Search Results - "SANSON, Marc"

Clinical trial of blood-brain barrier disruption by pulsed ultrasound by Carpentier, Alexandre, Canney, Michael, Vignot, Alexandre, Reina, Vincent, Beccaria, Kevin, Horodyckid, Catherine, Karachi, Carine, Leclercq, Delphine, Lafon, Cyril, Chapelon, Jean-Yves, Capelle, Laurent, Cornu, Philippe, Sanson, Marc, Hoang-Xuan, Khê, Delattre, Jean-Yves, Idbaih, Ahmed

“…The blood-brain barrier (BBB) limits the delivery of systemically administered drugs to the brain. Methods to circumvent the BBB have been developed, but none…”
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MGMT testing—the challenges for biomarker-based glioma treatment by Wick, Wolfgang, Weller, Michael, van den Bent, Martin, Sanson, Marc, Weiler, Markus, von Deimling, Andreas, Plass, Christoph, Hegi, Monika, Platten, Michael, Reifenberger, Guido

“…Key Points O 6 -methylguanine-DNA methyltransferase ( MGMT ) promoter methylation predicts responsiveness to alkylating chemotherapies in glioblastoma, but is…”
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Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma by Salam, Rana, Saliou, Alexa, Bielle, Franck, Bertrand, Mathilde, Antoniewski, Christophe, Carpentier, Catherine, Alentorn, Agusti, Capelle, Laurent, Sanson, Marc, Huillard, Emmanuelle, Bellenger, Léa, Guégan, Justine, Le Roux, Isabelle

“…Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it remains refractory to systemic therapy. Elimination of senescent cells…”
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IDH-wildtype lower-grade diffuse gliomas: the importance of histological grade and molecular assessment for prognostic stratification by Berzero, Giulia, Di Stefano, Anna Luisa, Ronchi, Susanna, Bielle, Franck, Villa, Chiara, Guillerm, Erell, Capelle, Laurent, Mathon, Bertrand, Laurenge, Alice, Giry, Marine, Schmitt, Yohann, Marie, Yannick, Idbaih, Ahmed, Hoang-Xuan, Khe, Delattre, Jean-Yves, Mokhtari, Karima, Sanson, Marc

“…Abstract Background Isocitrate dehydrogenase (IDH) wildtype (wt) grade II gliomas are a rare and heterogeneous entity. Survival and prognostic factors are…”
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Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas by SANSON, Marc, MARIE, Yannick, DELATTRE, Jean-Yves, PARIS, Sophie, IDBAIH, Ahmed, LAFFAIRE, Julien, DUCRAY, François, EL HALLANI, Soufiane, BOISSELIER, Blandine, MOKHTARI, Karima, HOANG-XUAN, Khe

“…Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at codon 132 have been found in 12% of glioblastomas. IDH1 codon 132 sequencing was…”
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N-cadherin expression level modulates integrin-mediated polarity and strongly impacts on the speed and directionality of glial cell migration by Camand, Emeline, Peglion, Florent, Osmani, Naël, Sanson, Marc, Etienne-Manneville, Sandrine

“…Perturbation of cell polarity is a hallmark of cancer cells. In carcinomas, loss of epithelial E-cadherin contributes to the loss of cell polarity and promotes…”
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A metabolic function of FGFR3-TACC3 gene fusions in cancer by Frattini, Véronique, Pagnotta, Stefano M., Tala, Fan, Jerry J., Russo, Marco V., Lee, Sang Bae, Garofano, Luciano, Zhang, Jing, Shi, Peiguo, Lewis, Genevieve, Sanson, Heloise, Frederick, Vanessa, Castano, Angelica M., Cerulo, Luigi, Rolland, Delphine C. M., Mall, Raghvendra, Mokhtari, Karima, Elenitoba-Johnson, Kojo S. J., Sanson, Marc, Huang, Xi, Ceccarelli, Michele, Lasorella, Anna, Iavarone, Antonio

