Search Results - "SANTUS, R"

Stratum corneum is an effective barrier to TiO2 and ZnO nanoparticle percutaneous absorption by Filipe, P, Silva, J N, Silva, R, Cirne de Castro, J L, Marques Gomes, M, Alves, L C, Santus, R, Pinheiro, T

“…There is increasing concern over the local and systemic side effects of TiO(2) and ZnO coated nanoparticles widely used in sun blockers. To determine the…”
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Photosensitisation by voriconazole-N-oxide results from a sequence of solvent and pH-dependent photochemical and thermal reactions by Morlière, P., Silva, A.M.S., Seixas, R.S.G.R., Boscá, F., Mazière, J.-C., Ferreira, J., Santus, R., Filipe, P.

“…The phototoxicity of voriconazole (VN) prescribed in the treatment of severe fungal infections is frequently reported. Its major metabolite, a N-oxide…”
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Endoplasmic reticulum and Golgi apparatus are the preferential sites of Foscan localisation in cultured tumour cells by TEITEN, M-H, BEZDETNAYA, L, MORLIERE, P, SANTUS, R, GUILLEMIN, F

“…Intracellular photosensitiser localisation significantly influences the mechanism of response to photodynamic therapy (PDT), since the primary sites of damage…”
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A molecular insight into the phototoxic reactions observed with vemurafenib, a first-line drug against metastatic melanoma by Morlière, P, Boscá, F, Silva, A M S, Teixeira, A, Galmiche, A, Mazière, J-C, Nourry, V, Ferreira, J, Santus, R, Filipe, P

“…The electronic properties of vemurafenib (VB) provide a rational basis for understanding its strong UVA-induced phototoxicity. Thus, solvation of hydrophobic…”
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Chemistry of free radicals produced by oxidation of endogenous α-aminoketones. A study of 5-aminolevulinic acid and α-aminoacetone by fast kinetics spectroscopy by Morlière, P., Hug, G.L., Patterson, L.K., Mazière, J.-C., Ausseil, J., Dupas, J.-L., Ducroix, J.-P., Santus, R., Filipe, P.

“…Excess 5-aminolevulinic acid (ALA) and α-aminoacetone (AA) are implicated in ketosis, porphyrinpathies and diabetes. Pathologic manifestations involve O2−,…”
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On the repair of oxidative damage to apoferritin: a model study with the flavonoids quercetin and rutin in aerated and deaerated solutions by Morlière, P, Mazière, J-C, Patterson, L K, Conte, M-A, Dupas, J-L, Ducroix, J-P, Filipe, P, Santus, R

“…Ferritin (Ft) impairment through (•)O2(-), H2O2, and (•)OH production occurs in the cases of ketoses, diabetes mellitus, acute intermittent porphyria and…”
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Plasma Lipoproteins as Mediators of the Oxidative Stress Induced by UV Light in Human Skin : A Review of Biochemical and Biophysical Studies on Mechanisms of Apolipoprotein Alteration, Lipid Peroxidation, and Associated Skin Cell Responses by Morlière, Patrice, Mazière, Jean-Claude, Filipe, Paulo, Santus, R., Freitas, João Pedro, Patterson, Larry K., Silva, João N.

“…There are numerous studies concerning the effect of UVB light on skin cells but fewer on other skin components such as the interstitial fluid. This review…”
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Low UVA doses activate the transcription factor NFAT in human fibroblasts by a calcium–calcineurin pathway by Mazière, Cécile, Morlière, Patrice, Louandre, Christophe, Conte, Marie-Alix, Gomilla, Cathy, Santus, René, Antonicelli, Franck, Hornebeck, William, Mazière, Jean-Claude

“…UVA radiation induces an inflammatory response as observed in erythema, and the cytokine genes involved in this response are under the control of the…”
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Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones by Ouédraogo, G, Morlière, P, Santus, R, Miranda, M.A, Castell, J.V

“…The phototoxic fluoroquinolones ofloxacin, lomefloxacin, norfloxacin, ciprofloxacin and BAYy 3118 have ionizable groups with p K a values close to neutrality…”
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Distribution of gadomelitol in a human breast tumor model in mice by Corot, C, Robert, P, Lancelot, E, Martinell, A, Santus, R

