Search Results - "SASSA, Takeshi"

Cyclization mechanism of phomopsene synthase: mass spectrometry based analysis of various site-specifically labeled terpenes by Shinde, Sandip S, Minami, Atsushi, Chen, Zhi, Tokiwano, Tetsuo, Toyomasu, Tomonobu, Kato, Nobuo, Sassa, Takeshi, Oikawa, Hideaki

“…Elucidation of the cyclization mechanism catalyzed by terpene synthases is important for the rational engineering of terpene cyclases. We developed a…”
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Stabilization of Physical RAF/14-3‑3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers by Molzan, Manuela, Kasper, Stefan, Röglin, Lars, Skwarczynska, Malgorzata, Sassa, Takeshi, Inoue, Takatsugu, Breitenbuecher, Frank, Ohkanda, Junko, Kato, Nobuo, Schuler, Martin, Ottmann, Christian

“…One-third of all human cancers harbor somatic RAS mutations. This leads to aberrant activation of downstream signaling pathways involving the RAF kinases…”
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Identification of a Biosynthetic Gene Cluster in Rice for Momilactones by Shimura, Kazuhiro, Okada, Atsushi, Okada, Kazunori, Jikumaru, Yusuke, Ko, Kwang-Wook, Toyomasu, Tomonobu, Sassa, Takeshi, Hasegawa, Morifumi, Kodama, Osamu, Shibuya, Naoto, Koga, Jinichiro, Nojiri, Hideaki, Yamane, Hisakazu

“…Rice diterpenoid phytoalexins such as momilactones and phytocassanes are produced in suspension-cultured rice cells treated with a chitin oligosaccharide…”
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Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi by Toyomasu, Tomonobu, Tsukahara, Mai, Kaneko, Akane, Niida, Rie, Mitsuhashi, Wataru, Dairi, Tohru, Kato, Nobuo, Sassa, Takeshi

“…Fusicoccins are a class of diterpene glucosides produced by the plant-pathogenic fungus Phomopsis amygdali. As modulators of 14-3-3 proteins, fusicoccins…”
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A Structural Rationale for Selective Stabilization of Anti-tumor Interactions of 14-3-3 proteins by Cotylenin A by Ottmann, Christian, Weyand, Michael, Sassa, Takeshi, Inoue, Takatsugu, Kato, Nobuo, Wittinghofer, Alfred, Oecking, Claudia

“…Cotylenin A, a fungal metabolite originally described as a cytokinin-like bioactive substance against plants shows differentiation-inducing and anti-tumor…”
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Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis by Otomo, K, Kenmoku, H, Oikawa, H, Konig, W.A, Toshima, H, Mitsuhashi, W, Yamane, H, Sassa, T, Toyomasu, T

“…Rice (Oryza sativa L.) produces ent-copalyl diphosphate (ent-CDP) and syn-CDP as precursors for several classes of phytoalexins and the phytohormones,…”
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Biosynthetic Gene-Based Secondary Metabolite Screening: A New Diterpene, Methyl Phomopsenonate, from the Fungus Phomopsis amygdali by Toyomasu, Tomonobu, Kaneko, Akane, Tokiwano, Tetsuo, Kanno, Yuya, Kanno, Yuri, Niida, Rie, Miura, Shigeyoshi, Nishioka, Taiki, Ikeda, Chiho, Mitsuhashi, Wataru, Dairi, Tohru, Kawano, Tomikazu, Oikawa, Hideaki, Kato, Nobuo, Sassa, Takeshi

“…The presence of the geranylgeranyl diphosphate synthase (GGS) gene is a common feature of gene clusters for diterpene biosynthesis. We demonstrated…”
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Molecular breeding of a fungus producing a precursor diterpene suitable for semi-synthesis by dissection of the biosynthetic machinery by Noike, Motoyoshi, Ono, Yusuke, Araki, Yuji, Tanio, Ryo, Higuchi, Yusuke, Nitta, Hajime, Hamano, Yoshimitsu, Toyomasu, Tomonobu, Sassa, Takeshi, Kato, Nobuo, Dairi, Tohru

“…Many clinically useful pharmaceuticals are semi-synthesized from natural products produced by actinobacteria and fungi. The synthetic protocols usually contain…”
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A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts by Kawakami, Koshi, Hattori, Miho, Inoue, Takatsugu, Maruyama, Yuriko, Ohkanda, Junko, Kato, Nobuo, Tongu, Miki, Yamada, Takaya, Akimoto, Miho, Takenaga, Keizo, Sassa, Takeshi, Suzumiy, Junji, Honma, Yoshio

“…Malignant cells in solid tumors survive under prolonged hypoxia and can be a source of resistance to current cancer therapies. Tumor hypoxia is also associated…”
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An Enzyme Catalyzing O-Prenylation of the Glucose Moiety of Fusicoccin A, a Diterpene Glucoside Produced by the Fungus Phomopsis amygdali by Noike, Motoyoshi, Liu, Chengwei, Ono, Yusuke, Hamano, Yoshimitsu, Toyomasu, Tomonobu, Sassa, Takeshi, Kato, Nobuo, Dairi, Tohru

