Search Results - "SARTOR, Maureen A"

annotatr: genomic regions in context by Cavalcante, Raymond G, Sartor, Maureen A

“…Analysis of next-generation sequencing data often results in a list of genomic regions. These may include differentially methylated CpGs/regions, transcription…”
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Machine learning approaches and databases for prediction of drug–target interaction: a survey paper by Bagherian, Maryam, Sabeti, Elyas, Wang, Kai, Sartor, Maureen A, Nikolovska-Coleska, Zaneta, Najarian, Kayvan

“…Abstract The task of predicting the interactions between drugs and targets plays a key role in the process of drug discovery. There is a need to develop novel…”
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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death by Han, Jaeseok, Back, Sung Hoon, Hur, Junguk, Lin, Yu-Hsuan, Gildersleeve, Robert, Shan, Jixiu, Yuan, Celvie L., Krokowski, Dawid, Wang, Shiyu, Hatzoglou, Maria, Kilberg, Michael S., Sartor, Maureen A., Kaufman, Randal J.

“…Protein misfolding in the endoplasmic reticulum (ER) leads to cell death through PERK-mediated phosphorylation of eIF2α, although the mechanism is not…”
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MethylSig: a whole genome DNA methylation analysis pipeline by Park, Yongseok, Figueroa, Maria E, Rozek, Laura S, Sartor, Maureen A

“…DNA methylation plays critical roles in gene regulation and cellular specification without altering DNA sequences. The wide application of reduced…”
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PePr: a peak-calling prioritization pipeline to identify consistent or differential peaks from replicated ChIP-Seq data by Zhang, Yanxiao, Lin, Yu-Hsuan, Johnson, Timothy D, Rozek, Laura S, Sartor, Maureen A

“…ChIP-Seq is the standard method to identify genome-wide DNA-binding sites for transcription factors (TFs) and histone modifications. There is a growing need to…”
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MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20 by REN, Xiao-Ping, JINGHAI WU, XIAOHONG WANG, SARTOR, Maureen A, JIANG QIAN, JONES, Keith, NICOLAOU, Persoulla, PRITCHARD, Tracy J, FAN, Guo-Chang

“…Recent studies have identified critical roles for microRNAs (miRNAs) in a variety of cellular processes, including regulation of cardiomyocyte death. However,…”
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Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data by Karnovsky, Alla, Weymouth, Terry, Hull, Tim, Tarcea, V. Glenn, Scardoni, Giovanni, Laudanna, Carlo, Sartor, Maureen A., Stringer, Kathleen A., Jagadish, H. V., Burant, Charles, Athey, Brian, Omenn, Gilbert S.

“…Motivation: Metabolomics is a rapidly evolving field that holds promise to provide insights into genotype-phenotype relationships in cancers, diabetes and…”
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A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation by Iwase, Shigeki, Brookes, Emily, Agarwal, Saurabh, Badeaux, Aimee I., Ito, Hikaru, Vallianatos, Christina N., Tomassy, Giulio Srubek, Kasza, Tomas, Lin, Grace, Thompson, Andrew, Gu, Lei, Kwan, Kenneth Y., Chen, Chinfei, Sartor, Maureen A., Egan, Brian, Xu, Jun, Shi, Yang

“…Mutations in a number of chromatin modifiers are associated with human neurological disorders. KDM5C, a histone H3 lysine 4 di- and tri-methyl…”
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LRpath: a logistic regression approach for identifying enriched biological groups in gene expression data by Sartor, Maureen A., Leikauf, George D., Medvedovic, Mario

“…Motivation: The elucidation of biological pathways enriched with differentially expressed genes has become an integral part of the analysis and interpretation…”
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Epigenetics: relevance and implications for public health by Rozek, Laura S, Dolinoy, Dana C, Sartor, Maureen A, Omenn, Gilbert S

“…Improved understanding of the multilayer regulation of the human genome has led to a greater appreciation of environmental, nutritional, and epigenetic risk…”
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Somatic expression of piRNA and associated machinery in the mouse identifies short, tissue-specific piRNA by Perera, Bambarendage P.U., Tsai, Zing Tsung-Yeh, Colwell, Mathia L., Jones, Tamara R., Goodrich, Jaclyn M., Wang, Kai, Sartor, Maureen A., Faulk, Christopher, Dolinoy, Dana C.

