Search Results - "SASAKI, Nobuya"

Tensin 2-deficient nephropathy: mechanosensitive nephropathy, genetic susceptibility by Sasaki, Hayato, Sasaki, Nobuya

“…Tensin 2 (TNS2), a focal adhesion protein, is considered to anchor focal adhesion proteins to β integrin as an integrin adaptor protein and/or serve as a…”
Get full text

Validation of the anesthetic effect of a mixture of remimazolam, medetomidine, and butorphanol in three mouse strains by Watanabe, Masaki, Nikaido, Yuko, Sasaki, Nobuya

“…Proper administration of anesthesia is indispensable for the ethical treatment of lab animals in biomedical research. Therefore, selecting an effective…”
Get full text

The grimace scale: a useful tool for assessing pain in laboratory animals by Onuma, Kenta, Watanabe, Masaki, Sasaki, Nobuya

“…Accurately and promptly assessing pain in experimental animals is extremely important to avoid unnecessary suffering of the animals and to enhance the…”
Get full text

Involvement of Bmal1 and Clock in Bromobenzene Metabolite-Induced Diurnal Renal Toxicity by Yoshioka, Hiroki, Yokota, Satoshi, Tominaga, Sarah, Tsukiboshi, Yosuke, Suzui, Masumi, Shinohara, Yasuro, Yoshikawa, Masae, Sasaki, Hayato, Sasaki, Nobuya, Maeda, Tohru, Miura, Nobuhiko

“…Circadian rhythms are endogenous oscillators that regulate 24 h behavioral and physiological processes. Our previous investigation demonstrated that…”
Get full text

Mitotic Spindle Positioning (MISP) Facilitates Colorectal Cancer Progression by Forming a Complex with Opa Interacting Protein 5 (OIP5) and Activating the JAK2-STAT3 Signaling Pathway by Hiura, Koki, Watanabe, Masaki, Hirose, Naoki, Nakano, Kenta, Okamura, Tadashi, Sasaki, Hayato, Sasaki, Nobuya

“…Patients with inflammatory bowel disease (IBD) who experience long-term chronic inflammation of the colon are at an increased risk of developing colorectal…”
Get full text

A single amino acid substitution in PRKDC is a determinant of sensitivity to Adriamycin-induced renal injury in mouse by Watanabe, Masaki, Takahashi, Yuki, Hiura, Koki, Nakano, Kenta, Okamura, Tadashi, Sasaki, Hayato, Sasaki, Nobuya

“…Adriamycin (ADR)-induced nephropathy is frequently utilized in rodent models of podocytopathy. However, the application of this model in mice is limited to a…”
Get full text

Genetic background strongly influences the transition to chronic kidney disease of adriamycin nephropathy in mice by Watanabe, Masaki, Hiura, Koki, Sasaki, Hayato, Okamura, Tadashi, Sasaki, Nobuya

“…Animal models of podocytopathy and chronic kidney diseases (CKD) help elucidate these pathologies. Adriamycin (ADR)-induced nephropathy is a common rodent…”
Get full text

Mitotic spindle positioning protein (MISP) deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis in mice by HIURA, Koki, MARUYAMA, Takumi, WATANABE, Masaki, NAKANO, Kenta, OKAMURA, Tadashi, SASAKI, Hayato, SASAKI, Nobuya

“…Inflammatory bowel disease (IBD) is classified into two types: Crohn’s disease and ulcerative colitis. In IBD, the imbalance between the pro-inflammatory and…”
Get full text

Molecular and Pathological Analyses of IARS1-Deficient Mice: An IARS Disorder Model by Watanabe, Masaki, Shishido, Koya, Kanehira, Nao, Hiura, Koki, Nakano, Kenta, Okamura, Tadashi, Ando, Ryo, Sasaki, Hayato, Sasaki, Nobuya

“…Most mitochondrial diseases are hereditary and highly heterogeneous. Cattle born with the V79L mutation in the isoleucyl-tRNA synthetase 1 (IARS1) protein…”
Get full text

Positive correlation between renal tubular flattening and renal tubular injury/interstitial fibrosis in murine kidney disease models by TAKAHASHI, Yuki, WATANABE, Masaki, HIURA, Koki, ISOBE, Ai, SASAKI, Hayato, SASAKI, Nobuya

“…The number of patients with chronic kidney disease (CKD) is growing continuously globally. In order to study pathogenesis and mechanisms, many animal models…”
Get full text

