Search Results - "SATOH, RYOSUKE"

ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer by Sugiura, Reiko, Satoh, Ryosuke, Takasaki, Teruaki

“…The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified by cell proliferation, differentiation, motility, and survival…”
Get full text

More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis by Sugiura, Reiko, Satoh, Ryosuke, Hagihara, Kanako, Takasaki, Teruaki

“…Fingolimod hydrochloride (FTY720) is a first-in-class of sphingosine-1-phosphate (S1P) receptor modulator approved to treat multiple sclerosis by its…”
Get full text

Fission Yeast PUF Proteins Puf3 and Puf4 Are Novel Regulators of PI4P5K Signaling by Satoh, Ryosuke, Tanaka, Taemi, Yoshida, Nobuyasu, Tanaka, Chiaki, Takasaki, Teruaki, Sugiura, Reiko

“…Phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) is a highly conserved enzyme that generates phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) by…”
Get full text

Rae1-mediated nuclear export of Rnc1 is an important determinant in controlling MAPK signaling by Satoh, Ryosuke, Hagihara, Kanako, Sugiura, Reiko

“…In eukaryotic cells, RNA binding proteins (RBPs) play critical roles in regulating almost every aspect of gene expression, often shuttling between the nucleus…”
Get full text

Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice by Kawase, Atsushi, Mukai, Hideyuki, Tateishi, Shunsuke, Kuroda, Shintaro, Kazaoka, Akira, Satoh, Ryosuke, Shimada, Hiroaki, Sugiura, Reiko, Iwaki, Masahiro

“…In receptor-type transcription factors-mediated cytochrome P450 (P450) induction, few studies have attempted to clarify the roles of protein kinase N (PKN) in…”
Get full text

Down‐regulation of dual‐specificity phosphatase 6, a negative regulator of oncogenic ERK signaling, by ACA‐28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB2 by Kanda, Yuki, Mizuno, Ayami, Takasaki, Teruaki, Satoh, Ryosuke, Hagihara, Kanako, Masuko, Takashi, Endo, Yuichi, Tanabe, Genzoh, Sugiura, Reiko

“…Dual‐specificity phosphatase 6 (DUSP6) is a key negative feedback regulator of the member of the RAS‐ERK MAPK signaling pathway that is associated with…”
Get full text

Chemical genetic analysis of FTY720‐ and Ca2+‐sensitive mutants reveals a functional connection between FTY720 and membrane trafficking by Hagihara, Kanako, Kanda, Yuki, Ishida, Kouki, Satoh, Ryosuke, Takasaki, Teruaki, Maeda, Takuya, Sugiura, Reiko

“…FTY720, a sphingosine‐1‐phosphate (S1P) analog, is used as an immune modulator to treat multiple sclerosis. Accumulating evidence has suggested the mode of…”
Get full text

Distinct modes of stress granule assembly mediated by the KH‐type RNA‐binding protein Rnc1 by Satoh, Ryosuke, Hara, Nobuki, Kawasaki, Aki, Takasaki, Teruaki, Sugiura, Reiko

“…We have previously identified the KH‐type RNA‐binding protein Rnc1 as an important regulator of the posttranscriptional expression of the MAPK phosphatase Pmp1…”
Get full text

Microchip electrophoresis utilizing an in situ photopolymerized Phos-tag binding polyacrylamide gel for specific entrapment and analysis of phosphorylated compounds by Yamamoto, Sachio, Himeno, Miyuki, Kobayashi, Masaya, Akamatsu, Miki, Satoh, Ryosuke, Kinoshita, Mitsuhiro, Sugiura, Reiko, Suzuki, Shigeo

“…A method was developed for the specific entrapment and separation of phosphorylated compounds using a Phos-tag polyacrylamide gel fabricated at the channel…”
Get more information

Stress granules as a feedback mechanism of MAPK signaling by sequestering PKC/Pck2 by Kanda, Yuki, Satoh, Ryosuke, Takasaki, Teruaki, Tomimoto, Naofumi, Tsuchiya, Kiko, Tsai, Chun An, Tanaka, Taemi, Kyomoto, Shu, Hamada, Kozo, Fujiwara, Toshinobu, Sugiura, Reiko

“…The PKC signaling is a highly conserved signaling module, which plays a central role in a myriad of physiological processes, ranging from cell proliferation to…”
Get full text

Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28 by Satoh, Ryosuke, Hamada, Naoya, Yamada, Ami, Kanda, Yuki, Ishikawa, Fumihiro, Takasaki, Teruaki, Tanabe, Genzoh, Sugiura, Reiko

“…[Display omitted] •ACA-28 (2a), an ERK-dependent apoptosis inducer preferentially kills melanoma cells.•Fifteen analogs of 2a were synthesized and analyzed for…”
Get full text

