Search Results - "SATO, TOMOAKI"

MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines by Tomita, Kazuo, Nagasawa, Taisuke, Kuwahara, Yoshikazu, Torii, Seiji, Igarashi, Kento, Roudkenar, Mehryar Habibi, Roushandeh, Amaneh Mohammadi, Kurimasa, Akihiro, Sato, Tomoaki

“…In cancer therapy, radioresistance or chemoresistance cells are major problems. We established clinically relevant radioresistant (CRR) cells that can survive…”
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Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability by Fukui, Roman, Saga, Ryo, Matsuya, Yusuke, Tomita, Kazuo, Kuwahara, Yoshikazu, Ohuchi, Kentaro, Sato, Tomoaki, Okumura, Kazuhiko, Date, Hiroyuki, Fukumoto, Manabu, Hosokawa, Yoichiro

“…Cancer stem-like cells (CSCs) within solid tumors exhibit radioresistance, leading to recurrence and distant metastasis after radiotherapy. To experimentally…”
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Non-coding RNAs in ferroptotic cancer cell death pathway: meet the new masters by Valashedi, Mehdi Rabiee, Bamshad, Chia, Najafi-Ghalehlou, Nima, Nikoo, Amirsadegh, Tomita, Kazuo, Kuwahara, Yoshikazu, Sato, Tomoaki, Roushandeh, Amaneh Mohammadi, Roudkenar, Mehryar Habibi

“…Despite the recent advances in cancer therapy, cancer chemoresistance looms large along with radioresistance, a major challenge in dire need of thorough and…”
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Neonatal maternal separation delays the GABA excitatory-to-inhibitory functional switch by inhibiting KCC2 expression by Furukawa, Minami, Tsukahara, Takao, Tomita, Kazuo, Iwai, Haruki, Sonomura, Takahiro, Miyawaki, Shouichi, Sato, Tomoaki

“…The excitatory-to-inhibitory functional switch of γ-aminobutyric acid (GABA; GABA switch), which normally occurs in the first to the second postnatal week in…”
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Kamishoyosan (a Japanese traditional herbal formula), which effectively reduces the aggressive biting behavior of male and female mice, and potential regulation through increase of Tph1, Tph2, and Esr2 mRNA levels by Igarashi, Kento, Kuchiiwa, Toshiko, Kuchiiwa, Satoshi, Iwai, Haruki, Tomita, Kazuo, Sato, Tomoaki

“…[Display omitted] •Kamishoyosan (KSS) reduced aggressiveness in isolation-reared male and female mice.•Co-preadministration of WAY-100635 and bicuculline…”
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Decreased mitochondrial membrane potential is an indicator of radioresistant cancer cells by Kuwahara, Yoshikazu, Tomita, Kazuo, Roudkenar, Mehryar Habibi, Roushandeh, Amaneh Mohammadi, Urushihara, Yusuke, Igarashi, Kento, Kurimasa, Akihiro, Sato, Tomoaki

“…To overcome radioresistant cancer cells, clinically relevant radioresistant (CRR) cells were established. To maintain their radioresistance, CRR cells were…”
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The reversibility of cancer radioresistance: a novel potential way to identify factors contributing to tumor radioresistance by Kuwahara, Yoshikazu, Tomita, Kazuo, Habibi Roudkenar, Mehryar, Mohammadi Roushandeh, Amaneh, Sato, Tomoaki, Kurimasa, Akihiro

“…To understand the molecular mechanisms responsible for radioresistance in cancer cells, we previously established clinically relevant radioresistant (CRR) cell…”
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Neuroprotective effect of oxytocin on cognitive dysfunction, DNA damage, and intracellular chloride disturbance in young mice after cranial irradiation by Igarashi, Kento, Iwai, Haruki, Tanaka, Koh-ichi, Kuwahara, Yoshikazu, Kitanaka, Junichi, Kitanaka, Nobue, Kurimasa, Akihiro, Tomita, Kazuo, Sato, Tomoaki

“…Cranial radiation therapy (CRT) is an effective treatment for brain tumors; however, it also causes brain injuries. The pediatric brain is considered…”
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CRISPR/Cas9-mediated knockout of Lcn2 in human breast cancer cell line MDA-MB-231 ameliorates erastin-mediated ferroptosis and increases cisplatin vulnerability by Valashedi, Mehdi Rabiee, Roushandeh, Amaneh Mohammadi, Tomita, Kazuo, Kuwahara, Yoshikazu, Pourmohammadi-Bejarpasi, Zahra, Kozani, Pouya Safarzadeh, Sato, Tomoaki, Roudkenar, Mehryar Habibi

“…Lipocalin 2 (Lcn2) is an antioxidant-related protein upregulated in various cellular stress conditions, especially cancer. In this study, we abrogated Lcn2…”
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Lipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA by Tomita, Kazuo, Takashi, Yuko, Ouchi, Yuya, Kuwahara, Yoshikazu, Igarashi, Kento, Nagasawa, Taisuke, Nabika, Hideki, Kurimasa, Akihiro, Fukumoto, Manabu, Nishitani, Yoshihiro, Sato, Tomoaki

