Search Results - "SATO, Kazuyuki"

Development of Drug Discovery Platforms Using Artificial Intelligence and Cheminformatics by Kawai, Kentaro, Karuo, Yukiko, Tarui, Atsushi, Sato, Kazuyuki, Kataoka, Makoto, Omote, Masaaki

“…Recently, remarkable progress has been achieved in artificial intelligence (AI), including machine learning. Various AI models have been proposed for drug…”
Get full text

Analysis of proton exchange membrane fuel cell catalyst layers for reduction of platinum loading at Nissan by Ohma, Atsushi, Mashio, Tetsuya, Sato, Kazuyuki, Iden, Hiroshi, Ono, Yoshitaka, Sakai, Kei, Akizuki, Ken, Takaichi, Satoshi, Shinohara, Kazuhiko

“…The biggest issue that must be addressed in promoting widespread use of fuel cell vehicles (FCVs) is to reduce the cost of the fuel cell system. Especially, it…”
Get full text

Importance of the Azole Moiety of Cimetidine Derivatives for the Inhibition of Human Multidrug and Toxin Extrusion Transporter 1 (hMATE1) by Shinya, Susumu, Kawai, Kentaro, Tarui, Atsushi, Karuo, Yukiko, Sato, Kazuyuki, Matsuda, Masaya, Kitatani, Kazuyuki, Kobayashi, Naoki, Nabe, Takeshi, Otsuka, Masato, Omote, Masaaki

“…Herein, we describe the design and synthesis of cimetidine analogs, as well as their inhibitory activity toward the human multidrug and toxin extrusion…”
Get full text

Analysis of Water Adsorption and Condensation in Catalyst Layers for Polymer Electrolyte Fuel Cells by Mashio, Tetsuya, Sato, Kazuyuki, Ohma, Atsushi

“…Water sorption isotherm of catalyst layers in polymer electrolyte fuel cells is analyzed by a mathematical model. The model takes into account multi-layer…”
Get full text

Pentafluorosulfanyl-substituted biaryl derivatives as MATE-type transporter inhibitors targeting drug-resistant bacteria by Shinya, Susumu, Kawai, Kentaro, Kobayashi, Naoki, Karuo, Yukiko, Tarui, Atsushi, Sato, Kazuyuki, Otsuka, Masato, Omote, Masaaki

“…[Display omitted] Multidrug and toxin extrusion (MATE) inhibitors improve the antimicrobial susceptibility of drug-resistant bacteria by preventing the efflux…”
Get full text

Identification and Synthesis of DDI-6, a Quinolinol Analog Capable of Activating Both Caenorhabditis elegans and Mouse Spermatozoa by Karuo, Yukiko, Shiraki, Riona, Yoshida, Ayaka, Tsunokawa, Ryo, Nakahara-Yamada, Mayuko, Tarui, Atsushi, Sato, Kazuyuki, Kawai, Kentaro, Omote, Masaaki, Nishimura, Hitoshi

“…Sperm activation is an essential process by which the male gametes become capable of fertilization. Because the process in Caenorhabditis elegans is readily…”
Get full text

Influence of Age on Global and Regional Brain Stiffness in Young and Middle‐Aged Adults by Takamura, Tomohiro, Motosugi, Utaroh, Sasaki, Yu, Kakegawa, Takashi, Sato, Kazuyuki, Glaser, Kevin J., Ehman, Richard L., Onishi, Hiroshi

“…Background An understanding of potential age‐related changes in brain stiffness and its regional variation is important for further clinical application of MR…”
Get full text

Synthesis of fluoroalkenes and fluoroenynes via cross-coupling reactions using novel multihalogenated vinyl ethers by Karuo, Yukiko, Hirata, Keita, Tarui, Atsushi, Sato, Kazuyuki, Kawai, Kentaro, Omote, Masaaki

“…In this study, we develop the synthesis methods of fluoroalkenes and fluoroenynes via Suzuki-Miyaura and Sonogashira cross-coupling reactions using novel…”
Get full text

Fluorophenylalkyl-substituted cyanoguanidine derivatives as bacteria-selective MATE transporter inhibitors for the treatment of antibiotic-resistant infections by Shinya, Susumu, Kawai, Kentaro, Kobayashi, Naoki, Karuo, Yukiko, Tarui, Atsushi, Sato, Kazuyuki, Otsuka, Masato, Omote, Masaaki

“…[Display omitted] Drug efflux pump inhibitors for the multidrug resistance protein HmrM, a member of the multidrug and toxin extrusion (MATE) family of…”
Get full text

Transient Respiratory-motion Artifact and Scan Timing during the Arterial Phase of Gadoxetate Disodium-enhanced MR Imaging: The Benefit of Shortened Acquisition and Multiple Arterial Phase Acquisition by Ichikawa, Shintaro, Motosugi, Utaroh, Sato, Kazuyuki, Shimizu, Tatsuya, Wakayama, Tetsuya, Onishi, Hiroshi