“…Piwi-interacting RNAs (piRNAs) are small non-coding RNAs that associate with PIWI proteins for transposon silencing via DNA methylation and are highly…”
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Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex by Bakulski, Kelly M, Dolinoy, Dana C, Sartor, Maureen A, Paulson, Henry L, Konen, John R, Lieberman, Andrew P, Albin, Roger L, Hu, Howard, Rozek, Laura S

“…Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset Alzheimer's disease (LOAD), but little has been done on a genome-wide…”
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Comprehensive enhancer-target gene assignments improve gene set level interpretation of genome-wide regulatory data by Qin, Tingting, Lee, Christopher, Li, Shiting, Cavalcante, Raymond G, Orchard, Peter, Yao, Heming, Zhang, Hanrui, Wang, Shuze, Patil, Snehal, Boyle, Alan P, Sartor, Maureen A

“…Revealing the gene targets of distal regulatory elements is challenging yet critical for interpreting regulome data. Experiment-derived enhancer-gene links are…”
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Heterogeneity of Human Breast Stem and Progenitor Cells as Revealed by Transcriptional Profiling by Colacino, Justin A., Azizi, Ebrahim, Brooks, Michael D., Harouaka, Ramdane, Fouladdel, Shamileh, McDermott, Sean P., Lee, Michael, Hill, David, Madden, Julie, Boerner, Julie, Cote, Michele L., Sartor, Maureen A., Rozek, Laura S., Wicha, Max S.

“…During development, the mammary gland undergoes extensive remodeling driven by stem cells. Breast cancers are also hierarchically organized and driven by…”
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Single-Cell Analysis of the Gene Expression Effects of Developmental Lead (Pb) Exposure on the Mouse Hippocampus by Bakulski, Kelly M, Dou, John F, Thompson, Robert C, Lee, Christopher, Middleton, Lauren Y, Perera, Bambarendage P U, Ferris, Sean P, Jones, Tamara R, Neier, Kari, Zhou, Xiang, Sartor, Maureen A, Hammoud, Saher S, Dolinoy, Dana C, Colacino, Justin A

“…Abstract Lead (Pb) exposure is ubiquitous with permanent neurodevelopmental effects. The hippocampus brain region is involved in learning and memory with…”
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Translational toxicoepigenetic Meta-Analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead exposure in mouse and human offspring by Petroff, Rebekah L., Dolinoy, Dana C., Wang, Kai, Montrose, Luke, Padmanabhan, Vasantha, Peterson, Karen E., Ruden, Douglas M., Sartor, Maureen A., Svoboda, Laurie K., Téllez-Rojo, Martha M., Goodrich, Jaclyn M.

“…[Display omitted] •Translational research is limited in environmental toxicology and epidemiology.•Perinatal DEHP and Pb exposure induces epigenetic (DNA…”
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Sex and tissue-specificity of piRNA regulation in adult mice following perinatal lead (Pb) exposure by Perera, Bambarendage P. U., Wang, Kai, Wang, Dongyue, Chen, Kathleen, Dewald, Alisa, Sriram, Swati, Goodrich, Jaclyn M., Svoboda, Laurie K., Sartor, Maureen A., Dolinoy, Dana C.

“…Lead (Pb) is a neurotoxicant with early life exposure linked to long-term health effects. Piwi-interacting RNAs (piRNAs) are small non-coding RNAs that…”
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Novel Epigenetic Biomarkers Mediating Bisphenol A Exposure and Metabolic Phenotypes in Female Mice by Anderson, Olivia S, Kim, Jung H, Peterson, Karen E, Sanchez, Brisa N, Sant, Karilyn E, Sartor, Maureen A, Weinhouse, Caren, Dolinoy, Dana C

“…There is compelling evidence that epigenetic modifications link developmental environmental insults to adult disease susceptibility. Animal studies have…”
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Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments by Sartor, Maureen A, Tomlinson, Craig R, Wesselkamper, Scott C, Sivaganesan, Siva, Leikauf, George D, Medvedovic, Mario

“…The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately…”
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Molecular Tumor Subtypes of HPV-Positive Head and Neck Cancers: Biological Characteristics and Implications for Clinical Outcomes by Qin, Tingting, Li, Shiting, Henry, Leanne E, Liu, Siyu, Sartor, Maureen A

“…Until recently, research on the molecular signatures of Human papillomavirus (HPV)-associated head and neck cancers mainly focused on their differences with…”
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