PKN3 is the major regulator of angiogenesis and tumor metastasis in mice by Mukai, Hideyuki, Muramatsu, Aiko, Mashud, Rana, Kubouchi, Koji, Tsujimoto, Sho, Hongu, Tsunaki, Kanaho, Yasunori, Tsubaki, Masanobu, Nishida, Shozo, Shioi, Go, Danno, Sally, Mehruba, Mona, Satoh, Ryosuke, Sugiura, Reiko

“…PKN, a conserved family member related to PKC, was the first protein kinase identified as a target of the small GTPase Rho. PKN is involved in various…”
Get full text

Spatial regulation of the KH domain RNA‐binding protein Rnc1 mediated by a Crm1‐independent nuclear export system in Schizosaccharomyces pombe by Satoh, Ryosuke, Matsumura, Yasuhiro, Tanaka, Akitomo, Takada, Makoto, Ito, Yuna, Hagihara, Kanako, Inari, Masahiro, Kita, Ayako, Fukao, Akira, Fujiwara, Toshinobu, Hirai, Shinya, Tani, Tokio, Sugiura, Reiko

“…Summary RNA‐binding proteins (RBPs) play important roles in the posttranscriptional regulation of gene expression, including mRNA stability, transport and…”
Get full text

Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1 by Mashud, Rana, Nomachi, Akira, Hayakawa, Akihide, Kubouchi, Koji, Danno, Sally, Hirata, Takako, Matsuo, Kazuhiko, Nakayama, Takashi, Satoh, Ryosuke, Sugiura, Reiko, Abe, Manabu, Sakimura, Kenji, Wakana, Shigeharu, Ohsaki, Hiroyuki, Kamoshida, Shingo, Mukai, Hideyuki

“…Knock-in mice lacking PKN1 kinase activity were generated by introducing a T778A point mutation in the catalytic domain. PKN1[T778A] mutant mice developed to…”
Get full text

Atg1, a key regulator of autophagy, functions to promote MAPK activation and cell death upon calcium overload in fission yeast by Takasaki, Teruaki, Utsumi, Ryosuke, Shimada, Erika, Bamba, Asuka, Hagihara, Kanako, Satoh, Ryosuke, Sugiura, Reiko

“…Autophagy promotes or inhibits cell death depending on the environment and cell type. Our previous findings suggested that Atg1 is genetically involved in the…”
Get full text

ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells by Khandakar, Golam Iftakhar, Satoh, Ryosuke, Takasaki, Teruaki, Fujitani, Kana, Tanabe, Genzoh, Sakai, Kazuko, Nishio, Kazuto, Sugiura, Reiko

“…The mitogen-activated protein kinase (MAPK)/ERK and phosphatidylinositol-3 kinase (PI3K)/AKT pathways are dysregulated in various human cancers, including…”
Get full text

Evaluation of a novel method for measurement of intracellular calcium ion concentration in fission yeast by Ogata, Fumihiko, Satoh, Ryosuke, Kita, Ayako, Sugiura, Reiko, Kawasaki, Naohito

“…The distribution of metal and metalloid species in each of the cell compartments is termed as “metallome”. It is important to elucidate the molecular mechanism…”
Get full text

Skb5, an SH3 adaptor protein, regulates Pmk1 MAPK signaling by controlling the intracellular localization of Mkh1 MAPKKK by Kanda, Yuki, Satoh, Ryosuke, Matsumoto, Saki, Ikeda, Chisato, Inutsuka, Natsumi, Hagihara, Kanako, Matzno, Sumio, Tsujimoto, Sho, Kita, Ayako, Sugiura, Reiko

“…The MAPK cascade is a highly conserved signaling module composed of MAPK/MAPKK/MAPKKK. MAPKKK Mkh1 is an initiating kinase in Pmk1 MAPK signaling, which…”
Get full text

Imp2, the PSTPIP homolog in fission yeast, affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission yeast by Kita, Ayako, Higa, Mari, Doi, Akira, Satoh, Ryosuke, Sugiura, Reiko

“…Cytokinesis is a highly ordered process that divides one cell into two cells, which is functionally linked to the dynamic remodeling of the plasma membrane…”
Get full text

Spatial control of calcineurin in response to heat shock in fission yeast by Higa, Mari, Kita, Ayako, Hagihara, Kanako, Kitai, Yuki, Doi, Akira, Nagasoko, Rie, Satoh, Ryosuke, Sugiura, Reiko

“…In fission yeast, Ppb1, the Ca2+/calmodulin‐dependent protein phosphatase calcineurin regulates multiple biological processes, such as cytokinesis,…”
Get full text