“…The study evaluates the tumor distribution of the rapid clearance blood pool agent (RCBPA) gadomelitol, in a breast tumor model. Different techniques were used…”
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Structure-activity relationship of macrocyclic and linear gadolinium chelates: investigation of transmetallation effect on the zinc-dependent metallopeptidase angiotensin-converting enzyme by Corot, C, Idee, J M, Hentsch, A M, Santus, R, Mallet, C, Goulas, V, Bonnemain, B, Meyer, D

“…Transmetallation between commercially available solutions of gadolinium (Gd) chelates and the zinc (Zn)-dependent angiotensin-converting enzyme (ACE) was…”
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Lysosomes Are Sites of Fluoroquinolone Photosensitization in Human Skin Fibroblasts: A Microspectrofluorometric Approach by Ouedraogo, G., Morliere, P., Bazin, M., Santus, R., Kratzer, B., Miranda, M. A., Castell, J. V.

“… The fluoroquinolone antibiotics are widely used despite their strong phototoxicity under solar UV irradiation. Although they are known as good photodynamic…”
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Ultraviolet-B–induced Inactivation of Human OGG1, the Repair Enzyme for Removal of 8-Oxoguanine in DNA by van der Kemp, P. Auffret, Blais, J-C., Bazin, M., Boiteux, S., Santus, R.

“…The OGG1 proteins are DNA N-glycosylases–apurinic-apyrimidinic lyases that are responsible for the removal of 8-oxo-7,8-dihydroguanine (8-oxoG) base in DNA…”
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Lysosomes, a key target of hydrophobic photosensitizers proposed for photochemotherapeutic applications by Gèze, M, Morlière, P, Mazière, J C, Smith, K M, Santus, R

“…Despite their important biological activity, lysosomes have been generally neglected as important primary targets of photosensitizers, because they are not…”
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Sensitization of skin fibroblasts to UVA by excess iron by Morlière, P, Salmon, S, Aubailly, M, Risler, A, Santus, R

“…Human skin chronically exposed to UV light is known to accumulate iron and to have an increased ferritin content as compared to unexposed areas. Iron…”
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UV-A irradiation induces a decrease in the mitochondrial respiratory activity of human NCTC 2544 keratinocytes by Djavaheri-Mergny, M, Marsac, C, Mazière, C, Santus, R, Michel, L, Dubertret, L, Mazière, J C

“…UV-A irradiation caused a dose-dependent decrease in cellular oxygen consumption (56%) and ATP content (65%) in human NCTC 2544 keratinocytes, one hour after…”
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Role of Nuclear Factor-Kappa B in Colon Cancer Cell Apoptosis Mediated by Aminopyropheophorbide Photosensitization by Matroule, J. Y., Hellin, Anne-Cécile, Morliere, P., Fabiano, A. S., Santus, R., Merville, Marie-Paule, Piette, Jacques

“…Aminopyropheophorbide (APP) is a second generation of photosensitizer for photodynamic therapy (PDT). We demonstrated that APP strongly absorbed red light and,…”
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Alteration of the Endocytotic Pathway by Photosensitization with Fluoroquinolones by Ouédraogo, G., Morlière, P., Mazière, C., Mazière, J. C., Santus, R.

“…The endocytotic pathway is profoundly altered by the UVA-induced photosensitization of HS 68 fibroblasts by the fluoroquinolone (FQ) antibiotics lomefloxacin,…”
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Comparison of the tumoral biodistribution of P792, a rapid clearance blood pool agent and Gd-DOTA in a C6 glioma cerebral tumor model in rats by Robert, P, Santus, R, Violas, X, Rémy, C, Corot, C

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Kinetics of the endocytotic pathway of Low Density Lipoprotein (LDL) in human endothelial cells line under shear stress: an in vitro confocal microscopy study by Traoré, M, Sun, R J, Fawzi-Grancher, S, Dumas, D, Qing, X, Santus, R, Stoltz, J-F, Muller, S

“…We studied the effect of mechanical forces (shear stress) on the kinetics of internalization of native LDL and ox-LDL in endothelial cell line ECV304. This…”
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