Search Results - "SANDS, SCOTT"

The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study by Azarbarzin, Ali, Sands, Scott A, Stone, Katie L, Taranto-Montemurro, Luigi, Messineo, Ludovico, Terrill, Philip I, Ancoli-Israel, Sonia, Ensrud, Kristine, Purcell, Shaun, White, David P, Redline, Susan, Wellman, Andrew

“…Abstract Aims Apnoea–hypopnoea index (AHI), the universal clinical metric of sleep apnoea severity, poorly predicts the adverse outcomes of sleep apnoea,…”
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The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial by Taranto-Montemurro, Luigi, Messineo, Ludovico, Sands, Scott A, Azarbarzin, Ali, Marques, Melania, Edwards, Bradley A, Eckert, Danny J, White, David P, Wellman, Andrew

“…There is currently no effective pharmacological treatment for obstructive sleep apnea (OSA). Recent investigations indicate that drugs with noradrenergic and…”
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More Than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea by Edwards, Bradley A, Redline, Susan, Sands, Scott A, Owens, Robert L

“…Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined by the apnea-hypopnea index (AHI). Continuous positive airway…”
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The Sleep Apnea-Specific Hypoxic Burden Predicts Incident Heart Failure by Azarbarzin, Ali, Sands, Scott A., Taranto-Montemurro, Luigi, Vena, Daniel, Sofer, Tamar, Kim, Sang-Wook, Stone, Katie L., White, David P., Wellman, Andrew, Redline, Susan

“…Heart failure (HF) is a leading cause of morbidity and mortality and although it is linked to sleep apnea, which physiological stressors most strongly…”
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Pro: can physiological risk factors for obstructive sleep apnea be determined by analysis of data obtained from routine polysomnography? by Sands, Scott A, Edwards, Bradley A

“…Key words: pathophysiology; endotypes; precision medicine…”
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Effects of the Combination of Atomoxetine and Oxybutynin on OSA Endotypic Traits by Taranto-Montemurro, Luigi, Messineo, Ludovico, Azarbarzin, Ali, Vena, Daniel, Hess, Lauren B., Calianese, Nicole A., White, David P., Wellman, Andrew, Sands, Scott A.

“…We recently showed that administration of the combination of the noradrenergic drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep…”
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Phenotyping Pharyngeal Pathophysiology using Polysomnography in Patients with Obstructive Sleep Apnea by Sands, Scott A, Edwards, Bradley A, Terrill, Philip I, Taranto-Montemurro, Luigi, Azarbarzin, Ali, Marques, Melania, Hess, Lauren B, White, David P, Wellman, Andrew

“…Therapies for obstructive sleep apnea (OSA) could be administered on the basis of a patient's own phenotypic causes ("traits") if a clinically applicable…”
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Pathogenesis of central and complex sleep apnoea by Orr, Jeremy E., Malhotra, Atul, Sands, Scott A.

“…ABSTRACT Central sleep apnoea (CSA) – the temporary absence or diminution of ventilatory effort during sleep – is seen in a variety of forms including periodic…”
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Apnea-Hypopnea Event Duration Predicts Mortality in Men and Women in the Sleep Heart Health Study by Butler, Matthew P, Emch, Jeffery T, Rueschman, Michael, Sands, Scott A, Shea, Steven A, Wellman, Andrew, Redline, Susan

“…Obstructive sleep apnea is a risk factor for mortality, but its diagnostic metric-the apnea-hypopnea index-is a poor risk predictor. The apnea-hypopnea index…”
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Hypoxic burden captures sleep apnoea-specific nocturnal hypoxaemia by Azarbarzin, Ali, Sands, Scott A, Taranto-Montemurro, Luigi, Redline, Susan, Wellman, Andrew

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Reboxetine Plus Oxybutynin for OSA Treatment: A 1-Week, Randomized, Placebo-Controlled, Double-Blind Crossover Trial by Perger, Elisa, Taranto Montemurro, Luigi, Rosa, Debora, Vicini, Stefano, Marconi, Mariapaola, Zanotti, Lucia, Meriggi, Paolo, Azarbarzin, Ali, Sands, Scott A, Wellman, Andrew, Lombardi, Carolina, Parati, Gianfranco

