Search Results - "SASAHARA, Kunihiro"

Stereoselective pharmacokinetics of RS-8359, a selective and reversible MAO-A inhibitor, by species-dependent drug-metabolizing enzymes by Takasaki, Wataru, Yamamura, Mayumi, Nozaki, Akiko, Nitanai, Takashi, Sasahara, Kunihiro, Itoh, Kunio, Tanaka, Yorihisa

“…RS‐8359, (±)‐4‐(4‐cyanoanilino)‐5,6‐dihydro‐7‐hydroxy‐7H‐cyclopenta[d]pyrimidine selectively and reversibly inhibits monoamine oxidase A (MAO‐A). After oral…”
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Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR) by Ishizuka, H, Konno, K, Naganuma, H, Sasahara, K, Kawahara, Y, Niinuma, K, Suzuki, H, Sugiyama, Y

“…Temocapril x HCl (alpha-((2S,6R)-6-[(1S)-1-ethoxy-carbonyl-3-phenyl-propyl]amino-5-oxo-2- (2-thienyl)perhydro-1,4-thiazepin-4-yl)acetic acid hydrochloride) is…”
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Pharmacokinetics of troglitazone, an antidiabetic agent: prediction of in vivo stereoselective sulfation and glucuronidation from in vitro data by Izumi, T, Hosiyama, K, Enomoto, S, Sasahara, K, Sugiyama, Y

“…Sulfation and glucuronidation, the major routes of metabolism of troglitazone, an antidiabetic agent, were examined in vitro using hepatic cytosol and…”
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An automated method for the simultaneous determination of pravastatin and its main metabolite in human plasma by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry by Kawabata, Kiyoshi, Matsushima, Nobuko, Sasahara, Kunihiro

“…A new method for the determination of pravastatin, a potent inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, and its main metabolite…”
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Trandolaprilat, an Angiotensin-Converting Enzyme Inhibitor, Is Not Excreted in Bile via an ATP-Dependent Active Transporter (cMOAT) by SHIONOIRI, Hiroshi, TAKASAKI, Izumi, MINAMISAWA, Kohsuke, ISHIZUKA, Hitoshi, KONNO, Kumiko, NAGANUMA, Hideo, SASAHARA, Kunihiro, KAWAHARA, Yukinori

“…Trandolapril is the prodrug of an angiotensin-converting enzyme (ACE) inhibitor. It has been proposed that its active metabolite, trandolaprilat, is mainly…”
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Influence of modes of ACNU administration on tissue and blood drug concentration in malignant brain tumors by Hori, T, Muraoka, K, Saito, Y, Sasahara, K, Inagaki, H, Inoue, Y, Adachi, S, Anno, Y

“…The water-soluble nitrosourea compound ACNU is also lipid-soluble at normal physiological pH levels. It lacks toxic effects on vision that nitrosoureas…”
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Pain relief model for a COX‐2 inhibitor in patients with postoperative dental pain by Rohatagi, Shashank, Kastrissios, Helen, Sasahara, Kunihiro, Truitt, Kenneth, Moberly, James B., Wada, Russell, Salazar, Daniel E.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Modelling and simulation are being increasingly used to support decision‐making in new drug development. • Novel…”
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Studies on Orally Active Cephalosporin Esters. II. : Chemical Stability of Pivaloyloxymethyl Esters in Phosphate Buffer Solution by MIYAUCHI, Masao, SASAHARA, Kunihiro, FUJIMOTO, Koichi, KAWAMOTO, Isao, IDE, Junya, NAKAO, Hideo

“…The degradation kinetics of pivaloyloxymethyl (POM) esters of cephalosporins in phosphate buffer solution (pH6-8) were investigated. The degradation of the…”
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Improvement of Bioavailability of Poorly Intestinally Absorbed Drugs from Medium-Chain Glyceride Base. Enhancement of the Rectal Absorption of Cefmetazole Sodium in Rabbits by SEKINE, MINORU, SASAHARA, KUNIHIRO, KOJIMA, TOSHIMASA, HASEGAWA, KAZUE, OKADA, RYUZO

“…Medium-chain glyceride (MCG) enhanced the bioavailability of cefmetazole sodium, a watersoluble β-lactam antibiotic, after rectal administration to rabbits…”
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Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach by Izumi, T, Enomoto, S, Hosiyama, K, Sasahara, K, Shibukawa, A, Nakagawa, T, Sugiyama, Y

