Search Results - "SANDER, Maike"

Pancreas Organogenesis: From Lineage Determination to Morphogenesis by Shih, Hung Ping, Wang, Allen, Sander, Maike

“…The pancreas is an essential organ for proper nutrient metabolism and has both endocrine and exocrine function. In the past two decades, knowledge of how the…”
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A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus by Wang, Gaowei, Sander, Maike

“…Pancreatic β-cell dysfunction contributes to type 2 diabetes mellitus (T2DM) pathogenesis. However, human islet studies have revealed few consistent molecular…”
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Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells by Taylor, Brandon L., Liu, Fen-Fen, Sander, Maike

“…Recently, loss of beta-cell-specific traits has been proposed as an early cause of beta cell failure in diabetes. However, the molecular mechanisms that…”
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Epigenetics and Epigenomics: Implications for Diabetes and Obesity by Rosen, Evan D, Kaestner, Klaus H, Natarajan, Rama, Patti, Mary-Elizabeth, Sallari, Richard, Sander, Maike, Susztak, Katalin

“…The American Diabetes Association convened a research symposium, "Epigenetics and Epigenomics: Implications for Diabetes and Obesity" on 17-19 November 2017…”
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Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma by Chen, Jingyu, Debebe, Anketse, Zeng, Ni, Kopp, Janel, He, Lina, Sander, Maike, Stiles, Bangyan L.

“…SOX9 (Sex-determining region Y Box 9) is a well-characterized transcription factor that is a marker for progenitor cells in various tissues. In the liver,…”
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Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors by Geusz, Ryan J., Wang, Allen, Lam, Dieter K., Vinckier, Nicholas K., Alysandratos, Konstantinos-Dionysios, Roberts, David A., Wang, Jinzhao, Kefalopoulou, Samy, Ramirez, Araceli, Qiu, Yunjiang, Chiou, Joshua, Gaulton, Kyle J., Ren, Bing, Kotton, Darrell N., Sander, Maike

“…FOXA pioneer transcription factors (TFs) associate with primed enhancers in endodermal organ precursors. Using a human stem cell model of pancreas…”
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Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk by Chiou, Joshua, Zeng, Chun, Cheng, Zhang, Han, Jee Yun, Schlichting, Michael, Miller, Michael, Mendez, Robert, Huang, Serina, Wang, Jinzhao, Sui, Yinghui, Deogaygay, Allison, Okino, Mei-Lin, Qiu, Yunjiang, Sun, Ying, Kudtarkar, Parul, Fang, Rongxin, Preissl, Sebastian, Sander, Maike, Gorkin, David U., Gaulton, Kyle J.

“…Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) creates new opportunities to dissect cell type–specific mechanisms of…”
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Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk by Greenwald, William W., Chiou, Joshua, Yan, Jian, Qiu, Yunjiang, Dai, Ning, Wang, Allen, Nariai, Naoki, Aylward, Anthony, Han, Jee Yun, Kadakia, Nikita, Regue, Laura, Okino, Mei-Lin, Drees, Frauke, Kramer, Dana, Vinckier, Nicholas, Minichiello, Liliana, Gorkin, David, Avruch, Joseph, Frazer, Kelly A., Sander, Maike, Ren, Bing, Gaulton, Kyle J.

“…Genetic variants affecting pancreatic islet enhancers are central to T2D risk, but the gene targets of islet enhancer activity are largely unknown. We generate…”
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Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma by Kopp, Janel L., von Figura, Guido, Mayes, Erin, Liu, Fen-Fen, Dubois, Claire L., Morris, John P., Pan, Fong Cheng, Akiyama, Haruhiko, Wright, Christopher V.E., Jensen, Kristin, Hebrok, Matthias, Sander, Maike

“…Tumors are largely classified by histologic appearance, yet morphologic features do not necessarily predict cellular origin. To determine the origin of…”
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ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis by Shih, Hung Ping, Panlasigui, Devin, Cirulli, Vincenzo, Sander, Maike

