Search Results - "SANDROCK, A. W"

MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS by MILLER, D. H, SOON, D, KAPPOS, L, HUTCHINSON, M, HAVRDOVA, E, LUBLIN, F. D, GIOVANNONI, G, WAJGT, A, RUDICK, R, LYNN, F, PANZARA, M. A, SANDROCK, A. W, FERNANDO, K. T, MACMANUS, D. G, BARKER, G. J, YOUSRY, T. A, FISHER, E, O'CONNOR, P. W, PHILLIPS, J. T, POLMAN, C. H

“…In a 2-year, placebo-controlled trial (the Natalizumab Safety and Efficacy in Relapsing Remitting Multiple Sclerosis [AFFIRM] study), involving 942 patients…”
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GLANCE : Results of a phase 2, randomized, double-blind, placebo-controlled study by GOODMAN, A. D, ROSSMAN, H, PANZARA, M. A, SANDROCK, A. W, BAR-OR, A, MILLER, A, MILLER, D. H, SCHMIERER, K, LUBLIN, F, KHAN, O, BORMANN, N. M, YANG, M

“…To evaluate the safety and tolerability of natalizumab when added to glatiramer acetate (GA) in patients with relapsing multiple sclerosis. The primary outcome…”
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Contrast letter acuity as a visual component for the Multiple Sclerosis Functional Composite by BALCER, L. J, BAIER, M. L, HEIDENREICH, F. R, JACOBS, D. A, MARKOWITZ, C. E, STUART, W. H, YING, G.-S, GALETTA, S. L, MAGUIRE, M. G, CUTTER, G. R, COHEN, J. A, KOOIJMANS, M. F, SANDROCK, A. W, NANO-SCHIAVI, M. L, PFOHL, D. C, MILLS, M, BOWEN, J, FORD, C

“…Visual dysfunction is one of the most common causes of disability in multiple sclerosis (MS). The Multiple Sclerosis Functional Composite (MSFC), a new…”
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Assessing disability progression with the Multiple Sclerosis Functional Composite by Rudick, RA, Polman, CH, Cohen, JA, Walton, MK, Miller, AE, Confavreux, C, Lublin, FD, Hutchinson, M, O’Connor, PW, Schwid, SR, Balcer, LJ, Lynn, F, Panzara, MA, Sandrock, AW

“…Background The initial Multiple Sclerosis Functional Composite (MSFC) proposal was a three-part composite of quantitative measures of ambulation, upper…”
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Maintenance of Acetylcholine Receptor Number by Neuregulins at the Neuromuscular Junction in Vivo by Sandrock, Alfred W., Dryer, Stuart E., Rosen, Kenneth M., Gozani, Shai N., Kramer, Rainer, Theill, Lars E., Fischbach, Gerald D.

“…ARIA (for acetylcholine receptor-inducing activity), a protein purified on the basis of its ability to stimulate acetylcholine receptor (AChR) synthesis in…”
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Estimating long-term effects of disease-modifying drug therapy in multiple sclerosis patients by Rudick, R A, Cutter, G R, Baier, M, Weinstock-Guttman, B, Mass, M K, Fisher, E, Miller, D M, Sandrock, A W

“…Two methods were used to estimate the long-term impact of disease-modifying drug therapy (DMDT) in patients with relapsing multiple sclerosis (MS) who…”
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Infusion-related hypersensitivity reactions during natalizumab treatment by PHILLIPS, J. T, O'CONNOR, P. W, LYNN, F, PANZARA, M. A, SANDROCK, A. W, HAVRDOVA, E, HUTCHINSON, M, KAPPOS, L, MILLER, D. H, POLMAN, C. H, LUBLIN, F. D, GIOVANNONI, G, WAJGT, A

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Gender effects on intramuscular interferon beta-1a in relapsing–remitting multiple sclerosis: analysis of 1406 patients by Rudick, RA, Kappos, L, Kinkel, R, Clanet, M, Phillips, JT, Herndon, RM, Sandrock, AW, Munschauer, FE

“…Background: We aimed to evaluate effects of gender on efficacy and safety of intramuscular (IM) interferon beta (IFNβ)-1a in patients with relapsing–remitting…”
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Proof of concept studies for tissue-protective agents in multiple sclerosis by Mehta, LR, Schwid, SR, Arnold, DL, Cutter, GR, Aradhye, S, Balcer, LJ, Calabresi, PA, Cohen, JA, Cole, PE, Glanzman, R, Goelz, S, Inglese, M, Kapoor, R, Kappos, L, Kreitman, R, Lublin, FD, Mann, A, Marrie, RA, O'Looney, P, Polman, CH, Ravina, BM, Reingold, SC, Richert, JR, Sandrock, AW, Waubant, E

