Search Results - "SANT'ANGELO, Derek"

Transfer of Maternal Immune Cells by Breastfeeding: Maternal Cytotoxic T Lymphocytes Present in Breast Milk Localize in the Peyer's Patches of the Nursed Infant by Cabinian, Allison, Sinsimer, Daniel, Tang, May, Zumba, Osvaldo, Mehta, Hetali, Toma, Annmarie, Sant'Angelo, Derek, Laouar, Yasmina, Laouar, Amale

“…Despite our knowledge of the protective role of antibodies passed to infants through breast milk, our understanding of immunity transfer via maternal…”
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Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function by Zhang, Yuanyue, Bailey, Jacob T., Xu, En, Singh, Kunal, Lavaert, Marieke, Link, Verena M., D’Souza, Shanti, Hafiz, Alex, Cao, Jian, Cao, Gaoyuan, Sant’Angelo, Derek B., Sun, Wei, Belkaid, Yasmine, Bhandoola, Avinash, McGavern, Dorian B., Yang, Qi

“…Increasing evidence indicates close interaction between immune cells and the brain, revising the traditional view of the immune privilege of the brain…”
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Histone deacetylase 3 is required for iNKT cell development by Thapa, Puspa, Romero Arocha, Sinibaldo, Chung, Ji Young, Sant’Angelo, Derek B., Shapiro, Virginia Smith

“…NKT cells are a distinct subset that have developmental requirements that often differ from conventional T cells. Here, we show that NKT-specific deletion of…”
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Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue by Lynch, Lydia, Michelet, Xavier, Zhang, Sai, Brennan, Patrick J, Moseman, Ashley, Lester, Chantel, Besra, Gurdyal, Vomhof-Dekrey, Emilie E, Tighe, Mike, Koay, Hui-Fern, Godfrey, Dale I, Leadbetter, Elizabeth A, Sant'Angelo, Derek B, von Andrian, Ulrich, Brenner, Michael B

“…i NKT cells in adipose tissue are anti-inflammatory. Brenner and colleagues show that adipose i NKT cells have a unique transcriptional program, produce IL-2…”
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Development of PLZF-expressing innate T cells by Alonzo, Eric S, Sant’Angelo, Derek B

“…Recent studies have shown that the transcriptional regulator promyelocytic leukemia zinc finger (PLZF) controls the development of essentially all of the…”
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The MHC Class II Antigen-Processing and Presentation Pathway Is Dysregulated in Type 1 Diabetes by Gilles, Ambroise, Hu, Lan, Virdis, Francesca, Sant'Angelo, Derek B, Dimitrova, Nevenka, Hedrick, Joseph A, Denzin, Lisa K

“…Peptide loading of MHC class II (MHCII) molecules is facilitated by HLA-DM (DM), which catalyzes CLIP release, stabilizes empty MHCII, and edits the…”
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Coexpression of YY1 Is Required to Elaborate the Effector Functions Controlled by PLZF in NKT Cells by Darcy, Patrick W, Jin, Kangxin, Osorio, Louis, Denzin, Lisa K, Sant'Angelo, Derek B

“…The promyelocytic leukemia zinc-finger transcription factor (PLZF) is essential for nearly all of the unique, innate-like functions and characteristics of NKT…”
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The BTB-ZF family of transcription factors: key regulators of lineage commitment and effector function development in the immune system by Beaulieu, Aimee M, Sant'Angelo, Derek B

“…Successful immunity depends upon the activity of multiple cell types. Commitment of pluripotent precursor cells to specific lineages, such as T or B cells, is…”
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Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53 by Chen, Liang, Foreman, Daniel P, Sant'Angelo, Derek B, Krangel, Michael S

“…Yin Yang 1 (YY1) is a zinc finger protein that functions as a transcriptional activator or repressor and participates in multiple biological processes,…”
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The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils by Zhang, Sai, Vieth, Joshua A, Krzyzanowska, Agata, Henry, Everett K, Denzin, Lisa K, Siracusa, Mark C, Sant'Angelo, Derek B

