Search Results - "SANTI, V"

Hydrogel drug delivery system with predictable and tunable drug release and degradation rates by Ashley, Gary W., Henise, Jeff, Reid, Ralph, Santi, Daniel V.

“…Many drugs and drug candidates are suboptimal because of short duration of action. For example, peptides and proteins often have serum half-lives of only…”
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Long-Term Stabilization of Maleimide–Thiol Conjugates by Fontaine, Shaun D, Reid, Ralph, Robinson, Louise, Ashley, Gary W, Santi, Daniel V

“…Michael-addition of a thiol to a maleimide is commonly used for bioconjugation of drugs to macromolecules. Indeed, both current FDA-approved antibody–drug…”
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A long-acting C-natriuretic peptide for achondroplasia by Schneider, Eric L, Carreras, Christopher W, Reid, Ralph, Ashley, Gary W, Santi, Daniel V

“…The C-natriuretic peptide (CNP) analog vosoritide has recently been approved for treatment of achondroplasia in children. However, the regimen requires daily…”
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Leishmaniavirus genetic diversity is not related to leishmaniasis treatment failure by Ginouvès, M., Couppié, P., Simon, S., Bourreau, E., Rogier, S., Brousse, P., Travers, P., Pommier de Santi, V., Demar, M., Briolant, S., Prévot, G.

“…The outcome of American tegumentary leishmaniasis (ATL) may depend on the presence of the Leishmania RNA virus (LRV). This virus may be involved in treatment…”
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A platform technology for ultra-long acting intratumoral therapy by Henise, Jeff, Hangasky, John A., Charych, Deborah, Carreras, Christopher W., Ashley, Gary W., Santi, Daniel V.

“…Intratumoral (IT) therapy is a powerful method of controlling tumor growth, but a major unsolved problem is the rapidity that injected drugs exit tumors,…”
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Interleukin 15 Pharmacokinetics and Consumption by a Dynamic Cytokine Sink by Hangasky, John A, Waldmann, Thomas A, Santi, Daniel V

“…Interleukin-15 (IL-15) is crucial for the proliferation and survival of NK and CD8 T memory cells, and of significant interest in immuno-oncology. Immune cell…”
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Epidemiology of respiratory pathogen carriage in the homeless population within two shelters in Marseille, France, 2015–2017: cross sectional 1-day surveys by Ly, T.D.A., Edouard, S., Badiaga, S., Tissot-Dupont, H., Hoang, V.T., Pommier de Santi, V., Brouqui, P., Raoult, D., Gautret, P.

“…To assess risk factors for respiratory tract infection symptoms and signs in sheltered homeless people in Marseille during the winter season, including…”
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Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates by Santi, Daniel V, Schneider, Eric L, Reid, Ralph, Robinson, Louise, Ashley, Gary W

“…Conjugation to macromolecular carriers is a proven strategy for improving the pharmacokinetics of drugs, with many stable polyethylene glycol conjugates having…”
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Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both? by Santi, Daniel V., Cabel, Luc, Bidard, François-Clément

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PLX038A, a long-acting SN-38, penetrates the blood-tumor-brain-barrier, accumulates and releases SN-38 in brain tumors to increase survival of tumor bearing mice by Jung, Jinkyu, Schneider, Eric L., Zhang, Wei, Song, Hua, Zhang, Meili, Chou, William, Meher, Niranjan, VanBrocklin, Henry F., Barcellos-Hoff, Mary Helen, Ozawa, Tomoko, Gilbert, Mark R., Santi, Daniel V.

“…Central nervous system tumors have resisted effective chemotherapy because most therapeutics do not penetrate the blood-tumor-brain-barrier. Nanomedicines…”
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Synthesis of Methyl Halides from Biomass Using Engineered Microbes by Bayer, Travis S, Widmaier, Daniel M, Temme, Karsten, Mirsky, Ethan A, Santi, Daniel V, Voigt, Christopher A

“…Methyl halides are used as agricultural fumigants and are precursor molecules that can be catalytically converted to chemicals and fuels. Plants and…”
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Leveraging long-acting IL-15 agonists for intratumoral delivery and enhanced antimetastatic activity by Hangasky, John A., Fernández, Rocío del Valle, Stellas, Dimitris, Hails, Guillermo, Karaliota, Sevasti, Ashley, Gary W., Felber, Barbara K., Pavlakis, George N., Santi, Daniel V.

