Search Results - "SANTOS, Robson A"

Counter-regulatory renin–angiotensin system in cardiovascular disease by Paz Ocaranza, Maria, Riquelme, Jaime A., García, Lorena, Jalil, Jorge E., Chiong, Mario, Santos, Robson A. S., Lavandero, Sergio

“…The renin–angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of angiotensin I…”
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Angiotensin-(1-7): beyond the cardio-renal actions by Passos-Silva, Danielle G, Verano-Braga, Thiago, Santos, Robson A S

“…It is well known that the RAS (renin-angiotensin system) plays a key role in the modulation of many functions in the body. AngII (angiotensin II) acting on…”
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MAS and its related G protein-coupled receptors, Mrgprs by Bader, Michael, Alenina, Natalia, Andrade-Navarro, Miguel A, Santos, Robson A

“…The Mas-related G protein-coupled receptors (Mrgprs or Mas-related genes) comprise a subfamily of receptors named after the first discovered member, Mas. For…”
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Alamandine acts via MrgD to induce AMPK/NO activation against ANG II hypertrophy in cardiomyocytes by Jesus, Itamar Couto Guedes de, Scalzo, Sérgio, Alves, Fabiana, Marques, Kariny, Rocha-Resende, Cibele, Bader, Michael, Santos, Robson A Souza, Guatimosim, Silvia

“…The renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases. New members of this system have been characterized and…”
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Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison by Villela, Daniel, Leonhardt, Julia, Patel, Neal, Joseph, Jason, Kirsch, Sebastian, Hallberg, Anders, Unger, Thomas, Bader, Michael, Santos, Robson A, Sumners, Colin, Steckelings, U Muscha

“…The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin-angiotensin system (RAS), i.e. they both mediate…”
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Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system by Santos, Robson A S, Ferreira, Anderson J, Verano-Braga, Thiago, Bader, Michael

“…Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in…”
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Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS by Leonhardt, Julia, Villela, Daniel C, Teichmann, Anke, Münter, Lisa-Marie, Mayer, Magnus C, Mardahl, Maibritt, Kirsch, Sebastian, Namsolleck, Pawel, Lucht, Kristin, Benz, Verena, Alenina, Natalia, Daniell, Nicholas, Horiuchi, Masatsugu, Iwai, Masaru, Multhaup, Gerhard, Schülein, Ralf, Bader, Michael, Santos, Robson A, Unger, Thomas, Steckelings, Ulrike Muscha

“…The angiotensin type 2 receptor (AT2R) and the receptor MAS are receptors of the protective arm of the renin-angiotensin system. They mediate strikingly…”
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Recent advances in the angiotensin‐converting enzyme 2–angiotensin(1–7)–Mas axis by Santos, Robson A. S., Ferreira, Anderson J., Simões e Silva, Ana Cristina

“…In the past few years, the classical concept of the renin–angiotensin system (RAS) has experienced substantial conceptual changes. The identification of: the…”
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Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart by Mercure, Chantal, Yogi, Alvaro, Callera, Glaucia E, Aranha, Anna B, Bader, Michael, Ferreira, Anderson J, Santos, Robson A. S, Walther, Thomas, Touyz, Rhian M, Reudelhuber, Timothy L

“…Angiotensin-converting enzyme 2 (ACE2) converts the vasopressor angiotensin II (Ang II) into angiotensin (1-7) [Ang(1-7)], a peptide reported to have…”
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Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary by Reis, Fernando M., M.D., Ph.D, Bouissou, Daniela R., M.D, Pereira, Virginia M., Ph.D, Camargos, Aroldo F., M.D., Ph.D, dos Reis, Adelina M., Ph.D, Santos, Robson A., M.D., Ph.D

“…Objective To investigate whether angiotensin (Ang)-(1-7), its receptor Mas, and angiotensin-converting enzyme type 2 (ACE2) are present in human ovary. Design…”
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Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney by Domenig, Oliver, Manzel, Arndt, Grobe, Nadja, Königshausen, Eva, Kaltenecker, Christopher C., Kovarik, Johannes J., Stegbauer, Johannes, Gurley, Susan B., van Oyen, Dunja, Antlanger, Marlies, Bader, Michael, Motta-Santos, Daisy, Santos, Robson A., Elased, Khalid M., Säemann, Marcus D., Linker, Ralf A., Poglitsch, Marko

“…Cardiovascular and renal pathologies are frequently associated with an activated renin-angiotensin-system (RAS) and increased levels of its main effector and…”
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Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress by Rabelo, Luiza A, Todiras, Mihail, Nunes-Souza, Valéria, Qadri, Fatimunnisa, Szijártó, István András, Gollasch, Maik, Penninger, Josef M, Bader, Michael, Santos, Robson A, Alenina, Natalia