“…The recent discovery that a combination of noradrenergic and antimuscarinic drugs improved upper airway muscle function during sleep and reduced OSA severity…”
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The Sleep Apnea-specific Pulse Rate Response Predicts Cardiovascular Morbidity and Mortality by Azarbarzin, Ali, Sands, Scott A, Younes, Magdy, Taranto-Montemurro, Luigi, Sofer, Tamar, Vena, Daniel, Alex, Raichel M, Kim, Sang-Wook, Gottlieb, Daniel J, White, David P, Redline, Susan, Wellman, Andrew

“…Randomized controlled trials have been unable to detect a cardiovascular benefit of continuous positive airway pressure (CPAP) in unselected patients with…”
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Reply to: Heart Rate Response in Obstructive Sleep Apnea: A Clue to Reveal Cardiovascular Benefit from Continuous Positive Airway Pressure? by Azarbarzin, Ali, Zinchuk, Andrey, Peker, Yüksel, Sands, Scott A

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A Detailed Mechanistic Understanding of Positional and Nonpositional OSA: What Side Are You On? by Edwards, Bradley A., Joosten, Simon A., Sands, Scott A.

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Hypoxia and Sleep-disordered Breathing: Friend or Foe? by Eckert, Danny J, Sands, Scott A

“…Eckert and Sands discuss the proof-of-concept physiology study by G.S. Panza and colleagues on hypoxia and sleep-disordered breathing. The rationale for the…”
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Quantifying the Arousal Threshold Using Polysomnography in Obstructive Sleep Apnea by Sands, Scott A, Terrill, Philip I, Edwards, Bradley A, Taranto Montemurro, Luigi, Azarbarzin, Ali, Marques, Melania, de Melo, Camila M, Loring, Stephen H, Butler, James P, White, David P, Wellman, Andrew

“…Abstract Study Objectives Precision medicine for obstructive sleep apnea (OSA) requires noninvasive estimates of each patient’s pathophysiological “traits.”…”
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Different antimuscarinics when combined with atomoxetine have differential effects on obstructive sleep apnea severity by Aishah, Atqiya, Lim, Richard, Sands, Scott A, Taranto-Montemurro, Luigi, Wellman, Andrew, Carberry, Jayne C, Eckert, Danny J

“…The combination of the noradrenergic agent atomoxetine plus the antimuscarinic oxybutynin has recently been shown to improve upper airway physiology and reduce…”
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Upper-Airway Collapsibility and Loop Gain Predict the Response to Oral Appliance Therapy in Patients with Obstructive Sleep Apnea by Edwards, Bradley A, Andara, Christopher, Landry, Shane, Sands, Scott A, Joosten, Simon A, Owens, Robert L, White, David P, Hamilton, Garun S, Wellman, Andrew

“…Oral appliances (OAs) are commonly used as an alternative treatment to continuous positive airway pressure for patients with obstructive sleep apnea (OSA)…”
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Endotypic Mechanisms of Successful Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea by Op de Beeck, Sara, Wellman, Andrew, Dieltjens, Marijke, Strohl, Kingman P, Willemen, Marc, Van de Heyning, Paul H, Verbraecken, Johan A, Vanderveken, Olivier M, Sands, Scott A

“…Approximately one-third of patients with obstructive sleep apnea (OSA) treated with hypoglossal nerve stimulation (HGNS) therapy are incomplete responders,…”
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Ventilatory Drive Withdrawal Rather Than Reduced Genioglossus Compensation as a Mechanism of Obstructive Sleep Apnea in REM Sleep by Messineo, Ludovico, Eckert, Danny J, Taranto-Montemurro, Luigi, Vena, Daniel, Azarbarzin, Ali, Hess, Lauren B, Calianese, Nicole, White, David P, Wellman, Andrew, Gell, Laura, Sands, Scott A

“…REM sleep is associated with reduced ventilation and greater obstructive sleep apnea (OSA) severity than non-REM (nREM) sleep for reasons that have not been…”
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