Search Results - "SASYNIUK, B. I"

A quantitative description of the E-4031-sensitive repolarization current in rabbit ventricular myocytes by Clay, J.R., Ogbaghebriel, A., Paquette, T., Sasyniuk, B.I., Shrier, A.

“…We have measured the E-4031-sensitive repolarization current (IKr) in single ventricular myocytes isolated from rabbit hearts. The primary goal of this…”
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Mechanism of reversal of toxic effects of amitriptyline on cardiac Purkinje fibers by sodium bicarbonate by Sasyniuk, B I, Jhamandas, V

“…Alkalinization with NaHCO3 can effectively reverse ventricular arrhythmias caused by amitriptyline intoxication, but the mechanism is unclear. To test whether…”
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Polymorphic ventricular tachycardias induced by D-sotalol and phenylephrine in canine preparations of atrioventricular block : initiation in the conduction system followed by spatially unstable re-entry by DERAKHCHAN, K, CARDINAL, R, BRUNET, S, KLUG, D, PHARAND, C, KUS, T, SASYNIUK, B. I

“…Polymorphic ventricular tachycardias (PVT) occur spontaneously in canine hearts under the combination of D-sotalol (S), bradycardia and phenylephrine (PE). We…”
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Modification of the frequency- and voltage-dependent effects of quinidine when administered in combination with tocainide in canine Purkinje fibers by VALOIS, M, SASYNIUK, B. I

“…Frequency- and voltage-dependent modification of drug-induced inhibition of maximal upstroke velocity of the action potential (Vmax) by the combined…”
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Frequency and voltage-dependent effects of mono-N-dealkyldisopyramide, the major metabolite of disopyramide, in canine ventricular tissue by Toy, W, Sasyniuk, B I

“…Mono-N-dealkyldisopyramide (MND), the major metabolite of disopyramide, reaches significant concentrations in patients; however, the contribution of MND to the…”
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Recent advances in understanding the mechanisms of drug-induced torsades de pointes arrhythmias by Sasyniuk, Betty I., Valois, Maria, Toy, William

“…QTU prolongation and polymorphic ventricular rachycardia “torsades de pointes” have occurred in association with electrolyte abnormalities and during therapy…”
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Halothane-epinephrine-induced cardiac arrhythmias and the role of heart rate by Zink, J, Sasyniuk, B I, Dresel, P E

“…The authors previously showed that cyclopropane-epinephrine-induced bigeminal arrhythmias can best be explained by a re-entrant mechanism. They have now…”
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Electrophysiological Actions of Disopyramide Phosphate on Canine Ventricular Muscle and Purkinje Fibers by Kus, Teresa, Sasyniuk, Betty I

“…Disopyramide phosphate is a new antiarrhythmic drug that has been shown to possess significant antiarrhythmic effects in animals and man. In the present…”
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Effects of disopyramide phosphate on ventricular arrhythmias in experimental myocardial infarction by Kus, T, Sasyniuk, B I

“…A myocardial infarction model in which infarction is the result of an occluding thrombus was used to evaluate the effectiveness of disopyramide phosphate (DP)…”
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Frequency- and voltage-dependent effects of disopyramide in canine Purkinje fibers by Flemming, M A, Sasyniuk, B I

“…The voltage- and frequency-dependent blocking actions of disopyramide were assessed in canine Purkinje fibers within the framework of concentrations, membrane…”
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Furosemide and vitamin E. Two problem drugs in neonatology by Aranda, J V, Chemtob, S, Laudignon, N, Sasyniuk, B I

“…This article focuses on some of the problems encountered with two of the drugs currently given to newborns…”
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Pharmacologic considerations in the therapy of neonatal apnea by Aranda, J V, Grondin, D, Sasyniuk, B I

“…Theophylline and caffeine are both effective stimulants of the central nervous system for the therapy of neonatal apnea. Both drugs are slowly eliminated from…”
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Antiarrhythmic drugs: electrophysiological and pharmacokinetic considerations by Sasyniuk, B I, Ogilvie, R I

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The electrophysiological effects of disopyramide phosphate on canine ventricular muscle and Purkinje fibers in normal and low potassium by Kus, T, Sasyniuk, B I

“…We studied the effect of lowering the extracellular potassium concentration ([K+]o) on the electrophysiological actions of disopyramide phosphate, a new…”
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Disopyramide phosphate: is it just another quinidine by Kus, T, Sasyniuk, B I

“…We compared the effects of a therapeutic concentration of disopyramide with those of quinidine and lidocaine on the action potential characteristics and on the…”
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Symposium on the management of ventricular dysrhythmias. Concept of reentry versus automaticity by Sasyniuk, B I

“…Arrhythmias can result from abnormal impulse initiation or conduction. Abnormal initiation results from either automaticity or triggered activity. Enhanced…”
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Electrophysiological effects of bretylium tosylate on subendocardial Purkinje fibers from infarcted canine hearts by Cardinal, R, Sasyniuk, B I

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The effect of diphenylhydantoin on conduction in isolated, blood-perfused dog hearts by Sasyniuk, B I, Dresel, P E

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Mechanism and site of origin of bigeminal rhythms in cyclopropane-sensitized dogs by Sasyniuk, B I, Dresel, P E

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Experimental amitriptyline intoxication: treatment of cardiac toxicity with sodium bicarbonate by Sasyniuk, B I, Jhamandas, V, Valois, M

“…Overdose with amitriptyline and other tricyclic antidepressants can result in ventricular conduction abnormalities as well as severe ventricular arrhythmias…”
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