Patrick, Sauvageau, Guy, Adams, David J., Wong, Chi C.

“…While oncogenes promote tumorigenesis, they also induce deleterious cellular stresses, such as apoptosis, that cancer cells must combat by coopting adaptive…”
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The methyltransferase G9a regulates HoxA9-dependent transcription in AML by Lehnertz, Bernhard, Pabst, Caroline, Su, Le, Miller, Michelle, Liu, Feng, Yi, Lin, Zhang, Regan, Krosl, Jana, Yung, Eric, Kirschner, Jeanette, Rosten, Patty, Underhill, T Michael, Jin, Jian, Hébert, Josée, Sauvageau, Guy, Humphries, R Keith, Rossi, Fabio M

“…Chromatin modulators are emerging as attractive drug targets, given their widespread implication in human cancers and susceptibility to pharmacological…”
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RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature by Lavallée, Vincent-Philippe, Lemieux, Sébastien, Boucher, Geneviève, Gendron, Patrick, Boivin, Isabel, Armstrong, Richard N., Sauvageau, Guy, Hébert, Josée

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A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene by Gavory, Gwenaëlle, Baril, Caroline, Laberge, Gino, Bidla, Gawa, Koonpaew, Surapong, Sonea, Thomas, Sauvageau, Guy, Therrien, Marc

“…Acute myeloid leukemia (AML) underlies the uncontrolled accumulation of immature myeloid blasts. Several cytogenetic abnormalities have been associated with…”
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Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers, Clinicians, and Patients: Scoping Literature Review by Lang, Michael, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy, Zawati, Ma'n H

“…This study aims to identify a novel potential use for web portals in health care and health research: their adoption for the purposes of rapidly sharing health…”
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