Search Results - "SARUTA, Takao"

Features of and preventive measures against hypertension in the young by Kawabe, Hiroshi, Azegami, Tatsuhiko, Takeda, Ayano, Kanda, Takeshi, Saito, Ikuo, Saruta, Takao, Hirose, Hiroshi

“…The Japanese hypertension guidelines report that essential hypertension is detected in 1-3% of upper elementary and high school students during blood pressure…”
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Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure by Kumagai, Hiroo, Oshima, Naoki, Matsuura, Tomokazu, Iigaya, Kamon, Imai, Masaki, Onimaru, Hiroshi, Sakata, Katsufumi, Osaka, Motohisa, Onami, Toshiko, Takimoto, Chie, Kamayachi, Tadashi, Itoh, Hiroshi, Saruta, Takao

“…Accentuated sympathetic nerve activity (SNA) is a risk factor for cardiovascular events. In this review, we investigate our working hypothesis that potentiated…”
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Ca2+ Channel Subtypes and Pharmacology in the Kidney by Hayashi, Koichi, Wakino, Shu, Sugano, Naoki, Ozawa, Yuri, Homma, Koichiro, Saruta, Takao

“…A large body of evidence has accrued indicating that voltage-gated Ca channel subtypes, including L-, T-, N-, and P/Q-type, are present within renal vascular…”
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Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial by Umemoto, Seiji, Ogihara, Toshio, Matsuzaki, Masunori, Rakugi, Hiromi, Ohashi, Yasuo, Saruta, Takao

“…Visit-to-visit blood pressure (BP) variability is an important predictor of stroke. However, which antihypertensive drug combination is better at reducing…”
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Effects of Calcium-Channel Blocker Benidipine-Based Combination Therapy on Cardiac Events　― Subanalysis of the COPE Trial by Umemoto, Seiji, Ogihara, Toshio, Matsuzaki, Masunori, Rakugi, Hiromi, Shimada, Kazuyuki, Kawana, Masatoshi, Kario, Kazuomi, Ohashi, Yasuo, Saruta, Takao, for the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial Group

“…Background:The Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) trial was conducted to compare the effects of regimens combining the…”
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Effects of calcium channel blocker benidipine-based combination therapy on target blood pressure control and cardiovascular outcome: a sub-analysis of the COPE trial by Umemoto, Seiji, Ogihara, Toshio, Matsuzaki, Masunori, Rakugi, Hiromi, Ohashi, Yasuo, Saruta, Takao

“…We compared three benidipine-based regimens-that is, benidipine plus angiotensin receptor blocker (ARB), β-blocker (BB) or thiazide-and found that the…”
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De novo novel splice‐site mutation in FLT4/VEGFR3 is associated with Milroy disease by Shibata, Yuka, Okamoto, Toshio, Saruta, Takao, Matsuoka, Fumiya, Fujieda, Mikiya, Sano, Shigetoshi

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Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin by Ichihara, Atsuhiro, Hayashi, Matsuhiko, Kaneshiro, Yuki, Suzuki, Fumiaki, Nakagawa, Tsutomu, Tada, Yuko, Koura, Yukako, Nishiyama, Akira, Okada, Hirokazu, Uddin, M Nasir, Nabi, A H M Nurun, Ishida, Yuichi, Inagami, Tadashi, Saruta, Takao

“…We found that when a site-specific binding protein interacts with the "handle" region of the prorenin prosegment, the prorenin molecule undergoes a…”
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Combination therapy of hypertension in the elderly: a subgroup analysis of the Combination of OLMesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial by Ogihara, Toshio, Saruta, Takao, Rakugi, Hiromi, Saito, Ikuo, Shimamoto, Kazuaki, Matsuoka, Hiroaki, Teramukai, Satoshi, Higaki, Jitsuo, Ito, Sadayoshi, Shimada, Kazuyuki

“…Combination of OLMesartan and a calcium channel blocker or a diuretic in Japanese elderly hypertensive patients (COLM) trial demonstrated that olmesartan…”
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Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for nonproteolytic activation of prorenin by Ichihara, Atsuhiro, Hayashi, Matsuhiko, Kaneshiro, Yuki, Suzuki, Fumiaki, Nakagawa, Tsutomu, Tada, Yuko, Koura, Yukako, Nishiyama, Akira, Okada, Hirokazu, Uddin, M. Nasir, Nabi, A.H.M. Nurun, Ishida, Yuichi, Inagami, Tadashi, Saruta, Takao