“…We have attempted to predict the human pharmacokinetics of troglitazone after oral administration based on animal data. Troglitazone is a new antidiabetic…”
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Sites of Action of CS-722, a Newly Synthesized Centrally Acting Muscle Relaxant by Tanabe, Mitsuo, Ishizuka, Hitoshi, Murayama, Takako, Kaneko, Tsugio, Tonohiro, Toshiyuki, Sakai, Jun-ichi, Nagano, Mitsuo, Sasahara, Kunihiro, Iwata, Nobuyoshi

“…Sites of the muscle relaxant action of CS-722 were investigated in rats. Doses injected intra-4th ventricularly (i.c.v.) or intrathecally (i.t.) were…”
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Sites of action of CS-722, a newly synthesized centrally acting muscle relaxant by Tanabe, Mitsuo, Ishizuka, Hitoshi, Murayama, Takako, Kaneko, Tsugio, Tonohiro, Toshiyuki, Sakai, Jun-ichi, Nagano, Mitsuo, Sasahara, Kunihiro, Iwata, Nobuyoshi

“…Sites of the muscle relaxant action of CS-722 were investigated in rats. Doses injected intra-4th ventricularly (i.c.v.) or intrathecally (i.t.) were…”
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Assessment of pharmacological effects and concentrations of RS-8359 on same rats by microdialysis by Kumagae, Yoshihiro, Muramoto, Keiko, Kaneko, Tsugio, Tonohiro, Toshiyuki, Matsui, Yoshiki, Ishizuka, Hitoshi, Sasahara, Kunihiro, Iwata, Nobuyoshi

“…RS-8359, which is under development as an anti-depressant, is a specific inhibitor of A-form monoamine oxidase (MAO-A). Dose-dependent increases in the…”
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HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINING THE CS-807 CONCENTRATION IN BODY FLUIDS by SEKINE, MINORU, SASAHARA, KUNIHIRO, ICHIKAWA, MASATO

“…The following results were obtained by high-performance liquid chromatography (HPLC) of R-3763, the active metabolite of CS-807, in human serum and urine. 1)…”
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Improvement of bioavailability of poorly absorbed drugs. IV. Mechanism of the promoting effect of medium chain glyceride on the rectal absorption of water soluble drugs by Sekine, M, Sasahara, K, Okada, R, Awazu, S

“…The mechanisms of the promoting effect of medium chain glyceride (MCG) containing glyceryl mono-, di- and tri-caprylate on rectal absorption of water soluble…”
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Improvement of bioavailability of poorly absorbed drugs. I. Effect of medium chain glyceride base on the rectal absorption of cefmetazole sodium in rats by Sekine, M, Sasahara, K, Kojima, T, Hasegawa, K, Okada, R, Awazu, S

“…The effect of medium chain glyceride on the rectal absorption of cefmetazole sodium is investigated using an in situ experiment in rats. Each glyceride…”
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Improvement of bioavailability of poorly absorbed drugs. V. Effect of surfactants on the promoting effect of medium chain glyceride for the rectal absorption of beta-lactam antibiotics in rats and dogs by Sekine, M, Sasahara, K, Hasegawa, K, Okada, R, Awazu, S

“…The promoting effects of medium chain glyceride (MCG) on the rectal absorption of beta-lactam antibiotics were compared among various experimental animals…”
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PHASE I CLINICAL STUDY OF CS-807, A NEW ORAL CEPHALOSPORIN by KOBAYASHI, SHINICHI, OGUCHI, KATSUJI, UCHIDA, EIJI, YASUHARA, HAJIME, SAKAMOTO, KOJI, SEKINE, MINORU, SASAHARA, KUNIHIRO

“…CS-807, a new cephalosporin for oral administration, is metabolized to an active metabolite (R-3763) by nonspecific esterase in the gut wall. R-3763 has been…”
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Studies on the Metabolism of Oxazolam. I. Distribution and Excretion Studies by SHINDO, HIDEYO, NAKAJIMA, EIICHI, YASUMURA, AKIRA, MURATA, HISASHI, HIRAOKA, TAKASHI, SASAHARA, KUNIHIRO

“…The distribution of orally and intravenously administered 14C-oxazolam was studied in mice by means of whole-body autoradiography and in rats by scintillation…”
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Improvement of bioavailability of poorly absorbed drugs. II. Effect of medium chain glyceride base on the intestinal absorption of cefmetazole sodium in rats and dogs by Sekine, M, Terashima, H, Sasahara, K, Nishimura, K, Okada, R, Awazu, S

“…The effect of medium chain glyceride (MCG) on the intestinal absorption of cefmetazole sodium (CMZ) was investigated in rats and dogs. In rats, MCG containing…”
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