Search Results - "SARMA, J. Vidya"

Extracellular histones are essential effectors of C5aR‐ and C5L2‐mediated tissue damage and inflammation in acute lung injury by Bosmann, Markus, Grailer, Jamison J., Ruemmler, Robert, Russkamp, Norman F., Zetoune, Firas S., Sarma, J. Vidya, Standiford, Theodore J., Ward, Peter A.

“…We investigated how complement activation promotes tissue injury and organ dysfunction during acute inflammation. Three models of acute lung injury (ALI)…”
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Role of extracellular histones in the cardiomyopathy of sepsis by Kalbitz, Miriam, Grailer, Jamison J., Fattahi, Fatemeh, Jajou, Lawrence, Herron, Todd J., Campbell, Katherine F., Zetoune, Firas S., Bosmann, Markus, Sarma, J. Vidya, Huber‐Lang, Markus, Gebhard, Florian, Loaiza, Randall, Valdivia, Hector H., Jalife, José, Russell, Mark W., Ward, Peter A.

“…ABSTRACT The purpose of this study was to define the relationship in polymicrobial sepsis (in adult male C57BL/6 mice) between heart dysfunction and the…”
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Complement Activation and the Resulting Placental Vascular Insufficiency Drives Fetal Growth Restriction Associated with Placental Malaria by Conroy, Andrea L., Silver, Karlee L., Zhong, Kathleen, Rennie, Monique, Ward, Peter, Sarma, J. Vidya, Molyneux, Malcolm E., Sled, John, Fletcher, Joseph F., Rogerson, Stephen, Kain, Kevin C.

“…Placental malaria (PM) is a major cause of fetal growth restriction, yet the underlying mechanism is unclear. Complement C5a and C5a receptor levels are…”
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Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury by Sladojevic, Nikola, Stamatovic, Svetlana M, Keep, Richard F, Grailer, Jamison J, Sarma, J. Vidya, Ward, Peter A, Andjelkovic, Anuska V

“…Abstract Proinflammatory mediators trigger intensive postischemic inflammatory remodeling of the blood–brain barrier (BBB) including extensive brain…”
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Drusen Complement Components C3a and C5a Promote Choroidal Neovascularization by Nozaki, Miho, Raisler, Brian J., Sakurai, Eiji, Sarma, J. Vidya, Barnum, Scott R., Lambris, John D., Chen, Yali, Zhang, Kang, Ambati, Balamurali K., Baffi, Judit Z., Ambati, Jayakrishna

“…Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30-50 million people worldwide. The…”
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Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box? by Flierl, Michael A, Rittirsch, Daniel, Huber-Lang, Markus, Sarma, J Vidya, Ward, Peter A

“…It is well established that catecholamines (CAs), which regulate immune and inflammatory responses, derive from the adrenal medulla and from presynaptic…”
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Anti‐inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury by Bosmann, Markus, Grailer, Jamison J., Zhu, Ketong, Matthay, Michael A., Sarma, J. Vidya, Zetoune, Firas S., Ward, Peter A.

“…These studies were undertaken to extend emerging evidence that β2 adrenergic receptor (β2AR) agonists, in addition to their bronchorelaxing effects, may have…”
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Generation of C5a in the absence of C3: a new complement activation pathway by Ward, Peter A, Huber-Lang, Markus, Sarma, J Vidya, Zetoune, Firas S, Rittirsch, Daniel, Neff, Thomas A, McGuire, Stephanie R, Lambris, John D, Warner, Roscoe L, Flierl, Michael A, Hoesel, Laszlo M, Gebhard, Florian, Younger, John G, Drouin, Scott M, Wetsel, Rick A

“…Complement-mediated tissue injury in humans occurs upon deposition of immune complexes, such as in autoimmune diseases and acute respiratory distress syndrome…”
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Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response by Flierl, Michael A, Rittirsch, Daniel, Nadeau, Brian A, Sarma, J Vidya, Day, Danielle E, Lentsch, Alex B, Huber-Lang, Markus S, Ward, Peter A

“…Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both…”
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Evidence for anti‐inflammatory effects of C5a on the innate IL‐17A/IL‐23 axis by Bosmann, Markus, Sarma, J. Vidya, Atefi, Gelareh, Zetoune, Firas S., Ward, Peter A.