“…Purpose: To investigate whether shortened acquisition or multiple arterial phase acquisition improves image quality of the arterial phase compared with…”
Get full text

Effect of Structural Descriptors on the Design of Cyclin Dependent Kinase Inhibitors Using Similarity‐based Molecular Evolution by Kawai, Kentaro, Karuo, Yukiko, Tarui, Atsushi, Sato, Kazuyuki, Omote, Masaaki

“…In this study, we evaluated the effect of structural descriptors on the in silico design of bioactive compounds. The authors have proposed a molecular design…”
Get full text

Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane by Karuo, Yukiko, Kametani, Ayaka, Tarui, Atsushi, Sato, Kazuyuki, Kawai, Kentaro, Omote, Masaaki

“…An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been…”
Get full text

Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles by Sato, Kazuyuki, Kawasaki, Akira, Karuo, Yukiko, Tarui, Atsushi, Kawai, Kentaro, Omote, Masaaki

“…Fluorescent molecules based on a fluorinated isoxazole scaffold were synthesized and investigated for their photochemical properties. The introduction of a…”
Get full text

LCP: Simple Representation of Docking Poses for Machine Learning: A Case Study on Xanthine Oxidase Inhibitors by Kawai, Kentaro, Asanuma, Yoshitaka, Kato, Toshiki, Karuo, Yukiko, Tarui, Atsushi, Sato, Kazuyuki, Omote, Masaaki

“…In this paper, we propose a simple descriptor called the ligand coordinate profile (LCP) for describing docking poses. The LCP descriptor is generated from the…”
Get full text

Rhodium-catalyzed homo-coupling reaction of aryl Grignard reagents and its application for the synthesis of an integrin inhibitor by Sato, Kazuyuki, Teranishi, Satoki, Sakaue, Atsushi, Karuo, Yukiko, Tarui, Atsushi, Kawai, Kentaro, Takeda, Hiroyuki, Kinashi, Tatsuo, Omote, Masaaki

“…A novel Rh-catalyzed one-pot homo-coupling reaction of aryl Grignard reagents was achieved. The reaction with bromobenzenes having an electron-donating group…”
Get full text

Decarboxylative Aldol Reaction of α,α-Difluoro-β-keto Esters: Easy Access to Difluoroenolate by Tarui, Atsushi, Shimomura, Hiroshi, Yasuno, Yohei, Karuo, Yukiko, Sato, Kazuyuki, Kawai, Kentaro, Omote, Masaaki

“…Yb­(OTf)3 promoted the Krapcho decarboxylation of 2,2-difluoro-3-oxopropanoate, and a subsequent aldol reaction was achieved. This process is the first example…”
Get full text

Improved Walking Through an Aperture in a Virtual Environment Transfers to a Real Environment: Introduction of Enriched Feedback and Gradual Increase in Task Difficulty by Suda, Yuki, Fukuhara, Kazunobu, Sato, Kazuyuki, Higuchi, Takahiro

“…Virtual reality (VR) could be used to set up a training protocol to improve one's collision-avoidance behavior. In our previous study, we developed a VR system…”
Get full text

Ligand-Promoted Asymmetric Imino-Reformatsky Reaction of Ethyl Dibromofluoroacetate by Tarui, Atsushi, Nishimura, Haruka, Ikebata, Takeshi, Tahira, Asuka, Sato, Kazuyuki, Omote, Masaaki, Minami, Hideki, Miwa, Yoshihisa, Ando, Akira

“…An enantio­selective Reformatsky reaction has been developed for the reaction of ethyl di­bromo­fluoro­acetate (1) with an imine. This method represents the…”
Get full text

Improving the Quality of Diffusion-weighted Imaging of the Left Hepatic Lobe Using Weighted Averaging of Signals from Multiple Excitations by Ichikawa, Shintaro, Motosugi, Utaroh, Tamada, Daiki, Wakayama, Tetsuya, Sato, Kazuyuki, Funayama, Satoshi, Onishi, Hiroshi

“…Background: Diffusion-weighted imaging (DWI) is useful for detecting and characterizing liver lesions but is sensitive to organ motion artifact, especially in…”
Get full text

Synthesis of Small Fluorescent Molecules and Evaluation of Photophysical Properties by Ogawa, Futa, Karuo, Yukiko, Yamazawa, Ryuji, Miyanaga, Kanae, Hori, Kazushige, Tani, Keita, Yamada, Kengo, Saito, Yuki, Funabiki, Kazumasa, Tarui, Atsushi, Sato, Kazuyuki, Ito, Kiyoshi, Kawai, Kentaro, Omote, Masaaki

“…A series of aniline-based fluorophores were newly synthesized. To increase their fluorescence quantum yields, it was particularly important to substitute…”
Get full text