Search Results - "SARKAR, Partha S"

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes by Chakraborty, Anirban, Tapryal, Nisha, Venkova, Tatiana, Horikoshi, Nobuo, Pandita, Raj K., Sarker, Altaf H., Sarkar, Partha S., Pandita, Tej K., Hazra, Tapas K.

“…DNA double-strand breaks (DSBs) leading to loss of nucleotides in the transcribed region can be lethal. Classical non-homologous end-joining (C-NHEJ) is the…”
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Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation by YANHUA ZHAO, BANERJEE, Srijita, DEY, Nilay, LEJEUNE, Wanda S, SARKAR, Partha S, BROBEY, Reynolds, ROSENBLATT, Kevin P, TILTON, Ronald G, CHOUDHARY, Sanjeev

“…Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative…”
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Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription by Gao, Rui, Chakraborty, Anirban, Geater, Charlene, Pradhan, Subrata, Gordon, Kara L, Snowden, Jeffrey, Yuan, Subo, Dickey, Audrey S, Choudhary, Sanjeev, Ashizawa, Tetsuo, Ellerby, Lisa M, La Spada, Albert R, Thompson, Leslie M, Hazra, Tapas K, Sarkar, Partha S

“…How huntingtin (HTT) triggers neurotoxicity in Huntington's disease (HD) remains unclear. We report that HTT forms a transcription-coupled DNA repair (TCR)…”
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The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis by Chatterjee, Arpita, Saha, Saikat, Chakraborty, Anirban, Silva-Fernandes, Anabela, Mandal, Santi M, Neves-Carvalho, Andreia, Liu, Yongping, Pandita, Raj K, Hegde, Muralidhar L, Hegde, Pavana M, Boldogh, Istvan, Ashizawa, Tetsuo, Koeppen, Arnulf H, Pandita, Tej K, Maciel, Patricia, Sarkar, Partha S, Hazra, Tapas K

“…DNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation, oxidative stress, various chemotherapeutic agents, and also as base…”
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Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3 by Gao, Rui, Liu, Yongping, Silva-Fernandes, Anabela, Fang, Xiang, Paulucci-Holthauzen, Adriana, Chatterjee, Arpita, Zhang, Hang L, Matsuura, Tohru, Choudhary, Sanjeev, Ashizawa, Tetsuo, Koeppen, Arnulf H, Maciel, Patricia, Hazra, Tapas K, Sarkar, Partha S

“…Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an untreatable autosomal dominant neurodegenerative disease, and the most…”
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Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10 by Yang, Wang-Yong, Gao, Rui, Southern, Mark, Sarkar, Partha S., Disney, Matthew D.

“…RNA is an important target for chemical probes of function and lead therapeutics; however, it is difficult to target with small molecules. One approach to…”
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Editorial: Neurodegeneration: From Disease Mechanism to Therapeutic Advancement by Sarkar, Partha S., Meola, Giovanni, Zhang, Nan

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Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation by Chakraborty, Anirban, Wakamiya, Maki, Venkova-Canova, Tatiana, Pandita, Raj K., Aguilera-Aguirre, Leopoldo, Sarker, Altaf H., Singh, Dharmendra Kumar, Hosoki, Koa, Wood, Thomas G., Sharma, Gulshan, Cardenas, Victor, Sarkar, Partha S., Sur, Sanjiv, Pandita, Tej K., Boldogh, Istvan, Hazra, Tapas K.

“…Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges for repairing oxidatively damaged bases via the base excision…”
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Polyglutamine Expansion in Huntingtin and Mechanism of DNA Damage Repair Defects in Huntington's Disease by Pradhan, Subrata, Gao, Rui, Bush, Keegan, Zhang, Nan, Wairkar, Yogesh P, Sarkar, Partha S

“…Emerging evidence suggests that DNA repair deficiency and genome instability may be the impending signs of many neurological diseases. Genome-wide association…”
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Preferential Repair of Oxidized Base Damage in the Transcribed Genes of Mammalian Cells by Banerjee, Dibyendu, Mandal, Santi M., Das, Aditi, Hegde, Muralidhar L., Das, Soumita, Bhakat, Kishor K., Boldogh, Istvan, Sarkar, Partha S., Mitra, Sankar, Hazra, Tapas K.

