Search Results - "SANDERSON, J."

Confluence, synnovation, and depauperons in plant diversification by Donoghue, Michael J., Sanderson, Michael J.

“…We review the empirical phylogenetic literature on plant diversification, highlighting challenges in separating the effects of speciation and extinction, in…”
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Effects of Neonicotinoid Pesticides on Promoter-Specific Aromatase (CYP19) Expression in Hs578t Breast Cancer Cells and the Role of the VEGF Pathway by Caron-Beaudoin, Élyse, Viau, Rachel, Sanderson, J Thomas

“…Aromatase (CYP19) is a key enzyme in estrogens biosynthesis. In the mammary gland, gene is expressed at low levels under the regulation of its I.4 promoter. In…”
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Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach by Sanderson, Michael J

“…Rates of molecular evolution vary widely between lineages, but quantification of how rates change has proven difficult. Recently proposed estimation procedures…”
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The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals by Sanderson, J Thomas

“…Various chemicals found in the human and wildlife environments have the potential to disrupt endocrine functions in exposed organisms. Increasingly, the…”
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Store‐operated calcium entry is required for sustained contraction and Ca2+ oscillations of airway smooth muscle by Chen, Jun, Sanderson, Michael J.

“…Key points Airway hyper‐responsiveness in asthma is driven by excessive contraction of airway smooth muscle cells (ASMCs). Agonist‐induced Ca2+ oscillations…”
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Hippocampal synaptic plasticity, spatial memory and anxiety by Bannerman, David M., Sprengel, Rolf, Sanderson, David J., McHugh, Stephen B., Rawlins, J. Nicholas P., Monyer, Hannah, Seeburg, Peter H.

“…In this Perspective, Seeburg and colleagues re-examine the role of the hippocampus in spatial learning in light of recent findings. They also suggest that the…”
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Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity by Heer, Collin D., Sanderson, Daniel J., Voth, Lynden S., Alhammad, Yousef M.O., Schmidt, Mark S., Trammell, Samuel A.J., Perlman, Stanley, Cohen, Michael S., Fehr, Anthony R., Brenner, Charles

“…Poly(ADP-ribose) polymerase (PARP) superfamily members covalently link either a single ADP-ribose (ADPR) or a chain of ADPR units to proteins using NAD as the…”
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Heart failure with a normal ejection fraction by Sanderson, J E

“…Nearly half of patients with symptoms of heart failure are found to have a normal left ventricular (LV) ejection fraction. This has variously been labelled as…”
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Review article: lactose intolerance in clinical practice – myths and realities by LOMER, M. C. E., PARKES, G. C., SANDERSON, J. D.

“…Summary Background  Approximately 70% of the world population has hypolactasia, which often remains undiagnosed and has the potential to cause some morbidity…”
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Pharmacogenetic variants in the DPYD, TYMS, CDA and MTHFR genes are clinically significant predictors of fluoropyrimidine toxicity by Loganayagam, A, Arenas Hernandez, M, Corrigan, A, Fairbanks, L, Lewis, C M, Harper, P, Maisey, N, Ross, P, Sanderson, J D, Marinaki, A M

“…Background: Fluoropyrimidine drugs are extensively used for the treatment of solid cancers. However, adverse drug reactions are a major clinical problem, often…”
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Fluorescence microscopy by Sanderson, Michael J, Smith, Ian, Parker, Ian, Bootman, Martin D

“…Fluorescence microscopy is a major tool with which to monitor cell physiology. Although the concepts of fluorescence and its optical separation using filters…”
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Evaluating the effects on steroidogenesis of estragole and trans-anethole in a feto-placental co-culture model by Yancu, Debbie, Vaillancourt, Cathy, Sanderson, J. Thomas

“…In this study, we determined whether estragole and its isomer trans-anethole interfered with feto-placental steroidogenesis in a human co-culture model…”
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Serotonin-estrogen interactions: What can we learn from pregnancy? by Hudon Thibeault, Andrée-Anne, Sanderson, J. Thomas, Vaillancourt, Cathy

“…We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked…”
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Effects of Neonicotinoids on Promoter-Specific Expression and Activity of Aromatase (CYP19) in Human Adrenocortical Carcinoma (H295R) and Primary Umbilical Vein Endothelial (HUVEC) Cells by Caron-Beaudoin, Élyse, Denison, Michael S, Sanderson, J Thomas

“…The enzyme aromatase (CYP19; cytochrome P450 19) in humans undergoes highly tissue- and promoter-specific regulation. In hormone-dependent breast cancer,…”
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The use of a unique co-culture model of fetoplacental steroidogenesis as a screening tool for endocrine disruptors: The effects of neonicotinoids on aromatase activity and hormone production by Caron-Beaudoin, Elyse, Viau, Rachel, Hudon-Thibeault, Andrée-Anne, Vaillancourt, Cathy, Sanderson, J. Thomas

“…Estrogen biosynthesis during pregnancy is dependent on the collaboration between the fetus producing the androgen precursors, and the placenta expressing the…”
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Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase by Laurent, Laetitia, Deroy, Kathy, St-Pierre, Joey, Côté, Francine, Sanderson, J. Thomas, Vaillancourt, Cathy

“…The role of placental serotonin has been an active topic of research notably because of its crucial role in brain development. However, which cell types…”
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r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock by SANDERSON, Michael J

“…Estimating divergence times and rates of substitution from sequence data is plagued by the problem of rate variation between lineages. R8s version 1.5 is a…”
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Intercellular Ca2+ Waves: Mechanisms and Function by Leybaert, Luc, Sanderson, Michael J.

“…Intercellular calcium (Ca 2+ ) waves (ICWs) represent the propagation of increases in intracellular Ca 2+ through a syncytium of cells and appear to be a…”
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On the dynamical structure of calcium oscillations by Sneyd, James, Han, Jung Min, Wang, Liwei, Chen, Jun, Yang, Xueshan, Tanimura, Akihiko, Sanderson, Michael J., Kirk, Vivien, Yule, David I.

“…Oscillations in the concentration of free cytosolic Ca2+ are an important and ubiquitous control mechanism in many cell types. It is thus correspondingly…”
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A General Model to Explain Repeated Turnovers of Sex Determination in the Salicaceae by Yang, Wenlu, Wang, Deyan, Li, Yiling, Zhang, Zhiyang, Tong, Shaofei, Li, Mengmeng, Zhang, Xu, Zhang, Lei, Ren, Liwen, Ma, Xinzhi, Zhou, Ran, Sanderson, Brian J, Keefover-Ring, Ken, Yin, Tongming, Smart, Lawrence B, Liu, Jianquan, DiFazio, Stephen P, Olson, Matthew, Ma, Tao

“…Abstract Dioecy, the presence of separate sexes on distinct individuals, has evolved repeatedly in multiple plant lineages. However, the specific mechanisms by…”
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