“…Oncogenic FGFR3–TACC3 gene fusions signal through phosphorylated PIN4 to trigger biogenesis of peroxisomes and synthesis of new proteins, enabling…”
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Temporary blood–brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma by Dréan, Antonin, Lemaire, Nolwenn, Bouchoux, Guillaume, Goldwirt, Lauriane, Canney, Michael, Goli, Larissa, Bouzidi, Amira, Schmitt, Charlotte, Guehennec, Jeremy, Verreault, Maïté, Sanson, Marc, Delattre, Jean-Yves, Mokhtari, Karima, Sottilini, Frédéric, Carpentier, Alexandre, Idbaih, Ahmed

“…Introduction Glioblastoma (GBM) is the most common and aggressive primary brain cancer in adults. Few cytotoxic chemotherapies have been shown to be effective…”
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Comparative assessment of 5 methods (methylation‐specific polymerase chain reaction, methylight, pyrosequencing, methylation‐sensitive high‐resolution melting, and immunohistochemistry) to analyze O6‐methylguanine‐DNA‐methyltranferase in a series of 100 glioblastoma patients by Quillien, Véronique, Lavenu, Audrey, Karayan‐Tapon, Lucie, Carpentier, Catherine, Labussière, Marianne, Lesimple, Thierry, Chinot, Olivier, Wager, Michel, Honnorat, Jérome, Saikali, Stephan, Fina, Frédéric, Sanson, Marc, Figarella‐Branger, Dominique

“…BACKGROUND: There is a strong need to determine the best technique for O6‐methylguanine‐DNA‐methyltranferase (MGMT) analysis, because MGMT status is currently…”
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Highly specific determination of IDH status using edited in vivo magnetic resonance spectroscopy by Branzoli, Francesca, Di Stefano, Anna Luisa, Capelle, Laurent, Ottolenghi, Chris, Valabrègue, Romain, Deelchand, Dinesh K, Bielle, Franck, Villa, Chiara, Baussart, Bertrand, Lehéricy, Stéphane, Sanson, Marc, Marjanska, Malgorzata

“…Mutations in the isocitrate dehydrogenase (IDH) enzyme affect 40% of gliomas and represent a major diagnostic and prognostic marker. The goals of this study…”
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Cystathionine as a marker for 1p/19q codeleted gliomas by in vivo magnetic resonance spectroscopy by Branzoli, Francesca, Pontoizeau, Clément, Tchara, Lucien, Di Stefano, Anna Luisa, Kamoun, Aurélie, Deelchand, Dinesh K, Valabrègue, Romain, Lehéricy, Stéphane, Sanson, Marc, Ottolenghi, Chris, Marjańska, Małgorzata

“…Abstract Background Codeletion of chromosome arms 1p and 19q (1p/19q codeletion) highly benefits diagnosis and prognosis in gliomas. In this study, we…”
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Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas by Verreault, Maite, Schmitt, Charlotte, Goldwirt, Lauriane, Pelton, Kristine, Haidar, Samer, Levasseur, Camille, Guehennec, Jeremy, Knoff, David, Labussière, Marianne, Marie, Yannick, Ligon, Azra H, Mokhtari, Karima, Hoang-Xuan, Khê, Sanson, Marc, Alexander, Brian M, Wen, Patrick Y, Delattre, Jean-Yves, Ligon, Keith L, Idbaih, Ahmed

“…p53 pathway alterations are key molecular events in glioblastoma (GBM). MDM2 inhibitors increase expression and stability of p53 and are presumed to be most…”
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Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial by Dubbink, Hendrikus J, Atmodimedjo, Peggy N, Kros, Johan M, French, Pim J, Sanson, Marc, Idbaih, Ahmed, Wesseling, Pieter, Enting, Roelien, Spliet, Wim, Tijssen, Cees, Dinjens, Winand N M, Gorlia, Thierry, van den Bent, Martin J

“…Histopathological diagnosis of diffuse gliomas is subject to interobserver variation and correlates modestly with major prognostic and predictive molecular…”
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Heterogeneity of Response to Iron-Based Metallodrugs in Glioblastoma Is Associated with Differences in Chemical Structures and Driven by FAS Expression Dynamics and Transcriptomic Subtypes by Vessières, Anne, Quissac, Emie, Lemaire, Nolwenn, Alentorn, Agusti, Domeracka, Patrycja, Pigeon, Pascal, Sanson, Marc, Idbaih, Ahmed, Verreault, Maïté

