Search Results - "SATO, Tatsunori"

Applications of fluorine-containing amino acids for drug design by Mei, Haibo, Han, Jianlin, Klika, Karel D., Izawa, Kunisuke, Sato, Tatsunori, Meanwell, Nicholas A., Soloshonok, Vadim A.

“…Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to two general trends in the modern pharmaceutical industry. Firstly, the…”
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Tailor‐Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals by Mei, Haibo, Han, Jianlin, White, Sarah, Graham, Daniel J., Izawa, Kunisuke, Sato, Tatsunori, Fustero, Santos, Meanwell, Nicholas A., Soloshonok, Vadim A.

“…Structural analysis of modern pharmaceutical practices allows for the identification of two rapidly growing trends: the introduction of tailor‐made amino acids…”
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Copper-Catalyzed Enantioselective Allylic Alkylation of Terminal Alkyne Pronucleophiles by Harada, Ayumi, Makida, Yusuke, Sato, Tatsunori, Ohmiya, Hirohisa, Sawamura, Masaya

“…The copper-catalyzed enantioselective allylic alkylation of terminal alkynes with primary allylic phosphates was developed by the use of a new chiral…”
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The planocerid flatworm is a main supplier of toxin to tetrodotoxin-bearing fish juveniles by Itoi, Shiro, Sato, Tatsunori, Takei, Mitsuki, Yamada, Riko, Ogata, Ryuya, Oyama, Hikaru, Teranishi, Shun, Kishiki, Ayano, Wada, Takenori, Noguchi, Kaede, Abe, Misato, Okabe, Taiki, Akagi, Hiroyuki, Kashitani, Maho, Suo, Rei, Koito, Tomoko, Takatani, Tomohiro, Arakawa, Osamu, Sugita, Haruo

“…Tetrodotoxin (TTX), a potent neurotoxin, is found in various phylogenetically diverse taxa. In marine environments, the pufferfish is at the top of the food…”
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Including planocerid flatworms in the diet effectively toxifies the pufferfish, Takifugu niphobles by Itoi, Shiro, Ueda, Hiroyuki, Yamada, Riko, Takei, Mitsuki, Sato, Tatsunori, Oshikiri, Shotaro, Wajima, Yoshiki, Ogata, Ryuya, Oyama, Hikaru, Shitto, Takahiro, Okuhara, Kazuya, Tsunashima, Tadasuke, Sawayama, Eitaro, Sugita, Haruo

“…Beginning with the larval stages, marine pufferfish such as Takifugu niphobles contain tetrodotoxin (TTX), an extremely potent neurotoxin. Although highly…”
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Optical Resolution of Rimantadine by Han, Jianlin, Takeda, Ryosuke, Sato, Tatsunori, Moriwaki, Hiroki, Abe, Hidenori, Izawa, Kunisuke, Soloshonok, Vadim A

“…This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure ( )-rimantadine…”
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Seasonal Changes in the Tetrodotoxin Content of the Flatworm Planocera multitentaculata by Yamada, Riko, Tsunashima, Tadasuke, Takei, Mitsuki, Sato, Tatsunori, Wajima, Yoshiki, Kawase, Makoto, Oshikiri, Shotaro, Kajitani, Yusuke, Kosoba, Keita, Ueda, Hiroyuki, Abe, Koko, Itoi, Shiro, Sugita, Haruo

“…Tetrodotoxin (TTX) is a potent neurotoxin that acts specifically on voltage-gated sodium channels on excitable membranes of muscle and nerve tissues. The…”
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Tandem Alkylation–Second-Order Asymmetric Transformation Protocol for the Preparation of Phenylalanine-Type Tailor-Made α‑Amino Acids by Takeda, Ryosuke, Kawashima, Aki, Yamamoto, Junya, Sato, Tatsunori, Moriwaki, Hiroki, Izawa, Kunisuke, Abe, Hidenori, Soloshonok, Vadim A

“…In this work, we disclose an advanced general process for the synthesis of tailor-made α-amino acids (α-AAs) via tandem alkylation–second-order asymmetric…”
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Diphenylmethane-based anion receptors bearing bis(p-toluenesulfonyl urea) groups by Higuchi, Shintaro, Sato, Tatsunori, Ito, Kazuaki