“…During pancreas development, epithelial buds undergo branching morphogenesis to form an exocrine and endocrine gland. Proper morphogenesis is necessary for…”
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Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors by De Vas, Matias G, Kopp, Janel L, Heliot, Claire, Sander, Maike, Cereghini, Silvia, Haumaitre, Cécile

“…Heterozygous mutations in the human HNF1B gene are associated with maturity-onset diabetes of the young type 5 (MODY5) and pancreas hypoplasia. In mouse, Hnf1b…”
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Sox9 plays multiple roles in the lung epithelium during branching morphogenesis by Rockich, Briana E, Hrycaj, Steven M, Shih, Hung Ping, Nagy, Melinda S, Ferguson, Michael A H, Kopp, Janel L, Sander, Maike, Wellik, Deneen M, Spence, Jason R

“…Lung branching morphogenesis is a highly orchestrated process that gives rise to the complex network of gas-exchanging units in the adult lung. Intricate…”
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LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development by Vinckier, Nicholas K., Patel, Nisha A., Geusz, Ryan J., Wang, Allen, Wang, Jinzhao, Matta, Ileana, Harrington, Austin R., Wortham, Matthew, Wetton, Nichole, Wang, Jianxun, Jhala, Ulupi S., Rosenfeld, Michael G., Benner, Christopher W., Shih, Hung-Ping, Sander, Maike

“…Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the…”
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Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors by Schaffer, Ashleigh E., Freude, Kristine K., Nelson, Shelley B., Sander, Maike

“…The molecular mechanisms that underlie cell lineage diversification of multipotent progenitors in the pancreas are virtually unknown. Here we show that the…”
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Epigenetic Priming of Enhancers Predicts Developmental Competence of hESC-Derived Endodermal Lineage Intermediates by Wang, Allen, Yue, Feng, Li, Yan, Xie, Ruiyu, Harper, Thomas, Patel, Nisha A., Muth, Kayla, Palmer, Jeffrey, Qiu, Yunjiang, Wang, Jinzhao, Lam, Dieter K., Raum, Jeffrey C., Stoffers, Doris A., Ren, Bing, Sander, Maike

“…Embryonic development relies on the capacity of progenitor cells to appropriately respond to inductive cues, a cellular property known as developmental…”
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In vivo-mimicking microfluidic perfusion culture of pancreatic islet spheroids by Jun, Yesl, Lee, JaeSeo, Choi, Seongkyun, Yang, Ji Hun, Sander, Maike, Chung, Seok, Lee, Sang-Hoon

“…Native pancreatic islets interact with neighboring cells by establishing three-dimensional (3D) structures, and are surrounded by perfusion at an interstitial…”
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Inferring time series chromatin states for promoter-enhancer pairs based on Hi-C data by Miko, Henriette, Qiu, Yunjiang, Gaertner, Bjoern, Sander, Maike, Ohler, Uwe

“…Co-localized combinations of histone modifications ("chromatin states") have been shown to correlate with promoter and enhancer activity. Changes in chromatin…”
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A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation by Shih, Hung Ping, Kopp, Janel L, Sandhu, Manbir, Dubois, Claire L, Seymour, Philip A, Grapin-Botton, Anne, Sander, Maike

“…In the pancreas, Notch signaling is thought to prevent cell differentiation, thereby maintaining progenitors in an undifferentiated state. Here, we show that…”
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Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration by Barrionuevo, Francisco J, Hurtado, Alicia, Kim, Gwang-Jin, Real, Francisca M, Bakkali, Mohammed, Kopp, Janel L, Sander, Maike, Scherer, Gerd, Burgos, Miguel, Jiménez, Rafael

“…The new concept of mammalian sex maintenance establishes that particular key genes must remain active in the differentiated gonads to avoid genetic sex…”
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Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice by Kopp, Janel L., Dubois, Claire L., Schaeffer, David F., Samani, Atefeh, Taghizadeh, Farnaz, Cowan, Robert W., Rhim, Andrew D., Stiles, Bangyan L., Valasek, Mark, Sander, Maike

“…Intraductal papillary mucinous neoplasias (IPMNs) are precancerous cystic lesions that can develop into pancreatic ductal adenocarcinomas (PDACs). These large…”
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