“…Accumulating evidence indicates that angiotensin-converting enzyme 2 (ACE2) plays a critical role in cardiovascular homeostasis, and its altered expression is…”
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Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response by Klempin, Friederike, Mosienko, Valentina, Matthes, Susann, Villela, Daniel C., Todiras, Mihail, Penninger, Josef M., Bader, Michael, Santos, Robson A. S., Alenina, Natalia

“…Physical exercise induces cell proliferation in the adult hippocampus in rodents. Serotonin (5-HT) and angiotensin (Ang) II are important mediators of the…”
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Structure-Based Identification of Small-Molecule Angiotensin-Converting Enzyme 2 Activators as Novel Antihypertensive Agents by Hernández Prada, José A, Ferreira, Anderson J, Katovich, Michael J, Shenoy, Vinayak, Qi, Yanfei, Santos, Robson A.S, Castellano, Ronald K, Lampkins, Andrew J, Gubala, Vladimir, Ostrov, David A, Raizada, Mohan K

“…Angiotensin-converting enzyme 2 (ACE2) is a key renin-angiotensin system enzyme involved in balancing the adverse effects of angiotensin II on the…”
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Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension by Feng, Yumei, Xia, Huijing, Cai, Yanhui, Halabi, Carmen M, Becker, Lenice K, Santos, Robson A.S, Speth, Robert C, Sigmund, Curt D, Lazartigues, Eric

“…RATIONALE:Angiotensin converting enzyme type 2 (ACE2) is a new member of the brain renin-angiotensin system, that might be activated by an overactive…”
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Endothelial Dysfunction and Elevated Blood Pressure in Mas Gene-Deleted Mice by Xu, Ping, Costa-Goncalves, Andrey C, Todiras, Mihail, Rabelo, Luiza A, Sampaio, Walkyria O, Moura, Marina M, Santos, Sergio Sousa, Luft, Friedrich C, Bader, Michael, Gross, Volkmar, Alenina, Natalia, Santos, Robson A.S

“…Mas codes for a G protein–coupled receptor that is implicated in angiotensin-(1-7) signaling. We studied the cardiovascular phenotype of Mas-deficient mice…”
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The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques by MONTECUCCO, Fabrizio, DI MARZO, Vincenzo, PELLI, Graziano, GALAN, Katia, PILET, Lucie, KUZMANOVIC, Kristina, BURGER, Fabienne, PANE, Bianca, SPINELIA, Giovanni, BRAUNERSREUTHER, Vincent, GAYET-AGERON, Angèle, PENDE, Aldo, DA SILVA, Rafaela F, LUCIANO VIVIANI, Giorgio, PALOMBO, Domenico, DALLEGRI, Franco, ROUX-LOMBARD, Pascale, SANTOS, Robson A. S, STERGIOPULOS, Nikos, STEFFENS, Sabine, MACH, François, VUILLEUMIER, Nicolas, CAPETTINI, Luciano, LENGLET, Sebastien, PAGANO, Sabrina, PISCITELLI, Fabiana, QUINTAO, Silvia, BERTOLOTTO, Maria

“…The activation of cannabinoid receptor type 2 (CB(2))-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the…”
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Angiotensin-(1-7) Counterregulates Angiotensin II Signaling in Human Endothelial Cells by Sampaio, Walkyria O, de Castro, Carlos Henrique, Santos, Robson A.S, Schiffrin, Ernesto L, Touyz, Rhian M

“…Angiotensin (Ang)-(1-7), acting through the Mas receptor, opposes the actions of Ang II. Molecular mechanisms for this are unclear. Here we sought to determine…”
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Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas by Morales, María Gabriela, Abrigo, Johanna, Acuña, María José, Santos, Robson A, Bader, Michael, Brandan, Enrique, Simon, Felipe, Olguin, Hugo, Cabrera, Daniel, Cabello-Verrugio, Claudio

“…Immobilization is a form of disuse characterized by a loss of strength and muscle mass. Among the main features are decreased IGF-1/Akt signalling and…”
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Lack of weight gain after angiotensin AT1 receptor blockade in diet‐induced obesity is partly mediated by an angiotensin‐(1–7)/Mas‐dependent pathway by Schuchard, Johanna, Winkler, Martina, Stölting, Ines, Schuster, Franziska, Vogt, Florian M, Barkhausen, Jörg, Thorns, Christoph, Santos, Robson A, Bader, Michael, Raasch, Walter

“…Background and Purpose Angiotensin AT1 receptor antagonists induce weight loss; however, the mechanism underlying this phenomenon is unknown. The Mas receptor…”
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