Search Results - "SATHISH SRINIVASAN, R"

Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves by Srinivasan, R Sathish, Oliver, Guillermo

“…Arteries, veins, and lymphatic vessels are functionally linked, and their physical interaction is tightly regulated. The lymphatic vessels communicate with the…”
Get full text

Plasticity of Button-Like Junctions in the Endothelium of Airway Lymphatics in Development and Inflammation by Yao, Li-Chin, Baluk, Peter, Srinivasan, R. Sathish, Oliver, Guillermo, McDonald, Donald M

“…Endothelial cells of initial lymphatics have discontinuous button-like junctions (buttons), unlike continuous zipper-like junctions (zippers) of collecting…”
Get full text

VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance by Yang, Ying, Cha, Boksik, Motawe, Zeinab Y., Srinivasan, R. Sathish, Scallan, Joshua P.

“…The lymphatic vasculature requires intraluminal valves to maintain forward lymph flow. Lymphatic valves form and are constantly maintained by oscillatory fluid…”
Get full text

Biochemical and mechanical signals in the lymphatic vasculature by Geng, Xin, Ho, Yen-Chun, Srinivasan, R. Sathish

“…Lymphatic vasculature is an integral part of the cardiovascular system where it maintains interstitial fluid balance. Additionally, lymphatic vasculature…”
Get full text

Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos by Yang, Ying, García-Verdugo, José Manuel, Soriano-Navarro, Mario, Srinivasan, R. Sathish, Scallan, Joshua P., Singh, Manvendra K., Epstein, Jonathan A., Oliver, Guillermo

“…The lymphatic vasculature preserves tissue fluid balance by absorbing fluid and macromolecules and transporting them to the blood vessels for circulation. The…”
Get full text

Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell by Oliver, Guillermo, Srinivasan, R Sathish

“…Lineage commitment and differentiation into mature cell types are mostly considered to be unidirectional and irreversible processes. However, recent results…”
Get full text

The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors by Srinivasan, R Sathish, Escobedo, Noelia, Yang, Ying, Interiano, Ashley, Dillard, Miriam E, Finkelstein, David, Mukatira, Suraj, Gil, Hyea Jin, Nurmi, Harri, Alitalo, Kari, Oliver, Guillermo

“…The mammalian lymphatic vasculature is important for returning fluids from the extracellular tissue milieu back to the blood circulation. We showed previously…”
Get full text

GATA2 regulates blood/lymph separation in a platelet‐dependent and lymphovenous valve‐independent manner by Mahamud, Md. Riaj, Geng, Xin, Chen, Lijuan, Ahmed, Zoheb, Ho, Yenchun, Srinivasan, R. Sathish

“…Introduction Lymphatic vessels collect interstitial fluid, immune cells, and digested lipids and return these bodily fluids to blood through two pairs of…”
Get full text

Promoting Lymphangiogenesis and Lymphatic Growth and Remodeling to Treat Cardiovascular and Metabolic Diseases by Liu, Xiaolei, Cui, Kui, Wu, Hao, Li, Kathryn S., Peng, Qianman, Wang, Donghai, Cowan, Douglas B., Dixon, J. Brandon, Sathish Srinivasan, R., Bielenberg, Diane R., Chen, Kaifu, Wang, Da-Zhi, Chen, Yabing, Chen, Hong

“…Lymphatic vessels are low-pressure, blind-ended tubular structures that play a crucial role in the maintenance of tissue fluid homeostasis, immune cell…”
Get full text

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126 by Mahamud, Md Riaj, Geng, Xin, Ho, Yen-Chun, Cha, Boksik, Kim, Yuenhee, Ma, Jing, Chen, Lijuan, Myers, Greggory, Camper, Sally, Mustacich, Debbie, Witte, Marlys, Choi, Dongwon, Hong, Young-Kwon, Chen, Hong, Varshney, Gaurav, Engel, James Douglas, Wang, Shusheng, Kim, Tae-Hoon, Lim, Kim-Chew, Srinivasan, R Sathish

“…Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the…”
Get full text

Intraluminal valves: development, function and disease by Geng, Xin, Cha, Boksik, Mahamud, Md Riaj, Srinivasan, R Sathish

