Search Results - "SARATHCHANDRA, Padmini"

Modulation of human valve interstitial cell phenotype and function using a fibroblast growth factor 2 formulation by Latif, Najma, Quillon, Alfred, Sarathchandra, Padmini, McCormack, Ann, Lozanoski, Alec, Yacoub, Magdi H, Chester, Adrian H

“…Valve interstitial cells (VICs) are fibroblastic in nature however in culture it is widely accepted that they differentiate into a myofibroblastic phenotype…”
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Intravascular donor monocytes play a central role in lung transplant ischaemia-reperfusion injury by Tatham, Kate Colette, O'Dea, Kieran Patrick, Romano, Rosalba, Donaldson, Hannah Elizabeth, Wakabayashi, Kenji, Patel, Brijesh Vipin, Thakuria, Louit, Simon, Andre Rudiger, Sarathchandra, Padmini, Marczin, Nandor, Takata, Masao

“…Primary graft dysfunction in lung transplant recipients derives from the initial, largely leukocyte-dependent, ischaemia-reperfusion injury. Intravascular…”
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Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver by Lexow, Jonas, Poggioli, Tommaso, Sarathchandra, Padmini, Santini, Maria Paola, Rosenthal, Nadia

“…Tamoxifen-inducible Cre-mediated manipulation of animal genomes has achieved wide acceptance over the last decade, with numerous important studies heavily…”
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Expression and function of mechanosensitive ion channels in human valve interstitial cells by Al-Shammari, Hessah, Latif, Najma, Sarathchandra, Padmini, McCormack, Ann, Rog-Zielinska, Eva A, Raja, Shahzad, Kohl, Peter, Yacoub, Magdi H, Peyronnet, Rémi, Chester, Adrian H

“…The ability of heart valve cells to respond to their mechanical environment represents a key mechanism by which the integrity and function of valve cusps is…”
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Cardiac tissue slices: preparation, handling, and successful optical mapping by Wang, Ken, Lee, Peter, Mirams, Gary R, Sarathchandra, Padmini, Borg, Thomas K, Gavaghan, David J, Kohl, Peter, Bollensdorff, Christian

“…Cardiac tissue slices are becoming increasingly popular as a model system for cardiac electrophysiology and pharmacology research and development. Here, we…”
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Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program by Yu, Joseph K., Sarathchandra, Padmini, Chester, Adrian, Yacoub, Magdi, Brand, Thomas, Butcher, Jonathan T.

“…Cardiac regeneration post-injury is a tantalizing feature of many lower vertebrates such as fishes and urodeles, but absent in adult humans. Restoration of…”
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Dominant regulation of long‐term allograft survival is mediated by microRNA‐142 by Anandagoda, Nelomi, Roberts, Luke B., Willis, Joanna C. D., Sarathchandra, Padmini, Xiao, Fang, Jackson, Ian, Hertweck, Arnulf, Kapoor, Puja, Jenner, Richard G., Howard, Jane K., Lord, Graham M.

“…Organ transplantation is often lifesaving, but the long‐term deleterious effects of combinatorial immunosuppression regimens and allograft failure cause…”
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Microvesicle-Mediated Communication Within the Alveolar Space: Mechanisms of Uptake by Epithelial Cells and Alveolar Macrophages by Soni, Sanooj, O'Dea, Kieran P, Abe, Eiko, Khamdan, Maryam, Shah, Sneh V, Sarathchandra, Padmini, Wilson, Michael R, Takata, Masao

“…Intra-alveolar microvesicles (MVs) are important mediators of inter-cellular communication within the alveolar space, and are key components in the…”
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Revealing new mouse epicardial cell markers through transcriptomics by Bochmann, Lars, Sarathchandra, Padmini, Mori, Federica, Lara-Pezzi, Enrique, Lazzaro, Domenico, Rosenthal, Nadia

“…The epicardium has key functions during myocardial development, by contributing to the formation of coronary endothelial and smooth muscle cells, cardiac…”
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Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction by Zarrinpashneh, Elham, Poggioli, Tommaso, Sarathchandra, Padmini, Lexow, Jonas, Monassier, Laurent, Terracciano, Cesare, Lang, Florian, Damilano, Federico, Zhou, Jessica Q, Rosenzweig, Anthony, Rosenthal, Nadia, Santini, Maria Paola

“…Serum and glucocorticoid inducible kinase 1 (SGK1) plays a pivotal role in early angiogenesis during embryonic development. In this study, we sought to define…”
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Extracellular matrix production by adipose-derived stem cells: Implications for heart valve tissue engineering by Colazzo, Francesca, Sarathchandra, Padmini, Smolenski, Ryszard T, Chester, Adrian H, Tseng, Yuan-Tsan, Czernuszka, Jan T, Yacoub, Magdi H, Taylor, Patricia M