“…Basophils are innate immune cells associated with type 2 immunity, allergic reactions, and host defense against parasite infections. In this study, we show…”
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NKAP Regulates Invariant NKT Cell Proliferation and Differentiation into ROR-γt-Expressing NKT17 Cells by Thapa, Puspa, Chen, Meibo W, McWilliams, Douglas C, Belmonte, Paul, Constans, Megan, Sant'Angelo, Derek B, Shapiro, Virginia Smith

“…Invariant NKT (iNKT) cells are a unique lineage with characteristics of both adaptive and innate lymphocytes, and they recognize glycolipids presented by an…”
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The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions by Hobbs, Robin M, Im, Jin S, Sant'Angelo, Derek B, Kim, Hye-Jung, Yi, Woelsung, Alonzo, Eric, Pandolfi, Pier Paolo, Uche, Olisambu U, Eladad, Sonia, Chua, Kevin, Eidson, Maggie, Kovalovsky, Damian

“…Invariant natural killer cells recognize glycolipids presented by CD1d molecules and can mediate rapid innate responses. Sant'Angelo and colleagues show that…”
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The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion by Zhu, Sining, Lalani, Almin I, Jin, Juan, Sant'Angelo, Derek, Covey, Lori R, Liu, Kebin, Young, Howard A, Ostrand-Rosenberg, Suzanne, Xie, Ping

“…Myeloid-derived suppressor cells (MDSCs) are aberrantly expanded in cancer patients and under other pathological conditions. These cells orchestrate the…”
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Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival by Uddin, Mohammad Nizam, Sultana, Dil Afroz, Lorentsen, Kyle J., Cho, Jonathan J., Kirst, Mariana E., Brantly, Mark L., Califano, Danielle, Sant’Angelo, Derek B., Avram, Dorina

“…Invariant natural killer T (iNKT) cells are innate-like T cells that recognize glycolipid antigens and play critical roles in regulation of immune responses…”
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TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells by Vieth, Joshua A, Das, Joy, Ranaivoson, Fanomezana M, Comoletti, Davide, Denzin, Lisa K, Sant'Angelo, Derek B

“…Sant’Angelo and colleagues show that disruption of a hydrophobic patch in the T cell antigen receptor on natural killer T cells alters their development, which…”
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PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals by Kovalovsky, Damian, Alonzo, Eric S, Uche, Olisambu U, Eidson, Maggie, Nichols, Kim E, Sant'Angelo, Derek B

“…The broad complex, tramtrack, bric-a-brac-zinc finger (BTB-ZF) transcription factor promyelocytic leukemia zinc finger (PLZF) is required for development of…”
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Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus by Osada, Masako, Singh, Varan J, Wu, Kenmin, Sant'Angelo, Derek B, Pezzano, Mark

“…Thymic microenvironments are essential for the proper development and selection of T cells critical for a functional and self-tolerant adaptive immune…”
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Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus by Kim, Hye-Jung, Alonzo, Eric S, Dorothee, Guillaume, Pollard, Jeffrey W, Sant'Angelo, Derek B

“…Developing thymocytes undergo a rigorous selection process to ensure that the mature T cell population expresses a T cell receptor (TCR) repertoire that can…”
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Development of Promyelocytic Zinc Finger and ThPOK-Expressing Innate γδ T Cells Is Controlled by Strength of TCR Signaling and Id3 by Alonzo, Eric S., Gottschalk, Rachel A., Das, Joy, Egawa, Takeshi, Hobbs, Robin M., Pandolfi, Pier Paolo, Pereira, Pablo, Nichols, Kim E., Koretzky, Gary A., Jordan, Martha S., Sant’Angelo, Derek B.

“…The broad-complex tramtrack and bric a brac-zinc finger transcriptional regulator(BTB-ZF), promyelocytic leukemia zinc finger (PLZF), was recently shown to…”
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Distinct PLZF + CD8αα + Unconventional T Cells Enriched in Liver Use a Cytotoxic Mechanism to Limit Autoimmunity by Sheng, Huiming, Marrero, Idania, Maricic, Igor, Fanchiang, Shaohsuan S, Zhang, Sai, Sant'Angelo, Derek B, Kumar, Vipin

“…Hepatic immune system is uniquely challenged to mount a controlled effector response to pathogens while maintaining tolerance to diet and microbial Ags. We…”
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