“…The circulatory system consists of the heart, blood vessels and lymphatic vessels, which function in parallel to provide nutrients and remove waste from the…”
Get full text

Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development by Geng, Xin, Cha, Boksik, Mahamud, Md. Riaj, Lim, Kim-Chew, Silasi-Mansat, Robert, Uddin, Mohammad K.M., Miura, Naoyuki, Xia, Lijun, Simon, Alexander M., Engel, James Douglas, Chen, Hong, Lupu, Florea, Srinivasan, R. Sathish

“…Lymph is returned to the blood circulation exclusively via four lymphovenous valves (LVVs). Despite their vital importance, the architecture and development of…”
Get full text

Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature by Srinivasan, R Sathish, Dillard, Miriam E, Lagutin, Oleg V, Lin, Fu-Jung, Tsai, Sophia, Tsai, Ming-Jer, Samokhvalov, Igor M, Oliver, Guillermo

“…The origin of the mammalian lymphatic vasculature has been debated for more than 100 years. Whether lymphatic endothelial cells have a single or dual, venous…”
Get full text

The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells by Srinivasan, R Sathish, Geng, Xin, Yang, Ying, Wang, Yingdi, Mukatira, Suraj, Studer, Michèle, Porto, Marianna P R, Lagutin, Oleg, Oliver, Guillermo

“…The homeobox gene Prox1 is crucial for mammalian lymphatic vascular development. In the absence of Prox1, lymphatic endothelial cells (LECs) are not specified…”
Get full text

Lymphatic Vasculature in Energy Homeostasis and Obesity by Ho, Yen-Chun, Srinivasan, R Sathish

“…Obesity is a leading cause of cardiovascular diseases and cancer. Body mass is regulated by the balance between energy uptake and energy expenditure. The…”
Get full text

Whole-mount Immunohistochemistry to Visualize Mouse Embryonic Dermal Lymphatic Vasculature by Geng, Xin, Srinivasan, Sathish R

“…Lymphatic vessels are abundant in the skin where they regulate interstitial fluid uptake and immune surveillance. Defects in dermal lymphatic vessels, such as…”
Get full text

Simplified method to quantify valve back‐leak uncovers severe mesenteric lymphatic valve dysfunction in mice deficient in connexins 43 and 37 by Castorena‐Gonzalez, Jorge A., Srinivasan, R. Sathish, King, Philip D., Simon, Alexander M., Davis, Michael J.

“…Key points Lymphatic valve defects are one of the major causes of lymph transport dysfunction; however, there are no accessible methods for quantitatively…”
Get full text

RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice by Lapinski, Philip E, Kwon, Sunkuk, Lubeck, Beth A, Wilkinson, John E, Srinivasan, R Sathish, Sevick-Muraca, Eva, King, Philip D

“…RASA1 (also known as p120 RasGAP) is a Ras GTPase-activating protein that functions as a regulator of blood vessel growth in adult mice and humans. In humans,…”
Get full text

Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling by Cha, Boksik, Geng, Xin, Mahamud, Md. Riaj, Zhang, Jenny Y., Chen, Lijuan, Kim, Wantae, Jho, Eek-hoon, Kim, Yeunhee, Choi, Dongwon, Dixon, J. Brandon, Chen, Hong, Hong, Young-Kwon, Olson, Lorin, Kim, Tae Hoon, Merrill, Bradley J., Davis, Michael J., Srinivasan, R. Sathish

“…Wnt/β-catenin signaling is necessary for lymphatic vascular development. Oscillatory shear stress (OSS) enhances Wnt/β-catenin signaling in cultured lymphatic…”
Get full text

S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling by Geng, Xin, Yanagida, Keisuke, Akwii, Racheal G, Choi, Dongwon, Chen, Lijuan, Ho, YenChun, Cha, Boksik, Mahamud, Md Riaj, Berman de Ruiz, Karen, Ichise, Hirotake, Chen, Hong, Wythe, Joshua D, Mikelis, Constantinos M, Hla, Timothy, Srinivasan, R Sathish

“…During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells (LECs) at the growing front sprout by forming filopodia. Those tip…”
Get full text