“…There is growing evidence that the complement activation product C5a positively or negatively regulates inflammatory functions. The studies presented here…”
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Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3 by Bosmann, Markus, Russkamp, Norman F, Strobl, Birgit, Roewe, Julian, Balouzian, Liza, Pache, Florence, Radsak, Markus P, van Rooijen, Nico, Zetoune, Firas S, Sarma, J Vidya, Núñez, Gabriel, Müller, Mathias, Murray, Peter J, Ward, Peter A

“…Severe sepsis and septic shock are leading causes of morbidity and mortality worldwide. Infection-associated inflammation promotes the development and…”
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Adverse functions of IL-17A in experimental sepsis by Flierl, Michael A, Rittirsch, Daniel, Gao, Hongwei, Hoesel, Laszlo M, Nadeau, Brian A, Day, Danielle E, Zetoune, Firas S, Sarma, J. Vidya, Huber-Lang, Markus S, Ferrara, James L.M, Ward, Peter A

“…IL-17A is a proinflammatory cytokine produced by a variety of cells. In the current study, we examined the role of IL-17A in sepsis induced in mice by cecal…”
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Acute Lung Injury Induced by Lipopolysaccharide Is Independent of Complement Activation by Rittirsch, Daniel, Flierl, Michael A, Day, Danielle E, Nadeau, Brian A, McGuire, Stephanie R, Hoesel, Laszlo M, Ipaktchi, Kyros, Zetoune, Firas S, Sarma, J. Vidya, Leng, Lin, Huber-Lang, Markus S, Neff, Thomas A, Bucala, Richard, Ward, Peter A

“…Although acute lung injury (ALI) is an important problem in humans, its pathogenesis is poorly understood. Airway instillation of bacterial LPS, a known…”
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The complement system by Sarma, J. Vidya, Ward, Peter A.

“…The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation…”
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Regulation of IL-17 Family Members by Adrenal Hormones During Experimental Sepsis in Mice by Bosmann, Markus, Meta, Fabien, Ruemmler, Robert, Haggadone, Mikel D, Sarma, J. Vidya, Zetoune, Firas S, Ward, Peter A

“…Severe sepsis is a life-threatening disease that causes major morbidity and mortality. Catecholamines and glucocorticoids often have been used for the…”
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C5 deficiency and C5a or C5aR blockade protects against cerebral malaria by Patel, Samir N, Berghout, Joanne, Lovegrove, Fiona E, Ayi, Kodjo, Conroy, Andrea, Serghides, Lena, Min-oo, Gundula, Gowda, D Channe, Sarma, J Vidya, Rittirsch, Daniel, Ward, Peter A, Liles, W Conrad, Gros, Philippe, Kain, Kevin C

“…Experimental infection of mice with Plasmodium berghei ANKA (PbA) provides a powerful model to define genetic determinants that regulate the development of…”
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Protective Effects of IL-6 Blockade in Sepsis Are Linked to Reduced C5a Receptor Expression by Riedemann, Niels C, Neff, Thomas A, Guo, Ren-Feng, Bernacki, Kurt D, Laudes, Ines J, Sarma, J. Vidya, Lambris, John D, Ward, Peter A

“…IL-6 is known to be an important pro- and anti-inflammatory cytokine, which is up-regulated during sepsis. Our previous work has suggested a role for IL-6 in…”
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Regulatory Effects of iNOS on Acute Lung Inflammatory Responses in Mice by Speyer, Cecilia L., Neff, Thomas A., Warner, Roscoe L., Guo, Ren-Feng, Sarma, J. Vidya, Riedemann, Niels C., Murphy, Megan E., Murphy, Hedwig S., Ward, Peter A.

“…The role of endogenous NO in the regulation of acute lung injury is not well defined. We investigated the effects of inducible nitric oxide synthase (iNOS) and…”
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Functions of the complement components C3 and C5 during sepsis by Flierl, Michael A, Rittirsch, Daniel, Nadeau, Brian A, Day, Danielle E, Zetoune, Firas S, Sarma, J. Vidya, Huber-Lang, Markus S, Ward, Peter A

“…Activation of the complement system is a key event in the pathogenesis of sepsis. Nevertheless, the exact mechanisms remain inadequately understood. In the…”
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Regulatory effects of estrogen on acute lung inflammation in mice by Speyer, Cecilia L, Rancilio, Nicholas J, McClintock, Shannon D, Crawford, Jeffrey D, Gao, Hongwei, Sarma, J Vidya, Ward, Peter A

“…The role of estrogen in the regulation of the inflammatory response is not well defined. In this study, we investigated the effects of ovarian hormones on the…”
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