Search Results - "SAUNDERS, A."

Self-harm and suicide in adolescents by Hawton, Keith, Prof, Saunders, Kate EA, MRCPsych, O'Connor, Rory C, Prof

“…Summary Self-harm and suicide are major public health problems in adolescents, with rates of self-harm being high in the teenage years and suicide being the…”
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Key considerations in the approach to congenital heart disease in dogs and cats by Saunders, A. B.

“…Congenital heart disease is an important subset of all cardiovascular disease in dogs and cats that is present at birth and most often detected in young…”
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Identifying psychiatric diagnosis from missing mood data through the use of log-signature features by Wu, Yue, Goodwin, Guy M., Lyons, Terry, Saunders, Kate E. A.

“…The availability of mobile technologies has enabled the efficient collection of prospective longitudinal, ecologically valid self-reported clinical…”
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A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response by Amin-Wetzel, Niko, Saunders, Reuben A., Kamphuis, Maarten J., Rato, Claudia, Preissler, Steffen, Harding, Heather P., Ron, David

“…When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER-protein-folding capacity to restore…”
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Turning down the heat: An enhanced understanding of the relationship between urban vegetation and surface temperature at the city scale by Duncan, J.M.A., Boruff, B., Saunders, A., Sun, Q., Hurley, J., Amati, M.

“…Guiding urban planners on the cooling returns of different configurations of urban vegetation is important to protect urban dwellers from adverse heat impacts…”
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Human polymorphism at microRNAs and microRNA target sites by Saunders, Matthew A, Liang, Han, Li, Wen-Hsiung

“…MicroRNAs (miRNAs) function as endogenous translational repressors of protein-coding genes in animals by binding to target sites in the 3' UTRs of mRNAs…”
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Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies by Harrington, C, Sawchak, S, Chiang, C, Davies, J, Donovan, C, Saunders, A M, Irizarry, M, Jeter, B, Zvartau-Hind, M, van Dyck, C H, Gold, M

“…Two phase 3 studies evaluated the efficacy and safety of rosiglitazone (RSG), a type 2 diabetes treatment, in an extended release (RSG XR) form as adjunctive…”
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Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs by Jost, Marco, Santos, Daniel A., Saunders, Reuben A., Horlbeck, Max A., Hawkins, John S., Scaria, Sonia M., Norman, Thomas M., Hussmann, Jeffrey A., Liem, Christina R., Gross, Carol A., Weissman, Jonathan S.

“…A lack of tools to precisely control gene expression has limited our ability to evaluate relationships between expression levels and phenotypes. Here, we…”
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Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients by Michalovich, David, Rodriguez-Perez, Noelia, Smolinska, Sylwia, Pirozynski, Michal, Mayhew, David, Uddin, Sorif, Van Horn, Stephanie, Sokolowska, Milena, Altunbulakli, Can, Eljaszewicz, Andrzej, Pugin, Benoit, Barcik, Weronika, Kurnik-Lucka, Magdalena, Saunders, Ken A., Simpson, Karen D., Schmid-Grendelmeier, Peter, Ferstl, Ruth, Frei, Remo, Sievi, Noriane, Kohler, Malcolm, Gajdanowicz, Pawel, Graversen, Katrine B., Lindholm Bøgh, Katrine, Jutel, Marek, Brown, James R., Akdis, Cezmi A., Hessel, Edith M., O’Mahony, Liam

“…In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute to disease…”
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Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome by Korbel, Jan O, Urban, Alexander Eckehart, Affourtit, Jason P, Godwin, Brian, Grubert, Fabian, Simons, Jan Fredrik, Kim, Philip M, Palejev, Dean, Carriero, Nicholas J, Du, Lei, Taillon, Bruce E, Chen, Zhoutao, Tanzer, Andrea, Saunders, A.C. Eugenia, Chi, Jianxiang, Yang, Fengtang, Carter, Nigel P, Hurles, Matthew E, Weissman, Sherman M, Harkins, Timothy T, Gerstein, Mark B, Egholm, Michael, Snyder, Michael