“…Isoprenoids form the largest family of compounds found in nature. Isoprenoids are often attached to other moieties such as aromatic compounds,…”
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Transannular Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to Fusicoccadiene, a Biosynthetic Intermediate of Fusicoccins by Toyomasu, Tomonobu, Tsukahara, Mai, Kenmoku, Hiromichi, Anada, Masahide, Nitta, Hajime, Ohkanda, Junko, Mitsuhashi, Wataru, Sassa, Takeshi, Kato, Nobuo

“…Enzymatic cyclization of geranylgeranyl diphosphate to fusicoccadiene involves a transannular proton transfer process. Label distribution in the cyclized…”
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Identification and functional analysis of brassicicene C biosynthetic gene cluster in Alternaria brassicicola by Minami, Atsushi, Tajima, Naoto, Higuchi, Yusuke, Toyomasu, Tomonobu, Sassa, Takeshi, Kato, Nobuo, Dairi, Tohru

“…The biosynthetic gene cluster of brassicicene C was identified in Alternaria brassicicola strain ATCC 96836 from genome database search. The biosynthetic gene…”
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Diterpene phytoalexins are biosynthesized in and exuded from the roots of rice [Oryza sativa] seedlings by Toyomasu, T.(Yamagata Univ. (Japan)), Kagahara, T, Okada, K, Koga, J, Hasegawa, M, Mitsuhashi, W, Sassa, T, Yamane, H

“…Rice (Oryza sativa L.) produces a variety of diterpene phytoalexins, such as momilactones, phytocassanes, and oryzalexins. Momilactone B was previously…”
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Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene, and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates by Nakano, Chiaki, Hoshino, Tsutomu, Sato, Tsutomu, Toyomasu, Tomonobu, Dairi, Tohru, Sassa, Takeshi

“…The enzymatic reaction of copalyl diphosphate (CDP), ent-CDP, syn-CDP, and tuberculosinyl diphosphate with the CYC2 enzyme from Kitasatospora griseola afforded…”
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Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET by Okubo, Yoshiro, Suhara, Tetsuya, Suzuki, Kazutoshi, Kobayashi, Kaoru, Inoue, Osamu, Terasaki, Omi, Someya, Yasuhiro, Sassa, Takeshi, Sudo, Yasuhiko, Matsushima, Eisuke, Iyo, Masaomi, Tateno, Yukio, Toru, Michio

“…Schizophrenia is believed to involve altered activation of dopamine receptors, and support for this hypothesis comes from the antipsychotic effect of…”
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Enhanced activation in the extrastriate body area by goal‐directed actions by Takahashi, Hidehiko, Shibuya, Tomohisa, Kato, Motoichiro, Sassa, Takeshi, Koeda, Michihiko, Yahata, Noriaki, Suhara, Tetsuya, Okubo, Yoshiro

“…Aim:  Neuroimaging studies on biological motion have established the view that the posterior superior temporal sulcus (pSTS) is involved in detecting intention…”
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Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones A, B, and oryzalexins A-F in rice by Otomo, K. (Yamagata Univ. (Japan)), Kanno, Y, Motegi, A, Kenmoku, H, Yamane, H, Mitsuhashi, W, Oikawa, H, Toshima, H, Itoh, H, Matsuoka, M, Sassa, T, Toyomasu, T

“…Riee(oryza sativa L.)produces diterpene phytoalex-ins,such as momilactones,oryzalexins,and phytocas-sanes.Using rice genome information and in vitro assay with…”
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Identification of Diterpene Biosynthetic Gene Clusters and Functional Analysis of Labdane-Related Diterpene Cyclases in Phomopsis amygdali by TOYOMASU, Tomonobu, NIIDA, Rie, KENMOKU, Hiromichi, KANNO, Yuri, MIURA, Shigeyoshi, NAKANO, Chiaki, SHIONO, Yoshihito, MITSUHASHI, Wataru, TOSHIMA, Hiroaki, OIKAWA, Hideaki, HOSHINO, Tsutomu, DAIRI, Tohru, KATO, Nobuo, SASSA, Takeshi

“…Two diterpene biosynthesis gene clusters in the fusicoccin-producing fungus, Phomopsis amygdali, were identified by genome walking from PaGGS1 and PaGGS4 which…”
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Characterization of a rice [Oryza sativa] gene family encoding type-A diterpene cyclases by Kanno, Y.(Yamagata Univ. (Japan)), Otomo, K, Kenmoku, H, Mitsuhashi, W, Yamane, H, Oikawa, H, Toshima, H, Matsuoka, M, Sassa, T, Toyomasu, T

“…We have previously isolated and characterized the rice (Oryza sativa) cDNAs, OsCyc1/OsCPS4, OsCyc2/ OsCPS2, OsKS4, OsDTC1/OsKS7, OsDTC2/OsKS8 and OsKS10, which…”
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Quantitative magnetic resonance spectroscopy of schizophrenia: Relationship between decreased N‐acetylaspartate and frontal lobe dysfunction by TANAKA, YOKO, OBATA, TAKAYUKI, SASSA, TAKESHI, YOSHITOME, EIJI, ASAI, YOSHIYUKI, IKEHIRA, HIROO, SUHARA, TETSUYA, OKUBO, YOSHIRO, NISHIKAWA, TORU

“…Numerous studies using proton magnetic resonance spectroscopy (1H‐MRS) have detected signal changes in schizophrenia. However, most studies investigated…”
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