Search Results - "SANGRAR, W"

Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems by Sangrar, W, Shi, C, Mullins, G, LeBrun, D, Ingalls, B, Greer, P A

“…The non-receptor tyrosine kinase Fer belongs to a distinct subfamily of F-BAR domain containing kinases implicated in vesicular trafficking and signaling…”
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Fps/Fes and Fer non‐receptor protein‐tyrosine kinases regulate collagen‐ and ADP‐induced platelet aggregation by Senis, Y. A., Sangrar, W., Zirngibl, R. A., Craig, A. W. B., Lee, D. H., Greer, P. A.

“…Fps/Fes and Fer proto‐oncoproteins are structurally related non‐receptor protein‐tyrosine kinases implicated in signaling downstream from cytokines, growth…”
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Vascular defects in gain‐of‐function fps/fes transgenic mice correlate with PDGF‐ and VEGF‐induced activation of mutant Fps/Fes kinase in endothelial cells by Sangrar, W., Mewburn, J. D., Vincent, S. G., Fisher, J. T., Greer, P. A.

“…Background: Fps/Fes is a cytoplasmic tyrosine kinase that is abundantly expressed in the myeloid, endothelial, epithelial, neuronal and platelet lineages…”
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Hemostatic and hematological abnormalities in gain‐of‐function fps/fes transgenic mice are associated with the angiogenic phenotype by Sangrar, W., Senis, Y., Samis, J. A., Gao, Y., Richardson, M., Lee, D. H., Greer, P. A.

“…The Fps/Fes tyrosine kinase has been implicated in the regulation of hematopoiesis and inflammation. Mice expressing an activated variant of Fps/Fes (MFps)…”
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Characterization of the interaction of recombinant apolipoprotein(a) with modified fibrinogen surfaces and fibrin clots by Sangrar, W, Koschinsky, M L

“…Elevated levels of lipoprotein(a) [Lp(a)] in plasma are a significant risk factor for the development of atherosclerotic disease, a property which may arise…”
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An identity crisis for fps/fes : Oncogene or tumor suppressor? by SANGRAR, Waheed, ZIRGNIBL, Ralph A, YAN GAO, MULLER, William J, ZONGCHAO JIA, GREER, Peter A

“…Fps/Fes proteins were among the first members of the protein tyrosine kinase family to be characterized as dominant-acting oncoproteins. Addition of retroviral…”
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Vascular defects in gain‐of‐function fps/festransgenic mice correlate with PDGF‐ and VEGF‐induced activation of mutant Fps/Fes kinase in endothelial cells by Sangrar, W., Mewburn, J.D., Vincent, S.G., Fisher, J.T., Greer, P.A.

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Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival by Sangrar, Waheed, Gao, Yan, Bates, Barbara, Zirngibl, Ralph, Greer, Peter A.

“…A substantial body of evidence implicates the cytoplasmic protein tyrosine kinase Fps/Fes in regulation of myeloid differentiation and survival. In this study…”
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Binding of recombinant apolipoprotein(a) to extracellular matrix proteins by van der Hoek, Y Y, Sangrar, W, Côté, G P, Kastelein, J J, Koschinsky, M L

“…Elevated levels of lipoprotein(a), which consists of apolipoprotein(a) [apo(a)] covalently linked to a low-density lipoprotein-like moiety, is an independent…”
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The fps/fes proto-oncogene regulates hematopoietic lineage output by Sangrar, Waheed, Gao, Yan, Zirngibl, Ralph A, Scott, Michelle L, Greer, Peter A

“…The fps/fes proto-oncogene is abundantly expressed in myeloid cells, and the Fps/Fes cytoplasmic protein-tyrosine kinase is implicated in signaling downstream…”
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Apolipoprotein(a) Enhances Platelet Responses to the Thrombin Receptor-Activating Peptide SFLLRN by Rand, Margaret L, Sangrar, Waheed, Hancock, Mark A, Taylor, Desiree M, Marcovina, Santica M, Packham, Marian A, Koschinsky, Marlys L

“…Elevated levels of lipoprotein(a) [Lp(a)] are correlated with an increased risk of atherosclerotic disease. We examined the effect of recombinant…”
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The Solution Phase Interaction between Apolipoprotein(a) and Plasminogen Inhibits the Binding of Plasminogen to a Plasmin-Modified Fibrinogen Surface by Sangrar, Waheed, Gabel, Brent R, Boffa, Michael B, Walker, John B, Hancock, Mark A, Marcovina, Santica M, Horrevoets, Anton J. G, Nesheim, Michael E, Koschinsky, Marlys L

“…In the present study, we assessed the binding of recombinant forms of apolipoprotein(a) [r-apo(a)] to plasminogen. Apo(a)−plasminogen interactions were…”
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Antifibrinolytic Effect of Recombinant Apolipoprotein(a) in Vitro Is Primarily Due to Attenuation of tPA-Mediated Glu-Plasminogen Activation by Sangrar, Waheed, Bajzar, Laszlo, Nesheim, Michael E, Koschinsky, Marlys L

“…The effect of a 17-kringle form of recombinant apo(a) [r-apo(a)] on in vitro fibrin clot lysis was studied. In these assays, fibrin clots were formed in the…”
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Apolipoprotein(a) attenuates endogenous fibrinolysis in the rabbit jugular vein thrombosis model in vivo by BIEMOND, B. J, FRIEDERICH, P. W, KOSCHINSKY, M. L, LEVI, M, SANGRAR, W, XIA, J, BÜLLER, H. R, TEN CATE, J. W

“…In many case-control as well as epidemiological studies, increased lipoprotein(a) [Lp(a)] levels are considered to constitute an independent risk factor for…”
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2.P.128 Recombinant apolipoprotein(a) and lipoprotein(a) enhance platelet responses to a thrombin receptor-activating peptide by Koschinsky, M.L., Sangrar, W., Marcovina, S.M., Taylor, D.M., Packham, M.A., Rand, M.L.

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Expression and characterization of apolipoprotein(a) kringle IV types 1, 2 and 10 in mammalian cells by Sangrar, W, Marcovina, S M, Koschinsky, M L

“…We have designed expression constructs containing sequences corresponding to apolipoprotein(a) kringle IV types 1, 2 and 10 and used these constructs to…”
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