“…4‐Hydroxynonenal (HNE) is an important product of plasma membrane lipid peroxidation, which is a cause of cell and tissue injury. Mitochondrial DNA…”
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Association between radiation-induced cell death and clinically relevant radioresistance by Kuwahara, Yoshikazu, Tomita, Kazuo, Urushihara, Yusuke, Sato, Tomoaki, Kurimasa, Akihiro, Fukumoto, Manabu

“…Radiotherapy (RT) is one of the major modalities for the treatment of human cancer and has been established as an excellent local treatment for malignant…”
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Mitochondria: how eminent in ageing and neurodegenerative disorders? by Bamshad, Chia, Najafi-Ghalehlou, Nima, Pourmohammadi-Bejarpasi, Zahra, Tomita, Kazuo, Kuwahara, Yoshikazu, Sato, Tomoaki, Feizkhah, Alireza, Roushnadeh, Amaneh Mohammadi, Roudkenar, Mehryar Habibi

“…Numerous factors are implicated in the onset and progression of ageing and neurodegenerative disorders, with defects in cell energy supply and free radicals…”
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Cashing in on ferroptosis against tumor cells: Usher in the next chapter by Valashedi, Mehdi Rabiee, Najafi-Ghalehlou, Nima, Nikoo, Amirsadegh, Bamshad, Chia, Tomita, Kazuo, Kuwahara, Yoshikazu, Sato, Tomoaki, Roushandeh, Amaneh Mohammadi, Roudkenar, Mehryar Habibi

“…Ferroptosis is a new type of non-apoptotic regulated cell death (RCD) driven by unrestricted lethal lipid peroxidation, which is totally distinct from other…”
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Immunological responses following the third dose of the BNT162b2 SARS-CoV-2 vaccine among Japanese healthcare workers by Tamura, Miku, Fujita, Retsu, Sato, Tomoaki, Sato, Ryohei, Kato, Yasuyuki, Nagasawa, Mitsuaki, Matsumoto, Tetsuya

“…A limited number of studies have shown a decline in antibody titers in healthcare workers beyond six months after the second dose of the BNT162b2 vaccine, and…”
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Direct antibiotic susceptibility testing of blood cultures of gram-negative bacilli using the Drug Susceptibility Testing Microfluidic (DSTM) device by Mizoguchi, Miyuki, Matsumoto, Yoshimi, Saito, Ryoichi, Sato, Tomoaki, Moriya, Kyoji

“…Proper treatment of bloodstream infections requires rapid, early determination of appropriate antibiotic agents, emphasizing the need for more rapid drug…”
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Type A Aortic Dissection After Thoracic Endovascular Aortic Repair by Higashigawa, Takatoshi, MD, Kato, Noriyuki, MD, Chino, Shuji, MD, Hashimoto, Takashi, MD, Shimpo, Hideto, MD, Tokui, Toshiya, MD, Mizumoto, Toru, MD, Sato, Tomoaki, MD, Okabe, Manabu, MD, Sakuma, Hajime, MD

“…Background Type A aortic dissection (TAAD) is a rare complication associated with thoracic endovascular aortic repair (TEVAR). Although TAAD can result in…”
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Mitochondrial transfer in PC-3 cells fingerprinted in ferroptosis sensitivity: a brand new approach targeting cancer metabolism by Nikoo, Amirsadegh, Roudkenar, Mehryar Habibi, Sato, Tomoaki, Kuwahara, Yoshikazu, Tomita, Kazuo, Pourmohammadi-Bejarpasi, Zahra, Najafi-Ghalehlou, Nima, Roushandeh, Amaneh Mohammadi

“…Despite recent therapeutic advancements, cancer remains one of the leading causes of death worldwide, with mitochondrial dysfunction being associated with…”
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Glycogen Synthase Kinase-3 Inhibitors Block Morphine-Induced Locomotor Activation, Straub Tail, and Depression of Rearing in Mice Via a Possible Central Action by Kitanaka, Junichi, Kitanaka, Nobue, Tomita, Kazuo, Hall, F. Scott, Igarashi, Kento, Uhl, George R., Sato, Tomoaki

“…We investigated morphine-induced Straub’s tail reaction (STR) in mice pretreated with or without glycogen synthase kinase-3 (GSK-3) inhibitors (SB216763 and…”
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Prospective audit and feedback implementation by a multidisciplinary antimicrobial stewardship team shortens the time to de-escalation of anti-MRSA agents by Yamaguchi, Ryo, Yamamoto, Takehito, Okamoto, Koh, Tatsuno, Keita, Ikeda, Mahoko, Tanaka, Takehiro, Wakabayashi, Yoshitaka, Sato, Tomoaki, Okugawa, Shu, Moriya, Kyoji, Suzuki, Hiroshi

“…Prospective audit and feedback (PAF) is considered an effective procedure for appropriate antibiotic use. However, its effect on the time to de-escalation is…”
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Comparative data on emotional (psychotic) aggressive biting behavior in mice of ddY strain measured by using two devices; Aggressive response meter and powerlab-compatible type aggressive response meter by Igarashi, Kento, Kuchiiwa, Satoshi, Kuchiiwa, Toshiko, Tomita, Kazuo, Sato, Tomoaki

“…The Aggressive Response Meter (ARM) has been validated for measuring emotional (psychotic) aggression triggered by mental irritation in mice. In the present…”
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