“…Introduction IL-15 agonists hold promise as immunotherapeutics due to their ability to induce the proliferation and expansion of cytotoxic immune cells…”
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Targeted Covalent Inactivation of Protein Kinases by Resorcylic Acid Lactone Polyketides by Schirmer, Andreas, Kennedy, Jonathan, Murli, Sumati, Reid, Ralph, Santi, Daniel V.

“…Resorcylic acid lactones containing a cis-enone are susceptible to Michael addition reactions and are potent inhibitors of several protein kinases. A…”
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A very long-acting IL-15: implications for the immunotherapy of cancer by Hangasky, John A, Chen, Wei, Dubois, Sigrid P, Daenthanasanmak, Anusara, Müller, Jürgen R, Reid, Ralph, Waldmann, Thomas A, Santi, Daniel V

“…BackgroundInterleukin-15 (IL-15) is an important cytokine necessary for proliferation and maintenance of natural killer (NK) and CD8+ T cells, and with great…”
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Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft by Fontaine, Shaun D., Hann, Byron, Reid, Ralph, Ashley, Gary W., Santi, Daniel. V.

“…Purpose Optimal efficacy of a macromolecular prodrug requires balancing the rate of drug release with the rate of prodrug elimination. Since circulating…”
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Total Synthesis of Long DNA Sequences: Synthesis of a Contiguous 32-kb Polyketide Synthase Gene Cluster by Kodumal, Sarah J., Patel, Kedar G., Reid, Ralph, Menzella, Hugo G., Welch, Mark, Santi, Daniel V., Stroud, Robert M.

“…To exploit the huge potential of whole-genome sequence information, the ability to efficiently synthesize long, accurate DNA sequences is becoming increasingly…”
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Treatments for hepatocellular carcinoma in elderly patients are as effective as in younger patients: a 20-year multicentre experience by Mirici-Cappa, Federica, Gramenzi, Annagiulia, Santi, Valentina, Zambruni, Andrea, Di Micoli, Antonio, Frigerio, Marta, Maraldi, Francesca, Di Nolfo, Maria Anna, Del Poggio, Paolo, Benvegnù, Luisa, Rapaccini, Gianludovico, Farinati, Fabio, Zoli, Marco, Borzio, Franco, Giannini, Edoardo Giovanni, Caturelli, Eugenio, Bernardi, Mauro, Trevisani, Franco

“…The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) is expected to increase. We compared the presenting features and outcome of HCC in…”
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A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases by Reid, Ralph, Piagentini, Misty, Rodriguez, Eduardo, Ashley, Gary, Viswanathan, Nina, Carney, John, Santi, Daniel V, Hutchinson, C. Richard, McDaniel, Robert

“…A putative catalytic triad consisting of tyrosine, serine, and lysine residues was identified in the ketoreductase (KR) domains of modular polyketide synthases…”
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Facile preparation of tetra‐polyethylene glycol hydrogel microspheres for drug delivery by cross‐flow membrane emulsification by Henise, Jeff, Yao, Brian, Ashley, Gary W., Santi, Daniel V.

“…The purpose of this work was to develop technology for facile, large‐scale production of tetra‐polyethylene glycol (PEG) hydrogel amino‐microspheres to serve…”
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Autoclave sterilization of tetra‐polyethylene glycol hydrogel biomaterials with β‐eliminative crosslinks by Henise, Jeff, Yao, Brian, Ashley, Gary W., Santi, Daniel V.

“…Sterilization of degradable polymeric biomaterials intended for injection presents a formidable challenge. Often, either the polymer backbone or labile…”
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