“…Structural variation of the genome involves kilobase- to megabase-sized deletions, duplications, insertions, inversions, and complex combinations of…”
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Sex chromosome turnovers and genetic drift: a simulation study by Saunders, Paul A., Neuenschwander, Samuel, Perrin, Nicolas

“…The recent advances of new genomic technologies have enabled the identification and characterization of sex chromosomes in an increasing number of nonmodel…”
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Mood Homeostasis, Low Mood, and History of Depression in 2 Large Population Samples by Taquet, Maxime, Quoidbach, Jordi, Gross, James J, Saunders, Kate E A, Goodwin, Guy M

“…Existing therapeutic options are insufficient to tackle the disease burden of depression, and new treatments are sorely needed. Defining new psychotherapeutic…”
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COVID-19 vaccination strategies depend on the underlying network of social interactions by Saunders, Helena A., Schwartz, Jean-Marc

“…Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, different mitigation and management strategies limiting economic and social activities…”
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A visual motion detection circuit suggested by Drosophila connectomics by Takemura, Shin-ya, Bharioke, Arjun, Lu, Zhiyuan, Nern, Aljoscha, Vitaladevuni, Shiv, Rivlin, Patricia K., Katz, William T., Olbris, Donald J., Plaza, Stephen M., Winston, Philip, Zhao, Ting, Horne, Jane Anne, Fetter, Richard D., Takemura, Satoko, Blazek, Katerina, Chang, Lei-Ann, Ogundeyi, Omotara, Saunders, Mathew A., Shapiro, Victor, Sigmund, Christopher, Rubin, Gerald M., Scheffer, Louis K., Meinertzhagen, Ian A., Chklovskii, Dmitri B.

“…Animal behaviour arises from computations in neuronal circuits, but our understanding of these computations has been frustrated by the lack of detailed…”
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SNOPT: An SQP Algorithm for Large-Scale Constrained Optimization by Gill, Philip E., Murray, Walter, Saunders, Michael A.

“…Sequential quadratic programming (SQP) methods have proved highly effective for solving constrained optimization problems with smooth nonlinear functions in…”
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Normalized Hurricane Damage in the United States: 1900–2005 by Pielke, Roger A, Gratz, Joel, Landsea, Christopher W, Collins, Douglas, Saunders, Mark A, Musulin, Rade

“…After more than two decades of relatively little Atlantic hurricane activity, the past decade saw heightened hurricane activity and more than $150 billion in…”
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Observation of Betatron X-Ray Radiation in a Self-Modulated Laser Wakefield Accelerator Driven with Picosecond Laser Pulses by Albert, F, Lemos, N, Shaw, J L, Pollock, B B, Goyon, C, Schumaker, W, Saunders, A M, Marsh, K A, Pak, A, Ralph, J E, Martins, J L, Amorim, L D, Falcone, R W, Glenzer, S H, Moody, J D, Joshi, C

“…We investigate a new regime for betatron x-ray emission that utilizes kilojoule-class picosecond lasers to drive wakes in plasmas. When such laser pulses with…”
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Effect of temperature on the rheological, textural, and sensory properties of butters from New Zealand market by Yang, X., Saunders, A., Mohan, M. S.

“…Texture and sensory studies at various temperatures are important in evaluating and improving the functionality of butter. While literature is scarce, we…”
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Personal protective equipment and infection prevention and control: a national survey of UK medical students and interim foundation doctors during the COVID-19 pandemic by Norton, Emma Jane, Georgiou, Ioannis, Fung, Alex, Nazari, Armin, Bandyopadhyay, Soham, Saunders, Kate E A

“…The adequacy of personal protective equipment (PPE) and infection prevention and control (IPC) training in UK medical students and interim Foundation Year 1…”
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Impact of deleterious mutations, sexually antagonistic selection, and mode of recombination suppression on transitions between male and female heterogamety by Saunders, Paul A, Neuenschwander, Samuel, Perrin, Nicolas

“…Deleterious mutations accumulating on non-recombining Y chromosomes can drive XY to XY turnovers, as they allow to replace the old mutation-loaded Y by a new…”
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