“…Diphenylmethane-based receptors ( 1 ) bearing urea units were prepared for anion recognition. Analogous anion receptors based on biphenyl ( 2 ),…”
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Endoscopic nasobiliary and nasopancreatic drainage contributing to healing of duodenal ulcer perforation: a case report by Enokida, Kohei, Kikuyama, Masataka, Kurokami, Takafumi, Shirane, Naofumi, Aoyama, Haruna, Aoyama, Hiroyuki, Sato, Tatsunori, Taki, Yusuke

“…A 75-year-old man with vomiting and right abdominal pain was admitted to the Department of Surgery in our hospital. With a diagnosis of perforated duodenal…”
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Tailor-made amino acids in the design of small-molecule blockbuster drugs by Han, Jianlin, Konno, Hiroyuki, Sato, Tatsunori, Soloshonok, Vadim A., Izawa, Kunisuke

“…The role of amino acids (AAs) in modern health industry is well-appreciated. Residues of individual AAs, or their chemical modifications, such as diamines and…”
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Tailor-Made α-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA) by Sato, Tatsunori, Izawa, Kunisuke, Aceña, José Luis, Liu, Hong, Soloshonok, Vadim A.

“…(1R,2S)‐1‐Amino‐2‐vinylcyclopropane‐1‐carboxylic acid (vinyl‐ACCA) is the essential pharmacophoric unit in a new generation of highly potent hepatitis C virus…”
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Cyclic tailor-made amino acids in the design of modern pharmaceuticals by Liu, Jiang, Han, Jianlin, Izawa, Kunisuke, Sato, Tatsunori, White, Sarah, Meanwell, Nicholas A., Soloshonok, Vadim A.

“…Tailor-made AAs are indispensable components of modern medicinal chemistry and are becoming increasingly prominent in new drugs. In fact, about 30% of…”
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Synthesis of fluorine-containing α-amino acids in enantiomerically pure form via homologation of Ni(II) complexes of glycine and alanine Schiff bases by Aceña, José Luis, Sorochinsky, Alexander E., Moriwaki, Hiroki, Sato, Tatsunori, Soloshonok, Vadim A.

“…•Comprehensive review of asymmetric synthesis of fluorine-containing amino acids via Ni(II) complex chemistry.•Methodologically flexible approaches including:…”
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A General Route to Bridged Azabicyclic Compounds Using Radical Translocation/Cyclization Reactions by Ikeda, Masazumi, Sato, Tatsunori

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Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases; Part 1: alkyl halide alkylations by Sorochinsky, Alexander E, Aceña, José Luis, Moriwaki, Hiroki, Sato, Tatsunori, Soloshonok, Vadim A

“…Alkylations of chiral or achiral Ni(II) complexes of glycine Schiff bases constitute a landmark in the development of practical methodology for asymmetric…”
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Sulfur-Directed Regioselective Radical Cyclization Leading to .beta.-Lactams: Formal Synthesis of (.+-.)-PS-5 and (+)-Thienamycin by Ishibashi, Hiroyuki, Kameoka, Chisato, Iriyama, Hiroko, Kodama, Kazuya, Sato, Tatsunori, Ikeda, Masazumi

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Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 2: Aldol, Mannich addition reactions, deracemization and (S) to (R) interconversion of α-amino acids by Sorochinsky, Alexander E, Aceña, José Luis, Moriwaki, Hiroki, Sato, Tatsunori, Soloshonok, Vadim

“…This review provides a comprehensive treatment of literature data dealing with asymmetric synthesis of α-amino-β-hydroxy and α,β-diamino acids via homologation…”
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Anion binding properties of tris(2-hydroxyphenyl)methanes by Sato, Tatsunori, Ito, Kazuaki

“…Tris(2-hydroxyphenyl)methane derivatives ( 1 ) displayed excellent selectivity for Cl − in comparison with other anions tested (Br − , I − and NO 3 − ) by 1 H…”
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Chemical Dynamic Kinetic Resolution and S/R Interconversion of Unprotected α-Amino Acids by Takeda, Ryosuke, Kawamura, Akie, Kawashima, Aki, Sato, Tatsunori, Moriwaki, Hiroki, Izawa, Kunisuke, Akaji, Kenichi, Wang, Shuni, Liu, Hong, Aceña, José Luis, Soloshonok, Vadim A.

“…Reported herein is the first purely chemical method for the dynamic kinetic resolution (DKR) of unprotected racemic α‐amino acids (α‐AAs), a method which can…”
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