“…Background There is considerable interest in tissue-protective treatments for multiple sclerosis (MS). Methods and Objectives We convened a group of MS…”
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ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses by Sandrock, AW, Jr, Goodearl, AD, Yin, QW, Chang, D, Fischbach, GD

“…Skeletal muscle ACh receptors (AChRs) accumulate at neuromuscular junctions (nmjs) at least partly because of the selective induction of AChR subunit genes in…”
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Benefit of interferon β-1a on MSFC progression in secondary progressive MS by COHEN, J. A, CUTTER, G. R, TSAO, E. C, WHITAKER, J. N, FISCHER, J. S, GOODMAN, A. D, HEIDENREICH, F. R, KOOIJMANS, M. F, SANDROCK, A. W, RUDICK, R. A, SIMON, J. H, SIMONIAN, N. A

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A Randomized, Placebo-Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis by Polman, Chris H, O'Connor, Paul W, Havrdova, Eva, Hutchinson, Michael, Kappos, Ludwig, Miller, David H, Phillips, J. Theodore, Lublin, Fred D, Giovannoni, Gavin, Wajgt, Andrzej, Toal, Martin, Lynn, Frances, Panzara, Michael A, Sandrock, Alfred W

“…This placebo-controlled, randomized trial of patients with relapsing multiple sclerosis demonstrated benefits of natalizumab (an α 4 integrin antagonist) in…”
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Merosin Promotes Neurite Growth and Schwann Cell Migration in Vitro and Nerve Regeneration in Vivo: Evidence Using an Antibody to Merosin, ARM-1 by Anton, Eva S., Sandrock, Alfred W., Matthew, William D.

“…Monoclonal antibodies that block the cellular function(s) of specific antigens can provide valuable probes for in vitro and in vivo bioassays. With the goal of…”
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ARIA Is Concentrated in the Synaptic Basal Lamina of the Developing Chick Neuromuscular Junction by Andrew D. J. Goodearl, Yee, Ann G., Sandrock, Alfred W., Corfas, Gabriel, Fischbach, Gerald D.

“…ARIA is a member of a family of polypeptide growth and differentiation factors that also includes glial growth factor (GGF), neu differentiation factor, and…”
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A randomized, double-blind, dose-comparison study of weekly interferon β-1a in relapsing MS by CLANET, M, RADUE, E. W, KAPPOS, L, HARTUNG, H. P, HOHLFELD, R, SANDBERG-WOLLHEIM, M, KOOIJMANS-COUTINHO, M. F, TSAO, E. C, SANDROCK, A. W

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Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis by Jacobs, Lawrence D, Beck, Roy W, Simon, Jack H, Kinkel, R. Phillip, Brownscheidle, Carol M, Murray, Thomas J, Simonian, Nancy A, Slasor, Peter J, Sandrock, Alfred W

“…Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system that most commonly affects women, with an onset typically…”
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Benefit of interferon beta-1a on MSFC progression in secondary progressive MS by Cohen, J A, Cutter, G R, Fischer, J S, Goodman, A D, Heidenreich, F R, Kooijmans, M F, Sandrock, A W, Rudick, R A, Simon, J H, Simonian, N A, Tsao, E C, Whitaker, J N

“…Interferon beta-1a (IFNbeta-1a, Avonex) is efficacious in relapsing forms of MS. Studies of other IFNbeta preparations in secondary progressive MS (SPMS)…”
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A randomized, double-blind, dose-comparison study of weekly interferon beta-1a in relapsing MS by Clanet, M, Radue, E W, Kappos, L, Hartung, H P, Hohlfeld, R, Sandberg-Wollheim, M, Kooijmans-Coutinho, M F, Tsao, E C, Sandrock, A W

“…Interferon beta-1a (IFNbeta-1a; Avonex) is effective for the treatment of relapsing MS; however, the optimal dose of IFNbeta-1a is not known. To determine…”
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Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies by Matthew, W D, Sandrock, Jr, A W

“…After immunization with a complex mixture of antigens, a considerable bias toward obtaining monoclonal antibodies to immunodominant determinants exists. By…”
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Identification of a Peripheral Nerve Neurite Growth-Promoting Activity by Development and Use of an in vitro Bioassay by Sandrock, Alfred W., Matthew, William D.

“…The effective regeneration of severed neuronal axons in the peripheral nerves of adult mammals may be explained by the presence of molecules in situ that…”
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