Susceptibility to adriamycin-induced hepatotoxicity in mice depends on PRKDC polymorphism by WATANABE, Masaki, KAKUTANI, Momoka, ANDO, Ryo, HIURA, Koki, SASAKI, Hayato, OKAMURA, Tadashi, SASAKI, Nobuya

“…Adriamycin (ADR) is an effective chemotherapy drug for various cancers but has serious side effects. ADR-induced liver damage is a common problem during…”
Get full text

Differences in susceptibility to ADR nephropathy among C57BL/6 substrains by Watanabe, Masaki, Kakutani, Momoka, Hiura, Koki, Sasaki, Hayato, Sasaki, Nobuya

“…Adriamycin (ADR) nephropathy is the most widely used nephropathy model to study the pathophysiological mechanisms of chronic kidney disease (CKD) in mice…”
Get full text

PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade by Ganbaatar, Otgontuya, Konnai, Satoru, Okagawa, Tomohiro, Nojima, Yutaro, Maekawa, Naoya, Minato, Erina, Kobayashi, Atsushi, Ando, Ryo, Sasaki, Nobuya, Miyakoshi, Daisuke, Ichii, Osamu, Kato, Yukinari, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko

“…Programmed death-1 (PD-1) is an immunoinhibitory receptor expressed on lymphocytes. Interaction of PD-1 with its ligand PD-ligand 1 (PD-L1) delivers inhibitory…”
Get full text

Automated scoring of glomerular injury in TNS2-deficient nephropathy by Shimada, Shuji, Tanimoto, Kyosuke, Sasaki, Hayato, Taga, Takumi, Sasaki, Takeru, Imagawa, Tomomi, Sasaki, Nobuya

“…Several artificial intelligence (AI) systems have been developed for glomerular pathology analysis in clinical settings. However, the application of AI systems…”
Get full text

Genetic locus responsible for diabetic phenotype in the insulin hyposecretion (ihs) mouse by Nakano, Kenta, Yanobu-Takanashi, Rieko, Shimizu, Yukiko, Takahashi, Yuki, Hiura, Koki, Watanabe, Masaki, Sasaki, Hayato, Okamura, Tadashi, Sasaki, Nobuya

“…Diabetic animal models have made significant contributions to understanding the etiology of diabetes and to the development of new medications. Our research…”
Get full text

Assessment of thiamylal sodium as a euthanasia drug in mice by WATANABE, Masaki, HASHIMOTO, Kazuki, ISHII, Yuki, TAKIMOTO, Hayato R, NIKAIDO, Yuko, SASAKI, Nobuya

“…Euthanasia agents should rapidly induce death and loss of consciousness without causing pain or distress. Various methods exist for the euthanasia of…”
Get full text

Establishment of renal proximal tubule cell lines derived from the kidney of p53 knockout mice by Sasaki, Hayato, Sugiyama, Makoto, Sasaki, Nobuya

“…The human cell line HK-2 is most commonly used as a model of renal proximal tubular epithelial cells (PTECs) for various studies despite the absence or low…”
Get full text

Deletion of the Tensin2 SH2-PTB domain, but not the loss of its PTPase activity, induces podocyte injury in FVB/N mouse strain by Sasaki, Hayato, Takahashi, Yuki, Ogawa, Tsubasa, Hiura, Koki, Nakano, Kenta, Sugiyama, Makoto, Okamura, Tadashi, Sasaki, Nobuya

“…Tensin2 (TNS2) is a focal adhesion-localized protein possessing N-terminal tandem protein tyrosine phosphatase (PTPase) and C2 domains, and C-terminal tandem…”
Get full text

Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing by MARUSUGI, Kiyoma, NAKANO, Kenta, SASAKI, Hayato, KIMURA, Junpei, YANOBU-TAKANASHI, Rieko, OKAMURA, Tadashi, SASAKI, Nobuya

“…Podocytes are terminally differentiated and highly specialized cells in the glomerulus, and they form a crucial component of the glomerular filtration barrier…”
Get full text

Does the routine handling affect the phenotype of disease model mice? by Ono, Maiko, Sasaki, Hayato, Nagasaki, Kenichi, Torigoe, Daisuke, Ichii, Osamu, Sasaki, Nobuya, Agui, Takashi

“…[Abstract] The three different mouse handling methods, picking up by tails, tunnels, and open hands were performed using the ICGN glomerulonephritis mouse and…”
Get full text