Search Results - "SATO, Ippei"

A novel, selective, and orally available antagonist for CC chemokine receptor 3 by Morokata, Tatsuaki, Suzuki, Keiko, Masunaga, Yohei, Taguchi, Katsunari, Morihira, Koichiro, Sato, Ippei, Fujii, Masahiro, Takizawa, Satoko, Torii, Yuichi, Yamamoto, Naoyoshi, Kaneko, Masayuki, Yamada, Toshimitsu, Takahashi, Koichiro, Shimizu, Yasuaki

“…CC chemokine ligand 11 (CCL11/eotaxin) and other CC chemokine receptor 3 (CCR3) ligands (CCL24/eotaxin-2, CCL26/eotaxin-3, CCL13/monocyte chemotactic…”
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In vitro and in vivo characterization of a novel CCR3 antagonist, YM-344031 by Suzuki, Keiko, Morokata, Tatsuaki, Morihira, Koichiro, Sato, Ippei, Takizawa, Satoko, Kaneko, Masayuki, Takahashi, Koichiro, Shimizu, Yasuaki

“…Eosinophils play a prominent proinflammatory role in a broad range of diseases, including atopic dermatitis and asthma. Eotaxin-1 and its receptor CCR3 are…”
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Synthesis and structure–activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study by Kuramochi, Takahiro, Kakefuda, Akio, Sato, Ippei, Tsukamoto, Issei, Taguchi, Taku, Sakamoto, Shuichi

“…A series of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives were prepared, and their inhibitory activities against the reverse and forward modes of…”
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Synthesis and structure–activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium–calcium exchanger by Kuramochi, Takahiro, Kakefuda, Akio, Yamada, Hiroyoshi, Sato, Ippei, Taguchi, Taku, Sakamoto, Shuichi

“…A series of 2-phenoxypyridine derivatives were prepared and evaluated for their inhibitory activity against the reverse and forward modes of the sodium–calcium…”
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Synthetic studies on altohyrtins (spongistatins): synthesis of the C15–C28 (CD) spiroacetal portion by Terauchi, Takeshi, Terauchi, Taro, Sato, Ippei, Tsukada, Tomoharu, Kanoh, Naoki, Nakata, Masaya

“…The C15–C28 portion of altohyrtins (spongistatins) was prepared in a convergent manner from methyl ( S)-3-hydroxy-2-methylpropionate, d-arabitol, and…”
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Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists by Nitta, Aiko, Iura, Yosuke, Inoue, Hideki, Sato, Ippei, Morihira, Koichiro, Kubota, Hirokazu, Morokata, Tatsuaki, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Imaoka, Takayuki, Takahashi, Toshiya

“…Optimization starting with our lead compound 1 (IC50=4.9nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward…”
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A dual antagonist for chemokine CCR3 receptor and histamine H1 receptor by SUZUKI, Keiko, MOROKATA, Tatsuaki, MORIHIRA, Koichiro, SATO, Ippei, TAKIZAWA, Satoko, KANEKO, Masayuki, TAKAHASHI, Koichiro, SHIMIZU, Yasuaki

“…Eosinophilic chemokines and histamine play distinct but important roles in allergic diseases. Inhibition of both eosinophilic chemokines and histamine,…”
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Discovery and structure–activity relationships of urea derivatives as potent and novel CCR3 antagonists by Nitta, Aiko, Iura, Yosuke, Tomioka, Hiroki, Sato, Ippei, Morihira, Koichiro, Kubota, Hirokazu, Morokata, Tatsuaki, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Imaoka, Takayuki, Takahashi, Toshiya

“…The synthesis and structure–activity relationships of ureas as CCR3 antagonists are described. Optimization starting with lead compound 2 (IC50=190nM) derived…”
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A dual antagonist for chemokine CCR3 receptor and histamine H 1 receptor by Suzuki, Keiko, Morokata, Tatsuaki, Morihira, Koichiro, Sato, Ippei, Takizawa, Satoko, Kaneko, Masayuki, Takahashi, Koichiro, Shimizu, Yasuaki

“…Eosinophilic chemokines and histamine play distinct but important roles in allergic diseases. Inhibition of both eosinophilic chemokines and histamine,…”
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Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…The 6-fluoro-2-naphthylmethyl derivatives were prepared, and their inhibitory activities against CCR3 and CYP2D6 were evaluated. In our previous study on…”
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Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Ohno, Kazuki, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…Acrylamide derivatives were prepared, and their inhibitory activity against CCR3 and in vitro metabolic stability against human liver microsomes (HLMs) were…”
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Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Hamada, Noritaka, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…The 6-fluoro-2-naphthylmethyl derivatives were prepared, and their inhibitory activities against CCR3 were evaluated. A novel class of potent CCR3 receptor…”
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Corrigendum to “Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists” [Bioorg. Med. Chem. 16 (2008) 144–156] by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Hamada, Noritaka, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

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Synthesis and structure-activity relationships of N-{1-[(6-fluoro2-naphthyl)methyl]piperidin-4-yl} benzamide derivatives as novel CCR3 antagonists : Nucleic Acid Modification for Fluoescence-Based Technologies by SATO, Ippei, MORIHIRA, Koichiro, TAKAHASHI, Toshiya, TAKEUCHI, Makoto, OHTA, Mitsuaki, TSUKAMOTO, Shin-Ichi, INAMI, Hiroshi, KUBOTA, Hirokazu, MOROKATA, Tatsuaki, SUZUKI, Keiko, HAMADA, Noritaka, IURA, Yosuke, NITTA, Aiko, IMAOKA, Takayuki

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Formal total synthesis of altohyrtin C (spongistatin 2). Part 1: Aldol approach to unite AB and CD spiroacetals by Terauchi, Takeshi, Terauchi, Taro, Sato, Ippei, Shoji, Wataru, Tsukada, Tomoharu, Tsunoda, Takashi, Kanoh, Naoki, Nakata, Masaya

“…The Mukaiyama aldol coupling of the second-generation C1C14 (AB) fragment of altohyrtins (spongistatins) with the model α-methyl-β-alkoxyaldehydes revealed…”
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Formal total synthesis of altohyrtin C (spongistatin 2). Part 2: Construction of fully elaborated ABCD and EF fragments by Terauchi, Takeshi, Tanaka, Taisaku, Terauchi, Taro, Morita, Masataka, Kimijima, Kyoko, Sato, Ippei, Shoji, Wataru, Nakamura, Yasuhiro, Tsukada, Tomoharu, Tsunoda, Takashi, Hayashi, Gouichirou, Kanoh, Naoki, Nakata, Masaya

“…Coupling of the C1C14 (AB) crotylstannane with the C15C28 (CD) aldehyde followed by stereochemical arrangements gave the C1C28 (ABCD) fragment of altohyrtin…”
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