“…We found that when a site-specific binding protein interacts with the “handle” region of the prorenin prosegment, the prorenin molecule undergoes a…”
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Impact of renal function on cardiovascular events in elderly hypertensive patients treated with efonidipine: Renal Subset Analysis of the Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS) by Hayashi, Koichi, Saruta, Takao, Goto, Yoshio, Ishii, Masao

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Combination therapy for hypertension in the elderly: a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial by Ogihara, Toshio, Matsuzaki, Masunori, Umemoto, Seiji, Rakugi, Hiromi, Matsuoka, Hiroaki, Shimada, Kazuyuki, Higaki, Jitsuo, Ito, Sadayoshi, Kamiya, Akira, Suzuki, Hiromichi, Ohashi, Yasuo, Shimamoto, Kazuaki, Saruta, Takao

“…The Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) trial demonstrated that the calcium-channel blocker benidipine-based…”
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Correlation between Serum Resistin Level and Adiposity in Obese Individuals by Azuma, Koichiro, Katsukawa, Fuminori, Oguchi, Shuji, Murata, Mitsuru, Yamazaki, Hajime, Shimada, Akira, Saruta, Takao

“…Objective: Resistin is associated with insulin resistance in mice and may play a similar role in humans. The aim of our study was to examine the relationship…”
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Adiponectin, an Adipocyte-Derived Protein, Predicts Future Insulin Resistance: Two-Year Follow-Up Study in Japanese Population by Yamamoto, Yukihiro, Hirose, Hiroshi, Saito, Ikuo, Nishikai, Kanako, Saruta, Takao

“…It has been reported that the serum adiponectin level was negatively correlated with body mass index (BMI), insulin resistance index, and triglycerides and was…”
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Aldosterone-Induced Organ Damage: Plasma Aldosterone Level and Inappropriate Salt Status by SATO, Atsuhisa, SARUTA, Takao

“…In recent years, it has been clarified that aldosterone can directly damage various organs, such as the heart, blood vessel, and kidneys, via non-epithelial…”
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Role of diabetes and obesity in outcomes of the candesartan antihypertensive survival evaluation in Japan (CASE-J) trial by Nakao, Kazuwa, Hirata, Masakazu, Oba, Koji, Yasuno, Shinji, Ueshima, Kenji, Fujimoto, Akira, Ogihara, Toshio, Saruta, Takao

“…The Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial assessed cardiovascular outcomes in high-risk hypertensive patients receiving…”
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Effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease: subanalysis of the CASE-J Study by Saruta, Takao, Hayashi, Koichi, Ogihara, Toshio, Nakao, Kazuwa, Fukui, Tsuguya, Fukiyama, Kohshiro

“…We examined the effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease (CKD) using the data from…”
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A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension: the REZALT study by Ogihara, Toshio, Saruta, Takao, Shimada, Kazuyuki, Kuramoto, Kizuku

“…A 12-week randomized, double-blind, four-arm parallel-group, comparative study was conducted in patients with essential hypertension to evaluate the…”
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Comparison of olmesartan combined with a calcium channel blocker or a diuretic in elderly hypertensive patients (COLM Study): safety and tolerability by Saruta, Takao, Ogihara, Toshio, Saito, Ikuo, Rakugi, Hiromi, Shimamoto, Kazuaki, Matsuoka, Hiroaki, Teramukai, Satoshi, Higaki, Jitsuo, Ito, Sadayoshi, Shimada, Kazuyuki

“…The cardiovascular effects of combined therapy with the angiotensin receptor blocker (olmesartan) and a dihydropyridine calcium channel blocker (CCB) or a…”
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Pioglitazone Lowers Systemic Asymmetric Dimethylarginine by Inducing Dimethylarginine Dimethylaminohydrolase in Rats by Wakino, Shu, Hayashi, Koichi, Tatematsu, Satoru, Hasegawa, Kazuhiro, Takamatsu, Ichiro, Kanda, Takeshi, Homma, Koichiro, Yoshioka, Kyoko, Sugano, Naoki, Saruta, Takao

“…Peroxisome proliferator activated receptor-gamma (PPARgamma) ligands increase nitric oxide (NO) production and reduce systemic blood pressure. Asymmetric…”
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