LYMPHOEPITHELIAL CARCINOMA IN THE LOWER LIP: A RARE CASE WITH AN AGGRESSIVE PRESENTATION

Lymphoepithelial Carcinoma (LEC) is an uncommon and aggressive subtype of head and neck squamous cell carcinoma (HNSCC) that bears a resemblance to the undifferentiated subtype of non-keratinizing nasopharyngeal carcinoma, often characterized by a prominent reactive lymphoplasmacytic infiltrate. A 5...

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Bibliographic Details
Published in:	Oral surgery, oral medicine, oral pathology and oral radiology Vol. 137; no. 6; p. e255
Main Authors:	GONÇALVES, Moisés Willian Aparecido, LIMA-SOUZA, Reydson Alcides DE, VIEIRA, Gustavo de Souza, SANTOS, Francisco Augusto Gomes, EGAL, Erika Said Abu, ALTEMANI, Albina, MARIANO, Fernanda Viviane
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-06-2024
Online Access:	Get full text
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Summary:	Lymphoepithelial Carcinoma (LEC) is an uncommon and aggressive subtype of head and neck squamous cell carcinoma (HNSCC) that bears a resemblance to the undifferentiated subtype of non-keratinizing nasopharyngeal carcinoma, often characterized by a prominent reactive lymphoplasmacytic infiltrate. A 56-year-old male presented at a healthcare facility with a painful, ulcerated, and vegetating lesion on the lower lip, which had been evolving for one year. The patient had a prior diagnosis of SCC and reported being an ex-smoker and ex-alcohol user. Surgical resection of the tumor was carried out, and microscopic examination revealed the diffuse infiltration of connective tissue by malignant epithelial cells, accompanied by a dense infiltrate of lymphoplasmacytic cells that extended into the underlying musculature. Perineural invasion and an eosinophilic infiltrate were also evident. Immunohistochemical analysis indicated that the neoplastic cells were positive for AE1/AE3 and p63, supporting the diagnosis of carcinoma. Subsequently, the patient underwent neck dissection and received chemoradiotherapy. As of the 1-year follow-up, there have been no indications of recurrence or metastasis. This case report is supported by CAPES.
ISSN:	2212-4403 2212-4411
DOI:	10.1016/j.oooo.2023.12.518