“…Abstract A key challenge in tissue engineering a heart valve is to reproduce the major tissue structures responsible for native valve function. Here we…”
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Endothelium-Dependent Regulation of the Mechanical Properties of Aortic Valve Cusps by El-Hamamsy, Ismail, MD, Balachandran, Kartik, MS, Yacoub, Magdi H., FRS, Stevens, Louis M., MD, SM, Sarathchandra, Padmini, PhD, Taylor, Patricia M., PhD, Yoganathan, Ajit P., PhD, Chester, Adrian H., PhD

“…Objectives The aim of this study was to evaluate the role of valve endothelium in regulating the mechanical properties of aortic valve cusps. Background…”
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Organ Culture Model of Aortic Valve Calcification by Chester, Adrian H., Sarathchandra, Padmini, McCormack, Ann, Yacoub, Magdi H.

“…A significant amount of knowledge has been gained with the use of cell-based assays to elucidate the mechanisms that mediate heart valve calcification…”
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Characterization of porcine aortic valvular interstitial cell 'calcified' nodules by Cloyd, Kristy L, El-Hamamsy, Ismail, Boonrungsiman, Suwimon, Hedegaard, Martin, Gentleman, Eileen, Sarathchandra, Padmini, Colazzo, Francesca, Gentleman, Molly M, Yacoub, Magdi H, Chester, Adrian H, Stevens, Molly M

“…Valve interstitial cells populate aortic valve cusps and have been implicated in aortic valve calcification. Here we investigate a common in vitro model for…”
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Atypical Expression of Smooth Muscle Markers and Co-activators and Their Regulation in Rheumatic Aortic and Calcified Bicuspid Valves by Latif, Najma, Sarathchandra, Padmini, McCormack, Ann, Yacoub, Magdi H, Chester, Adrian H

“…We have previously reported that human calcified aortic cusps have abundant expression of smooth muscle (SM) markers and co-activators. We hypothesised that…”
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Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold by Yacoub, Magdi H., Tseng, Yuan-Tsan, Kluin, Jolanda, Vis, Annemijn, Stock, Ulrich, Smail, Hassiba, Sarathchandra, Padmini, Aikawa, Elena, El-Nashar, Hussam, Chester, Adrian H., Shehata, Nairouz, Nagy, Mohamed, El-sawy, Amr, Li, Wei, Burriesci, Gaetano, Salmonsmith, Jacob, Romeih, Soha, Latif, Najma

“…Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the…”
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Expression of Follistatin-Related Genes Is Altered in Heart Failure by Lara-Pezzi, Enrique, Felkin, Leanne E, Birks, Emma J, Sarathchandra, Padmini, Panse, Kalyani D, George, Robert, Hall, Jennifer L, Yacoub, Magdi H, Rosenthal, Nadia, Barton, Paul J. R

“…Follistatins play roles in diverse biological processes including cell proliferation, wound healing, inflammation, and skeletal muscle growth, yet their role…”
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Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor by Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng

“…Elevated serum concentrations of leucine-rich α-2-glycoprotein (LRG1) have been reported in patients with inflammatory, autoimmune, and cardiovascular…”
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Biocompatibility and Application of Carbon Fibers in Heart Valve Tissue Engineering by Tseng, Yuan-Tsan, Grace, Nabil F, Aguib, Heba, Sarathchandra, Padmini, McCormack, Ann, Ebeid, Ahmed, Shehata, Nairouz, Nagy, Mohamed, El-Nashar, Hussam, Yacoub, Magdi H, Chester, Adrian, Latif, Najma

“…The success of tissue-engineered heart valves rely on a balance between polymer degradation, appropriate cell repopulation, and extracellular matrix (ECM)…”
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Calcineurin Splicing Variant Calcineurin Aβ1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy by FELKIN, Leanne E, NARITA, Takuya, ROSENTHAL, Nadia, LARA-PEZZI, Enrique, GERMACK, Renee, SHINTANI, Yasunori, TAKAHASHI, Kunihiko, SARATHCHANDRA, Padmini, LOPEZ-OLANETA, Marina M, GOMEZ-SALINERO, Jesus M, SUZUKI, Ken, BARTON, Paul J. R

“…Calcineurin is a calcium-regulated phosphatase that plays a major role in cardiac hypertrophy. We previously described that alternative splicing of the…”
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