“…Glioblastoma (GBM) is the most frequent and deadliest primary brain cancer in adults, justifying the search for new treatments. Some members of the iron-based…”
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Current therapeutic approaches to diffuse grade II and III gliomas by Picca, Alberto, Berzero, Giulia, Sanson, Marc

“…The 2016 WHO classification of Tumors of the Central Nervous System brought major conceptual and practical changes in the classification of diffuse gliomas, by…”
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Genome-wide association study identifies multiple susceptibility loci for glioma by Kinnersley, Ben, Labussière, Marianne, Holroyd, Amy, Di Stefano, Anna-Luisa, Broderick, Peter, Vijayakrishnan, Jayaram, Mokhtari, Karima, Delattre, Jean-Yves, Gousias, Konstantinos, Schramm, Johannes, Schoemaker, Minouk J., Fleming, Sarah J., Herms, Stefan, Heilmann, Stefanie, Schreiber, Stefan, Wichmann, Heinz-Erich, Nöthen, Markus M., Swerdlow, Anthony, Lathrop, Mark, Simon, Matthias, Bondy, Melissa, Sanson, Marc, Houlston, Richard S.

“…Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma…”
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CIC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas by Gleize, Vincent, Alentorn, Agusti, Connen de Kérillis, Léa, Labussière, Marianne, Nadaradjane, Aravidan A, Mundwiller, Emeline, Ottolenghi, Chris, Mangesius, Stephanie, Rahimian, Amithys, Ducray, François, Mokhtari, Karima, Villa, Chiara, Sanson, Marc

“…Objective CIC gene is frequently mutated in oligodendroglial tumors with 1p19q codeletion. However, clinical and biological impact remain poorly understood…”
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A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas by Rosenberg, Shai, Simeonova, Iva, Bielle, Franck, Verreault, Maite, Bance, Bertille, Le Roux, Isabelle, Daniau, Mailys, Nadaradjane, Arun, Gleize, Vincent, Paris, Sophie, Marie, Yannick, Giry, Marine, Polivka, Marc, Figarella-Branger, Dominique, Aubriot-Lorton, Marie-Hélène, Villa, Chiara, Vasiljevic, Alexandre, Lechapt-Zalcman, Emmanuèle, Kalamarides, Michel, Sharif, Ariane, Mokhtari, Karima, Pagnotta, Stefano Maria, Iavarone, Antonio, Lasorella, Anna, Huillard, Emmanuelle, Sanson, Marc

“…Chordoid glioma (ChG) is a characteristic, slow growing, and well-circumscribed diencephalic tumor, whose mutational landscape is unknown. Here we report the…”
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Imaging growth as a predictor of grade of malignancy and aggressiveness of IDH-mutant and 1p/19q-codeleted oligodendrogliomas in adults by Roux, Alexandre, Tauziede-Espariat, Arnault, Zanello, Marc, Peeters, Sophie, Zah-Bi, Gilles, Parraga, Eduardo, Edjlali, Myriam, Lechapt, Emmanuèle, Shor, Natalia, Bellu, Luisa, Berzero, Giulia, Dormont, Didier, Dezamis, Edouard, Chretien, Fabrice, Oppenheim, Catherine, Sanson, Marc, Varlet, Pascale, Capelle, Laurent, Dhermain, Frédéric, Pallud, Johan

“…Abstract Background We quantified the spontaneous imaging growth rate of oligodendrogliomas. We assessed whether (i) it discriminates between World Health…”
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MGMT Promoter Methylation Is Prognostic but Not Predictive for Outcome to Adjuvant PCV Chemotherapy in Anaplastic Oligodendroglial Tumors: A Report From EORTC Brain Tumor Group Study 26951 by van den Bent, Martin J, Dubbink, Hendrikus J, Sanson, Marc, van der Lee-Haarloo, Cathleen R, Hegi, Monika, Jeuken, Judith W M, Ibdaih, Ahmed, Brandes, Alba A, Taphoorn, Martin J B, Frenay, Marc, Lacombe, Denis, Gorlia, Thierry, Dinjens, Winand N M, Kros, Johan M

“…O6-methylguanine-methyltransferase (MGMT) promoter methylation has been shown to predict survival of patients with glioblastomas if temozolomide is added to…”
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