“…Preferential repair of bulky DNA adducts from the transcribed genes via nucleotide excision repair is well characterized in mammalian cells. However,…”
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Correction: The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis by Chatterjee, Arpita, Saha, Saikat, Chakraborty, Anirban, Silva-Fernandes, Anabela, Mandal, Santi M, Neves-Carvalho, Andreia, Liu, Yongping, Pandita, Raj K, Hegde, Muralidhar L, Hegde, Pavana M, Boldogh, Istvan, Ashizawa, Tetsuo, Koeppen, Arnulf H, Pandita, Tej K, Maciel, Patricia, Sarkar, Partha S, Hazra, Tapas K

“…[This corrects the article DOI: 10.1371/journal.pgen.1004749.]…”
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Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome by Mandal, Santi M., Hegde, Muralidhar L., Chatterjee, Arpita, Hegde, Pavana M., Szczesny, Bartosz, Banerjee, Dibyendu, Boldogh, Istvan, Gao, Rui, Falkenberg, Maria, Gustafsson, Claes M., Sarkar, Partha S., Hazra, Tapas K.

“…The repair of reactive oxygen species-induced base lesions and single strand breaks (SSBs) in the nuclear genome via the base excision (BER) and SSB repair…”
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Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells by Liu, Zilong, Liu, Yongping, Gao, Rui, Li, Haixia, Dunn, Tiffany, Wu, Ping, Smith, Robert G, Sarkar, Partha S, Fang, Xiang

“…Alcohol intoxication results in neuronal apoptosis, neurodegeneration and manifest with impaired balance, loss of muscle coordination and behavioral changes…”
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Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10 by Xia, Guangbin, McFarland, Karen N, Wang, Kang, Sarkar, Partha S, Yachnis, Anthony T, Ashizawa, Tetsuo

“…Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant cerebellar degenerative disorder, variably associated with epilepsy. 1 The mutation responsible…”
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The future of cancer treatment: combining radiotherapy with immunotherapy by Dagar, Gunjan, Gupta, Ashna, Shankar, Abhishek, Chauhan, Ravi, Macha, Muzafar A, Bhat, Ajaz A, Das, Dayasagar, Goyal, Rajeev, Bhoriwal, Sandeep, Pandita, Raj K, Prasad, Chandra Prakash, Sarkar, Partha S, Pandita, Tej K, Singh, Mayank

“…Radiotherapy (RT) and immunotherapy (IT) are the powerful tools for cancer treatment which act through the stimulation of immune response, and evidence suggest…”
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Klotho Ameliorates Chemically Induced Endoplasmic Reticulum (ER) Stress Signaling by Banerjee, Srijita, Zhao, Yanhua, Sarkar, Partha S., Rosenblatt, Kevin P., Tilton, Ronald G., Choudhary, Sanjeev

“…Background: Both endoplasmic reticulum (ER) stress, a fundamental cell response associated with stress-initiated unfolded protein response (UPR), and loss of…”
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Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability by McFarland, Karen N, Liu, Jilin, Landrian, Ivette, Gao, Rui, Sarkar, Partha S, Raskin, Salmo, Moscovich, Mariana, Gatto, Emilia M, Teive, Hélio A G, Ochoa, Adriana, Rasmussen, Astrid, Ashizawa, Tetsuo

“…Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder caused by a noncoding ATTCT pentanucleotide expansion. An inverse…”
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Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast by Cherng, Nicole, Shishkin, Alexander A., Schlager, Lucas I., Tuck, Ryan H., Sloan, Laura, Matera, Robert, Sarkar, Partha S., Ashizawa, Tetsuo, Freudenreich, Catherine H., Mirkin, Sergei M., Petes, Thomas D.

“…Spinocerebellar ataxia 10 (SCA10) is an autosomal dominant disease caused by large-scale expansions of the (ATTCT) n repeat within an intron of the human…”
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Klotho depletion contributes to increased inflammation in Kidney of the db/db mouse model of diabetes via RelA [.sup.536] phosphorylation by Zhao, Yanhua, Banerjee, Srijita, Dey, Nilay, LeJeune, Wanda S, Sarkar, Partha S, Brobey, Reynolds, Rosenblatt, Kevin P, Tilton, Ronald G, Choudhary, Sanjeev

“…OBJECTIVE--Klotho is an anti-aging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to…”
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Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts by Reddy, Sita, Sarkar, Partha S, Appukuttan, Binoy, Han, Jennifer, Ito, Yoshihiro, Ai, Cuiwei, Tsai, Wenli, Chai, Yang, Stout, J. Timothy

“…Myotonic dystrophy (DM) is an autosomal dominant disorder characterized by skeletal muscle wasting, myotonia, cardiac arrhythmia, hyperinsulinaemia, mental…”
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