Search Results - "SANGHVI, Viraj R"
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The Cellular TAR RNA Binding Protein, TRBP, Promotes HIV-1 Replication Primarily by Inhibiting the Activation of Double-Stranded RNA-Dependent Kinase PKR
Published in Journal of Virology (01-12-2011)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Journal Article -
2
A re-examination of global suppression of RNA interference by HIV-1
Published in PloS one (28-02-2011)“…The nature of the interaction between replicating HIV-1 and the cellular RNAi pathway has been controversial, but it is clear that it can be complex and…”
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Journal Article -
3
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
Published in Cell (08-08-2019)“…The NRF2 transcription factor controls a cell stress program that is implicated in cancer and there is great interest in targeting NRF2 for therapy. We show…”
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Journal Article -
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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
Published in Nature (London) (04-09-2014)“…The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A RNA helicase-dependent mechanism of translational…”
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Journal Article -
5
Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation
Published in The Journal of biological chemistry (01-05-2024)“…The Hippo signaling is instrumental in regulating organ size, regeneration, and carcinogenesis. The cytoskeleton emerges as a primary Hippo signaling…”
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Journal Article -
6
A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes
Published in The Journal of immunology (1950) (15-09-2022)“…The activation of memory T cells is a very rapid and concerted cellular response that requires coordination between cellular processes in different…”
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Journal Article -
7
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules
Published in Cancer research (Chicago, Ill.) (15-04-2021)“…Pancreatic adenocarcinoma (PDAC) epitomizes a deadly cancer driven by abnormal KRAS signaling. Here, we show that the eIF4A RNA helicase is required for…”
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Journal Article -
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Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma
Published in Science translational medicine (28-06-2017)“…Follicular lymphoma (FL) is an incurable form of B cell lymphoma. Genomic studies have cataloged common genetic lesions in FL such as translocation t(14;18),…”
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Journal Article -
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NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy
Published in Cancers (05-02-2021)“…Inhibition of the eIF4A RNA helicase with silvestrol and related compounds is emerging as a powerful anti-cancer strategy. We find that a synthetic silvestrol…”
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Journal Article -
10
Frequent 4EBP1 Amplification Induces Synthetic Dependence on FGFR Signaling in Cancer
Published in Cancers (13-05-2022)“…The eIF4E translation initiation factor has oncogenic properties and concordantly, the inhibitory eIF4E-binding protein (4EBP1) is considered a tumor…”
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Journal Article -
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Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia
Published in Science signaling (18-11-2014)“…The posttranscriptional control of gene expression by microRNAs (miRNAs) is highly redundant, and compensatory effects limit the consequences of the…”
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Journal Article -
12
RNA silencing as a cellular defense against HIV‐1 infection: progress and issues
Published in The FASEB journal (01-10-2012)“…MicroRNAs (miRNAs) are known to have a role in gene regulation that is closely integrated into the pathways that control virtually all fundamental cell…”
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Journal Article -
13
SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma
Published in JCI insight (08-11-2024)“…End stage liver disease is marked by portal hypertension, systemic elevations in ammonia, and development of hepatocellular carcinoma (HCC). While these…”
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Journal Article -
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Expression of interfering RNAs from an HIV-1 Tat-inducible chimeric promoter
Published in Virus research (2011)“…The therapeutic value of antiviral interfering RNAs could be improved by technologies that limit their expression to the infected cell population. The HIV-1…”
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Journal Article -
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Polycistronic expression of interfering RNAs from RNA polymerase III promoters
Published in Methods in molecular biology (Clifton, N.J.) (2012)“…In many RNA silencing applications, there is a benefit to expressing multiple interfering RNAs simultaneously. This can be achieved by using a single RNA…”
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Journal Article -
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Abstract 878: Frequent 4EBP1 amplification induces synthetic dependence on FGFR signaling in cancer
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…The eIF4E translation initiation factor has oncogenic properties and concordantly, the inhibitory eIF4E-binding protein (4EBP1) is considered a tumor…”
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Journal Article -
17
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
Published in Nature (London) (04-09-2014)Get full text
Journal Article -
18
Interactions between HIV-1 and host cell RNAi pathways and the characterization of a conditional promoter for use in RNAi-based anti-HIV-1 therapeutics
Published 01-01-2011“…RNA interference is an evolutionarily conserved mechanism of gene regulation with a role in antiviral defense in invertebrates. It has been of interest to…”
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Dissertation -
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Interactions between HIV-1 and host cell RNAi pathways and the characterization of a conditional promoter for use in RNAi-based anti-HIV-1 therapeutics
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Dissertation